MсKee's Pathology of the Skin V.2 P.3

196 Pages·106.556 MB·English

by  Calonje E., Lazar A.

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9
|FOURTH EDITION VOLUME ONE
MCKEE’S
PATHOLOGY
SKIN
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SAUNDERS
ELSEVIER
M K
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Pathology

Skin
of the
Commissioning Editor: William R. Schmitt
Development Editors: Louise Cook & Rachael Harrison
Editorial Assistant: Kirsten Lowson
Project Manager: Nancy Arnott
Design: Kirsteen Wright
Illustration Manager: Merlyn Harvey
Marketing Manager (USA): Tracie Pasker
IFourth Edition
M K
c ee’s
Pathology
Skin
of the
I
with Clinical Correlations
Volume 1
Eduardo Calonje Alexander Lazar
MD, DipRCPath MD, PhD
Director of Dermatopathology Associate Professor
Department of Dermatopathology Departments of Pathology and Dermatology
St John's Institute of Dermatology Sections of Dermatopathology and Sarcoma Pathology
St Thomas' Hospital Faculty, Sarcoma Research Center and Graduate School
London, UK of Biomedical Science
The University of Texas M.D. Anderson Cancer Center
Thomas Brenn
MD, PhD, FRCPath Houston, Texas, USA
Consultant Dermatopathologist and Honorary Senior
Editor-in-Chief
Lecturer
Department of Pathology Phillip H McKee
MD, FRCPath
Western General Hospital and The University
Formerly Associate Professor of Pathology and
of Edinburgh
Director, Division of Dermatopathology
Edinburgh, UK
Department of Surgical Pathology
Brigham and Women's Hospital and Harvard Medical
School
Boston, MA, USA
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LSEVIERI
ELSEVIER
SAUNDERS
SAUNDERS an imprint of Elsevier Limited
© 2012, Elsevier Limited All rights reserved.
First edition 1989
Second edition 1996
Third edition 2005
Fourth edition 2012
The right of Eduardo Calonje, Thomas Brenn, Alexander Lazar and Phillip H McKee to be identified as author
of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. No
part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical,
including photocopying, recording, or any information storage and retrieval system, without permission in
writing from the publisher. Details on how to seek permission, further information about the Publisher's
permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the
Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the
individual contributions contained in it are protected under copyright by the Publisher (other than as may be
noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our
understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any
information, methods, compounds, or experiments described herein. In using such information or methods they
should be mindful of their own safety and the safety of others, including parties for whom they have a professional
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With respect to any drug or pharmaceutical products identified, readers are advised to check the most current
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To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability
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British Library Cataloguing in Publication Data
McKee's Pathology of the Skin. – 4th ed.
1. Skin–Diseases. 2. Skin–Histopathology.
I. Pathology of the skin II. Calonje, Eduardo. III. McKee,
Phillip H. Pathology of the skin.
616.5'07-dc22
ISBN-13: 978 1 4160 5649 2
Working together to grow
libraries in developingcountries
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ELSEVIER BOOKAID SabreFoundation
International
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Contents
List of Contributors vii
Preface to the fourth edition x
Acknowledgements xi
Dedications xii
Glossary xiii
Volume 1
1 The structure and function of skin 1 11 Diseases of the oral mucosa 362
John A. McGrath Sook-Bin Woo
2 Specialized techniques in dermatopathology 32 12 Diseases of the anogenital skin 437
Pratistadevi A. Ramdial, Boris C. Bastian, John Goodlad, Eduardo Calonje, Sallie Neill, Chris Bunker,
John K. McGrath and Alexander Lazar Nick Francis, Alcides Chaux and Antonio C Cubilla
3 Disorders of keratinization 46 13 Degenerative and metabolic diseases 520
Dieter Metze Nooshin Brinster and Eduardo Calonje
4 Inherited and autoimmune subepidermal blistering 14 Cutaneous adverse reactions to drugs 590
