Table Of ContentBIOMEDICAL SCIENCE Srinivasan
Gobbi MELATONIN
Shillcutt
Suzen
Therapeutic Value and
Neuroprotection
There is growing interest in the field of melatonin research regarding its neurobiological
mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and
Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic
potential of melatonin and melatonin agonists in treating neurodegenerative diseases and
other ailments. Topics include
• The basic aspects of melatonin’s physiology, including its production,
bioavailability, and metabolism
• The functional importance of melatonin receptors and their role in
mediating the therapeutic effectiveness of melatonin in cancer
• Melatonin’s effect on the regulation of blood pressure, sleep, and
circadian rhythms
• The cardioprotective role of melatonin
• The neuroprotective role in glaucoma, Alzheimer’s disease,
Parkinson’s disease, and neurodegenerative diseases
• Use as a therapeutic agent for treating epilepsy and degenerative discs
• Treatment for obesity, diabetes mellitus, and other metabolic disorders
• Protective role in peri-natal hypoxic-ischemia
The contributors also examine the discovery of a number of melatonergic agonists, their
potential role as antioxidants, and their therapeutic applications in treating glaucoma,
Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders.
Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the
book is a significant milestone in our knowledge about advances in melatonin’s physiology
and its therapeutic application in a number of disorders.
Edited by
Venkatramanujan Srinivasan • Gabriella Gobbi
Samuel D. Shillcutt • Sibel Suzen
K22184
ISBN: 978-1-4822-2009-4
90000
9 781482 220094
K22184_Cover_PubGr.indd All Pages 8/6/14 9:42 AM
MELATONIN
Therapeutic Value and
Neuroprotection
Venkatramanujan Srinivasan
Sri Sathya Sai Medical Educational and Research Foundation
An International Medical Sciences Research Study Center
Tamilnadu, India
NHS Department of Mental Health, Hospital “G. Mazzini”, ASL Teramo Italy
Department of Neurosciences; University “G.D Annunzio, Chiety, Italy
Gabriella Gobbi
Department of Psychiatry
McGill University, and McGill University Health Center
Montreal, Quebec, Canada
Samuel D. Shillcutt
Department of Psychiatry and Behavioural Sciences
Mercer University School of Medicine
Macon, Georgia, USA
Sibel Suzen
Departmental of Pharmaceutical Chemistry
Faculty of Pharmacy, Ankara University
Ankara, Turkey
CRC Press
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Contents
Preface...............................................................................................................................................ix
Acknowledgments .............................................................................................................................xi
Editors ............................................................................................................................................xiii
Contributors ...................................................................................................................................xvii
Chapter 1 Melatonin Production and Bioavailability ...................................................................1
Emel Öykü Çetin, Yiğit Uyanıkgil, Mehmet Turgut, and Meral Baka
Chapter 2 Deviations of Melatonin Levels and Signaling in Aging and Diseases:
Options and Limits of Treatment ...............................................................................11
Rüdiger Hardeland
Chapter 3 Pineal Gland Volume and Melatonin .........................................................................19
Niyazi Acer, Süleyman Karademir, and Mehmet Turgut
Chapter 4 Melatonin’s Beneficial Effects in Metabolic Syndrome
with Therapeutic Applications ...................................................................................29
Venkataramanujam Srinivasan, Yoshiji Ohta,
Javier Espino, Rahimah Zakaria, and Mahaneem Mohamed
Chapter 5 Therapeutic Applications of Melatonin in Pediatrics.................................................49
