Table Of Content·�
Martindale
TheC ompleDtreuR eference
g
Thirty-Eediigthitohn
Volume
1:1 -1120
Volume
2:1 121-2314
Volume
3:2 315-3444
Volume
4:3 445-4596
(RP)
PharmaceuticParle ss
·�
Martindale
TheC ompleDtreuR eference
g
Thirty-Eediigthitohn
(RP)
PharmaceuticParle ss
PublishbeydP harmaceutiPcraels s
1 LambetHhi ghS treeLto,n doSnE 17 JNU,K
©PharmaceutPirceas2ls0 14
(RP)
isa tradmea rko fP harmaceuPtriecsasl
PharmaceuPtriecsailsst hep ublishdiinvgi soifot nh eR oyaPlh armaceutical
SocieotfyG reaBtr itain
Firesdti tioofMn a rtindTahleEe x:t rPah armacopwoaesip au blisihne1 d8 83.
SquirCeo'msp aniwoans i ncorporiantt ehdet wenty-tehdiirtdii on1n 9 52.
Thirty-eeidgihttihpo unb lis2h0e1d4
TypesbeytD atSat andarLdtsd
PrintiendI tablyyL EGOS .p.A.
ISB9N7 80 8571113 95
ISS0N2 63-5364
Alrli ghrtess ervNeodp .a rotf t hipsu blicamtaiyob ne
reproducsetdo,r ienda retriseyvsatle omr,t ransmiitnta endy
formo rb ya nym eansw,i thotuhte p riowrr ittpeenr missoifo n
thec opyrihgohltd er.
Thep ublismhaekre nso r epresenteaxtpiroens,os rei dm plied,
witrhe gartdot hea ccuraocfty h ei nformactoinotna inientd h is
booka nds hanlolt b el iabsloef ,a ars i sp ermissbiybl laew f,o r
anyc laiwmh etheirnc ontraocrtt o rfto lro ssaersi sionugto f
ori nc onnectwiiotnth h eu seo ft heb ook
Theb ooks houlbde i nterprientl eidg ohftp rofessional
knowledagned s upplemenatsen de cessbayrs yp ecialised
publicatainodpn rso dulcitt eraTthuerr ee.a dsehro uledn sure
thatth ei nformabteiionnug s edi sc onsistweintntho rmal,
generaalclcye ptheeda lthcparraec tice.
A catalorgeuceo frodtr h ibso okis a vailafbrloetm h eB ritLiisbhr ary
Contents
Prefacpe v
A guidteo M artindalpe v i
Abbreviatipo nisx
ContractNeadm esf orI onsa ndG roupsp xii
AtomiWce ightosft heE lementsp xiv
VolumAe
• Monograopndh rsu agnsd a ncilsluabrsyt ances
AnalgesAinctsi -inflammaDtrourgysa n dA ntipyretpi 3cs CoughS uppressaEnxtpse ctoraMnutcso lytiacnsdN asal
Anthelmintipc 1s4 3 Decongestanpt 1s6 51
Antibacterpi a1l6s8 DermatologDircuaglsa ndS unscreenps 1 681
AntidemenDtriuag sp 388 DisinfectaanndtP sr eservatipv 1e7s3 0
Antidepressapn 3t9s7 Electrolypt 1e7s7 5
Antidiabetpi 4c5s8 Gasesp 1797
Antiepileppt 5ic0s6 GastrointesDtriungaspl 1803
Antifungapl 5s6 3 GeneraAln aesthetipc 1s8 96
AntigoDurtu gsp 600 GrowthH ormonea ndi tMso dulatorps 1 918
Antihistamipn 6e1s0 Immunosuppressapn 1t9s3 2
Antimalaripa 6l4s4 LocaAln aesthetipc 1s9 76
AntimigraDirnueg sp 670 MiotiMcysd riataincdsA ntiglaucoDmrau gsp 1999
Antimyasthenpi 6c8s4 MusclRee laxantps 2 014
Antineoplaspt 6i9cs1 NeuromuscuBllaorc kerps 2 028
AntiparkinsoDnriuagns p 889 NutritioAngaeln tasn dV itaminps 2 042
Antiprotozopa 9l1s9 ObstetDrriucg sp 2129
Antivirapl 9s5 1 PesticiadnedRs e pellenpt 2s1 47
AnxiolySteidca tivHeysp notiacnsd A ntipsychotpi 1c0s2 8 PharmaceutEixccailp ienpt 2s1 63