diseases 99 Nooshin Brinster
5 Acantholytic disorders 151
15 Neutrophilic and eosinophilic
6 Spongiotic, psoriasiform and pustular dermatoses 631
dermatoses 180
16 Vascular diseases 658
7 Lichenoid and interface dermatitis 219
17 Idiopathic connective tissue
Wei-Lien Wang and Alexander Lazar
disorders 711
Bostjan Luzar and Eduardo Calonje
8 Superficial and deep perivascular inflammatory
dermatoses 259
18 Infectious diseases of the skin 760
9 Granulomatous, necrobiotic and perforating Wayne Grayson
dermatoses 281
10 Inflammatory diseases of the subcutaneous fat 326
Bostjan Luzar and Eduardo Calonje
Volume 2
19 Human immunodeficiency virus (HIV) 22 Diseases of the hair 967
and acquired immunodeficiency Rodrigo Restrepo and Eduardo Calonje
syndrome (AIDS)-associated cutaneous
diseases 896 23 Diseases of the nails 1051
Pratistadevi K. Ramdial and Wayne Grayson Josette Andre, Ursula Sass and Anne Theunis
20 Disorders of pigmentation 912 24 Tumors of the surface epithelium 1076
21 Diseases of collagen and elastic tissue 935 25 Melanocytic nevi 1150
Wei-Lien Wang and Alexander Lazar Bostjan Luzar, Boris C. Bastian and Eduardo Calonje
vi Contents
26 Melanoma 1221 30 Cutaneous metastases and Paget's disease
Boris C. Bastian and Alexander Lazar of the skin 1421
Doina Ivan, Alexander Lazar and Eduardo Calonje
27 Tumors of the conjunctiva 1268
Jacob Péer and Shahar Frenkel 31 Tumors of the hair follicle 1445
32 Tumors and related lesions of the sebaceous
28 Sentinel lymph node biopsies 1296
glands 1488
Alistair J. Cochran
33 Tumors of the sweat glands 1508
29 Cutaneous lymphoproliferative
34 Cutaneous cysts 1571
diseases and related
disorders 1311 35 Connective tissue tumors 1588
John Goodlad and Eduardo Calonje
Index I1
Chapter
List of Contributors
Josette André, MD Alistair J. Cochran, MD
Head of the Dermatology and Dermatopathology Department. Distinguished Professor of Pathology and Laboratory
CHU Saint-Pierre - CHU Brugmann Medicine and Surgery
Hôpital Universitaire des Enfants Reine Fabiola Department of Pathology and Laboratory Medicine
Université Libre de Bruxelles David Geffen School of Medicine at UCLA
Brussels, Belgium Los Angeles, CA, USA
Ch 23: Diseases of the nails with Ursula Sass and Anne Ch 28: Sentinel node biopsies
Theunis
Antonio C. Cubilla, MD
Boris C. Bastian, MD
Instituto de Patología e Investigación
Chairman, Department of Pathology
Asuncion, Paraguay
The James Ewing Alumni Chair
Ch 12: Diseases of the anogenital skin with Eduardo
Member, Human Oncology and Pathogenesis Program
Calonje, Sallie Neill, Chris Bunker, Nick Francis and Alcides
Memorial Sloan-Kettering Cancer Center
Chaux
Professor of Pathology
Weill Cornell Medical College
New York, NY, USA Nick Francis, FRCPath
Ch 2: Specialized techniques in dermatopathology with
Consultant Histopathologist
Pratistadevi K Ramdial, John Goodlad, John A. McGrath and
Imperial College Healthcare NHS trust
Alexander Lazar
Honorary Senior Lecturer
Ch 25: Melanocytic nevi with Eduardo Calonje
Imperial College Faculty of Medicine
Ch 26: Melanoma with Alexander Lazar
London, UK
Ch 12: Diseases of the anogenital skin with Eduardo
Nooshin K. Brinster, MD
Calonje, Sallie Neill, Chris Bunker, Alcides Chaux, Antonio C
Assistant Professor Cubilla
Department of Pathology and Dermatology
Director of Dermatopathology
Shahar Frenkel, MD, PhD
VCU Medical Center
Richmond, VA, USA Ocular Oncologist and Ophthalmic Pathologist
Ch 13: Degenerative and metabolic diseases Specialized Ocular Oncology Service
Ch 14: Cutaneous adverse reactions to drugs Ophthalmic Pathology Laboratory
Jerusalem, Israel
Chris Bunker, MA, MD, FRCP Lecturer in Ophthalmology
Department of Ophthalmology
Consultant Dermatologist
Hadassah – Hebrew University Medical Center
University College and Chelsea and Westminster Hospitals
Jerusalem, Israel
London;
Ch 27: Tumors of the conjunctiva with Jacob Pe'er
Professor of Dermatology
University College London
London, UK John Goodlad, MD, FRCPath
Ch 12: Diseases of the anogenital skin with Eduardo Calonje,
Consultant Haematopathologist and Honorary
Sallie Neill, Nick Francis, Alcides Chaux, Antonio C Cubilla
Senior Lecturer
Department of Pathology
Alcides Chaux, MD
Western General Hospital and University of Edinburgh
