Table Of ContentMECHANISMS OF HEART FAILURE
DEVELOPMENTS IN CARDIOVASCULAR MEDICINE
121. S. Sideman, R. Beyar and A.G. Kleber (eds.): Cardiac Electrophysiology, Circulation, and
Transport. Proceedings of the 7th Henry Goldberg Workshop (Berne, Switzerland, 1990).
1991. ISBN 0-7923-1145-0.
122. D.M. Bers: Excitation-Contraction Coupling and Cardiac Contractile Force. 1991. ISBN
0-7923-1186-8.
123. A.-M. Salmasi and A.N. Nicolaides (eds.): Occult Atherosclerotic Disease. Diagnosis,
Assessment and Management. 1991. ISBN 0-7923-1188-4.
124. J.A.E. Spaan: Coronary Blood Flow. Mechanics, Distribution, and Control. 1991. ISBN
0-7923-1210-4.
125. R.W. Stout (ed.): Diabetes and Atherosclerosis. 1991. ISBN 0-7923-1310-0.
126. A.G. Herman (ed.): Antithrombotics. Pathophysiological Rationale for Pharmacological
Interventions. 1991. ISBN 0-7923-1413-1.
127. N.H.J. Pijls: Maximal Myocardial Perfusion as a Measure of the Functional Significance of
Coronary Arteriogram. From a Pathoanatomic to a Pathophysiologic Interpretation of the
Coronary Arteriogram. 1991. ISBN 0-7923-1430-1.
128. J.H.C. Reiber and E.E. v.d. Wall (eds.): Cardiovascular Nuclear Medicine and MRI.
Quantitation and Clinical Applications. 1992. ISBN 0-7923-1467-0.
129. E. Andries, P. Brugada and R. Stroobrandt (eds.): How to Face "the Faces" of Cardiac
Pacing. 1992. ISBN 0-7923-1528-6.
130. M. Nagano, S. Mochizuki and N.S. Dhalla (eds.): Cardiovascular Disease in Diabetes.
1992. ISBN 0-7923-1554-5.
131. P.W. Serruys, B.H. Strauss and S.B. King III (eds.): Restenosis after Intervention with
New Mechanical Devices. 1992. ISBN 0-7923-1555-3.
132. P.J. Walter (ed.): Quality of Life after Open Heart Surgery. 1992. ISBN 0-7923-1580-4.
133. E.E. van der Wall, H. Sochor, A. Righetti and M.G. Niemeyer (eds.): What is new in
Cardiac Imaging? SPECT, PET and MRI. 1992. ISBN 0-7923-1615-0.
134. P. Hanrath, R. Uebis and W. Krebs (eds.); Cardiovascular Imaging by Ultrasound. 1992.
ISBN 0-7923-1755-6.
135. F.H. Messerli (ed.): Cardiovascular Disease in the Elderly, 3rd ed. 1992. ISBN 0-7923-
1859-5.
136. J. Hess and G.R. Sutherland (eds.); Congenital Heart Disease in Adolescents and Adults.
1992. ISBN 0-7923-1862-5.
137. J.H.C. Reiber and P.W. Serruys (eds.): Advances in Quantitative Coronary Arteriography.
1993. ISBN 0-7923-1863-3.
138. A.-M. Salmasi and A.S. Iskandrian (eds.): Cardiac Output and Regional Flow in Health
and Disease. 1993. ISBN 0-7923-1911-7.
139. J.H. Kingman, N.M. van Hemel and K.I. Lie (eds.): Atrial Fibrillation, a Treatable
Disease? 1992. ISBN 0-7923-2008-5.
140. B. Ostadal, N.S. Dhalla (eds.): Heart Function in Health and Disease. 1993. ISBN 0-7923-
2052-2.
141. D. Noble and Y.E. Earm (eds.): Ionic Channels and Effect of Taurine on the Heart. Proceedings
of an International Symposium (Seoul, Korea, 1992). 1993. ISBN 0-7923-2199-5.
142. H.M. Piper and CJ. Preusse (eds.): Ischemia-reperfusion in Cardiac Surgery. 1993. ISBN 0-
7923-2241-X.
143. J. Roelandt, E.J. Gussenhoven and N. Bom (eds.): Intravascular Ultrasound. 1993. ISBN 0-
7923-2301-7.
