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Megaloblastic Anemia היגולוטמהל סרוק 'ד הנש – תימינפ האופרל אובמ ו"סשת ברפדלוג הדע ר"ד Diagnostic approach based on RBC’s indices MCV < 80 fl 80 fl < MCV < 98 fl MCV > 98 fl Microcytic Normocytic Macrocytic anemia anemia anemia Macrocytic Anemia (MCV>100) Morphology Peripheral blood & Bone Marrow Megaloblastic Non-Megaloblastic Reticulocyte count Vit B12, Folate Increased Decreased/Normal deficiency Hemorrhage Alcoholism Hemolysis Liver Disease Cold agglutinins Hypothyroidism BM failure: MDS, Aplastic Anemia DNA Synthesis DNA Methotrexate blocks here Thymidine monophosphate (dTMP) DHF Methyl B12 Methyl THF THF (plasma factor) 5,10 Methylene THF Deoxyuridine THF - tetrahydrofolate monophosphate DHF - dihydrofolate (dUMP) B12/Folate deficiency affects all dividing cells 1. Ineffective Hematopoiesis Ineffective Erythropoiesis Anemia Ineffective Leukopoiesis Leukopenia Ineffective Thrombopoiesis Thrombocytopenia ↓↓↓↓ 2. RBC survival Normal Erythropoiesis (Bone Marrow) Megaloblastic Erythropoiesis Megaloblastosis (Giant Band Forms in Bone Marrow) Megaloblastic Changes – Young Megakarocyte (Bone Marrow) Peripheral Blood (2) Normal Megaloblastic Changes

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Pernicious Anemia – Clinical Presentation. “lemon yellow” pallor the finding of a low B12 level is an all-too common finding in the workup of patients.

Megaloblastic Anemia 1 PDF

41 Pages·2010·0.73 MB·English

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by Unknow| 2010| 41 pages| 0.73| English

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Pernicious Anemia – Clinical Presentation. “lemon yellow” pallor the finding of a low B12 level is an all-too common finding in the workup of patients.

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Author:	Unknown
Publication Year:	2010
Pages:	41
Language:	English
File Size:	0.73
Format:	PDF
Price:	FREE

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