Memory Loss, Alzheimer's Disease and Dementia: A Practical Guide for Clinicians

943 Pages·2021·19.493 MB·English

by  Andrew E. Budson MD, Paul R. Solomon PhD

Memory Loss, Alzheimer’s
Disease, and Dementia
A Practical Guide for Clinicians
THIRD EDITION
Andrew E. Budson, MD
Neurology Service, Section of Cognitive & Behavioral Neurology, Veterans
Affairs Boston Healthcare System, Boston, MA
Alzheimer’s Disease Research Center & Department of Neurology, Boston
University School of Medicine, Boston, MA
Harvard Medical School, Boston, MA
The Boston Center for Memory, Newton, MA
Paul R. Solomon, PhD
Department of Psychology, Program in Neuroscience, Williams College,
Williamstown, MA
The Boston Center for Memory, Newton, MA

Table of Contents
Title page
Any screen, Any time, Anywhere
Copyright
Praise for the First Edition
Praise for the Second Edition
Preface to the Third Edition
How To Use This Book
Acknowledgments
Disclosures
About the Authors
Video Table of Contents
Section I: Evaluating the Patient With Memory Loss or
Dementia
1. Why Diagnose and Treat Memory Loss, Alzheimer’s Disease, and
Dementia?
Helping the Patient
Helping the Family or Other Caregiver
Saving Money
Planning for the Future
Quality Versus Quantity
References
2. Evaluating the Patient With Memory Loss or Dementia
Talking With The Family
In the Clinic
At the Bedside
History
Review of Systems
Medical History
Allergies to Medications
Social History
Family History
Physical Examination
Cognitive Tests and Questionnaires
Screening in the Clinic
Laboratory Studies
Structural Imaging Studies
Functional Imaging Studies
Tests that Suggest Alzheimer’s Disease
Summary
References
3. Subjective Cognitive Decline, Mild Cognitive Impairment, and
Dementia
A Three-Step Approach
The Spectrum of Cognitive Changes
Is Dementia Present?
Is Mild Cognitive Impairment Present?
Is Subjective Cognitive Decline Present?
Which Clinical Syndrome is Present?
What is the Underlying Pathology?
References
Section II: Differential Diagnosis of Memory Loss and
Dementia
4. Alzheimer’s Disease
Prevalence, Prognosis, and Definition
Alzheimer’s Pathology
Neurochemistry
Diagnostic Criteria
Risk Factors, Pathology, and Pathophysiology
Common Signs, Symptoms, and Stages
Things to Look for in the History
Things to Look for on the Physical and Neurological Examination
Pattern of Impairment on Cognitive Tests
Laboratory Studies
Structural Imaging Studies
Molecular and Functional Imaging Studies
Differential Diagnosis
Treatments
References
5. Primary Age-Related Tauopathy
Prevalence, Pathology, Genetics, and Definition
Clinical Features, History, and Pattern of Impairment on Cognitive
Tests
Things to Look for on the Physical and Neurological Examination
Laboratory Studies
Structural Imaging Studies
Functional and Molecular Imaging Studies
Differential Diagnosis
Treatments
References
6. Limbic-predominant Age-related TDP-43 Encephalopathy
Prevalence, Prognosis, and Definition
Clinical Diagnosis
Pathology, Pathophysiology, and Genetics
Common Signs, Symptoms, and Stages
Things to Look for in the History
Things to Look for on the Physical and Neurological Examination
Pattern of Impairment on Cognitive Tests
Laboratory Studies
Structural Imaging Studies
Functional and Molecular Imaging Studies
Differential Diagnosis
Treatments
References
7. Vascular Cognitive Impairment and Vascular Dementia
Prevalence, Prognosis, and Definition
Criteria
Risk Factors, Pathology, and Pathophysiology
Common Signs, Symptoms, and Stages
Things to Look for in the History
Things to Look for on the Physical and Neurological Examination
Pattern of Impairment on Cognitive Tests
Laboratory Studies
Structural Imaging Studies
Functional and Molecular Imaging Studies
Differential Diagnosis
Treatments (see also Table 7.1)
References
8. Dementia With Lewy Bodies
Prevalence, Prognosis, and Definition
Criteria and Diagnosis
Risk Factors, Pathology, and Pathophysiology
Common Signs, Symptoms, and Stages
Things to Look for in the History
Things to Look for on the Physical and Neurological Examination
Pattern of Impairment on Cognitive Tests
Laboratory, Sleep, and Electroencephalography Studies
Structural Imaging Studies
Functional Imaging Studies
Differential Diagnosis
Treatments (Table 8.2)
References
9. Primary Progressive Aphasia and Apraxia of Speech
Prevalence, Definition, and Pathology
Criteria
Common Signs, Symptoms, and Stages (Table 9.2)
Things to Look for in the History
Things to Look for on the Physical and Neurological Examination