BlooPdr oducPtlsa smEax pandearnsd H aemostatipc 1s1 21 Radiopharmaceutpi c2a2l2s2
BoneM odulatiDnrgu gsp 1167 SexH ormoneasn dt heiMro dulatorps 2 231
BronchodilaatnodAr nst i-asthDmrau gsp 1195 StimulaanntdsA norectipc s2 314
CardiovascDurluagrs p 1242 Thyroiadn dA ntithyrDoriudg sp 2332
ChelatoArnst idotaensd A ntagonispt 1s5 37 UrologiDcraulg sp 2347
ContraMsetd ia p 1580 VaccinIemsm unoglobulainndsA ntiserpa 2 373
Corticosterpo 1i5d9s7 MiscellaneDoruusg sa ndO theSru bstanceps 2 426
VolumBe
• Preparapt 2i65o3n s
• DirecotfMo arnyu factpu 3r98e5r s
• PharmaceTuetriimcnsVa alr iloaunsg uagp 4e0s89
• GenerIanld epx 41 10
• CyriIlnldiecpx 4 5 66
ivA boutth aeu thors
Aboutth aeu thors
Martindailspe u blishbeydt heP harmaceutPirceaslts h,e p ublishdiinvgi siooftn h eR oyaPlh armaceutSioccaile tCyo.n tenitsc reataendd
updatebdy t heM artindale EdTietaomr,ai a glr oupo fp harmaciasntdsl ifsec iengcrea duatweist hr elevaenxtp ertiwsheo areg iven
formatlr ainiinnlg i terateuvrael uatainodns earchitnegc hniquaessw ,e lla so n-the-jtorba iniinnig n ternparlo cedurTehse.E ditorial
Teami ss upportbeyda numbero fe xterncaoln tributors.
Editor: AlisoBnr ayfieBlPdh,a rmM,R PharmS
EditorSitaalf f: CatheriRnMe CadarBtP,h armG,r adDipHospPhMarRmP,h armS
ElainEa C rehanM,C hem
KathleeEna ger, BPharm
ElizabeSt Fho anM,A (Cantab)
AustiCn G ibbonBsS,c ,M Sc
ChloeS AJH atwalB,S c,MR es
SueW H o,B PharmM,R PharmS
SoniZa K han,M Pharm,P GCertPharmPrac
RebeccEa L uckhursBtS,c
JeanM acKershaBnS,c P,g Dip
DeirdMrec GuirkB,C omm,M Pharm,M RPharmS
Sandra SutBtPohna,r mM,S cM ed,C erPtr ojMngt
Contributors:I anA BaxteBrS,c ,P hD,M RPharmS
MildreDda visB,A ,B Sc,Ph D,M RPharmS
MariaEn FentonM,S c,C MPP
EileeJn L aughtoBnP,h armP,h D,M RPharmS
JuliMe McGlashan, BPhDairpml,n fSMcR,P harmS
RosaliMncdL arneByP,h armM,S c
GaiCl NeathercoBaStc,,M RPharmS
ClaiHr eN ortonB,Sc
PriyPaa teMlP,h arm,M RPharmS
SueJ Shankie, BPhMaSrcm,M, R PharmS
Prefav ce
Preface
Drugi nformatiisoc no nstandtelvye lopianstg h eu seo fe xistidnrgu gs • updaterde vieownst het reatmeonfat c utley mphoblalsetuikca emia
growsn,e w drugse mergen,e w preparatiaornels a uncheadn,d old andn on-smaclelll lu ngc ancewrh,i chp rototyap nee wa pproatcoh
preparatiaorena sb andonerde,f ormulaotrer de,d efinTehde.n eedso f ourt reatmernetv iews
thosper actispihnagr macayn dm edicianreea lscoh anginagn,dd urinigt s • revispeadr acetanmoomlo gramfso rt het reatmeonftp aracetamol
longh istoMrayr tindahlaese volvetdom eett hosnee edbsy becoming poisoning
muchm oret hana simpleen cyclopaoefdm iead icinIetas i.m st op rovide • extensrievvei siooftn h ep orphyraibas tracts
healthcparroef essiowniatlhes v aluatuendb,i asiendf ormatoino dnr ugs • expansioofnt hec overaogfep roprietparreyp arattiooc nosv e4r3
andm edicinuesse dt hroughotuhtew orldO.u rc onteinsta lscoa refully countrainedsr egionisn,c ludCihnign a