GU Research Fellow, Edinburgh, UK
Department of Pathology Ch 2: Specialized techniques in dermatopathology with
Johns Hopkins University School of Medicine Pratistadevi K Ramdial, Boris C. Bastian, John A. McGrath and
Baltimore, MD, USA Alexander Lazar
Ch 12: Diseases of the anogenital skin with Eduardo Calonje, Ch 29 Cutaneous lymphoproliferative diseases and related
Sallie Neill, Chris Bunker, Nick Francis, and Antonio C Cubilla disorders with Eduardo Calonje
viii List of Contributors
Wayne Grayson, MBChB, PhD, FCPath(SA) Sallie Neill, MB ChB, FRCP
Consultant Anatomical Pathologist and Dermatopathologist Consultant Dermatologist
AMPATH National Laboratories; Guys and St Thomas' NHS Trust
Honorary Associate Professor London, UK
School of Pathology Ch 12: Diseases of the anogenital skin with Eduardo Calonje,
University of the Witwatersrand, Johannesburg Chris Bunker, Nick Francis, Alcides Chaux, Antonio C Cubilla
Johannesburg, South Africa
Ch 18: Infectious diseases of the skin
Jacob Pe'er, MD
Ch 19: Human immunodeficiency virus (HIV) and
acquired immunodeficiency syndrome Professor and Chairman
(AIDS)-associated cutaneous diseases with Department of Ophthalmology
Pratistadevi K Ramdial Jonas Friedenwald Professor of Ophthalmic Research
Hadassah – Hebrew University Medical Center
Jerusalem, Israel
Doina Ivan, MD
Ch 27: Tumors of the conjunctiva with Shahar Frenkel
Assistant Professor
Departments of Pathology and Dermatology
Pratistadevi K. Ramdial, MBChB, FCPath(SA)
Section of Dermatopathology
The University of Texas M.D. Anderson Cancer Center Professor and Head
Houston, TX, USA Department of Anatomical Pathology
Ch 30: Cutaneous metastases and Paget's disease Nelson R. Mandela School of Medicine
of the skin with Alexander Lazar and Eduardo Calonje University of Kwazulu-Natal and the National Health
Laboratory Service
Durban, South Africa
Boštjan Luzar, MD, PhD
Ch 2: Specialized techniques in dermatopathology with
Professor of Pathology Boris C. Bastian, John Goodlad, John A. McGrath and
Consultant Pathologist Alexander Lazar
Institute of Pathology Ch 19: Human immunodeficiency virus (HIV) and acquired
Medical Faculty University of Ljubljana immunodeficiency syndrome (AIDS)-associated cutaneous
Ljubljana, Slovenia diseases with Wayne Grayson
Ch 10: Inflammatory diseases of the subcutaneous fat with
Eduardo Calonje
Rodrigo Restrepo, MD
Ch 17: Idiopathic connective tissue disorders with Eduardo
Calonje Director, Dermatopathology Fellowship Program
Universidad CES;
Professor of Dermatopathology
John A. McGrath, MD, FRCP
Universidad Pontificia Bolivariana;
Professor of Molecular Pathology Director, Laboratory of Pathology
St John's Institute of Dermatology Clinica Medellin
King's College London Medellin, Colombia
Guy's Hospital Ch 22: Diseases of the hair with Eduardo Calonje
London, UK
Ch 1: The structure and function of skin
Ursula Sass, MD
Ch 2: Specialized techniques in dermatopathology with
Pratistadevi K Ramdial, Boris C. Bastian, John Goodlad and Assistant Professor
Alexander Lazar Dermatology and Dermatopathology Department
CHU Saint-Pierre
Université Libre de Bruxelles
Dieter Metze, MD
Brussels, Belgium
Professor of Dermatology Ch 23: Diseases of the nails with Josette André and Anne
Director, Dermatopathology Unit Theunis
Department of Dermatology
University Hospital Münster
Münster, Germany
Ch 3: Disorders of keratinization
List of Contributors ix
Anne Theunis, MD Sook-Bin Woo, DMD, MMSc
Assistant Professor Associate Professor
Dermatopathology and Pathology Department Department of Oral Medicine, Infection and Immunity
CHU Saint-Pierre and Institut Bordet Harvard School of Dental Medicine, Boston, MA, USA;
Université Libre de Bruxelles Attending Dentist and Consultant Pathologist
Brussels, Belgium Brigham and Women's Hospital
Ch 23: Diseases of the nails with Josette André and Ursula Boston, MA, USA
Sass Co-Director
Center for Oral Pathology Strata Pathology Services Inc.
Wei-Lien Wang, MD Lexington, MA, USA
Ch 11: Diseases of the oral mucosa
Assistant Professor
Department of Pathology
Sections of Dermatopathology and Sarcoma Pathology
The University of Texas M.D. Anderson Cancer Center
Houston, TX, USA
Ch 7: Lichenoid and interface dermatoses with Alexander
Lazar
Ch 21: Diseases of collagen and elastic tissue with Alexander
Lazar