Methyl acrylate - Santa Cruz Biotechnology, Inc.

13 Pages·2011·0.39 MB·English

Methyl acrylate
sc-215333

Material Safety Data Sheet
Hazard Alert Code Key: EXTREME HIGH MODERATE LOW

Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME

Methyl acrylate
STATEMENT OF HAZARDOUS NATURE

CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200.
NFPA
3
FLAMMABILITY
3 2
HEALTH HAZARD INSTABILITY
SUPPLIER
Santa Cruz Biotechnology, Inc.
2145 Delaware Avenue
Santa Cruz, California 95060
800.457.3801 or 831.457.3800

EMERGENCY:
ChemWatch
Within the US & Canada: 877-715-9305
Outside the US & Canada: [phone]
(1-800-CHEMCALL) or call [phone]
SYNONYMS
C4-H6-O2, H2C=CHCOOCH3, "acrylic acid, methyl ester", "propenoic acid, methyl ester", "methyl propenate", "methyl propenoate",
"methyl 2-propenoate"
Section 2 - HAZARDS IDENTIFICATION
CHEMWATCH HAZARD RATINGS
Min Max
Flammability: 3
Toxicity: 2
Body Contact: 2 Min/Nil=0
Low=1
Reactivity: 2 Moderate=2
High=3
Chronic: 2
Extreme=4
CANADIAN WHMIS SYMBOLS
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EMERGENCY OVERVIEW
RISK
May cause SENSITISATION by inhalation and skin contact.
Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Highly flammable.
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS

SWALLOWED
! Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or
may produce serious damage to the health of the individual.
EYE
! Irritation of the eyes may produce a heavy secretion of tears (lachrymation).
! The vapour when concentrated has pronounced eye irritation effects and this gives some warning of high vapour concentrations.
If eye irritation occurs seek to reduce exposure with available control measures, or evacuate area.
! There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after
instillation.
Severe inflammation may be expected with pain.
SKIN
! Skin contact with the material may be harmful; systemic effects may resultfollowing absorption.
! The material may cause moderate inflammation of the skin either following direct contact or after a delay of some time.
Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.

! Minor exposure to methyl acrylate may cause sensitisation in some cases In a vase study involving 105 exposed workers 53.
7 % showed the clinical presence of three allergies (dermatitis, eczema, urticaria).
! Open cuts, abraded or irritated skin should not be exposed to this material.
! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects.
Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
INHALED
! Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful.
! The material can cause respiratory irritation in some persons.
The body's response to such irritation can cause further lung damage.
! Inhalation of quantities of liquid mist may be extremely hazardous, even lethal due to spasm, extreme irritation of larynx and bronchi,
chemical pneumonitis and pulmonary edema.
! If exposure to highly concentrated vapor atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and unless
resuscitated - death.
! There is some evidence to suggest that this material can cause, if inhaled once, irreversible damage of organs.
! The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere
developing.
Before starting consider control of exposure by mechanical ventilation.
CHRONIC HEALTH EFFECTS
! Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic
problems.
Inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population.
Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population.
There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or
biochemical systems.
In a 13-week study of methyl acrylate, rats were given up to 20 mg/kg/day in drinking water. Treatment related effects were seen in rats
receiving higher doses and included spontaneous renal disease. The no-observed-effect level (NOEL) was 5 mg/kg/day.
In an inhalation study rats, rabbits and guinea pigs were exposed to methyl methacrylate 7 hours/day. All animals exposed at 578 ppm
(two-seven times) died. These animals exhibited ocular and respiratory tract irritation, salivation, laboured breathing, lethargy and/or
convulsions. Signs of toxicity at 237 ppm were similar to those at 578 ppm.
Rats exposed to methyl methacrylate vapour for up to 2 years showed concentration-related changes in the transitional region between
the respiratory and olfactory nasal epithelium ranging from very mild to mild atrophy of ciliated and olfactory cells. No animals showed
signs of squamous cell metaplasia at concentrations up to 135 ppm. Corneal opacification and vascularisation occurred at all
concentrations. Severity was dependent on concentration and duration.
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Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
methyl acrylate 96-33-3 >98
inhibitor stabiliser, must be present for
transport and storage; more inhibitor means
longer storage life
typically
4-methoxyphenol (MEHQ) 150-76-5 0.001-0.1
Section 4 - FIRST AID MEASURES
SWALLOWED
· IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. · Where Medical attention is not
immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise:
EYE
! If this product comes in contact with the eyes: · Wash out immediately with fresh running water. · Ensure complete irrigation of the eye
by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids.
SKIN
! If skin contact occurs: · Immediately remove all contaminated clothing, including footwear · Flush skin and hair with running water (and
soap if available).
INHALED
· If fumes or combustion products are inhaled remove from contaminated area. · Lay patient down. Keep warm and rested.
NOTES TO PHYSICIAN
! for poisons (where specific treatment regime is absent):
----------------------------------------------------------------------------------------------------------------BASIC TREATMENT
----------------------------------------------------------------------------------------------------------------
· Establish a patent airway with suction where necessary.
· Watch for signs of respiratory insufficiency and assist ventilation as necessary.
Treat symptomatically.
If exposure has been severe and/or symptoms marked, observation in hospital for 48 hours should be considered due to possibility of
delayed pulmonary edema.
Section 5 - FIRE FIGHTING MEASURES
Vapor Pressure (mmHg): 67.806 @ 20C
Upper Explosive Limit (%): 12.0

