Middleton's Allergy 2-Volume Set: Principles and Practice

1896 Pages·2013·29.59 MB·English

by  N. Franklin Adkinson

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Middleton’s
ALLERGY
PRINCIPLES AND PRACTICE
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Middleton’s
ALLERGY
PRINCIPLES AND PRACTICE
E I G H T H E D I T I O N — V O L U M E 1
N. Franklin Adkinson, Jr., MD Stephen T. Holgate, MD,
Professor of Medicine DSc, FMedSci
Division of Allergy and Clinical Immunology
MRC Professor of Immunopharmacology
Department of Medicine
Clinical and Experimental Sciences
Johns Hopkins University School of Medicine
Faculty of Medicine
Baltimore, Maryland, USA
Southampton University and General Hospital
Southampton, United Kingdom
Bruce S. Bochner, MD
Professor of Medicine and Director Robert F. Lemanske, Jr., MD
Division of Allergy and Clinical Immunology
Professor of Pediatrics and Medicine
Department of Medicine
Head, Division of Pediatric Allergy,
Johns Hopkins University School of Medicine
Immunology, and Rheumatology
Baltimore, Maryland, USA
University of Wisconsin School of
Medicine and Public Health
A. Wesley Burks, MD
Madison, Wisconsin, USA
Professor and Chair, Pediatrics
Physician-in-Chief Robyn E. O’Hehir, FRACP,
North Carolina Children’s Hospital PhD, FRCPath
University of North Carolina at Chapel Hill
Professor and Director
Chapel Hill, North Carolina, USA
Department of Allergy, Immunology, and
Respiratory Medicine
William W. Busse, MD
Alfred Hospital and Monash University
Professor of Medicine
Melbourne, Victoria, Australia
Department of Medicine
Allergy, Pulmonary, and Critical
Care Medicine
University of Wisconsin School of
Medicine and Public Health
Madison, Wisconsin, USA
1600 John F. Kennedy Blvd.
Ste. 1800
Philadelphia, PA 19103-2899
MIDDLETON’S ALLERGY PRINCIPLES AND PRACTICE Volume 1 PN 9996092240
Eighth Edition Volume 2 PN 9996092305
Two-volume set ISBN: 978-0-323-08593-9
Copyright © 2014 by Saunders, an imprint of Elsevier Inc.
Copyright © 2009, 2003, 1998, 1993, 1988, 1983, 1978, by Mosby, an affiliate of Elsevier Inc.
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Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden
our understanding, changes in research methods, professional practices, or medical treatment may become
necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and
using any information, methods, compounds, or experiments described herein. In using such information
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Library of Congress Cataloging-in-Publication Data
Middleton’s allergy : principles and practice. —8th edition / N. Franklin Adkinson Jr. … [et al.].
p. ; cm.
Allergy
Includes bibliographical references and index.
ISBN 978-0-323-08593-9 (two-volume set : alk. paper)
I. Adkinson, N. Franklin, Jr. (Newton Franklin), 1943- II. Middleton, Elliott, Jr., 1925-1999.
III. Title: Allergy.
[DNLM: 1. Hypersensitivity. 2. Immunity. WD 300]
RC584
616.97—dc23
2013014886
Cover image adapted from Figure 21.2 in Pathophysiology of Allergic Inflammation by Peter J. Barnes.