Emilio J. Sanchez-Barcelo, Maria D. Mediavilla, and Russel J. Reiter
Chapter 6 Neuroprotective Effect of Melatonin on Perinatal Hypoxia–Ischemia ......................59
Daniel Alonso-Alconada, Antonia Alvarez, and Enrique Hilario
Chapter 7 Melatonin as a Therapeutic Agent for Sepsis .............................................................71
Edward H. Sharman and Stephen C. Bondy
Chapter 8 Melatonin’s Cardioprotective Role .............................................................................89
Alberto Dominguez-Rodriguez and Pedro Abreu-Gonzalez
Chapter 9 Melatonin: Therapeutic Value and Neuroprotection in Stroke ..................................97
Max Franzblau, Nick Franzese, Gabriel S. Gonzales-Portillo,
Chiara Gonzales-Portillo, Meaghan Staples, Mia C. Borlongan,
Naoki Tajiri, Yuji Kaneko, and Cesar V. Borlongan
iii
iv Contents
Chapter 10 Melatonin’s Antiapoptotic Activity in Neurodegenerative Diseases .......................111
Xin Wang, Yingjun Guan, Wenyu Fu, Shuanhu Zhou, and Zheng-Hong Qin
Chapter 11 MT Melatonin Receptors: Their Role in Sleep and Neuropsychiatric Disorders .....133
2
Stefano Comai and Gabriella Gobbi
Chapter 12 Melatonin: Its Hepatoprotective Actions and the Role of Melatonin Receptors ......143
Alexander M. Mathes
Chapter 13 Melatonin Signaling in the Control of Plasmodium Development
and Replication ......................................................................................................157
Alexandre Budu and Célia R. S. Garcia
Chapter 14 Melatonin: Regulator of Adult Hippocampal Neurogenesis ....................................167
Gerardo B. Ramírez-Rodríguez and Leonardo Ortiz-López
Chapter 15 Comparison of Neuroprotective Effect of Melatonin in the Nigrostriatal and
Mesolimbic Dopaminergic Systems of the Zitter Rat ..............................................179
Shuichi Ueda, Ayuka Ehara, Kenichi Inoue, Tomoyuki Masuda,
Shin-ichi Sakakibara, and Kanji Yoshimoto
Chapter 16 Melatonin’s Neuroprotective Role in Parkinson’s Disease.......................................189
Venkataramanujam Srinivasan, Timo Partonen,
Mahaneem Mohamed, Rahimah Zakaria, Asma Hayati Ahmad,
Charanjit Kaur, Domenico De Berardis, Edward C. Lauterbach,
Samuel D. Shillcutt, and U.S. Srinivasan
Chapter 17 Neuroprotective Role of Melatonin in Glaucoma ....................................................203
Ruth E. Rosenstein, María C. Moreno, Pablo Sande, Marcos Aranda,
María F. González Fleitas, and Nicolás Belforte
Chapter 18 Melatonin Receptors and Their Preventive Role in Carcinogenesis ........................223
Raffaela Santoro, Maria Ferraiuolo, Giovanni Blandino,
Paola Muti, and Sabrina Strano
Chapter 19 Enhancement of Antitumor Activity of Ursolic Acid by Melatonin
in Colon Cancer Cells ..............................................................................................233
Wei Guo, Jingshu Wang, and Wuguo Deng
Chapter 20 Synthetic Melatonin Receptor Ligands ....................................................................249
Silvia Rivara, Marco Mor, Annalida Bedini, and Gilberto Spadoni
Contents v
Chapter 21 Evaluation of Synthetic Melatonin Analog Antioxidant Compounds ......................259
Sibel Suzen
Chapter 22 Melatonin’s Analogues in Glaucoma .......................................................................269
Hanan Awad Alkozi and Jesús Pintor
Chapter 23 Melatonergic Drugs as Therapeutic Agents for Insomnia
and Depressive Disorders .........................................................................................289
Venkataramanujam Srinivasan, Domenico De Berardis,
Amnon Brzezinski, Rahimah Zakaria, Zahiruddin Othman,
Samuel D. Shillcutt, Edward C. Lauterbach, Gregory M. Brown,
and Timo Partonen
Chapter 24 Agomelatine: A Neuroprotective Agent with Clinical Utility beyond
Depression and Anxiety ...........................................................................................309
Cecilio Álamo, Francisco López-Muñoz, and Pilar García-García
Chapter 25 Melatonergic Antidepressant Agomelatine in Depressive and Anxiety Disorders .....325
