Middleton's Allergy: Principles and Practice E-Dition, 2-Volume Set

3702 Pages·2007·52.16 MB·English

by  N. Franklin Adkinson Jr. Jr. MD

I
II
III

MIDDLETON'S
ALLERGY
Principles & Practice

Sixth edition

With more than 683 illustrations and 35 color plates
Edited by
N. Franklin Adkinson Jr. MD
Professor of Medicine and Training Program Director,
Division of Allergy and Clinical Immunology,
The Johns Hopkins Asthma and Allergy Center,
The Hopkins Bayview Medical Campus,
Baltimore, Maryland
John W. Yunginger MD
Emeritus Consultant in Pediatrics and Internal Medicine (Allergy),
Mayo Clinic and Foundation,
Emeritus Professor of Pediatrics,
Mayo Medical School,
Rochester, Minnesota
William W. Busse MD
Charles E. Reed Professor of Medicine,
University of Wisconsin,
Hospital and Clinics,
Head, Allergy and Clinical Immunology,
Department of Medicine,
University of Wisconsin School of Medicine,
Madison, Wisconsin
Bruce S. Bochner MD
Professor of Medicine and Director,
Division of Allergy and Clinical Immunology,
The Johns Hopkins Asthma and Allergy Center,
The Hopkins Bayview Medical Campus,
Baltimore, Maryland
Stephen T. Holgate MD, DSc, FRCP, FMed Sci
MRC Clinical Professor of Immunopharmacology,
Southampton General Hospital School of Medicine,
University of Southampton,
Southampton, United Kingdom
F. Estelle R. Simons MD, FRCPC
Professor and Head,
Section of Allergy and Clinical Immunology,
Department of Pediatrics and Child Health,
University of Manitoba,
Winnipeg, Manitoba, Canada

http://avaxho.me/blogs/ChrisRedfield
IV

The Curtis Center
Independence Square West
Philadelphia, Pennsylvania 19106
MIDDLETON'S ALLERGY PRINCIPLES & PRACTICE, 6th EDITION 0-323-01425-9
Copyright © 2003, Mosby, Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any
information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Health Sciences
Rights Department in Philadelphia, PA, USA: phone: [phone], fax: [phone], e-mail: [email protected]. You may also complete
your request on-line via the Elsevier Science homepage (http://www.elsevier.com), by selecting ‘Customer Support’ and then ‘Obtaining Permissions’.
NOTICE
Medicine is an ever-changing field. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in
treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer
of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the
treating physician, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the
publisher nor the editors assume any liability for any injury and/or damage to persons or property arising from this publication.

Previous editions copyrighted 1978, 1983, 1988, 1993, 1998
International Standard Book Number 0-323-01425-9
Acquisitions Editor: Catherine Carroll
Developmental Editor: Jennifer Shreiner
Publishing Services Manager: Patricia Tannian
Senior Project Manager: Anne Altepeter
Book Design Manager: Gail Morey Hudson
Cover Design: Jen Brockett
Printed in the United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
V