Specific Gravity (water=1): 0.956 @ 25C
Lower Explosive Limit (%): 2.5
EXTINGUISHING MEDIA
· Foam.
· Dry chemical powder.
FIRE FIGHTING
· Alert Emergency Responders and tell them location and nature of hazard.
· May be violently or explosively reactive.
When any large container (including road and rail tankers) is involved in a fire,
consider evacuation by 1000 metres in all directions.
GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS
· Liquid and vapor are highly flammable.
· Severe fire hazard when exposed to heat, flame and/or oxidizers.
Combustion products include: carbon dioxide (CO2), other pyrolysis products typical of burning organic material.
Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions.
FIRE INCOMPATIBILITY
! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result.
PERSONAL PROTECTION
Glasses:
Chemical goggles.
Gloves:
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1.BUTYL 2.TEFLON 3.PVA
Respirator:
Type A Filter of sufficient capacity
Section 6 - ACCIDENTAL RELEASE MEASURES
MINOR SPILLS
· Remove all ignition sources.
· Clean up all spills immediately.

MAJOR SPILLS
· Clear area of personnel and move upwind.
· Alert Emergency Responders and tell them location and nature of hazard.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
· Most acrylic monomers have low viscosity therefore pouring, material transfer and processing of these materials do not necessitate
heating.
· Viscous monomers may require heating to facilitate handling. To facilitate product transfer from original containers, product must be
heated to no more than 60 deg. C. (140 F.), for not more than 24 hours.
· Containers, even those that have been emptied, may contain explosive vapours.
· Do NOT cut, drill, grind, weld or perform similar operations on or near containers.

Contains low boiling substance:
Storage in sealed containers may result in pressure buildup causing violent rupture of containers not rated appropriately.
· Check for bulging containers.
· Vent periodically.
· DO NOT allow clothing wet with material to stay in contact with skin.
· Avoid all personal contact, including inhalation.
· Wear protective clothing when risk of exposure occurs.
RECOMMENDED STORAGE METHODS
! Packing as supplied by manufacturer. Plastic containers may only be used if approved for flammable liquid.
· For low viscosity materials (i): Drums and jerricans must be of the non-removable head type. (ii): Where a can is to be used as an inner
package, the can must have a screwed enclosure.
· For materials with a viscosity of at least 2680 cSt. (23 deg. C).
STORAGE REQUIREMENTS

