Table Of ContentMicrobiology
of
Chlamydia
Editor
Almen L. Barron, Ph.D.
Professor and Chairman
Department of Microbiology and Immunology
University of Arkansas for Medical Sciences
Little Rock, Arkansas
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PREFACE
Organisms classified in the genus Chlamydia were once considered to be unusual viruses
and are now known to be obligate intracellular procaryons with a unique reproductive cycle.
Older medical knowledge associated these organisms with trachoma, inclusion conjunctivitis,
lymphogranuloma venereum, and psittacosis. Current medicine is concerned with their role
in sexually transmitted disease, infertility in females, pneumonitis of the newborn, and
possibly pneumonia in the absence of an avian reservoir. In this book we attempt to state
the microbiology of Chlamydia as we understand it with regard to their nature as micro-
organisms and as pathogens. The editor is grateful to the contributors for their cooperation,
patience, and commitment to excellence.
Almen L. Barron
THE EDITOR
Almen L. Barron Ph.D. is Professor and Chairman, Department of Microbiology and
Immunology, University of Arkansas for Medical Sciences, Little Rock. A Canadian by
birth, he received his Ph.D. at Queen's University, Kingston, Ontario in 1953. He joined
the Department of Bacteriology, University of Buffalo (later State University of New York
at Buffalo) in 1954 to work on the Salk vaccine field trial under the direction of Dr. David
T. Karzon. He remained at Buffalo until 1974 when he assumed his present position. Research
at Buffalo was mainly focused on Echoviruses and viral immunology. In 1964 he received
a Fulbright Research Scholar award and worked in the laboratory of the late Professor Hans
Bernkopf, Hebrew University — Hadassah Medical School, Jerusalem, Israel. It was there
that his interest in Chlamydia was kindled. Early research was on chlamydial hemagglutinin
and biological properties. Later studies involved the role of Chlamydia in genital tract
infections using animal models, which have continued to the present. Other activities have
included co-editing Microbiology: Basic Principles and Clinical Applications (Macmillan)
with Dr. Noel R. Rose, membership on Bacteriology and Mycology Study Section, NIH,
and service on the editorial boards for Infection and Immunity and Proceedings of the Society
for Experimental Biology and Medicine.
CONTRIBUTORS
Gerald I. Byrne, Ph.D. Roger G. Rank, Ph.D.
Associate Professor Associate Professor
Department of Medical Microbiology Department of Microbiology and
University of Wisconsin Medical School Immunology
Madison, Wisconsin University of Arkansas for Medical
Sciences
Little Rock, Arkansas
Thomas P. Hatch, Ph.D.
Associate Professor Julius Schachter, Ph.D.
Department of Microbiology and Professor
Immunology Departments of Laboratory Medicine, and
University of Tennessee, Memphis Epidemiology and International Health
Memphis, Tennessee University of California at San Francisco
San Francisco, California
Cho-chou Kuo, M.D., Ph.D. Richard S. Stephens, Ph.D., M.S.P.H.
Professor Assistant Adjunct Professor
Department of Pathobiology Department of Laboratory Medicine
University of Washington University of California at San Francisco
Seattle, Washington San Francisco, California
Johannes Storz, D.V.M., Ph.D.
Akira Matsumoto, D.Sc. Professor and Department Head
Associate Professor Department of Veterinary Microbiology
Department of Microbiology and Parasitology
Kawasaki Medical School School of Veterinary Medicine
Kurashiki, Okay ama, Japan Louisiana State University
Baton Rouge, Louisiana
James W. Moulder, Ph.D. Michael E. Ward, Ph.D.
Professor Emeritus Senior Lecturer
Department of Molecular Genetics and Department of Medical Microbiology
Cell Biology Southampton University Medical School
University of Chicago Southampton, England
Chicago, Illinois
Dwight M. Williams, M.D.
Associate Professor
Wilbert J. Newhall V, Ph.D. Department of Medicine
Assistant Professor University of Texas Health Science
Department of Medicine Center and Audie L. Murphy V.A.
Indiana University School of Medicine Hospital
Indianapolis, Indiana San Antonio, Texas
This book is dedicated to my grandson, Jared Joseph Barron, born June 11, 1986,
from Zaydie with love.
TABLE OF CONTENTS
CHLAMYDIA AS ORGANISMS
Chapter 1
Characteristics of Chlamydiae 3
J. W. Moulder
Chapter 2
Structural Characteristics of Chlamydial Bodies 21
A. Matsumoto
Chapter 3
Macromolecular and Antigenic Composition of Chlamydiae 47
W. J. Newhall, V
Chapter 4
The Chlamydial Developmental Cycle 71
M. E. Ward
Chapter 5
Metabolism of Chlamydia 97
T. P. Hatch
Chapter 6
Chlamydial Genetics Ill
R. S. Stephens
Chapter 7
Host Cell Relationships 135
G. I. Byrne
CHLAMYDIA AS PATHOGENS
Chapter 8
Overview of Human Diseases 153
J. Schachter
Chapter 9
Overview of Animal Diseases Induced by Chlamydial Infections 167
J. Storz
Chapter 10
Host Response 193
C.-c. Kuo
Chapter 11
Stimulation of Immune Response 209
D. M. Williams
Chapter 12
Role of the Immune Response 217
R. G. Rank
Index 237
Chlamydia as Organisms