structutroee dn ablree adetrosf intdh iisn formateiaosni alnyd q uicklyT,h eM artindeadliet ortieaalmh aveb eena ssisbtyem da nyi ndividiuna ls
whetheirti st oa nswesrp eciqfuiecs tioanbso udtr ugosr t og ivae broad thep roductoifot nh iesd itiaonnd,i ti st heir valuable conthreilbpu tion that
overvioefwp harmaceuttiocpailc s. toe nsurMea rtindale's validairtedy u.e t oTL hiannBakl sa dhA,l essandro
Ourr eadesrhso ulndo tet haMta rtindiasln eo ta booko fs tandartdhse: GabbiJ,u dyv anE ngeldorp GasStpeellaGaao rdse,cJ ,a nH ornM,o ntserrat
inclusioofan substanocrea preparatiisno ont t ob e considearsea d JaneA,n driuKsa iryMsa,r iKao uimtzCia,r lOal iveiKraam,i lRaa mesova,
recommendatfioourns en,o rd oeist c onfearn ys tatounst hes ubstanocre ElsSai monG,y ongyvSeor6 sC,a rinTau kukinRoo,b erWta silewsLkair,r y
preparatainodrn e adearrser emindtehda ktn owledagned b esptr actiinc eC allahaannd,F ranSkw itzer.
thifsi eladr ec onstancthlayn ging. Wcohnislied ereafbfloer htasv eb een Thet eamh avea lsboe ena blteo c aloln t hea dvicaen de xpertoifso et her
madet oc hectkh em ateriianMl a rtindanleei,t htehre p ublisnheorrt he memberso ft heR oyalP harmaceutical SPohcairemtayc'esu tPirceasls
authoarcsc epatn yr esponsibfiolrei rtryo arnsd o missioTnhse.p ublishedri visiIonpn a.r ticutlhaeEr d,i twooru ldl ikteot hanRka cheRly ana ndt he
anda uthomrask en or epresentaetxiporne,s soerid m plietdh,ad to seasr e stafofft heB ritiNsaht ional FormCullaairrPyer, e stoann dt hes tafoff
correfcotpr a rticpuulrapro saensdr eadesrhso ulcdh ecukp t od atper oductS tockleDyr'usgI nteractainodnS sa,mD rivaenrd t heS cientceea mT.h anks
informatcioodne,os f c onducatn,d s aferteyg ulatiTohnesr .e adeirsa lso area lsdou et oT amsin CouasnidnL si nda Pauflourts h,e ipra tienacned
assumetdo p ossetshsen ecessakrnyo wledtgoei nterptrheeit n formatigouni danicneh andlitnhgev arious asopfpe rcotdsu cianp gr inptu blication,
thatM artindaplreo videIst.i s t her esponsiboifl pirtayc titiotnoe rasn dt oD aviGdr angeMre,s fiMne bratKea,r Pla rsonasn,dI anW hitef,o r
determidnoes ageasn dt reatmenftosri ndividpuaatli enttask,i nign to theitre chnical exipnpe rrotdiuscei ng daingdpi rtiandlta taseWtes a.r ea lso
accouunptt od atteh erapeusttiancd aradnsdt, o t akael alp proprisaatfee tyg rateffourtl h es uppoorftK areBna xteFrr,a nGki bsoann,d A linLao urie.
precautions. TheE ditowro ulda lsloi kteo t hanSke anS weetmanP,au lB lakeG,a il
Furthdeert aiolnts h eb asiecd itorpihaill osobpehhyi ncdo ntecnrte atioNne,a thercoAantn,e ParsonSsu,s anH andy,F auziaHha shmiJ,o anna
asw elals g uidanocneh owt hed atias s eotu ta,r ep rovidiendt heg uidteo Humm,K elKlail bP,r iyPaa teGle,r dVai edgEel,i zabKeitnhg a,n dC hristine
Martindsaelcet ioonnt hen extp age. IskandTahre.i irn puotv ert hey earasn dt ot hiesd itihoans b eeng reatly
valueadn di sn otf orgotten.
