Table Of ContentMETASTASIS
Clinical and Experimental Aspects
Proceedings of the EORTC Metastasis Group International Conference
on Clinical and Experimental Aspects of Metastasis, London, April 21-23,
1980
edited by
K. HELLMANN
Imperial Cancer Research Fund
London, England
P. HILGARD
Bristol-Myers International
Brussels, Belgium
S. ECCLES
Institute of Cancer Research
Sutton, Surrey, England
•
1980
SPRINGER-SCIENCE+BUSINESS MEDIA, B.V.
ISBN 978-94-009-8927-6 ISBN 978-94-009-8925-2 (eBook)
DOI 10.1007/978-94-009-8925-2
Copyrigh t © 1980 by Springer Science+Business Media Dordrecht
OriginaJly published by MartÎnus Nijhoff Publishers in 1980
Softcover reprint ofthe hardcover lst edition 1980
Ali rights reserved. No part of this publication may be reproduced, stored in a retrieval
system, or transmitted in any form or by any means, mechanical, photocopying, recording,
or otherwise, without the prior written permission of the publisher:
Springer-Science+Business Media, B. V.
DEVELOPMENTS IN ONCOLOGY
VOLUME 4
Previously published in this series:
1. F.J. Cleton and J.W.I.M. Simons, eds., Genetic Origins of Tumor Cells
ISBN 90-247-2272-1
2. J. Aisner and P. Chang, eds., Cancer Treatment Research
ISBN 90-247-2358-2
3. B.W. Ongerboer de Visser, D.A. Bosch and W.M.H. van Woerkom-Eykenboom, eds.,
Neuro-Oncology: Clinical and Experimental Aspects
ISBN 90-247-2421-X
Series ISBN: 90-247-2338-8
METASTASIS
PREFACE
The Metastasis Group of the European Organization for
Research on Treatment of Cancer (EORTC) held an International
Meeting at the Royal Institution in London on April 2lst-23rd,
1980. The subject was "Clinical and Experimental Aspects of
Metastasis" and these Proceedings are the record of that
Meeting.
Almost all of those who presented a paper or a poster
have written up their contributions as chapters of the
Proceedings and we have made no distinction here between
posters and oral communications. The Organizers and Editors
owe a considerable debt of gratitude to all the contributors
who without exception presented the results of their work in
a clear and concise manner that did much to reveal the essence
of the complex problems central to current thinking on met
astasis. Moreover most manuscripts arrived well within the
deadline - a circumstance which in our experience is unusual.
Of the large audience who attended the Meeting many had
come from the far distant corners of the World and to them as
well as to the presenters of papers the Organizers wish to
express their deep appreciation.
The Organizers would also like to express their indebted
ness to the organizations whose financial contribution made
this EORTC Metastasis Group Meeting possible and a list of
them follows.
VI
The keen interest which was shown in the Meeting has led
many to ask about future meetings and these it is hoped can be
arranged before long, though the framework within which this
will take place remains to be settled.
for the EORTC Metastasis Group
K. Hellmann, Chairman
P. Hilgard, co-Chairman
S. Eccles
VII
ACKNOWLEDGEMENTS
The Organizing Committee, which consisted of:
J. Castro, London
S. Eccles, Sutton
K. Hellmann, London
P. Hilgard, Brussels
F. Spreafico, Milano
thanks the following for their generous support of the EORTC
Metastasis Conference
Abbott Laboratories Ltd.
Bayer Pharma-Forschungszentrum
Boehringer Ingelheim Ltd.
Boots Co. Ltd.
Bristol-Myers International
Cancer Research Campaign
Dome Laboratories
Eli Lilly & Co. Ltd.
Glaxo Holdings
Imperial Cancer Research Fund
I.C.I. Ltd.
Lederle Laboratories Ltd.
Monsanto Company
Montedison Pharmaceuticals Ltd.
Roche Products Ltd.
Wellcome Foundation Ltd.
They would also like to thank all the staff of the Cancer
Chemotherapy Department, Imperial Cancer Research Fund who
helped at the Meeting and whose unstinting efforts made this
occasion run as smoothly as it did.
They would particularly like to thank Mrs. Jean Hartley
who not only organized the secretariat, but who also collated
all the papers of the Proceedings and retyped many of them.
Thanks are also due to Ms. Stephanie Jibson whose valiant
efforts resulted in the exhaustive Index of this book.
