Table Of ContentConference Proceedings of the Society for Experimental Mechanics Series
Srinivasan Arjun Tekalur
Pablo Zavattieri
Chad S Korach Editors
Mechanics of Biological
Systems and Materials,
Volume 6
Proceedings of the 2015 Annual Conference on
Experimental and Applied Mechanics
Conference Proceedings of the Society for Experimental Mechanics Series
Series Editor
Kristin B. Zimmerman, Ph.D
Society for Experimental Mechanics
Bethel, CT, USA
More information about this series at h ttp://www.springer.com/series/8922
Srinivasan Arjun Tekalur (cid:129) Pablo Zavattieri (cid:129) Chad S. Korach
Editors
Mechanics of Biological Systems
and Materials, Volume 6
Proceedings of the 2015 Annual Conference
on Experimental and Applied Mechanics
Editors
Srinivasan Arjun Tekalur Pablo Zavattieri
Michigan State University Purdue University
East Lansing , MI , USA West Lafayette , USA
Chad S. Korach
Department of Mechanical Engineering
State University of New York at Stony Brook
Stony Brook , NY , USA
ISSN 2191-5644 ISSN 2191-5652 (electronic)
Conference Proceedings of the Society for Experimental Mechanics Series
ISBN 978-3-319-21454-2 ISBN 978-3-319-21455-9 (eBook)
DOI 10.1007/978-3-319-21455-9
Library of Congress Control Number: 2015945112
Springer Cham Heidelberg New York Dordrecht London
© The Society for Experimental Mechanics, Inc. 2016
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Pref ace
Mechanics of Biological Systems and Materials represents one of nine volumes of technical papers presented at the SEM
2015 SEM Annual Conference and Exposition on Experimental and Applied Mechanics organized by the Society for
Experimental Mechanics and held in Costa Mesa, CA, June 8–11, 2015. The complete Proceedings also include volumes
on Dynamic Behavior of Materials; Challenges In Mechanics of Time-Dependent Materials; Advancement of Optical
Methods in Experimental Mechanics; Experimental and Applied Mechanics; MEMS and Nanotechnology; Mechanics of
Composite and Multifunctional Materials; Fracture, Fatigue, Failure and Damage Evolution; and Residual Stress,
Thermomechanics and Infrared Imaging, Hybrid Techniques and Inverse Problems. Each collection presents early fi nd-
ings from experimental and computational investigations on an important area within Experimental Mechanics, the
Mechanics of Biological Systems and Materials being one of these areas. This volume summarizes the exchange of ideas
and information among scientists and engineers involved in the research and analysis of how mechanical loads interact
with the structure, properties, and function of living organisms and their tissues. The scope includes experimental, imag-
ing, numerical, and mathematical techniques and tools spanning various length and time scales. Establishing this sympo-
sium at the Annual Meeting of the Society for Experimental Mechanics provides a venue where state-of-the-art
experimental methods can be leveraged in the study of biomechanics. A major goal of the symposium was for participants
to collaborate in the asking of fundamental questions and the development of new techniques to address bio-inspired
problems in society, human health, and the natural world. The organizers would like to thank all the speakers and staff at
SEM for enabling a successful program.
East Lansing, MI, USA Srinivasan Arjun Tekalur
West Lafayette, IN, USA Pablo Zavattieri
Stony Brook, NY, USA Chad S. Korach
v
Contents
1 Damage in Brain Tissue Due to Single Bubble Cavitation Shock ...................................................................... 1
Ghatu Subhash , Saranya Canchi , Yu Hong , Malisa Sarntinoranont , and Michael A. King
2 Inflation Test of the Human Optic Nerve Head Using Digital Volume Correlation ......................................... 7
Dan E. Midgett , Harry A. Quigley , Mary E. Pease , Christian Franck , Jennet Toyjanova ,
and Thao D. Nguyen
3 In Situ NANO-Indentation of Round Window Membrane ................................................................................. 17
Hirobumi Watanabe , Anil K. Lalwani , and Jeffrey W. Kysar
4 Transient Response of the Eardrum Excited by Localized Mechanical Forces ................................................ 31
P. Razavi , I. Dobrev , M. Ravicz , J. T. Cheng , C. Furlong , and J. J. Rosowski
5 In Vitro Quantification of Optimal Impact Properties for Microneedle Penetration ...................................... 39
K. Moronkeji , S. Todd , I. Dawidowska , and R. Akhtar
6 DIC Measurements of the Human Heart During Cardiopulmonary Bypass Surgery ..................................... 51
Mikko Hokka , Nikolas Mirow , Horst Nagel , Sebastian Vogt , and Veli-Tapani Kuokkala
7 Comparing 2D and 3D Digital Image Correlation for an Inflation Test............................................................ 61
Barbara J. Murienne and Thao D. Nguyen
8 Determination of Cardiac Wall Deformations from MRI Images ...................................................................... 69
C.A. Sciammarella , L. Lamberti , and A. Boccaccio
9 A Deeper Look Into Immature Porcine Zona Pellucida Visco-hyperelasticity ................................................. 85
A. Boccaccio , L. Lamberti , M. Papi , M. De Spirito , and C. Pappalettere
10 Induced Coupling Between Contractile Cells ....................................................................................................... 91
