Table Of ContentMetal Ions in Life Sciences 12
Series Editors: Astrid Sigel · Helmut Sigel · Roland K.O. Sigel
Lucia Banci Editor
Metallomics
and the Cell
Metallomics and the Cell
Metal Ions in Life Sciences
Volume 12
Guest Editor:
Lucia Banci
Series Editors:
Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
For further volumes:
http://www.springer.com/series/8385 and http://www.mils-series.com
Astrid Sigel (cid:129) Helmut Sigel (cid:129) Roland K.O. Sigel
Series Editors
Lucia Banci
Editor
Metallomics and the Cell
Editor
Lucia Banci Department of Chemistry
Centro Risonanze Magnetiche University of Florence
University of Florence Via della Lastruccia 5
Via Luigi Sacconi 6 I-50019 Sesto Fiorentino (Florence), Italy
I-50019 Sesto Fiorentino (Florence), Italy
[email protected]fi .it
Series Editors
Astrid Sigel Helmut Sigel
Department of Chemistry Department of Chemistry
Inorganic Chemistry Inorganic Chemistry
University of Basel University of Basel
Spitalstrasse 51 Spitalstrasse 51
CH-4056 Basel CH-4056 Basel
Switzerland Switzerland
[email protected] [email protected]
Roland K.O. Sigel
Institute of Inorganic Chemistry
University of Zürich
Winterthurerstrasse 190
CH-8057 Zürich
Switzerland
[email protected]
ISSN 1559-0836 ISSN 1868-0402 (electronic)
ISBN 978-94-007-5560-4 ISBN 978-94-007-5561-1 (eBook)
DOI 10.1007/978-94-007-5561-1
Springer Dordrecht Heidelberg New York London
Library of Congress Control Number: 2013933450
© Springer Science+Business Media Dordrecht 2013
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of
the material is concerned, speci fi cally the rights of translation, reprinting, reuse of illustrations, recitation,
broadcasting, reproduction on micro fi lms or in any other physical way, and transmission or information
storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology
now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection
with reviews or scholarly analysis or material supplied speci fi cally for the purpose of being entered and
executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this
publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s
location, in its current version, and permission for use must always be obtained from Springer. Permissions
for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to
prosecution under the respective Copyright Law.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
While the advice and information in this book are believed to be true and accurate at the date of
publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for
any errors or omissions that may be made. The publisher makes no warranty, express or implied, with
respect to the material contained herein.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
Dedication to Ivano Bertini
Ivano Bertini passed away untimely on July 7, 2012, at the age of 71. With him the
Bioinorganic Community lost one of its giants. Ivano left his traces all the way from
Inorganic Chemistry through Magnetic Resonance and Biochemistry to the Medical
Sciences with more than 6 50 papers. He and his group in Florence, known for their
pioneering NMR work, solved over 150 protein structures. Thanks to his enthusiasm,
driving personality, and the way he viewed international relationships, he was
initiator and cofounder of the I nternational Conferences on Bioinorganic C hemistry
(ICBICs), the European Biological Inorganic Chemistry Conferences (EuroBICs),
the E urasia Conferences on Chemical Sciences (EuAsC2S), the E uropean
Conferences on Chemistry for Life Sciences (ECCLS), the C hianti Workshops , and
more. Ivano was also one of the founders of the S ociety for Biological Inorganic
Chemistry (SBIC) and the fi rst Editor of the J ournal of Biological Inorganic Chemistry
v
vi
(JBIC). To name just a few of his initiatives and impacts, which last but not least
included also the foundation of CERM, the Magnetic Resonance Center of the
University of Florence.
This volume M etallomics and the Cell is devoted to Ivano, who coauthored
Chapter 1 of this book, and who was fascinated by the “omics” sciences and the
possibilities they offer for understanding life. It is thus no surprise to read in the
mentioned chapter …” It is the duty of the bioinorganic chemistry community to
convince funding agencies that the research on metallomes and metallomics deserves
attention” and support. He was a true protagonist of new ideas!
There is no way to list here all the achievements of Ivano Bertini and therefore, we
simply close by saying: THANK YOU, Ivano, for what you did for us, the chemical
sciences and the scienti fi c community in general – you will never be forgotten!
Sesto Fiorentino (Florence) , Italy Lucia Banci
Basel , Switzerland Astrid Sigel
Basel , Switzerland Helmut Sigel
Zürich , Switzerland Roland K. O. Sigel
Historical Development and Perspectives
of the Series
Metal Ions in Life Sciences*
It is an old wisdom that metals are indispensable for life. Indeed, several of them,
like sodium, potassium, and calcium, are easily discovered in living matter. However,
the role of metals and their impact on life remained largely hidden until inorganic
chemistry and coordination chemistry experienced a pronounced revival in the
1950s. The experimental and theoretical tools created in this period and their appli-
cation to biochemical problems led to the development of the fi eld or discipline now
known as B ioinorganic Chemistry , Inorganic Biochemistry , or more recently also
often addressed as B iological Inorganic Chemistry .
