Mechanisms of Adiponectin Action

224 Pages·2019·10.385 MB·English

by  Tania Fiaschi (editor)

International Journal o f
Molecular Sciences
Mechanisms of
Adiponectin Action
Edited by
Tania Fiaschi
Printed Edition of the Special Issue Published in
International Journal of Molecular Sciences
www.mdpi.com/journal/ijms
Mechanisms of Adiponectin Action

Mechanisms of Adiponectin Action
SpecialIssueEditor
TaniaFiaschi
MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade
SpecialIssueEditor
TaniaFiaschi
UniversitadegliStudidiFirenze
Italy
EditorialOffice
MDPI
St.Alban-Anlage66
4052Basel,Switzerland
This is a reprint of articles from the Special Issue published online in the open access journal
InternationalJournalofMolecularSciences(ISSN1422-0067)in2019(availableat: https://www.mdpi.
com/journal/ijms/specialissues/adiponectinaction)
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Contents
AbouttheSpecialIssueEditor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
TaniaFiaschi
MechanismsofAdiponectinAction
Reprintedfrom:Int.J.Mol.Sci.2019,20,2894,doi:10.3390/ijms20122894 . . . . . . . . . . . . . . 1
MatthewP.Krause,KevinJ.MilneandThomasJ.Hawke
Adiponectin—ConsiderationforitsRoleinSkeletalMuscleHealth
Reprintedfrom:Int.J.Mol.Sci.2019,20,1528,doi:10.3390/ijms20071528 . . . . . . . . . . . . . . 4
TaniaGamberi,FrancescaMagheriniandTaniaFiaschi
AdiponectininMyopathies
Reprintedfrom:Int.J.Mol.Sci.2019,20,1544,doi:10.3390/ijms20071544 . . . . . . . . . . . . . . 21
Andrea Tumminia, Federica Vinciguerra, Miriam Parisi, Marco Graziano, Laura Sciacca,
RobertoBarattaandLuciaFrittitta
AdiposeTissue,ObesityandAdiponectin:RoleinEndocrineCancerRisk
Reprintedfrom:Int.J.Mol.Sci.2019,20,2863,doi:10.3390/ijms20122863 . . . . . . . . . . . . . . 31
SheetalParida,SumitSiddharthandDipaliSharma
Adiponectin,Obesity,andCancer:ClashoftheBigwigsinHealthandDisease
Reprintedfrom:Int.J.Mol.Sci.2019,20,2519,doi:10.3390/ijms20102519 . . . . . . . . . . . . . . 51
Luca Gelsomino, Giuseppina Daniela Naimo, Stefania Catalano, Loredana Mauro and
SebastianoAndo`
TheEmergingRoleofAdiponectininFemaleMalignancies
Reprintedfrom:Int.J.Mol.Sci.2019,20,2127,doi:10.3390/ijms20092127 . . . . . . . . . . . . . . 78
AlixBarbe,AliceBongrani,NamyaMellouk,AnthonyEstienne,PatrycjaKurowska,Je´re´my
Grandhaye,YaelleElfassy,RachelLevy,AgnieszkaRak,PascalFromentandJoe¨lleDupont
MechanismsofAdiponectinActioninFertility:AnOverviewfromGametogenesistoGestation
inHumansandAnimalModelsinNormalandPathologicalConditions
Reprintedfrom:Int.J.Mol.Sci.2019,20,1526,doi:10.3390/ijms20071526 . . . . . . . . . . . . . . 97
Nina Smolinska, Karol Szeszko, Kamil Dobrzyn, Marta Kiezun, Edyta Rytelewska,
KatarzynaKisielewska,MarlenaGudelska,KingaBors,JoannaWyrebek,GrzegorzKopij,
BarbaraKaminskaandTadeuszKaminski
Transcriptomic Analysis of Porcine Endometrium during Implantation after In Vitro
StimulationbyAdiponectin
Reprintedfrom:Int.J.Mol.Sci.2019,20,1335,doi:10.3390/ijms20061335 . . . . . . . . . . . . . . 134
HidekatsuYanaiandHiroshiYoshida
Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic
Progression:MechanismsandPerspectives
Reprintedfrom:Int.J.Mol.Sci.2019,20,1190,doi:10.3390/ijms20051190 . . . . . . . . . . . . . . 155
YaeniKimandCheolWheePark
MechanismsofAdiponectinAction:ImplicationofAdiponectinReceptorAgonisminDiabetic
KidneyDisease
Reprintedfrom:Int.J.Mol.Sci.2019,20,1782,doi:10.3390/ijms20071782 . . . . . . . . . . . . . . 180
v
PhilJuneParkandEun-GyungCho
Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate
Adiponectin-InducedHairGrowthFactorsinHumanDermalPapillaCells
Reprintedfrom:Int.J.Mol.Sci.2019,20,1859,doi:10.3390/ijms20081859 . . . . . . . . . . . . . . 192
YuuOkura,TakeshiImao,SeisukeMurashima,HarukiShibata,AkihiroKamikavwa,Yuko
Okamatsu-Ogura,MasayukiSaitoandKazuhiroKimura
InteractionofNerveGrowthFactorwithAdiponectinandSPARCOppositelyModulatesits
BiologicalActivity
Reprintedfrom:Int.J.Mol.Sci.2019,20,1541,doi:10.3390/ijms20071541 . . . . . . . . . . . . . . 202
vi
About the Special Issue Editor
Tania Fiaschi received her M.S. degree in Biological Sciences from the University of Florence,
Italy. ShethenreceivedherPh.D.inBiochemistryandspecializationinBiochemistryandClinical
Chemistry, also from the University of Florence. Since 2007, her research has focused on the
regenerativeeffectsofadiponectininskeletalmuscle.Heractualinterestisinthestudyofadiponectin
involvement in the amelioration of inherited myopathies such as Duchenne muscular dystrophy,
Bethlemmyopathy,andUllrichcongenitalmusculardystrophy.SheiscurrentlyservingasAssociate
ProfessorinMolecularBiologyattheUniversityofFlorence.
vii