Majcohra nfogrte hs3e8 T EHd ition Ourd igivtearls ioofMn a rtindawlhei,c ihs u pdateqdu arterilsay v,a ilable
Therhea veb eens evercahla ngetost hinse we ditioofMn a rtindabluett, h e on MedicinesComp(lwewtwe.m edicinescomcpolme)tI.et m. aintaitnhse
mosts trikiisin tgns e wf ormaTth.e c ovedre sighna sb eenr efresahneddt, o familliaayro uotft hep rinptu blicatbiutoa,ns i ti sn otl imitiendi tssi ze,
overcomaec o mmonp robletmh,ep aglea yohuat sb eent otarlely- designeexdt rcao ntenstu cha st hea rchicvhea pteofrd eletmeodn ograpahnsd
witha newa ndl argfeorn tT.h iesn surtehsa tth ep agei se asiteorr eaads graphirceaplr esentaotfti hoenc sh emicsatlr uctuorfme asn yo ft hed rugs
welals m akinigtq uickteorf intdh ei nformattihoern e adeirsl ookifnogr area lsaov ailaFbolrem .o rei nformataiboonu tth ed igitparlo ducptl,e ase
ont hep ageA.l ongsitdheia sn,d i nr espontsoue s efre edbatchke,l ayouotf visoiutr w ebsite.
them onographhsa sb eenr estructaunrder de adewrisl nlo w finda We contintuoev aluoeu rr eaderfse'e dbaacnkd a nyonew ishintgo
monographu'sse ast t hes tarotfa monograpkhn;o winhgo w a druga cts contaucstm ayd os oa to ure maiald dresPsh:p [email protected]
andi su sedm ayh eltpo c ontextuaalniyss ueb sequeandtv eresfef ecatnsd
precautiroenlsa tteodt hatd rugI.n additiao nd,r ug'nso menclature LondonF,e brua2r0y1 4
informatiisho ing hlighwtietdh iint osw n shadetde xbto x.T oa llofwo r
thesceh angetsh,ec hemicsatlr uctgurraep hiacrsen ol ongerre produicne d
thep rinetd itioonfMs a rtindahloew;e vert,h eyr emaianv ailaobnl oeu r
digitpalla tfoMremd,i cinesComplete.
Alongsimduec ho ft her evalidawtoiroktn h aitsu ndertakweint he very
editioofnM artindaolteh,ec rh angefso rt hiesd itiionnc lude:
• over2 00n ewm onograpihnsc luding:
• thes odium-gluccoo-ster ansp2o ritnehri bitcoarnsa,g liflaonzdi n
dapagliflhoazviebn e,e na ddeads a newd rugg routpo t hec hapter
ona ntidiabdertuigcs
• thea ntivirdaalcsl,a taasnvdsi orf osbufvoiurrs ,ei nt hem anagement
ofh epatiCt is
• restructuorfti hnegs ectioonnd iabetmeesl litmuasn agemenitnt he
antidiabdertuigccsh aptetroi, m provietr se adability
viA toM artindale
A guidteoM artindale
Martindacloen taiinnsf ormatoino dnr ugisn c liniucsaelw orldwidaes, covebro ths chedulreedv isiooftn h ec ontenatn.d r evisioofpn a rticular
wella s selectiendv estigatainodn vaelt erinadrryu gsh,e rbaaln d poinitnsr eactitoonn e wi nformataisio tna rrives.
complementamreyd icinepsh,a rmaceutiecxacli pienvtist,a minasn d The revisiporno ceduirnev olvtehse e ditorwirailt erre -evaluating
nutritioangaeln tvsa,c cinreasd,i opharmaceuctoinctarlamsse,td iaa nd standiinngf ormataisosne,s snienwgl y-collreecfteerde nfcoerqs u aliatnyd
diagnosatgiecn tmse,d icingaals edsr,u gosf a busaen dr ecreatidornuagls ,r elevanacned,s earchibnigb liogradpahtiacb asaensd t heI nternteot
toxiscu bstandciessi,n fectaanndpt ess,t icides. identify furtheri ncfaonrdmiadtaitoen .