By 1970 B ioinorganic Chemistry was established and further promoted by the
book series M etal Ions in Biological S ystems founded in 1973 (edited by H.S., who
was soon joined by A.S.) and published by Marcel Dekker, Inc., New York, for
more than 30 years. After this company ceased to be a family endeavor and its
acquisition by another company, we decided, after having edited 44 volumes of the
MIBS series (the last two together with R.K.O.S.) to launch a new and broader
minded series to cover today’s needs in the L ife Sciences . Therefore, the Sigels new
series is entitled
Metal Ions in Life Sciences.
After publication of the fi rst four volumes (2006–2008) with John Wiley & Sons,
Ltd., Chichester, UK, and the next fi ve volumes (2009–2011) with the Royal Society
of Chemistry, Cambridge, UK, we are happy to join forces now in this still new
endeavor with Springer Science & Business Media B.V., Dordrecht, The Netherlands;
a most experienced Publisher in the S ciences .
*Reproduced with some alterations by permission of John Wiley & Sons, Ltd., Chichester, UK
(copyright 2006) from pages v and vi of Volume 1 of the series Metal Ions in Life Sciences (MILS-1).
vii
viii Historical Development and Perspectives of the Series
The development of B iological Inorganic Chemistry during the past 40 years
was and still is driven by several factors; among these are (i) the attempts to reveal
the interplay between metal ions and peptides, nucleotides, hormones or vitamins,
etc., (ii) the efforts regarding the understanding of accumulation, transport, metabo-
lism and toxicity of metal ions, (iii) the development and application of metal-based
drugs, (iv) biomimetic syntheses with the aim to understand biological processes as
well as to create ef fi cient catalysts, (v) the determination of high-resolution structures
of proteins, nucleic acids, and other biomolecules, (vi) the utilization of powerful
spectros-copic tools allowing studies of structures and dynamics, and (vii), more
recently, the widespread use of macromolecular engineering to create new biologi-
cally relevant structures at will. All this and more is and will be re fl ected in the
volumes of the series M etal Ions in Life Sciences .
The importance of metal ions to the vital functions of living organisms, hence, to
their health and well-being, is nowadays well accepted. However, in spite of all the
progress made, we are still only at the brink of understanding these processes.
Therefore, the series M etal Ions in Life S ciences will endeavor to link coordination
chemistry and biochemistry in their widest sense. Despite the evident expectation
that a great deal of future outstanding discoveries will be made in the interdisciplinary
areas of science, there are still “language” barriers between the historically separate
spheres of chemistry, biology, medicine, and physics. Thus, it is one of the aims of
this series to catalyze mutual “understanding”.
It is our hope that M etal Ions in Life Sciences proves a stimulus for new activities
in the fascinating “ fi eld” of Biological Inorganic Chemistry . If so, it will well serve
its purpose and be a rewarding result for the efforts spent by the authors.
Astrid Sigel and Helmut Sigel
Department of Chemistry, Inorganic Chemistry,
University of Basel, CH-4056 Basel, Switzerland
Roland K.O. Sigel
Institute of Inorganic Chemistry,
Unversity of Zürich, CH-8057 Zürich, Switzerland
October 2005,
October 2008,
and August 2011
Preface to Volume 12
Metallomics and the Cell
In this volume of the Metal Ions in Life Sciences series a broad and complete coverage
of the “omics” approach to the fi eld of metal ions in biological systems is presented
and discussed in a cellular context, i.e., in the frame of a cell or of living systems,
underlining the complexity of the interactions between living systems and inorganic
elements.
In Chapter 1 general concepts are elaborated and the de fi nition of the metallome
is provided, as the ensemble of all the biomolecules in a system which bind a given
metal ion or an inorganic element in general, or are affected by that element. The
metallome is therefore a dynamic property which depends on the conditions of the
system. Metallomics is the systematic study of a metallome and of the functional
connections and interactions of the metal ion with the genome, proteome, metabo-
lome, and other biomolecules in an organism. The role of bioinformatics and infor-
mation technology are also discussed, and this knowledge framed in a cellular
context. The need of this perspective is required in order to describe the functional
processes. The ultimate goal of reaching a systems biology vision from the know-
ledge of the interlinks and connections among the various pathways and processes
involving metal ions in the cell is discussed.
Chapter 2 presents an overview of the most suitable methods for the analysis of
metal distributions in a cell, and how this distribution is affected by the cellular
status and conditions.
In the following, from Chapter 3 through 15, the metallome relative to various
metal ions is described, limited to the essential metal ions for at least one domain
of life. So the chapters encompass sodium and potassium and range to magnesium,
calcium, and then to manganese, iron, cobalt, nickel, copper, zinc, as well as molyb-
denum and tungsten. When needed and/or enough knowledge is available, the metal-
lome description has been subdivided based on the type of organism, i.e., bacteria and
eukaryotic ones, as well on the type of cofactors, e.g., heme for iron. An overview
of the most relevant biomolecules (mostly proteins) functionally interacting with
ix