144. M.E. Safar and M.F. O'Rourke (eds.): The Arterial System in Hypertension. 1993. ISBN 0-
7923-2343-2.
145. P.W. Serruys, D.P. Foley and P.J. de Feyter (eds.): Quantitative Coronary Angiography in
Clinical Practice. 1993. ISBN 0-7923-2368-8.
146. J. Candell-Riera and D. Ortega-Alcalde (eds.): Nuclear Cardiology in Everyday Practice. 1993.
ISBN 0-7923-2374-2.
147. P. Cummins (ed.): Growth Factors and the Cardiovascular System. 1993. ISBN 7923-2401-3.
148. K. Przyklenk, R.A. Kloner and D.M. Yellon (eds.): Ischemic Preconditioning: The Concept of
Endogenous Cardioprotection. 1993. ISBN 0-7923-2410-2.
MECHANISMS OF HEART FAILURE
Edited by
PAWAN K. SINGAL, IAN M.C. DIXON, ROBERT E. BEAMISH,
AND NARANJAN S. DHALLA
MRC Group i n Experimental Cardiology
Division of Cardiovascular Sciences
St. Boniface General Hospital Research Centre
Faculty of Medicine, University of Manitoba
Winnipeg, Canada
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Copyright © 1995 Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1995
Softcover reprint of the hardcover 1st edition 1995
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system
or transmitted in any form or by any means, mechanical, photo-copying, recording, or other
wise, without the prior written permission of the publisher, Springer Science+Business Media, LLC.
Printed on acid-free paper.
Library of Congress Cataloging-in-Publication Data
Mechanisms of heart failure/editors, Pawan K. Singal... [et al.].
p. cm.-(Developments in cardiovascular medicine: 167)
Based on papers selected from poster presentations made at the
International Conference on Heart Failure held May 20-23, 1994 in
Winnipeg, Canada.
Includes index.
ISBN 978-1-4613-5827-5 ISBN 978-1-4615-2003-0 (eBook)
DOI 10.1007/978-1-4615-2003-0
1. Heart failure—Pathophysiology—Congresses. 2. Myocardium—
Diseases—Congresses. I. Singal, Pawan K. II. International
Conference on Heart Failure (1994: Winnipeg, Man.) III. Series.
[DNLM: 1. Cardiac Output, Low—congresses. 2. Heart Failure,
Congestive—congresses. 3. Myocardial Diseases—congresses. WG
210 M486 1995]
RC685.C53M43 1995
616.1'29—dc20
DNLM/DLC
for Library of Congress 95-14335
CIP
DEDICATION
ALBERT WOLLENBERGER, PH.D., BERLIN, GERMANY
This book is dedicated to Dr. Albert Wollenberger, who identified changes
in energy metabolism in the failing heart in the late 1940s. His pioneering
work laid the foundation for the concept of the biochemical basis of heart
failure. The leadership role he provided as President of the International
Society for Heart Research is highly valued.
CONTENTS
Contributing authors XI
Preface XXI
Acknowledgments XX111
I. SUBCELLULAR BASIS OF HEART FAILURE
1. Tumor Necrosis Factor-Alpha in Chronic Heart Failure 3
T. BACHETTI, A. CORTI, A. GIORDANO, AND R. FERRARI
2. Myocardial Ribonuclease Activity in Heart Failure 9
P.]. O'BRIEN, H. SHEN, AND 1.K. GWATHMEY
3. p-Adrenergic Receptor Mechanisms in Heart Failure 19
R. SETHI, N. TAKEDA, M. NAGANO, AND N.S. DHALLA
4. Vascular a-Adrenergic Function in Congestive heart Failure 37
Q.P. FENG AND ].M.O. ARNOLD
5. Altered Myocardial Neurotransmitter and 1,2-Diacylglycerol Concentrations in