Brian J. Williams and M. Taher A. Saif
11 In-Vivo Indentation Testing of Sheep Spinal Cord with Meninges .................................................................... 99
Haitao Zhang , Phillip Falkner , and Chad Cai
12 Polydimethylsiloxane Lanes Enhance Sarcomere Organization
in Human ESC- Derived Cardiomyocytes ............................................................................................................. 105
Brett N. Napiwocki , Max R. Salick , Randolph S. Ashton , and Wendy C. Crone
13 Electrospin Fiber Affect on the Strength of Metal–Cement Interfaces ............................................................. 113
S. Riahinezhad , Y. Li , and M. Khandaker
vii
viii Contents
14 A Nanomechanics Based Investigation into Interface Thermomechanics of Collagen
and Chitin Based Biomaterials .............................................................................................................................. 119
Tao Qu , Devendra Verma , and Vikas Tomar
15 The Growth and Mechanical Properties of Abalone Nacre Mesolayer ............................................................. 127
Yan Chen , MariAnne Sullivan , and Barton C. Prorok
16 Novel Bending Fatigue Testing of Small Medical Device Cables ........................................................................ 133
Haitao Zhang and Bernard Li
17 Complex Shear Modulus of Hydrogels Using a Dynamic Nanoindentation Method ....................................... 141
R. Akhtar , E.R. Draper , D.J. Adams , and H. Pfaff
18 Characterization of Acoustically- Induced Forces of the Human Eardrum ...................................................... 147
Morteza Khaleghi , Cosme Furlong , Jeffrey Tao Cheng , and John J. Rosowski
Chapter 1
Damage in Brain Tissue Due to Single Bubble Cavitation Shock
Ghatu Subhash, Saranya Canchi, Yu Hong, Malisa Sarntinoranont, and Michael A. King
Abstract A novel experimental technique was developed to visualize and control single bubble cavitation initiation, growth,
and its collapse. The influence of this process on a nearby tissue surrogate was investigated and then extended to a rat brain
tissue.ThetechniqueutilizedamodifiedpolymerHopkinsonpressurebarsystemwhichtransmitsasimulatedblastpressure
wave with over and under pressure components to a fluid-filled test chamber implanted with a seed gas bubble. Growth and
collapse of this bubble was visually recorded with a high speed camera. Using Raleigh-Plessat equation, bubble collapse
pressures 29–125 times that of peak blast overpressure are predicted to be the source of localized shock waves. Finally, the
value of this experimental platform to investigate the single bubble cavitation- induced fluid jet impact on a rat brain tissue
and the associated damage evolution is illustrated.
Keywords Cavitation•Traumaticbraininjury•Agarosehydrogel•Shockwave•Braintissue
1.1 Introduction
Blast-inducedtraumaticbraininjury(bTBI),a‘signatureinjury’ofmoderndaywarfare,hasaffectedseveralthousandsof
soldiers returning from the recent wars [1]. Symptoms of these patients often range from mood swings to memory loss.
Numerous possible mechanisms have been proposed including injury due to rapid accelerating—decelerating forces in the
brain, multiple wave reflections with in the brain, impedance mismatch between heterogeneous tissue types, and cavitation
[2].Hereweconcernourselveswithcavitationcausedbyblastwavesconsistingoflargeoverpressure(compressive)and
smaller underpressure (tensile) components. The blast wave impinges on the head, leading to a portion of the wave being
transmitted into cerebrospinal fluid (CSF) and brain tissue, both of which carry dissolved gasses. Within the short time
period of blast wave transmission, there is potential for cavitation bubbles to form (during under-pressure phase), grow, and
collapse within fluid spaces inside the head. When these bubbles collapse, considerable energy is released either in the form
of local shock waves or generation of a high-speed fluid jet which may cause additional damage as it impinges on tissue.
Such cavitation damage of material surfaces is well established since the original work of Rayleigh who first studied pitting
of ship propeller blades or water turbine blades [3, 4]whichiscommonlyreferredtoas‘cavitationerosion’.Thus,collaps-
ing cavitation bubbles in the brain may cause local damage to nearby tissues or blood vessels.
A fundamental problem in the study of cavitation is that a testing platform is not readily available to control bubble
growth and collapse. In this study, a novel experimental system capable of investigating single bubble cavitation was devel-
oped. The system was first utilized to quantify the dynamic behavior of a tissue surrogate from single bubble collapse. In the
second phase the system is used to investigate damage in a biological tissue.
G. Subhash (*)•S.Canchi•Y.Hong•M.Sarntinoranont
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA
e-mail: [email protected]
M.A. King
Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32611, USA
© The Society for Experimental Mechanics, Inc. 2016 1
S.A. Tekalur et al. (eds.), Mechanics of Biological Systems and Materials, Volume 6,
Conference Proceedings of the Society for Experimental Mechanics Series, DOI 10.1007/978-3-319-21455-9_1