· Storage requires stabilizing inhibitor content and dissolved oxygen content to be monitored. Refer to manufacturer's recommended
levels.
· DO NOT overfill containers so as to maintain free head space above product.
· Store below 38 deg. C.
· Store in original containers in approved flame-proof area.
· No smoking, naked lights, heat or ignition sources.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
TWA STEL STEL Peak TWA
Source Material TWA ppm Peak ppm Notes
mg/m! ppm mg/m! mg/m! F/CC
___________ ___________ _______ _______ _______ _______ _______ _______ _______ _______
methyl acrylate
Canada - Alberta
(Methyl acrylate
Occupational 2 7
(Acrylic acid, methyl
Exposure Limits
ester))
Canada - British
Columbia methyl acrylate
2 Skin; S
Occupational (Methyl acrylate)
Exposure Limits
US NIOSH
Recommended methyl acrylate
10 35 [skin]
Exposure Limits (Methyl acrylate)
(RELs)
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US OSHA
Permissible methyl acrylate
10 35
Exposure Levels (Methyl acrylate)
(PELs) - Table Z1
TLV Basis:
eye
irritation;
eye
US ACGIH
methyl acrylate damage;
Threshold Limit 2
(Methyl acrylate) skin &
Values (TLV)
upper
respiratory
tract
irritation
US - Minnesota
Permissible methyl acrylate
10 35
Exposure Limits (Methyl acrylate)
(PELs)
US - Vermont
Permissible
Exposure Limits
methyl acrylate
Table Z-1-A 10 35
(Methyl acrylate)
Transitional
Limits for Air
Contaminants
US - Vermont
Permissible
Exposure Limits methyl acrylate
10 35
Table Z-1-A Final (Methyl acrylate)
Rule Limits for
Air Contaminants
US - Tennessee
Occupational
methyl acrylate
Exposure Limits - 10 35
(Methyl acrylate)
Limits For Air
Contaminants
US - California
Permissible
methyl acrylate
Exposure Limits 10 35
(Methyl acrylate)
for Chemical
Contaminants
US - Idaho -
methyl acrylate
Limits for Air 10 35
(Methyl acrylate)
Contaminants
Canada -
Quebec
Permissible
methyl acrylate
Exposure Values 2 7
(Methyl acrylate)
for Airborne
Contaminants
(English)
US - Hawaii Air
methyl acrylate
Contaminant 10 35
(Methyl acrylate)
Limits
US - Alaska
methyl acrylate
Limits for Air 10 35
(Methyl acrylate)
Contaminants
Canada -
Saskatchewan
Occupational
Health and methyl acrylate
2 4 Skin, SEN
Safety (Methyl acrylate)
Regulations -
Contamination
Limits
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Canada - Yukon
Permissible
methyl acrylate
Concentrations
(Methyl acrylate - 10 35 10 35
for Airborne
Skin)
Contaminant
Substances
US - Washington
Permissible methyl acrylate
10 20
exposure limits of (Methyl acrylate)
air contaminants
US - Michigan
Exposure Limits methyl acrylate
10 35
for Air (Methyl acrylate)
Contaminants
TLV Basis:
eye
irritation;
Canada - Prince eye
Edward Island methyl acrylate damage;
2
Occupational (Methyl acrylate) skin &
Exposure Limits upper
respiratory
tract
irritation
US - Wyoming
Toxic and
Hazardous
methyl acrylate
Substances 10 35
(Methyl acrylate)
Table Z1 Limits
for Air
Contaminants
TLV Basis:
eye
irritation;
Canada - Nova eye
Scotia methyl acrylate damage;
2
Occupational (Methyl acrylate) skin &
Exposure Limits upper
respiratory
tract
irritation
US - Oregon
Permissible methyl acrylate
10 35
Exposure Limits (Methyl acrylate)
(Z-1)
Canada -
Northwest
methyl acrylate
Territories
(Methyl acrylate - 10 35 20 70
Occupational
Skin)
Exposure Limits
(English)
Canada - British
4-methoxyphenol
Columbia
(MEHQ) 5
Occupational
(4-Methoxyphenol)
Exposure Limits
US - Minnesota
4-methoxyphenol
Permissible
(MEHQ) 5
Exposure Limits
(4-Methoxyphenol)
(PELs)
US NIOSH
4-methoxyphenol
Recommended
(MEHQ) 5
Exposure Limits
(4-Methoxyphenol)
(RELs)
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Canada - Alberta 4-methoxyphenol
Occupational (MEHQ) 5
Exposure Limits (4-Methoxyphenol)
US - Vermont
Permissible
4-methoxyphenol
Exposure Limits
(MEHQ) 5
Table Z-1-A Final
(4-Methoxyphenol)
Rule Limits for
Air Contaminants
US - California
Permissible 4-methoxyphenol
Exposure Limits (MEHQ) 5
for Chemical (4-Methoxyphenol)
Contaminants
US - Tennessee
Occupational 4-methoxyphenol
Exposure Limits - (MEHQ) 5
Limits For Air (4-Methoxyphenol)
Contaminants
US - Michigan
4-methoxyphenol
Exposure Limits
(MEHQ) 5
for Air
(4-Methoxyphenol)
Contaminants
US - Washington
4-methoxyphenol
Permissible
(MEHQ) 5 10
exposure limits of
(4-Methoxyphenol)
air contaminants
Canada -
Saskatchewan
Occupational
4-methoxyphenol
Health and
(MEHQ) 5 10
Safety
(4-Methoxyphenol)
Regulations -
Contamination
Limits
Canada -
Quebec
Permissible 4-methoxyphenol
Exposure Values (MEHQ) 5
for Airborne (4-Methoxyphenol)
Contaminants
(English)
TLV Basis:
US ACGIH 4-methoxyphenol eye
Threshold Limit (MEHQ) 5 irritation;
Values (TLV) (4-Methoxyphenol) skin
damage
TLV Basis:
Canada - Nova
4-methoxyphenol eye
Scotia
(MEHQ) 5 irritation;
Occupational
(4-Methoxyphenol) skin
Exposure Limits
damage
TLV Basis:
Canada - Prince
4-methoxyphenol eye
Edward Island
(MEHQ) 5 irritation;
Occupational
(4-Methoxyphenol) skin
Exposure Limits
damage
ENDOELTABLE
PERSONAL PROTECTION