Thei nformatoino onv er6 000d rugasn do thesru bstanicsea sr ranged Oncet hem aterifaolnr e wc ontehnats b eenr e-evaluaantdeu dp dateidt,
intmoo nograpthhsa cto ntadine taiolns n omenclatuprreo,p ertaineds ,i sr igorously rbeyva i seewceodn d ediwtroirtiteaorle nsurneo to nlyt hat
actioTnhse.s tee xste ctiosnusm maritshee r elevainntf ormatniootna,b lya lclh angeasr ev aliadn da ppropribauttae l,s toh aitm portapnoti nhtasv e
forl icensuesde sf,o lloweidfa, p propribayt er,e ferenacbesdt raocrt sn otb eenm issed.
revietwhsa etx panudp ont hed etaiglisv einn t het exotr a dda dditionalT hem ateriiastl h enp assedt hteeo d itowrh,op erforamf si nahli.g h-level
informatMiuolnt.i censttrued imeest,-a a nalysaensd,s ystemarteivci ewsc hecka nda pprovoaflt hed ataT.h isp rocesissd esignteode nsure
plaayn i mportarnotli en t hes tudoyf d rugt reatmeanntd,t heifri ndingcso nsisteonfac pyp roaacnhd s tylaesw, e lals o fferainno gp portuntiopt iyc k
andc onclusiaornecs o nsideirnem du cho fo urc ontenHto.w evert,h eries upa nye rrotrhsa mta yh aveb eenm isseCdh.a ngeasn dq uestiaonrsef ed
alsao p lacfeo rt hea necdotraelp oarntd t hes malslt udayn,d i nformatiboanc kt ot hew riter.
froms uchso urciesis n cludwehde rea ppropriIanct oem.p ilitnhget exotf a Keyingp,r oof-readianngd, d ose-checkiOnngc.e a pprovbeydt he
Martindamloen ographu,s ei sm ade oft hed rug'lsi censperdo ducte ditor, contentc ancb hema andgeeis n t hed atabawshei,c hh asr emained
informataispo unb lisihnev da riocuosu ntrainedsa pprovbeydt her elevanutn touchuendt itlh isst agaesa securimteya surTeh.e sceh angeasr et hen
regulataourtyh oritAiceksn.o wledgemiesna tl sgoi vetno i nformatiporno ofrefaodre rrorcso,r recitfen de cessaarnyd,a nyc orrectcihoencsk ed.
referenfcreodm a numbero fa uthoritastoiuvreci ensc luditnhgeB ritisEhx tenseilveec trotneisct ifnogsr p ellisntgy,la en,df ormaitsa lscoa rrioeudt
NationFaolr mulatryh,e B ritiNsaht ionFaolr mulafryo rC hildrtehne,B ritisaht a lslt ages.
PharmacopotehieaE ,u ropeaPnh armacopotehieaU ,n iteSdt atNeast ional Thea mendecdo ntentth enu ndergoaens i ndependreenvt ieowf t he
Formulaaryn,d t heU nitSetda tPehsa rmacopeia. dosien formataigoani nisttrs e corded soTuhricse sr.e ivsip eewr formbeyda
Ina dditidoins,e atsree atmernetv iewosf feorv ervieowfsn earl7y0 0 writenro ti nvolviendt heo rigicnoanlt egnetn eratpiroonc esasn,di sa n
diseasaensdt hed ruguss edi nt heitrr eatmeanlto.n wgi thk eyr eferencaedsd itiosnaafle guaargda intshte i nadvertiennttr oducotfip oont entially
andg uideliCnreoss.s -referaernepc reosv idbeedt weetnh ester eatmendta ngeroduoss ee rrors.
revieawnsd r elevadnrtu gm onographs. ReleasOen.c ep asatl tlh esset agetsh,ed ataar ec learfeodrr eleaasned
Preparatsiuomnmsa rioefsm oret ha1n8 0,0p0r0o prieptraordyu cftrso m canb ep ublishiendt hen extu pdatoef t heM artindale pdriogdiutcatls ;
43 countrioers r egionasr ei ncludeIdn.f ormatiiospn r ovideodn changetsot hep rinvte rsiwoinl alp peairnt hen exte dition.
proprietnaarmye ,m anufactuorred ri stribcuotuonrt,r y/reogfio orni gin, Additioncahle ckfso rp ublicatiSoonm.e a dditiocnhaelc kasr em ade
activien gredieanntdsa , s ummaryo ft hei ndicatiaosgn isv ebny the befoprueb lishaip nrgi netd itioofMn a rtindaAl see.c onidn dependdeonste
manufacturPearg.en umberlsi nki ngredietnota sn appropridartueg revieowfa lclh apteirsms a deb ye xterneaxlp erts.
monograpwhh erep ossible.