CONTENTS
The Significance of Metastases to the Surgeon • • . . • 1
H. Ellis
The Spread of Rectal Cancer into Veins and the
Mechanism of Distant Embolism • . . . • 3
I.C. Talbot
Squamous Carcinomas of the Head & Neck: Patterns
and Mechanisms of Local Invasion and
Metastasis 9
R.L. Carter
The Relationship between Malignant Melanoma
Morphology, Metastases and Patient Survival 13
B. Boeryd, J. Eldh and L.-E. Peterson
Animal Tumour Models: The Intrusion of Artefacts 18
H.B. Hewitt
Models of Prostate, Breast, Lung and Intestinal
Carcinomas which Metastasize in Rats • . 23
M. Pollard
A New In-Vitro Model to Study Tumour Cell Invasion 28
R. Tchao, A.B. Schleich, M. Frick and A. Mayer
Invasiveness and the "Metastatic Potential" of
Tumour Cells • . . • • . • • . • 33
C. Meyvisch, P. Van Hoorde and M. Mareel
A Possibility of Predicting the Metastatic
Potential of Tumours by Implantation into
Chick Embryo Blastoderms • . . • • • 38
G.V. Sherbet and M.S. Lakshmi
An Experimental Study on the Barrier Function of
Lymph Nodes to Tumor Cells • • • • • 45
K. Kohno, T. Yamaguchi and T. Takahashi
X
CONTENTS
Metastases from DMBA-Induced Carcinomas in
Hamster Cheek Pouch .•...••. 50
G.T.Craig
Quantitation and Cellular Growth of Occult
Metastases of a Rat Mammary Carcinoma 55
H. Speakman and B. Dixon
Comparison of Natural and Artificial Lung
Metastases from a Murine Tumour of
Spontaneous Origin 60
A.C. Begg and K.A. Smith
Growth Inhibition of Simulated Metastases by a
Large Primary Tumor • • • • . 65
s.
Ohl, F. Schuning and e.G. Schmidt
Quantitative Studies on Metastasis using Yoshida
Rat Ascites Hepatomas, with Special
Reference to the Biological Characteristics
in Metastasizability and Drug Sensitivity • 69
H. Sate, M. Suzuki and H. Satoh
Canine Osteosarcoma and Canine Mammary Carcinoma . . 75
L.N. Owen
Selection of a Human Malignant Melanoma X
Hamster Hybrid Cell Line by Metastasis 80
J.F. Watkins
Morphological Aspects of the Interaction of
Blood Coagulation and Tumour Dissemination. 85
K.P. Dingemans
Cancer Cell Procoagulant Activity, Warfarin
and Experimental Metastases . • . • . • • . • 90
M. Colucci, F. Delaini, G.de Bellis Vitti,
D. Locati, A. Poggi, N. Semeraro and M.B. Donati
XI
CONTENTS
Molecular Mechanism of Fibrinolysis and its
Potential Role in Metastasis •••. 95
S.A. Cederholm-Williams
Fibrinolysis and Anticoagulation in Colo-Rectal
Cancer The Way Ahead • • • . . 100
H. White, J. Griffiths and A. Salsbury
Studies on Factors Influencing the Lodgement
of Circulating Tumour Cells . • • • 105
G. Skolnik, M. Alpsten and L. Ivarsson
Critical Analysis of Experimental Models for the
Antimetastatic Effects of Anticoagulants 109
B. Moat and P. Hilgard
Effect of Fibrinolysis Inhibition on the Growth
and Hematogenous Dissemination of Cancer. 116
K. Tanaka, M. Kinjo, A. Iwakawa, H. Ogawa
and N. Tanaka
Mechanisms Behind the Inhibiting Effect of
Tranexamic Acid on Tumour Growth and
Spread • . . • • • • • • . ..•• 122
H.-I. Peterson and A. Sundbeck
The Inhibitory Effect of Sulfated Polysaccharides,
Ancrod or Tranexamic Acid on Pulmonary
Metastases in Animals • • • • • • • • • • • 127
T. Yamashita, Y. Higuchi and E. Tsubura
Prostacyclin as a Marker for Diagnosing and
Staging Carcinoma of the Prostate • • 132
0. Khan, C.N. Hensby, H.D. Mitcheson and
G. Williams
Prostaglandins and Metastasis 136
M.J. Tisdale
The Application of a Defibrinogenating Snake
Venom Enzyme in Experimental Tumor
Metastasis . • • • • • 142
F.S. Markland, K.M. Hwang, S.S. Bajwa and
G.B. Patkos