International Journal o f
Molecular Sciences
Editorial
Mechanisms of Adiponectin Action
TaniaFiaschi
DipartimentodiScienzeBiomediche,SperimentalieCliniche“M.Serio”,UniversitàdegliStudidiFirenze,
VialeMorgagni50,50134Firenze,Italy;tania.fiaschi@unifi.it;Tel.:[phone]
Published:13June2019
Adiponectin,themostabundantsecretedadipokine,hasreceivedgreatattentionfromthescientific
communitysinceitsdiscovery[1].Thehugenumberofstudiesisjustifiedbytheinsulin-sensitizing
roleandthebeneficialeffectsofadiponectinindiabeticconditions[2,3].Overtheyears,alargebody
ofevidencehassupportedapleiotropicroleofthehormoneindifferenttissuesinwhichitinfluences
variedphysiologicalaspectsbothinhealthyandindiseasedconditions.
ThisSpecialIssue,entitled“MechanismsofAdiponectinAction”,showsthepleiotropicroleof
adiponectinbypresentingthreeresearcharticlesandsevenreviewsfocusedonrecentfindingsabout
adiponectinindifferenttargettissues.TheSpecialIssuecontainstworeviewsaboutadiponectinin
skeletalmuscle,aclassicaladiponectintargettissue,inwhichthehormoneaffectsbothmetabolic[4]
andregenerativeproperties[5].Krauseetal.reportacloserelationshipbetweenphysicalexerciseand
expressionandcirculatinglevelsofadiponectininbothhealthyanddiseasedpopulation.Indeed,a
higheradiponectinlevelisassociatedwithgreaterphysicalactivity,whilesomeconditions,suchas
inactiveobese,pre-diabetic,anddiabeticpatients,arecharacterizedbydecreasedadiponectinlevels.
Therestorationofproperadiponectinlevelscanbeachievedwithphysicalexercise,andthisleadsto
increasedinsulinsensitivity[6].Gamberietal.discussesthecurrentknowledgeaboutadiponectinin
myopathies(bothnon-inherited/acquiredandinheritedmyopathies). Thepaperreportsthatsome
myopathies(asDuchennemusculardystrophyandcollagenVI-relatedmyopathies)arecharacterized
byadecreasedcirculatingadiponectinlevelandthathormonereplenishmentinducesbeneficialeffects
inthediseasedmuscles[7].Studiesabouttheinvolvementofadiponectinincancerhavebeengrowing
inthelastyears.Paridaetal.reporthowobesityandadiposityarecloselyrelatedtocancerprogression
inseveraltypesoftumors(suchasliver,pancreatic,prostate,andcolorectalcancers). Obesityacts
bydysregulatingadipokineproduction,leadingtotheupregulationofoncogenicadipokines,such
asleptin,andthedownregulationofadiponectin,whichplaysaprotectiveroleinobesity-associated
cancers[8].Abouttherelationshipbetweenobesityandcancer,Gelsominoetal.describetheroleof
adiponectinintheonsetofobesity-associatedfemalecancers(suchascervical,ovarian,endometrial,and
breastcancers),reportingthatadiponectinexertsanti-proliferativeactionsinsomefemalecancers[9].
Barbeetal. reportanoverviewoftheexpressionlevelsandsignalingpathwaysofadiponectinin
maleandfemalereproductivetract,fromgametogenesistoembryoimplantationandembryonal
development.Inaddition,theauthorsdescribesomediseasesassociatedwithinfertility,characterized
byalteredadiponectinlevels(suchaspolycysticovarysyndrome,ovarianandendometrialcancers,
endometriosis, gestationaldiseases, preeclampsia, andfoetalgrowthrestriction)[10]. Smolinska
etal. reportaresearcharticledescribingacomparativetranscriptomicstudyperformedincontrol
andadiponectin-treatedendometrialtissuesisolatedfrom15-to16-day-pregnantpigs.Thefindings
evidencethatadiponectinaffectsprocessesimportantforreproductivesuccess,suchascellproliferation,
celladhesion,andsynthesisofsteroids,prostaglandins,andcytokines[11].Theanti-atherogenicrole
ofadiponectinhasbeenwidelyrecognized. Yanaietal. illustratethemechanismsunderlyingthe
anti-atherogenicroleofthehormone,describingmethods(suchasweightloss,exercise,administration
ofnutritionalfactorsandanti-diabeticdrugs)leadingtotheriseofcirculatingadiponectin,whichhave
beenproventohaveprotectiveeffectsagainstatheroscleroticprogression[12].Aroleofadiponectin
Int.J.Mol.Sci.2019,20,2894;doi:10.3390/ijms20122894 1 www.mdpi.com/journal/ijms