Right Ventricular Hypertrophy and Failure in Rats 51
K. OKUMURA, Y. YAMADA, H. MATSUI, M. SHINODA, K. NARUSE, Y. TOKI,
H. HASHIMOTO, AND T. ITO
6. Metabolic Changes in Nonischemic Myocardium During Pump Failure 63
H. ISHIOKA, E. GESHI, T. WATANABE, T. IWATA, S. ITOH, S. MUKAE, M. MOCHIZUKI,
K. UMETSU, N. KONNO, T. YANAGISHITA, AND T. KATAGIRI
viii Contents
7. Cardiac Extracellular Matrix and its Role in the Development of Heart
Failure 75
H. JU AND I.M.C. DIXON
8. SHHF/Mcc:fa~ Rat Model: A Genetic Model of Congestive Heart Failure 91
S.A. MCCUNE, S. PARK, M.J. RADIN, AND R.R. JURIN
9. Left Ventricular Mass and Diastolic Function in Young Individuals with a first
elevated "Casual" Blood Pressure 107
S.M. DE LENA, E. ESCUDERO, D. OLANO, AND H.E. CINGOLANI
10. Factors Responsible for Left Ventricular Underfilling in Pure Mitral
Stenosis 117
A. SURDACKI, J. LEGUTKO, P. TUREK, D. DUDEK, K. ZMUDKA, AND J.S. DUBIEL
11. Improved Preservation of Myocardial ultrastructure in Perfusion-Fixed Human
Heart Explants 129
A.M. GERDES, J.H. PROKOSCH-GRAVES, H.E. SETTLES, J.A. BURBACH, AND
D.D. SCHOCKEN
12. Involvement of Leukotoxin in the Pathogenesis of Patients with Extensive
Burns 143
K. KOSAKA, K. SUZUKI, M. HAYAKAWA, S. SUGIYAMA, AND T. OZAWA
13. Differential Regulation of Calmodulin-Dependent Cyclic Nucleotide
Phosphodiesterase Isozymes 153
R.K. SHARMA, J. KALRA, AND Y. TAN
II. PATHOPHYSIOLOGIC ASPECTS OF CARDIOMYOPATHIES
14. Adriamycin Cardiomyopathy and its Prevention in an Animal Model 169
N. SIVESKI-ILISKOVIC, T. LI, AND P.K. SINGAL
15. Alterations in Sarcolemmal Phospholipid Base Exchange Enzymatic Activities in
Diabetic Cardiomyopathy 177
A. VECCHINI, L. BINAGLIA, P. DI NARDO, M. MINIERI, J.-A.E. HAYS, V. PANAGIA, AND
N.S. DHALLA
16. Myocardial Lipid Peroxidation and Diabetes 185
S.K. JAIN
17. Molecular Biologic Changes of Adenine Nucleotide Translocator inJ-2-N
Cardiomyopathic Hamsters 197
M. KATO, s. YAMASHINA, M. TSUCHIYA, N. TAKEDA, S. MOCHIZUKI, T. MORISHITA,
AND M. NAGANO
18. Renin-Angiotensin System and the Congenital Cardiomyopathic Hamster 203
C. LAMBERT, Y. MASSILLON, AND S. MELOCHE
19. Dietary Mercury Induces Congestive Cardiomyopathy in the Arctic 215
I. ASMUSSEN
20. Peripheral Resistance to Atrial Natriuretic Peptide in Patients with Idiopathic
Dilated 221
G. IERVASI, A. CLERICO, S. BERTI, A. PILO, F. VITEK, C. MANFREDI, M.R. IASCONE,
S. MAFFEI, AND A. BIAGINI
Contents ix
21. Effect of Ethanol on Allylamine-Induced Subendocardial Fibrosis 239
K. KATO, M. NAKAZAWA, F. MAS ANI, T. IZUMI, A. SHIBATA, AND S. IMAI
22. Nitric Oxide: Friend and Foe in Myocardial Ischemia and Reperfusion 249
R.C. KUKREJA
23. Role of Leukocytes and Subcellular Abnormalities in Diastolic Dysfunction
During Ischemia-Reperfusion 263
J.S. JUGGI, F. GHAAIDI, A. OWUNWANNE, K.S. BHATIA, AND Y. MAKDISI
24. Calcium Channel Blockade Ameliorates Cardiac Dysfunction and Failure in
Ischemic Cardiomyopathy 277
J.M. CAPASSO
25. Alterations in Autonomic Nervous System and Heart Mitochondrial Function in
Rats Treated with Cyclophosphamide 295
S. SUGIYAMA, N. HIEDA, N. AKIYAMA, Y. HANAKI, AND T. OZAWA
III. TREATMENT OF HEART FAILURE
