Microsystems for Pharmatechnology: Manipulation of Fluids, Particles, Droplets, and Cells

353 Pages·2016·10.065 MB·English

by  Andreas Dietzel (eds.)

Andreas Dietzel E ditor
Microsystems for
Pharmatechnology
Manipulation of Fluids, Particles,
Droplets, and Cells
Microsystems for Pharmatechnology

Andreas Dietzel
Editor
Microsystems for
Pharmatechnology
Manipulation of Fluids, Particles,
Droplets, and Cells
Editor
AndreasDietzel
InstituteofMicrotechnology
TechnischeUniversita¨tBraunschweig
Braunschweig,Germany
PVZ—CenterofPharmaceuticalEngineering
TechnischeUniversita¨tBraunschweig
Braunschweig,Germany
ISBN978-3-319-26918-4 ISBN978-3-319-26920-7 (eBook)
DOI10.1007/978-3-319-26920-7
LibraryofCongressControlNumber:2015958783
SpringerChamHeidelbergNewYorkDordrechtLondon
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Preface
Astheworldbecomesincreasinglyconcernedaboutaffordablehealthcare,fastand
effectivescreeningmethodsfordrugsindifferentformulationsarerequiredinthe
course of their development. Moreover, a more personalized medicine demands
production of drugs in very small volumes. For both, the microfluidic approach
seemsideallysuited.Withminiaturizedsystemsthatcanberealizedbymicrofab-
rication processes, new tools for research and development but also new products
become available. New and better technologies for screening, for production
by micro-reaction technology and micro-bioreactors, for small-scale processing
of drug formulations, as well as for drug delivery are under development. Inter-
disciplinary research involving typical engineering disciplines and life science
disciplines is the key for a further development of this field. This challenge has
been accepted by the Center of Pharmaceutical Engineering (PVZ) of the TU
Braunschweigestablishedin2012whereresearchgroupsfromthepharmaceutical
sciences, from biology, from process engineering, and from microtechnology
intensively collaborate. Many but not all chapters of this book are written by
authorsactiveinthisresearchcenter.
Thebookshallprovideacomprehensivestate-of-the-artreviewofmicrofluidic
approaches and applications in pharma technology. It shall help students and
postgraduate students with an interdisciplinary interest from both the pharmaceu-
ticalfieldandtheengineeringfieldbutalsoprocessdevelopersinthepharmaceu-
tical industry and scientists with an overview of technologies and applications in
thisgrowingfieldofresearch.
I am grateful to all the authors for their excellent contributions to this book.
I want to thank the management team of the PVZ, in particular Christel Mu¨ller-
GoymannandArnoKwade,thekeypersonstobringtheirvisionandideasintothe
reality of the new research center PVZ and Heike Bunjes, with whom I enjoy
leadingthepostgraduateprogram“μ-Props”inwhichtopicsofthisbookcontinue
inongoingresearch.SpecialthanksgotoSabineKral-Aulichwhofarinexcessof
whatIcouldexpecthelpedmeincompletingthebookbykeepingcontactwiththe
v
vi Preface
authors and with the publisher and by working on all the details and adjustments
necessary to bring the manuscripts and this book into a suitable format without
losingherpatience.
Braunschweig,Germany AndreasDietzel
September2015
Contents
1 ABriefIntroductiontoMicrofluidics. . . . . . . . . . . . . . . . . . . . . 1
A.Dietzel
2 FabricationofMicrofluidicDevices. . . . . . . . . . . . . . . . . . . . . . . 23
M.Leester-Scha¨del,T.Lorenz,F.Ju¨rgens,andC.Richter
3 SurfaceFunctionalizationofMicrofluidicDevices. . . . . . . . . . . . 59
M.Eichler,C.-P.Klages,andK.Lachmann
4 Microbioreactors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
R.Krull,S.Llad(cid:1)o‐Maldonado,T.Lorenz,S.Demming,
andS.Bu¨ttgenbach
5 MicrosystemsforEmulsification. . . . . . . . . . . . . . . . . . . . . . . . . 153
H.BunjesandC.C.Mu¨ller-Goymann
6 On-ChipFabricationofDrugDeliverySystems. . . . . . . . . . . . . 181
M.Windbergs
7 MicrosystemsforDispersingNanoparticles. . . . . . . . . . . . . . . . . 197
C.Schilde,T.Gothsch,S.Beinert,andA.Kwade
8 ParticlesinMicrofluidicSystems:Handling,Characterization,
andApplications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
T.P.Burg
9 RespiratoryDrugDelivery. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257
H.Wachtel
vii
viii Contents
10 DrugDeliveryThroughMicroneedles. . . . . . . . . . . . . . . . . . . . . 275
R.Luttge
11 OrganonChip. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
N.Beißner,T.Lorenz,andS.Reichl
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341
Contributors
S. Beinert TU Braunschweig, Institut fu¨r Partikeltechnik, Braunschweig,
Germany
N. Beißner Institut fu¨r Pharmazeutische Technologie, Technische Universita¨t
Braunschweig,Braunschweig,Germany
PVZ—Center of Pharmaceutical Engineering, Technische Universita¨t
Braunschweig,Braunschweig,Germany
H. Bunjes Institut fu¨r Pharmazeutische Technologie, Technische Universita¨t
Braunschweig,Braunschweig,Germany
PVZ—Center of Pharmaceutical Engineering, Technische Universita¨t
Braunschweig,Braunschweig,Germany
T.P.Burg MaxPlanckInstituteforBiophysicalChemistry,G€ottingen,Germany
S. Bu¨ttgenbach IMT—Institute of Microtechnology, Technische Universita¨t
Braunschweig,Braunschweig,Germany
S. Demming IMT—Institute of Microtechnology, Technische Universita¨t
Braunschweig,Braunschweig,Germany
GlobalTechnologyChemicalIntermediates,BASFSE,Ludwigshafen,Germany
A. Dietzel IMT—Institute of Microtechnology, Technische Universita¨t Braun-
schweig,Braunschweig,Germany
PVZ—Center of Pharmaceutical Engineering, Technische Universita¨t
Braunschweig,Braunschweig,Germany
M. Eichler Fraunhofer IST—Institute for Surface Engineering and Thin Films,
Braunschweig,Germany
T. Gothsch TU Braunschweig, Institut fu¨r Partikeltechnik, Braunschweig,
Germany
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