Medical bioinformatics and biochemistry (diabormatics)

176 Pages·2019·6.523 MB·English

by  Ijen Bhattacharya (editor), Rajneesh Prajapat (editor)

BIOCHEMISTRY RESEARCH TRENDS

M B
EDICAL IOINFORMATICS
B
AND IOCHEMISTRY

(D )
IABORMATICS

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B R T
IOCHEMISTRY ESEARCH RENDS

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BIOCHEMISTRY RESEARCH TRENDS

M B
EDICAL IOINFORMATICS
B
AND IOCHEMISTRY

(D )
IABORMATICS

RAJNEESH PRAJAPAT
AND
IJEN BHATTACHARYA
EDITORS
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ISBN: (cid:28)(cid:26)(cid:27)(cid:16)(cid:20)(cid:16)(cid:24)(cid:22)(cid:25)(cid:20)(cid:23)(cid:16)(cid:28)(cid:24)(cid:22)(cid:16)(cid:20)(cid:3)(cid:11)(cid:72)(cid:37)(cid:82)(cid:82)(cid:78)(cid:12)
Library of Congress Control Number: 2019931108

Published by Nova Science Publishers, Inc. † New York
CONTENTS

Preface vii
Chapter 1 Diabetes and Diabormatics: An Introcuction 1
Rajneesh Parapet, Ijen Bhattacharya
and Uday Kumar Gupta
Chapter 2 Combined Effect of Vitamin C and E Dose
on Type 2 Diabetes Patients 11
Rajneesh Prajapat, Ijen Bhattacharya
and Anupam Jakhalia
Chapter 3 In-Silico Structure Modelling and Docking
Studies Using Dipeptidyl Peptidase-4 (DPP4)
Inhibitors against Diabetes Type-2 21
Rajneesh Prajapat and Ijen Bhattacharya
Chapter 4 Homology Modelling and Structural Validation
of Type 2 Diabetes Associated Transcription
Factor 7-Like 2 (TCF7L2) 45
Rajneesh Prajapat, Ijen Bhattacharya
and Anoop Kumar
vi Contents
Chapter 5 Effect of Vitamin E and C Supplementation
on Oxidative Stress in Diabetic Patients 57
Rajneesh Prajapat and Ijen Bhattacharya
Chapter 6 In Silico Structure Analysis of Type 2 Diabetes
Associated Cysteine Protease Calpain-10
(CAPN10) 67
Rajneesh Prajapat and Ijen Bhattacharya
Chapter 7 To Evaluate the Role of Leptin in Diabetes
for Male and Female Subjects 87
Jaipal Singh, Ashish Sharma, Parduman Singh
and Rajneesh Prajapat
Chapter 8 Study of Leptin and Adiponectin in Type 2
Diabetes Mellitus 99
Jaipal Singh and Ashish Sharma
Chapter 9 Study on Correlation of Inflammatory Markers
on Type-II Diabetes 111
Krattika Singhal and Sandesh Shrestha
Chapter 10 Nano-Diabetology 125
Rupesh Kumar Basniwal and V. K. Jain
Chapter 11 Effect of Ajowan Seed Powder on Oxidative
Stress in Normal and Niddm Patients 145
Parul Gupta
About the Editors 155
Index 159
Related Nova Publications 165
PREFACE

Diabetes is a group of complex metabolic disorders principally
characterized by insulin resistance, pancreatic beta cell dysfunction, and
associated hyperglycemia. This disease is increasing to epidemic
proportions in many countries throughout the world. Diabetes is also
associated with accelerated atherosclerotic macro vascular disease
affecting arteries that supply the heart, brain and lower extremities. As a
result, patients with diabetes have higher risk of myocardial infarction,
stroke and limb amputation. Large prospective clinical studies show a
strong relationship between glycaemia and diabetic microvascular
complications in both type 1 and type 2 diabetes. Hyperglycaemia and
insulin resistance both seem to have important roles in the pathogenesis
of macrovascular complications.
Molecular Docking continues to be a great promise in the field of
computer based drug design. Several simulation models have been
proposed to study the physiology and pathophysiology of diabetes.
Biological databases and Atlas plays an important role in getting up-to-
date global report on diabetes. Like so many other areas of medicine, Bio
informatics has had a profound impact on diabetes research. The DPP-4
inhibitors are a newer class of drugs that lowers glucose by blocking an
enzyme, thereby prolonging incretion effect in vivo.
viii Rajneesh Prajapat and Ijen Bhatyacharya
This book is based on the recent development in the research
dynamics of medical bioinformatics, biochemistry and the progress in
these fields. It also provides current reference material for students
entering in the field of medical biochemistry and bioinformatics
academics and research as well as scientists already familiar with the
area. The development in genomic sequencing and in silico biology has
provided the data needed to accomplish comparisons of derived protein
sequences, the results of which may be used to formulate and test
hypotheses about biochemical function. The book is a useful source of
knowledge for MBBS, BSc, MSc/MD/MS and PhD level students
looking for an accessible introduction of the subject.