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RESPIRATOR
• type a filter of sufficient capacity.
EYE
· Safety glasses with side shields.
· Chemical goggles.
HANDS/FEET
! NOTE: The material may produce skin sensitization in predisposed individuals. Care must be taken, when removing gloves and other
protective equipment, to avoid all possible skin contact.
Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include: such as:
· frequency and duration of contact,
· chemical resistance of glove material,
· glove thickness and
· dexterity
Select gloves tested to a relevant standard (e.g. Europe EN 374, US F739).
· When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater
than 240 minutes according to EN 374) is recommended.
· When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes
according to EN 374) is recommended.
· Contaminated gloves should be replaced.
Gloves must only be worn on clean hands. After using gloves, hands should be washed and dried thoroughly. Application of a
non-perfumed moisturiser is recommended.
General warning: Do NOT use latex gloves! Use only recommended gloves - using the wrong gloves may increase the risk:
Use of thin nitrile rubber gloves: Nitrile rubber (0.1 mm) Excellent
Exposure condition Short time use; (few minutes less than 0.5 hour)
tactibility ("feel"), powder-free Disposable Inexpensive Give
Little physical stress
adequate protection to low molecular weigh acrylic monomers
Use of medium thick nitrile rubber gloves Nitrile rubber, NRL (latex)
free; <0.45 mm Moderate tactibility ("feel"), powder-free Disposable
Exposure condition Medium time use; less than 4 hours Physical
Moderate price Gives adequate protection for most acrylates up to
stress (opening drums, using tools, etc.)
4 hours Do NOT give adequate protection to low molecular weight
monomers at exposures longer than 1 hour
Nitrile rubber, NRL (latex) free; >0.56 mm low tactibility ("feel"),
powder free High price Gives adequate protection for most
acrylates in combination with commonly used solvents up to 8
Exposure condition Long time Cleaning operations
hours Do NOT give adequate protection to low molecular weight
monomers at exposures longer than 1 hour Avoid use of ketones
and acetates in wash-up solutions.
Where none of this gloves ensure safe handling (for example in long term handling of acrylates containing high levels of acetates and/ or
ketones, use laminated multilayer gloves.
Guide to the Classification and Labelling of UV/EB Acrylates Third edition, 231 October 2007 - Cefic.
OTHER
· Overalls.
· PVC Apron.
· Some plastic personal protective equipment (PPE) (e.g. gloves, aprons, overshoes) are not recommended as they may produce static
electricity.
· For large scale or continuous use wear tight-weave non-static clothing (no metallic fasteners, cuffs or pockets), non sparking safety
footwear.
ENGINEERING CONTROLS
! For flammable liquids and flammable gases, local exhaust ventilation or a process enclosure ventilation system may be required.
Ventilation equipment should be explosion-resistant.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL PROPERTIES
Liquid.
Mixes with water.

