Table Of ContentR.E. Mansel
O. Fodstad
W.G. Jiang
Editors
Cancer Metastasis - Biology and Treatment 11
Metastasis of
Breast Cancer
(cid:5)(cid:6)(cid:0)(cid:4)
Metastasis of Breast Cancer
Cancer Metastasis – Biology and Treatment
VOLUME 11
SeriesEditors
RichardJ.Ablin,Ph.D.,UniversityofArizona,CollegeofMedicineandTheArizonaCancer
Center,AZ,U.S.A.
WenG.Jiang,M.D.,WalesCollegeofMedicine,CardiffUniversity,Cardiff,U.K.
AdvisoryEditorialBoard
HaroldF.Dvorak,M.D.
PhilGold,M.D.,Ph.D.
DannyWelchPh.D.
HiroshiKobayashi,M.D.,Ph.D.
RobertE.Mansel,M.S.,FRCS.
KlausPantelPh.D.
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Editors:Jean-MichelFoidartandRuthJ.Muschel
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Volume11:MetastasisofBreastCancer
Editors:Robe rt E.Ma nsel,Oy steinFod stad and Wen G.Jiang
ISBN1-4020-5866-7
Metastasis of Breast
Cancer
Edited by
Robert E. Mansel
Cardiff University School of Medicine
Oystein Fodstad
UniversityofSouth Alabama
and
W en G.Jiang
CardiffUniversitySchool ofMedicine
AC.I.P.CataloguerecordforthisbookisavailablefromtheLibraryofCongress.
ISBN978-1-4020-5866-0(HB)
ISBN978-1-4020-5867-7(e-book)
PublishedbySpringer,
P.O.Box17,3300AADordrecht,TheNetherlands.
www.springer.com
Printedonacid-freepaper
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©2007Springer
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TABLE OF CONTENTS
List of Contributors …………………………………..……… ix
Chapter 1 …………………………………………… 1
Metastasis of breast cancer: an introduction
Robert E. Mansel, Oystein Fodstad, and Wen G. Jiang
Chapter 2 …………………………………………… 7
The genetic control of breast cancer metastasis
Rajeev S. Samant, Oystein Fodstad, and Lalita A. Shevde
Chapter 3 …………………………………………… 31
BRCA1 in initiation, invasion, and metastasis of breast
cancer: a perspective from the tumor microenvironment
Shaun D. McCullough, Yanfen Hu, and Rong Li
Chapter 4 …………………………………………… 47
Cell motility and breast cancer metastasis
Marc E. Bracke, Daan De Maeseneer, Veerle Van Marck,
Lara Derycke, Barbara Vanhoecke, Olivier De Wever, and
Herman T. Depypere
Chapter 5 …………………………………………… 77
Tight junctions and metastasis of breast cancer
Tracey A. Martin
Chapter 6 …………………………………………… 111
Cell adhesion molecules in breast cancer invasion
and metastasis
Lalita A. Shevde and Judy A. King
vi Table of contents
Chapter 7 …………………………………………… 137
Endocrine resistance and breast cancer invasion
Stephen Hiscox, Julia Gee, and Robert I. Nicholson
Chapter 8 …………………………………………… 151
The role of aromatase and other oestrogen producing
enzymes in mammary carcinogenesis
Mohamed Salhab and Kefah Mokbel
Chapter 9 …………………………………………… 171
The role of the HGF regulatory factors in breast cancer
Christian Parr and Wen G. Jiang
Chapter 10 …………………………………………… 203
The insulin-like growth factor-1 ligand in breast cancer
management
Yoon M. Chong, Ash Subramanian, and Kefah Mokbel
Chapter 11 …………………………………………… 219
Lymphangiogenesis and metastatic spread of breast
cancer
Mahir A. Al-Rawi and Wen G Jiang
Chapter 12 …………………………………………… 241
Breast cancer secreted factors alter the bone
microenvironment
Valerie A. Siclari, Theresa A. Guise, and John M. Chirgwin
Chapter 13 …………………………………………… 259
Cyclooxygenease-2 and breast cancer
Gurpreet Singh-Ranger and Kefah Mokbel
Chapter14 …………………………………………… 279
Prognostic and predictive factors in human breast
cancer
Soe Maunglay, Douglas C. Marchion, and Pamela N.