Contributors

N. Franklin Adkinson Jr. MD
Professor of Medicine and Training Program Director,
Division of Allergy and Clinical Immunology,
The Johns Hopkins Asthma and Allergy Center,
The Hopkins Bayview Medical Campus,
Baltimore, Maryland, USA
Cheryl Adolphson MS
Senior Science Writer,
Department of Immunology,
Mayo Clinic and Foundation,
Rochester, Minnesota, USA
Rafeul Alam MD, PhD
Veda and Chauncey Ritter Chair in Immunology,
Professor and Director,
Division of Allergy and Immunology,
National Jewish Medical and Research Center,
Denver, Colorado, USA
Philip W. Askenase MD
Chief,
Section of Allergy and Clinical Immunology, Internal Medicine,
Yale University School of Medicine,
Attending Physician,
Yale–New Haven Medical Center,
New Haven, Connecticut, USA
Bharat Awsare MD
Fellow,
Division of Critical Care, Pulmonary, Allergic, and Immunologic Diseases,
Jefferson Medical College,
Thomas Jefferson University,
Philadelphia, Pennsylvania, USA
Claus Bachert MD, PhD
Professor of Surgery,
Ear, Nose, and Throat Department,
University Hospital Ghent,
Ghent, Belgium
Mark Ballow MD
Professor of Pediatrics,
State University of New York,
Buffalo School of Medicine and Biomedical Sciences,
Director,
Allergy/Clinical Immunology Fellowship Training Program
Chief,
Allergy, Clinical Immunology, and Pediatric Rheumatology Division,
Children's Hospital of Buffalo,
Buffalo, New York, USA
Peter J. Barnes DM, DSc, FRCP
Professor of Thoracic Medicine,
National Heart and Lung Institute,
Imperial College,
London, United Kingdom
Neal P. Barney MD
Associate Professor of Ophthalmology,
Ophthalmology Department,
University of Wisconsin,
Associate Professor of Medicine and Visual Sciences,
Ophthalmology and Visual Sciences Department,
University of Wisconsin Hospital and Clinics,
Madison, Wisconsin, USA
Vikas Batra MD
Fellow,
Division of Critical Care, Pulmonary, Allergic, and Immunologic Diseases,
Jefferson Medical College,
Thomas Jefferson University,
Philadelphia, Pennsylvania, USA
Bruce S. Bochner MD
Professor of Medicine and Director,
Division of Allergy and Clinical Immunology,
Department of Medicine,
Division of Allergy and Clinical Immunology,
The Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA
Mark Boguniewicz MD
Senior Faculty Member,
Department of Pediatrics,
National Jewish Medical and Research Center,
Denver, Colorado, USA
Larry Borish MD
Associate Professor of Medicine,
Asthma and Allergic Disease Center,
University of Virginia School of Medicine,
Charlottesville, Virginia, USA
Louis-Philipe Boulet MD, FRCPC, FCCP
Professor of Medicine,
Université Laval,
Respirologist,
Centre de Pneumologie,
Institut de Cardiologie et de Pneumologie de L'Université Laval,
Sainte-Foy, Quebec, Canada
Jean Bousquet MD, PhD
Professor of Respiratory Medicine,
Université Montpellier,
Professor,
CHU Montpellier,
Montpellier, France
William M.L. Bowerfind MD
Research Fellow,
Department of Medicine,
The Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA
VI
David H. Broide MD, ChB
Professor of Medicine,
Department of Medicine,
University of California—San Diego,
La Jolla, California, USA
Rebecca Hatcher Buckley MD
J. Buren Sidbury Professor of Pediatrics,
Department of Pediatrics and Immunology,
Duke University Medical Center,
Chief,
Division of Allergy and Immunology,
Department of Pediatrics,
Duke University Medical Center,
Durham, North Carolina, USA
Robert K. Bush MD
Professor of Medicine,
University of Wisconsin—Madison,
Chief of Allergy,
William S. Middleton VA Hospital,
Madison, Wisconsin, USA
William W. Busse MD
Professor of Medicine,
University of Wisconsin Hospital and Clinics,
Head,
Allergy and Clinical Immunology,
Department of Medicine,
University of Wisconsin School of Medicine,
Madison, Wisconsin
William J. Calhoun MD
Associate Professor of Medicine,
Division of Pulmonary, Allergy, and Critical Care Medicine,
University of Pittsburgh Medical Center,
Pittsburgh, Pennsylvania, USA
Lisa Cameron PhD
Postdoctoral Fellow,
Arizona Respiratory Center,
Functional Genomic Lab,
University of Arizona,
Tucson, Arizona, USA
Brendan J. Canning PhD
Associate Professor of Medicine,
Department of Medicine,
Division of Allergy and Clinical Immunology,
The Johns Hopkins University School of Medicine,
Baltimore, Maryland, USA
Margaretha L. Casselbrant MD, PhD
Professor of Otolaryngology,
University of Pittsburgh School of Medicine,
Director of Clinical Research and Education,
Department of Pediatric Otolaryngology,
Children's Hospital of Pittsburgh,
Pittsburgh, Pennsylvania, USA
Pota Christodoulopoulos MSc
Postdoctoral Fellow,
Meakins Christie Laboratories,
McGill University,
Montreal, Quebec, Canada
Martin K. Church M PHARM, PhD, DSc
Professor of Experimental Immunopharmacology,
Dermatopharmacology Unit,
University of Southampton,
Southampton, Hampshire, United Kingdom
Lauren Cohn MD
Assistant Professor,
Department of Internal Medicine,
Section of Pulmonary and Critical Care Medicine,
Yale University School of Medicine,
Attending Physician,