Table Of ContentStudies in Mechanobiology, Tissue Engineering and
Biomaterials 18
Andrés Díaz Lantada E ditor
Microsystems
for Enhanced
Control of Cell
Behavior
Fundamentals, Design and Manufacturing
Strategies, Applications and Challenges
Studies in Mechanobiology, Tissue
Engineering and Biomaterials
Volume 18
Series editor
Amit Gefen, Ramat Aviv, Israel
More information about this series at http://www.springer.com/series/8415
é í
Andr s D az Lantada
Editor
Microsystems for Enhanced
Control of Cell Behavior
Fundamentals, Design and Manufacturing
Strategies, Applications and Challenges
123
Editor
Andrés DíazLantada
MechanicalEngineering
Universidad Politecnica deMadrid
Madrid
Spain
ISSN 1868-2006 ISSN 1868-2014 (electronic)
Studies in Mechanobiology,Tissue EngineeringandBiomaterials
ISBN978-3-319-29326-4 ISBN978-3-319-29328-8 (eBook)
DOI 10.1007/978-3-319-29328-8
LibraryofCongressControlNumber:2016930671
©SpringerInternationalPublishingSwitzerland2016
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To my beloved Melike,
How can my muse want subject to invent,
While thou dost breathe, that pour’st into my
verse
Thine own sweet argument, too excellent
For every vulgar paper to rehearse?
O! give thy self the thanks, if aught in me
Worthy perusal stand against thy sight;
For who’s so dumb that cannot write to thee,
When thou thy self dost give invention light?
Be thou the tenth Muse, ten times more in
worth
Than those old nine which rhymers invocate;
And he that calls on thee, let him bring forth
Eternal numbers to outlive long date.
If my slight muse do please these curious
days,
The pain be mine, but thine shall be the
praise.
William Shakespeare
To our daughter Seda,
If you can keep your head when all about you
Are losing theirs and blaming it on you;
If you can trust yourself when all men doubt
you,
But make allowance for their doubting too:
If you can wait and not be tired by waiting,
Or, being lied about, don’t deal in lies,
Or being hated don’t give way to hating,
And yet don’t look too good, nor talk too
wise;
If you can dream, and not make dreams your
master;
If you can think, and not make thoughts your
aim,
If you can meet with Triumph and Disaster
And treat those two impostors just the same…
…If you can fill the unforgiving minute
With sixty seconds worth of distance run,
Yours is the Earth and everything that’s in it,
And—which is more—you’ll be a Woman, my
Daughter!
Rudyard Kipling
Preface
Lastdecadeshaveseenremarkableadvancesincomputer-aideddesign,engineering
and manufacturing technologies, multi-variable simulation tools, medical imaging,
biomimetic design, rapid prototyping, micro- and nano-manufacturing methods,
andinformationmanagementresources,allofwhichareexpandingthehorizonsof
most biomedical engineering fields and the related medical device industry.
Emerging areas such as tissue engineering and biofabrication, which depend on
biomedical microsystems or microdevices capable of interacting with cells and
tissues, such as cell culture systems, scaffolds, and advanced implants, are directly
bound to these technological advances.
The present book covers such topics in depth, with an applied perspective and
providing several case studies that help to analyze and understand the key factors
ofthedifferentstageslinkedtothedevelopmentofbiomedicalmicrosystemsaimed
atinteractingatacellularlevel,fromtheconceptualanddesignsteps,tothe(rapid)
prototyping, validation, and industrialization phases. Main current research chal-
lenges and future potential are also discussed, taking into account relevant social
demands and a growing market already exceeding billions of dollars. In time,
advanced biomedical microdevices will decisively change procedures and result in
the medical world, dramatically improving diagnoses and therapies for several
types of pathologies. But if these biodevices are to fulfill present expectations,
today’s engineers need a thorough grounding in related design, simulation, testing
and manufacturing technologies, and intimate cooperation between experts of
different areas has to be promoted, as is also analyzed within this handbook.
The text is aimed at anyone working or simply interested in biomedical engi-
neering, in the tissue engineering and biofabrication areas and in the medical
devices industry, including physicians, scientists, and industrial, biomedical,
chemical,electrical,andmaterialsengineers.Itisalsoacomprehensiveintroduction
for students studying biomedical engineering at masters level, as well as
for researchers planning to carry out a Ph.D., linked to the development of
biomedical microdevices for interacting with cells and tissues, and pursuing
improvements in tissue engineering materials, methods and (bio)devices, towards
vii
viii Preface
effective biofabrication strategies. Designed for maximum readability, without
compromising scientific rigor, this handbook provides a broad overview of these
rapidly evolving disciplines, also discussing main breakthroughs and expectations.
I truly hope it might be of help for students and researchers and even motivate
them to follow some of the research directions outlined.
Madrid Andrés Díaz Lantada
December 2015
Acknowledgements
No book is ever the product of one person’s efforts, and certainly this one was no
different. It would never have become truth without the help and suggestions of
many supportive relatives, friends, and colleagues, only a proportion of which
I have space to acknowledge here.
I owe a great deal to my colleagues and students at Universidad Politécnica
de Madrid who through their own research, comments, and questions have
encouraged,supported,andenlightenedme.Ithasbeenapleasuretoworktogether
with them in research tasks, which have led to interesting solutions detailed in
several chapters of the handbook.
Professor Dr. Pilar Lafont Morgado has enlightened my career with her partic-
ularconceptionofuniversity,initsbroadestsense,andoftheconnectionsbetween
teaching, learning, and research. Professor Dr. Josefa Predestinación García-Ruíz
hasbeenacheerfulco-workerandIhavelearnedfromherexperiencesandwisdom,
not only about cells, but very especially about life. Professors Alisa Morss Clyne
andJürgenStampflgavemetheopportunityofliving extraordinary experiencesin
their research labs, atDrexelUniversity and at theTechnical University of Vienna
respectively, andmade mefeelathome,while helpingmetoexpand myhorizons.
ProfessorJoseLuisEndrinohasbeenanadmirableresearchcolleagueandisnowa
good friend, always ready for interesting discussions and hands-on tasks.
IamverygratefultoMr.PedroOrtegoGarcía,whoseexpertisehasbeenofgreat
help for the manufacture and trials of many of the prototypes included, as case
studies, in the different chapters of the handbook. Researchers including Hernán
Alarcón, Miguel Ángel de Alba, Adrián de Blas, Gillian Begasse, Alberto
Bustamante, Enrique Colomer, Diego Curras, Sébastien Deschapms, Graciela
Fernández, Axel Michel, Javier Mousa, Beatriz Pareja, Miguel de la Peña, Jeff
Resnick,MiguelTéllez,SantiagoValido,andBeatrizdelVallehavesupportedme
with engineering tasks.
ix