Münster
Table of contents vii
Chapter 15 …………………………………………… 307
Molecular imaging in metastatic breast cancer
C.P. Schröder, G.A.P. Hospers, P.H.B. Willemse, P.J.
Perik, E.F.J. de Vries, P.L. Jager, W.T.A. van der Graaf,
M.N. Lub-de Hooge, and E.G.E. de Vries
Chapter 16 …………………………………………… 321
Detection of disseminated tumor cells in the bone
marrow and blood of breast cancer patients
Volkmar Müller and Klaus Pantel
Chapter 17 …………………………………………… 333
Sentinel lymph node biopsy in early-stage breast cancer
Amit Goyal and Robert E. Mansel
Chapter 18 …………………………………………… 355
Surgical management of patients with metastatic breast
cancer
Adam I. Riker, SuHu Liu, Mona Hagmaier, Matthew J. D.
D’lessio, and Charles E. Cox
Chapter 19 …………………………………………… 373
Therapeutic aspect of metastatic breast cancer:
chemotherapy
Robert C.F. Leonard and Thinn P. Pwint
Chapter 20 …………………………………………… 389
The diagnosis and treatment of bone metastases
in breast cancer
Allan Lipton
Chapter 21 …………………………………………… 405
Hormonal therapies of metastatic breast cancer:
the past and the present
Jürgen Geisler and Per Eystein Lønning
Index …………………………………………… 425
LIST OF CONTRIBUTORS
Al-Rawi, Mahir A., MB, BCh, PhD, Metastasis and Angiogenesis
Research Group, Cardiff University School of Medicine, Heath Park,
Cardiff CF14 4XN, UK
Bracke, Marc, PhD, Professor, Laboratory of Experimental Cancer
Research, Department of Experimental Cancer Research, Radiotherapy
and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000
Gent, Belgium
Chirgwin, John M., PhD, Professor of Internal Medicine, Division of
Endocrinology, University of Virginia PO Box 801401, Charlottesville
VA 22908-1401, USA
Chong, Yoon M., Department of Breast & Endocrine Surgery, St.
George’s Hospital, London, SW17 0QT, UK
Cox, Charles E., M.D., University of South Florida, Moffitt Cancer
Center, 13902 Magnolia Drive, Tampa, FL 33612, USA; Mitchell Cancer
Institute, University of South Alabama, Mobile, Alabama, USA
D’Alessio, Matthew J., MD, University of South Alabama-Mitchell
Cancer Institute, 301 North University Blvd., MSB 2015, Mobile, AL
36688, USA
De Maeseneer, Daan, Laboratory of Experimental Cancer Research,
Department o f Experimental Cancer Research, Radiotherapy and Nuclear
Medicine, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium
ix
x List of contributors
de Vries, E.F.J., Nuclear Medicine and Molecular Imaging, University
Medical Centre Groningen, Groningen, The Netherlands
de Vries, Elisabeth G.E., MD, PhD, Department of Medical Oncology,
University of Groningen and University Medical Center, P.O. Box 30.001,
9700 RB, Groningen, The Netherlands.
De Wever, Olivier, Laboratory of Experimental Cancer Research, Depart-
ment of Experimental Cancer Research, Radiotherapy, and Nuclear
Medicine, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium
Depypere, Herman T., Department of Gynaecological Oncology,
University Hospital, De Pintelaan 185, B-9000 Gent, Belgium
Derycke, Lara, Laboratory of Experimental Cancer Research, Depart-
ment of Experimental Cancer Research, Radiotherapy, and Nuclear
Medicine, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium
Fodstad, Oystein, PhD, Director of Research, Professor of Cancer Biology
and Pharmacology, Michell Cancer Institute, University of South Alabama,
307 N. University Blvd., MSB 2015, Mobile, AL 36688, USA
Gee, Julia, Tenovus Centre for Cancer Research, Welsh School of Phar-
macy, Cardiff University, Heath Park, Cardiff, CF10 3XF, UK
Geisler, Jürgen, Consultant, Section of Oncology, Department of
Medicine, Haukeland University Hospital, N-5021 Bergen, Norway
Goyal, Amit, MB, MD, Lecturer, University Department of Surgery,
Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN,
UK
Guise, Theresa A., Division of Endocrinology, University of Virginia
PO Box 801401, Charlottesville VA 22908-1401, USA