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CONTENTS
Volume 1 16 Biology of Eosinophils 265
HIROHITO KITA | BRUCE S. BOCHNER
SECTION A
17 Biology of Neutrophils 280
Basic Sciences Underlying Allergy and
Immunology 1 KATHERINE J. BAINES | JODIE L. SIMPSON | PETER G. GIBSON
18 Biology of Monocytes and
1 Innate Immunity 2
Macrophages 292
ANDREW H. LIU | RICHARD B. JOHNSTON, JR. |
MATTHEW J. FENTON KIAN FAN CHUNG | IAN M. ADCOCK
2 Adaptive Immunity 20 19 Airway Epithelial Cells 302
JAVIER CHINEN | THOMAS A. FLEISHER | WILLIAM T. SHEARER DARRYL KNIGHT | JEREMY HIROTA
3 Immunoglobulin Structure and Function 30 20 Noncontractile Functions of Airway Smooth
Muscle 315
DIANE F. JELINEK | JAMES T. LI
BRIAN G. OLIVER | JANETTE K. BURGESS | JUDITH BLACK |
4 Immune Tolerance 45 REYNOLD A. PANETTIERI, JR.
MÜBECCEL AKDIS | CEZMI A. AKDIS
21 Pathophysiology of Allergic
Inflammation 327
5 Cytokines in Allergic Inflammation 65
PETER J. BARNES
JOHN W. STEINKE | LANNY J. ROSENWASSER | LARRY BORISH
22 Genetics and Epigenetics in Allergic Diseases
6 Cellular Adhesion in Inflammation 83
and Asthma 343
DAVID H. BROIDE | P. SRIRAMARAO
JOHN W. HOLLOWAY
7 Chemokines 98
23 Immunobiology of IgE and IgE
ZAMANEH MIKHAK | ANDREW D. LUSTER
Receptors 364
8 The Complement System 113 HANS C. OETTGEN
KATHLEEN E. SULLIVAN | ANETE S. GRUMACH
24 Neuronal Control of Airway Function in
9 Lipid Mediators of Hypersensitivity and Allergy 378
Inflammation 139 BRADLEY J. UNDEM | BRENDAN J. CANNING
R. STOKES PEEBLES, JR. | JOSHUA A. BOYCE
25 Resolution of Allergic Inflammation 389
10 Molecular Biology and Genetic DAVID A. DORWARD | CHRISTOPHER D. LUCAS | KEITH C. ALLEN |
ADRIANO G. ROSSI
Engineering 162
SUDHIR GUPTA | LEMAN YEL SECTION B
Aerobiology and Allergens 397
11 Signal Transduction 184
PAUL J. BERTICS | CYNTHIA J. KOZIOL-WHITE |
26 The Structure and Function of Allergens 398
MONICA L. GAVALA | GREGORY J. WIEPZ
GEOFFREY A. STEWART | JONATHAN P. RICHARDSON |
12 Biology of Lymphocytes 203 JIHUI ZHANG | CLIVE ROBINSON
LAUREN COHN | CATHERINE HAWRYLOWICZ | ANURADHA RAY
27 Aerobiology of Outdoor Allergens 430
13 Antigen-Presenting Dendritic Cells 215 RICHARD W. WEBER
BART N. LAMBRECHT | HAMIDA HAMMAD
28 Indoor Allergens 453
14 Biology of Mast Cells and Their Mediators 228 THOMAS A.E. PLATTS-MILLS
PETER BRADDING | HIROHISA SAITO
29 Preparation and Standardization of Allergen
Extracts 470
15 Biology of Basophils 252
JAY E. SLATER | ROBERT E. ESCH
JOHN T. SCHROEDER
v
vi Contents
30 Air Pollution: Indoor and Outdoor 482 45 Respiratory Tract Mucosal Immunology 715
MICHELLE L. HERNANDEZ | DAVID B. PEDEN HOLGER GARN | HARALD RENZ
31 Particulate and Pollen Interactions 497 46 Airway Smooth Muscle Function in
JOHANNES RING | JEROEN BUTERS | HEIDRUN BEHRENDT Asthma: Extracellular Matrix and Airway
Remodeling 730
32 Effect of the Food Matrix and Processing on ANDREW J. HALAYKO | THAI TRAN
the Allergenic Activity of Foods 508
E.N. CLARE MILLS 47 Airway Mucus and the Mucociliary
System 739
SECTION C
DUNCAN F. ROGERS
The Skin 517
48 Epidemiology of Asthma and Allergic
33 Structure of the Skin and Cutaneous Airway Diseases 754
Immunology 518 GRAHAM DEVEREUX | ELIZABETH C. MATSUI |
PETER G.J. BURNEY
DOUGLAS A. PLAGER | THOMAS BIEBER | MARK R. PITTELKOW
49 Ontogeny of Immune Development and
34 Atopic Dermatitis 540
Its Relationship to Allergic Diseases
MARK BOGUNIEWICZ | DONALD Y.M. LEUNG
and Asthma 790
35 Contact Dermatitis 565 SUSAN L. PRESCOTT | CHRISTINE SEROOGY
ROSEMARY L. NIXON | THOMAS DIEPGEN 50 Asthma Pathogenesis 812
36 Urticaria and Angioedema 575 STEPHEN T. HOLGATE | PETER D. SLY
SARBJIT S. SAINI 51 Mouse Models of Allergic Airways
Disease 842
37 Hereditary Angioedema and Bradykinin-
CLARE LLOYD | IAN P. LEWKOWICH | MARSHA WILLS-KARP |
Mediated Angioedema 588
SEJAL SAGLANI
BRUCE L. ZURAW | SANDRA C. CHRISTIANSEN
52 Diagnosis of Asthma in Infants and
38 Immune Complex–Mediated Diseases 602 Children 861
