Meyler's Side Effects of Drugs Used in Anesthesia (Meylers Side Effects)

275 Pages·2008·4 MB·english

by  Aronson J.K.

Meyler’s Side Effects of Drugs Used in Anesthesia
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Meyler’s Side Effects of
Drugs Used in Anesthesia
Editor
J K Aronson, MA, DPhil, MBChB, FRCP, FBPharmacolS, FFPM (Hon)
Oxford, United Kingdom
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Contents
Preface vii
General Anesthetics 1
Local Anesthetics 79
Neuromuscular Blocking Drugs and Muscle Relaxants 179
Index of drug names 265
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Preface producedannuallyinstead.Thefour-yearlyvolumecould
then concentrate on providing a complementary critical
Thisvolumecoverstheadverseeffectsofmedicinesused encyclopaedic survey of the entire field. The first Side
in anesthesia. The material has been collected from EffectsofDrugsAnnualwaspublishedin1977.Thefirst
Meyler’s Side Effects of Drugs: The International encyclopaedic edition of Meyler’s Side Effects of Drugs,
Encyclopedia of Adverse Drug Reactions and which appeared in 1980, was labelled the ninth edition,
Interactions (15th edition, 2006, in six volumes), which andsincethenanewencyclopaediceditionhasappeared
was itself based on previous editions of Meyler’s Side everyfouryears.The15theditionwaspublishedin2006,
Effects of Drugs, and from the Side Effects of Drugs inbothhardandelectronicversions.
Annuals (SEDA) 28, 29, and 30. The main contributors
of this material were JK Aronson, Z Baudoin, HMD
Cardwell, P Flisberg, SA Jackson, I Kurowski, T
Monograph structure
Ledowski, M Leuwer, DJ O’Connor, A Raajkumar, SA
Schug,IDWelters,YYoung,andOZuzan.
Thisvolumeisinthreesections:
(cid:2) general anesthetics—a general introduction to their
adverse effects, followed by monographson individual
A brief history of the Meyler series inhalationalandintravenousanesthetics;
(cid:2) local anesthetics—a general introduction to their
Leopold Meyler was a physician who was treated for
adverse effects, including the adverse effects of differ-
tuberculosis after the end of the Nazi occupation of The
ent routes of administration, followed by monographs
Netherlands.AccordingtoProfessorWimLammers,writ-
onindividuallocalanesthetics;
ing a tribute in Volume VIII (1975), Meyler got a fever
(cid:2) neuromuscularblockingagentsandmusclerelaxants—
from para-aminosalicylic acid, but elsewhere Graham
ageneralintroductiontotheiradverseeffects,followed
Dukes has written, based on information from Meyler’s
bymonographsonindividualagents.
widow, that it was deafness from dihydrostreptomycin;
perhaps it was both. Meyler discovered that there was IneachmonographintheMeylerseriestheinformationis
no single text to which medical practitioners could look organized into sections as shown on the next page
for information about unwanted effects of drug therapy; (althoughnotallthesectionsarecoveredineachmono-
Louis Lewin’s text ‘‘Die Nebenwirkungen der graph).
Arzneimittel’’ (‘‘The Untoward Effects of Drugs’’) of
1881 had long been out of print (SEDA-27, xxv-xxix).
Meyler therefore determined to make such information
Drug names
availableandpersuadedtheNetherlandspublishingfirm
of Van Gorcum to publish a book, in Dutch, entirely
Drugs have usually been designated by their recom-
devoted to descriptions of the adverse effects that drugs
mended or proposed International Non-proprietary
could cause. He went on to agree with the Elsevier
Names (rINN or pINN); when these are not available,
Publishing Company, as it was then called, to prepare
chemical names have been used. In some cases brand
and issue an English translation. The first edition of 192
nameshavebeenused.
pages(SchadelijkeNevenwerkingenvanGeneesmiddelen)
appearedin1951andtheEnglishversion(SideEffectsof
Drugs)ayearlater.
The book was a great success, and a few years later Spelling
Meyler started to publish what he called surveys of
unwantedeffectsofdrugs.Eachsurveycoveredaperiod Forindexingpurposes,Americanspellinghasbeenused,
oftwotofouryears.Theywerelabelledasvolumesrather e.g.anemia,estrogenratherthananaemia,oestrogen.
than editions, and after Volume IV had been published
Meyler could no longer handle the task alone. For sub-
sequent volumes he recruited collaborators, such as
Cross-references
Andrew Herxheimer. In September 1973 Meyler died
unexpectedly, and Elsevier invited Graham Dukes to ThevariouseditionsofMeyler’sSideEffectsofDrugsare
takeovertheeditingofVolumeVIII. citedinthetextasSED-l3,SED-14,etc;theSideEffects
DukespersuadedElsevierthatthepublishedliterature ofDrugsAnnualsarecitedasSEDA-1,SEDA-2,etc.
was too large to be comfortably encompassed in a four- JKAronson
yearlycycle,andhesuggestedthatthevolumesshouldbe Oxford,June2008
8 Preface
OrganizationofmaterialinmonographsintheMeylerseries(not Bodytemperature
allsectionsareincludedineachmonograph) Multiorganfailure
Trauma
Generalinformation Death
Drugstudies Long-termeffects
Observationalstudies Drugabuse
Comparativestudies Drugmisuse
Drug-combinationstudies Drugtolerance
Placebo-controlledstudies Drugresistance
Systematicreviews Drugdependence
Organsandsystems Drugwithdrawal
Cardiovascular Genotoxicity
Respiratory Cytotoxicity
Ear,nose,throat Mutagenicity
Nervoussystem Tumorigenicity
Neuromuscularfunction Second-generationeffects
Sensorysystems Fertility
Psychological Pregnancy
Psychiatric Teratogenicity
Endocrine Fetotoxicity
Metabolism Lactation
Nutrition Breastfeeding
Electrolytebalance Susceptibilityfactors
Mineralbalance Geneticfactors
Metalmetabolism Age
Acid-basebalance Sex
Fluidbalance Physiologicalfactors
Hematologic Disease
Mouth Otherfeaturesofthepatient
Teeth Drugadministration
Salivaryglands Drugformulations
Gastrointestinal Drugadditives
Liver Drugcontaminationandadulteration
Biliarytract Drugdosageregimens
Pancreas Drugadministrationroute
Urinarytract Drugoverdose
Skin Interactions
Hair Drug-druginteractions
Nails Food-druginteractions
Sweatglands Drug-deviceinteractions
Serosae Smoking
Musculoskeletal Otherenvironmentalinteractions
Sexualfunction Interferencewithdiagnostictests
Reproductivesystem Diagnosisofadversedrugreactions
Breasts Managementofadversedrugreactions
Immunologic Monitoringtherapy
Autacoids References
Infectionrisk
GENERAL ANESTHETICS