26. Combined Aerobic and Strength Training in Congestive Heart Failure Patients:
Pilot Project on Safety and Feasibility 307
R. GUTIERREZ,M. HAYKOWSKY, L.K. HILL, 1. CLUETT, A. IGNASZEWSKI, D.P. HUMEN,
AND K.K. TEO
27. Factors Relating to 6 Minute Walk Performance in Heart Failure Patients 315
M.C. HENDRICAN, R.S. MCKELVIE, N. MCCARTNEY, G.H. GUYATT, AND S. YUSUF
28. Dynamic Cardiomyoplasty: Management of Heart Failure Using Autologous
Skeletal Muscle 323
J.N.K.ODIM
29. Cardiac Cell Transplantation 337
R.-K. LI, D.A.G. MICKLE, R.D. WEISEL, M.K. MOHABEER, AND J. ZHANG
30. Effects of Catalase on Volume-Overload Heart Failure 349
K. PRASAD, J.B. GUPTA, J. KALRA, B. BHARADWAJ, S.V. MANTHA, AND P. LEE
31. Major Determinants of Survival and Nonsurvival ofIntra-aortic balloon
Pumping 359
K. PI, E.B. DIETHRICH, P.C. BLOCK, M.G. WARNER, Z. PI, A. AHMAD, AND H.L. GATELY
32. End-Stage Ischemic Heart Disease: Effects of Complete Myocardial
Revascularization and Left Ventricular Patch Repair Following Scar
Resection 369
M. DI DONATO, M. MAIOLI, M. SABATIER, A. TOSO, F. FANTINI, AND V. DOR
33. Acute Enoximone Effect on Systemic Hemodynamics, Renal Function, and
Hormonal Activation in Patients with Heart Failure 375
S. BERTI, C. PALMIERI, R. BONINI, M. RAVANI, A. CLERICO, G. IERVASI, P. GAZZETTI,
S. PUGLIESE, AND A. BIAGINI
34. Angiotensin II Receptor Antagonist, E-4177, Inhibits Progression of Reactive
Cardiac Hypertrophy Associated with Myocardial Infarction in Rats 387
T. HATA, N. MAKINO, I.M.C. DIXON, M. NOZAKI, K. MASUTOMO, S. TAGUCHI, AND
T. YANAGA
x Contents
35. Effects of Catecholamine and Amrinone on the Metabolism of Noni nfarcted
Myocardium in Cardiogenic Shock 401
T. IWATA, S. MUKAE, T. WATANABE, H. ISHIOKA, S. ITOH, K. UMETSU, E. GESHI,
N. KONNO, T. YANAGISHITA, AND T. KATAGIRI
36. Effects of Angiotensin Converting Enzyme Inhibitors on Acute Heart Failure
Induced in the Anesthetized Dog with Microsphere Injection 411
M. NAKAZAWA, Y. TAKAHASHI, M. OKUHIRA, T. ISHIHARA, K. IWASAKI,
T. SAWANOBORI, AND S. IMAI
37. Recruitment of Ventricular Function with Adjunctive Nitrate Therapy After Late
Reperfusion 425
B.I. JUGDUTT
38. Neuromuscular Assessment of Heart Failure Patients 433
J.L. O'BRIEN, A.L. HICKS, AND R.S. MCKELVIE
CONTRIBUTING AUTHORS
AftabAhmad Tiziana Bachetti
Starr-Wood Cardiac Group, Fondazione Clinica del Lovoro
P.c. 240 Centro di Fisiopatologia Cardiovascolare
9155 S.W. Barnes Rd., Suite "S. Maugeri", Via Pinidolo 23
Portland, OR 97225 25064 Gussago, Brescia
U.S.A. Italy
Naohiko Akiyama Sergio Berti
Department of Biomedical Chemistry Instituto Di Fisiologica Clinica Del CNR
Faculty of Medicine Via Savi, N. 8
University of Nagoya Pisa 56100
Tsuruma, Showa-ku Italy
Nagoya 466
Japan
Baikunth Bharadwaj
Department of Physiology, College of
J. Malcolm O. Arnold Medicine
Cardiology Division University of Saskatchewan
Victoria Hospital Saskatoon, SK S7N OWO
375 South Street Canada
London, ON N6A 4G5
Canada
K.S. Bhatia
Department of Physiology
Inger Asmussen Faculty of Medicine
Department of Medicine/Cardiology Kuwait University
Nykobing Mors Sygehus P.O. Box 24923
DK 7900 Nykobing Mors 13110 Safat
Denmark Kuwait