State Liquid Molecular Weight 86.09
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Melting Range (°F) -105 Viscosity Not Available
Boiling Range (°F) 176 Solubility in water (g/L) Miscible
Flash Point (°F) 27TCC pH (1% solution) Not applicable.
Decomposition Temp (°F) Not available. pH (as supplied) Not applicable
Autoignition Temp (°F) 779 Vapor Pressure (mmHg) 67.806 @ 20C
Upper Explosive Limit (%) 12.0 Specific Gravity (water=1) 0.956 @ 25C
Lower Explosive Limit (%) 2.5 Relative Vapor Density (air=1) 2.95
Volatile Component (%vol) 100 Evaporation Rate >1 BuAc=1 Fast
Gas group IIB
APPEARANCE
Clear highly flammable liquid; floats on water. Solubility in water 5%. Soluble in alcohol and hydrocarbons. Strong acrid ester smell at low

exposures, unpleasant at high concentrations Stabilised reactive monomer. Inhibitor level should be regularly checked. Inhibitor system
requires oxygen to function, hence bulk storages may require aeration. Do NOT STORE under nitrogen as polymerisation will occur.
Ecotoxicity of acrylates is a function of n-octanol/ water partition coefficient (log Pow, log Kow). Compounds with a log Pow >5 exhibit
simple narcosis, but at lower log Pow the toxicity of acrylates is greater than predicted for simple narcotics. log Kow 0.8
Material Value
Section 10 - CHEMICAL STABILITY
CONDITIONS CONTRIBUTING TO INSTABILITY
· Material contains a stabilizer / polymerization inhibitor system that provides workable but not indefinite shelf life.