Domenico De Berardis, Michele Fornaro, Venkataramanujam Srinivasan,
Stefano Marini, Nicola Serroni, Daniela Campanella, Gabriella Rapini,
Luigi Olivieri, Felice Iasevoli, Alessandro Valchera, Giampaolo Perna,
Maria Antonia Quera-Salva, Monica Mazza, Marilde Cavuto, Ida Potena,
Giovanni Martinotti, and Massimo Di Giannantonio
Chapter 26 Effects of Melatonin and Melatonergic Drugs in Transgenic
Mouse Models of Alzheimer’s Disease ....................................................................339
Beatriz B. Otalora, M. Angeles Rol, and Juan A. Madrid
Chapter 27 Melatonin’s Mitochondrial Protective Role in Alzheimer’s Mice: Role of
Melatonin Receptors ................................................................................................353
Vedad Delic and Patrick C. Bradshaw
Chapter 28 Melatonin and Its Therapeutic Implications in Injuries of the Developing
Brain and Retina .......................................................................................................375
Gurugirijha Rathnasamy, Eng-Ang Ling, and Charanjit Kaur
Chapter 29 Melatonin’s Protection against Human Prion-Mediated Neurotoxicity ...................389
Jae-Kyo Jeong and Sang-Youel Park
Chapter 30 Melatonin’s Protection against Methamphetamine Toxicity
in Neuroblastoma Cells ............................................................................................397
Banthit Chetsawang
vi Contents
Chapter 31 Melatonin’s Beneficial Effects on Dopaminergic Neurons
in the Rat Model of Parkinson’s Disease .................................................................409
Manisha Gautam, Reshu Gupta, Ravinder Kumar Saran, and Bal Krishana
Chapter 32 Antiepileptic Effects of Melatonin ...........................................................................421
M. Hakan Seyithanoğlu, Mehmet Turgut, Meliha Gündağ Papaker,
Mustafa Ayyıldız, Süleyman Kaplan, and Saffet Tüzgen
Chapter 33 Analgesic Effects of Melatonin ................................................................................431
Selçuk Yavuz, Mehmet Turgut, Özlem Yalçınkaya Yavuz, and Teoman Aydın
Chapter 34 Effects of Melatonin on the Proliferative and
Differentiative Activity of Neural Stem Cells ..........................................................441
Saime İrkören, Heval Selman Özkan, and Mehmet Turgut
Chapter 35 Role of Melatonin in Collagen Synthesis .................................................................447
Özgür Taşpınar, Mehmet Turgut, Engin Taştaban, and Teoman Aydın
Chapter 36 Melatonin Use in Peripheral Nerve Injury ...............................................................457
Mehmet Emin Önger, Süleyman Kaplan, Ebru Elibol, Ömür Gülsüm Deniz,
and Berrin Zühal Altunkaynak
Chapter 37 Neuroprotective Role of Melatonin and Its Agonists: Neuroprotective Role of
Melatonin against Dexamethasone-Induced Neurotoxicity .....................................463
Aziza B. Shalby and Hanaa H. Ahmed
Chapter 38 Does Melatonin Have a Protective Role against Side Effects of Nonsteroidal
Anti-Inflammatory Drugs? .......................................................................................469
Ebru Elibol, Berrin Zühal Altunkaynak, Ömür Gülsüm Deniz,
Mehmet Emin Önger, and Süleyman Kaplan
Chapter 39 Melatonin: Pharmacological Aspects and Clinical Trends ......................................485
Emiliano Ricardo Vasconcelos Rios
Chapter 40 Protective Effects of Melatonin in Radiation-Induced Nephrotoxicity ...................493
Eda Kucuktulu and Uzer Kucuktulu
Chapter 41 Melatonin and Familial Mediterranean Fever .........................................................499
Engin Taştaban, Mehmet Turgut, and Teoman Aydın
Contents vii
Chapter 42 Effects of Melatonin on Osteoblastic and Osteoclastic
Activities of Bone Tissue ........................................................................................505
Meliha Gündağ Papaker, M. Hakan Seyithanoğlu, Mehmet Turgut,
Süleyman Kaplan, and Saffet Tüzgen
Chapter 43 Phyto-Melatonin: A Novel Therapeutic Aspect of Melatonin in Nature’s Way ......515
Chandana Haldar, Somenath Ghosh, and Amaresh Kumar Singh