MICHAEL M. FRANK | C. GARREN HESTER THERESA W. GUILBERT | ROBERT F. LEMANSKE, JR. |
DANIEL J. JACKSON
SECTION D
The Eye 617 53 Management of Asthma in Infants and
Children 876
39 Allergic and Immunologic Diseases of DANIEL J. JACKSON | ROBERT F. LEMANSKE, JR. |
THERESA W. GUILBERT
the Eye 618
NEAL P. BARNEY | ELLEN B. COOK | JAMES L. STAHL 54 Diagnosis of Asthma in Adults 892
LOUIS-PHILIPPE BOULET
SECTION E
Respiratory Tract 639 55 Management of Asthma in Adolescents and
Adults 902
40 The Nose and Control of Nasal Airflow 640
SANDY R. DURRANI | WILLIAM W. BUSSE
RONALD ECCLES
56 Emergency Treatment and Approach to the
41 Nasal Provocation Testing 652 Patient with Acute Asthma 923
GUY W. SCADDING | TREVOR T. HANSEL | STEPHEN R. DURHAM CARLOS A. CAMARGO, JR. | BRIAN H. ROWE
42 Allergic and Nonallergic Rhinitis 664 57 Approach to the Patient with Exercise-
JONATHAN CORREN | FUAD M. BAROODY | RUBY PAWANKAR Induced Bronchoconstriction 938
TEAL S. HALLSTRAND
43 Rhinosinusitis and Nasal Polyps 686
CLAUS BACHERT | LIEN CALUS | PHILIPPE GEVAERT 58 Asthma and Allergic Diseases during
Pregnancy 951
44 Development, Structure, and Physiology in
MICHAEL SCHATZ | ROBERT S. ZEIGER | REUBEN FALKOFF |
Normal Lung and in Asthma 700 CHRISTINA CHAMBERS | ERIC MACY | MICHAEL H. MELLON
CHARLES G. IRVIN
Contents vii
59 Occupational Allergy and Asthma 970 73 Human Immunodeficiency Virus and Allergic
CATHERINE LEMIÈRE | OLIVIER VANDENPLAS Disease 1175
SARAH K. NICHOLAS | MARY E. PAUL | WILLIAM T. SHEARER
60 Pathology of Asthma 986
RAKESH K. KUMAR | PETER K. JEFFERY 74 Laboratory Tests for Allergic and
Immunodeficiency Diseases 1187
61 Allergic Bronchopulmonary Aspergillosis and ROBERT G. HAMILTON
Hypersensitivity Pneumonitis 1000
JO A. DOUGLASS | ALESSANDRA SANDRINI | 75 Eosinophilia and Eosinophil-Related
STEPHEN T. HOLGATE | ROBYN E. O’HEHIR Disorders 1205
AMY D. KLION | PETER F. WELLER
62 Immunologic Nonasthmatic Diseases of
the Lung 1014 76 Mastocytosis 1224
MICHAEL C. SNELLER | JOSEPH R. FONTANA |
DEAN D. METCALFE
JAMES H. SHELHAMER
63 Approach to the Patient with Chronic 77 Anaphylaxis 1237
Cough 1032 SIMON G.A. BROWN | STEPHEN F. KEMP | PHILLIP L. LIEBERMAN
J. MARK MADISON | RICHARD S. IRWIN
78 Insect Allergy 1260
64 Bronchial Challenge Testing 1042 DAVID B.K. GOLDEN
DONALD W. COCKCROFT
79 Drug Allergy 1274
65 Lung Imaging 1056 GÜLFEM E. ÇELIK | WERNER J. PICHLER |
N. FRANKLIN ADKINSON, JR.
MARIO CASTRO | SEAN B. FAIN | CHRISTOPHER E. BRIGHTLING
80 Hypersensitivity to Aspirin and Other
66 Aerosols and Aerosol Drug Delivery
Nonsteroidal Antiinflammatory Drugs 1296
Systems 1066
HAE-SIM PARK | MAREK L. KOWALSKI | MARIO SANCHEZ-BORGES
BETH L. LAUBE | MYRNA B. DOLOVICH
81 Reactions to Foods 1310
Volume 2 ANNA NOWAK-WE˛GRZYN | A. WESLEY BURKS |
HUGH A. SAMPSON
SECTION F
82 Reactions to Food and Drug
Gastrointestinal Tract 1083
Additives 1340
ROBERT K. BUSH | STEVE L. TAYLOR
67 Gastrointestinal Mucosal Immunology 1084
M. CECILIA BERIN | GLENN T. FURUTA | SEEMA S. ACEVES 83 Oral Food Challenge Testing 1357
ROBERT A. WOOD
68 Eosinophilic Gastrointestinal Disorders 1095
MARC E. ROTHENBERG 84 Food Allergy Management 1365
SCOTT H. SICHERER | GIDEON LACK | STACIE M. JONES
SECTION G
Systemic Disease 1107 85 Adverse Reactions to Vaccines for Infectious
Diseases 1384
69 Clinical Significance of JOHN M. KELSO | MATTHEW J. GREENHAWT
Immunoglobulin E 1108
SECTION H
PHILIP H. SMITH | DENNIS R. OWNBY
Therapeutics 1405
70 In Vivo Methods for the Study and Diagnosis
of Allergy 1119 86 Allergen Control for Prevention and
ANCA MIRELA CHIRIAC | JEAN BOUSQUET | PASCAL DEMOLY Management of Allergic Diseases 1406
ADNAN CUSTOVIC | EUAN TOVEY
71 Approach to the Patient with Recurrent
Infections 1133 87 Injection Immunotherapy for Inhalant
MARK BALLOW | HEATHER K. LEHMAN Allergens 1416
HAROLD S. NELSON
72 Primary Immunodeficiency Diseases 1144
REBECCA H. BUCKLEY | JORDAN S. ORANGE