· Storage at higher temperatures and long term storage may result in polymerization with solidification. In larger quantities e.g. 200 l
drums, this may result in generation of heat (exotherm) which may release highly irritating hot vapor.
STORAGE INCOMPATIBILITY
! Methyl acrylate:
· may polymerise explosively when heated above 21 C, or in light, or when when inhibitor concentrations fall to low levels
· storage containers may explode at elevated temperatures
· reacts violently with strong oxidisers
· is incompatible with strong acids, alkalis, aliphatic amines, alkanolamines, polyvinyl chloride, mercaptans, nitro- compounds,
perborates, azides, ethers, ketones, aldehydes, nitrates, nitrites, reducing agents, acid anhydrides, acid chlorides, concentrated mineral
acids, metal salts, strong bases,
· is usually stored below 10 deg C
· vapour may block vents and confined spaces after forming solid polymers
NOTE: Contact with alkali solutions will remove inhibitor and render material unstable on storage.
Avoid oxygen content of less than 5%.
For acrylic and methacrylic acid esters:
· Avoid contact with strong acids, strong alkalies, oxidising agents, polymerisation initiators (peroxides, persulfates), iron or rust
· Avoid heat, flame, sunlight, x-rays or ultra-violet radiation.
· Polymerisation may occur at elevated temperature and in presence of ignition sources - polymerisation of large quantities may be
violent (even explosive).
· Store below 38 deg. C.
· Avoid any contamination of this material as it is very reactive and any contamination is potentially hazardous.
· Avoid strong bases.
Contamination with polymerization catalysts - peroxides, persulfates, oxidizing agents - also strong acids, strong alkalies, will cause
polymerization with exotherm - generation of heat.
Polymerization of large quantities may be violent - even explosive.
For incompatible materials - refer to Section 7 - Handling and Storage.
Section 11 - TOXICOLOGICAL INFORMATION
methyl acrylate
TOXICITY AND IRRITATION
! unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
! Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's edema. The pathogenesis of
contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type.
METHYL ACRYLATE:
TOXICITY IRRITATION
Oral (rat) LD50: 277 mg/kg Skin (rabbit): 10 mg/24h
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Dermal (rabbit) LD50: 1243 mg/kg Skin: Irritant (OECD 404)
Inhalation (rat) LC50: 6350 ppm/4h Eye: SEVERE (Draize) *
Oral (Rat) LD50: 75 mg/kg * Eye (rat): 578 ppm/49h Int.
Inhalation (Rat) LC50: 5700 mg/m!/4h * Eye (rabbit): 100 mg/24h - Moderate
Dermal (Rabbit) LD50: 1250 mg/kg *
Inhalation (Rat) LC50: 1350 ppm/4h
Inhalation (Human) TCLo: 75 ppm
! Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a
non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of
highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic
individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A
reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge
testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of
RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration
of exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high
concentrations of irritating substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is
characterised by dyspnea, cough and mucus production.
Allergic reactions involving the respiratory tract are usually due to interactions between IgE antibodies and allergens and occur rapidly.
Allergic potential of the allergen and period of exposure often determine the severity of symptoms.
Attention should be paid to atopic diathesis, characterized by increased susceptibility to nasal inflammation, asthma and eczema.
Exogenous allergic alveolitis is induced essentially by allergen specific immune-complexes of the IgG type; cell-mediated reactions (T
lymphocytes) may be involved. Such allergy is of the delayed type with onset up to four hours following exposure.
Where no "official" classification for acrylates and methacrylates exists, there has been cautious attempts to create classifications in the
absence of contrary evidence. For example
Monalkyl or monoarylesters of acrylic acids should be classified as R36/37/38 and R51/53
Monoalkyl or monoaryl esters of methacrylic acid should be classified as R36/37/38.
The material may cause severe skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling,
the production of vesicles, scaling and thickening of the skin. Repeated exposures may produce severe ulceration.
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
Based on the available oncogenicity data and without a better understanding of the carcinogenic mechanism the Health and
Environmental Review Division (HERD), Office of Toxic Substances (OTS), of the US EPA previously concluded that all chemicals that
contain the acrylate or methacrylate moiety (CH2=CHCOO or CH2=C(CH3)COO) should be considered to be a carcinogenic hazard
unless shown otherwise by adequate testing.
This position has now been revised and acrylates and methacrylates are no longer de facto carcinogens.
Chronic toxicity
Genetic toxicity: Results from a number of mutagenicity studies with microorganisms, mammalian cell culture and mammals are
available. Taking into account all of the information, there is no indication that the substance is mutagenic.
Carcinogenicity: In long-term animal studies in which the substance was given by inhalation, a carcinogenic effect was not observed.
Reproductive toxicity: The results of animal studies gave no indication of a fertility impairing effect.
Developmental toxicity/teratogenicity: In animal studies the substance did not cause malformations.
Other information: development of pulmonary edema
*BASF MSDS
TOXICITY IRRITATION
4-METHOXYPHENOL (MEHQ):
Skin
(rabbit):
Oral (rat) LD50: 1600 mg/kg 6000
mg/12d-I
Mild

! The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin
redness, swelling, the production of vesicles, scaling and thickening of the skin.
CARCINOGEN
US - Rhode Island Hazardous
methyl acrylate IARC
Substance List

US - Rhode Island Hazardous
4-methoxyphenol (MEHQ) IARC
Substance List
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