Hotwh ien forimasar trgeiadon n
Phiplhoyas nmode thodology Martindiasld ei vidiendt 2o v olumes:
Martindaulsee'assr ea sv ariaesdi tuss erHso.w evert,h ep rimaariym sa re: VolumeA covers:
• tos ummaricslei nicuaslelfyiu nlf ormatoinoa nld lr ugasn dm edicines • Monographso n drugsa nd ancillasruyb stanceTsh.i ss ection
arountdh ew orld contaionvse r6 000m onographasr rangiend4 9 chapterTsh.e se
• to providaec curatuen,b iaseadn,d reasonabcloym prehensive chaptegresn erablrliyn tgo gethmeorn ograpohnsd rugasn dg rouposf
informatiinoa n c oncifsoer mat drugtsh ahta ves imiluasre osr a ctioTnhse.d iseatsree atmernetv iews,
• top roviad el ead-tiont hep ublisheevdi denbcaes ef romw hichw e whichp roviddees criptoifod niss easteosg ethweirt hr eviewosft he
derivoeu ri nformation choicoeft reatmenatrseu, s ually loicnta hteec dh aptienrt roduction.
Toa chietvhee a bovaei ms, worpkriancgt ihcaevset ob es afaen de fficient,T hec haptteirt lMeids cellanDerouugsas n dO theSru bstanccoenst ains
whilmea kinogp timuums eo fa vailaibnlfeo rmatTihoinss.e ctidoens cribes monograpohns drugnso te asicllya ssifhieerdb,a lasn,d d rugnso
someo ft hesweo rkinpgr actices. longeurs edc linicbaultl ys otfii lnlt ereTshte.ra er ea lsmoo nographs
ont oxiscu bstantcheese ,f fecotfws h ichm ayr equidrreu gt herapy.
VolumeB includes:
Datcao llection
• PreparationTsh.i ss ectiocno ntaionsv er1 80,00p0r oprietary
Thet eamp roactimvoenliyt otrh ep ublislhietde raftouprro et entcioanlt ent
preparatfiroonmas rangoef c ountrainedsr egionTsh.ei nformation
updateTsh.i isn volvreesg ulasrelayr chsienlge cmtaejdo mre dicjaolu rnals
provideidn cludtehse p roprietnaarmye ,t hem anufacturoerr
andw ebsitoefrs e gulataourtyh oristuicehas s E MA,F DA.H ealtCha nada,
distributthoear c,t ivien grediewnittshc ross-refetroet nhceed sr ug
and MHRA; others ourceosf high-qualsiytsyt ematriecv iewasn d
monographasn,d a summaryo ft hei ndicatiaosng si vebny the
guideliinnecsl,u dtihnegC ochranlei braarnydN ICEa,r ea lsmoo nitored,
manufacturer.
as arep harmacopoeial. govearnndm WeHnOt alp.u blicatifoonrs ,
• Directoroyf manufacturerIsn. M artindatlhee nameso f
informatrieolna ttiond gr ugasn dd rugt herapy.
manufacturaenrdds i stribuatroear bsb reviaTtheedi.fr u lnla mesa re
Thel isotfs ourcuesse dh asb eend evelopoevde mra nyy earbsy a nalysis
giveinn t hidsi rectotroyg ethweirt hc ontacdte taiilfsa vailable.
ofp reviocuist atiaonndsi ,sr eviewaendd u pdaterde gularly.
Manufacturerresc'o rdasr el isteadl phabeticTahlilsyd .i rectory
Licensperdo duicntf ormatfioor4n 3 c ountrainedsr egioinses v aluated,
contaionvse r2 0,00e0n tries.
tom aintatihne w idespto ssibcloev eraogfed rugisn u sei nternationally.
• Pharmaceutictaelr msi n varioulsa nguageTsh.i si ndexl ists
Preparatniaomne sm,a nufacturienrgsr,e dieanntdsl ,i censuesde sa re
nearl5y6 00o ft hec ommoneprh armaceutfiocramlas n dr outeisn1 3
includientd h ei nterMnaarlt inddaaltea bafsoerr e viedwu rintgh er evision
majoEru ropealna nguagIetis s.p rovidaesda na idt ot hen on-native
process.
speakienri nterpreptaicnkga gipnrgo,d ucitn formatoirop nr,e scrip
tionwsr ittienna nothelra nguage.
Editoprrioacle sses • Generailn dexT.o m aket hef ulluesseto ft hec ontenotfMs a rtindale
Writer,e viewa,n da pproveT.o m aintatihne q ualiatnyd c urrenocfy theg enerianld esxh ouladl waybse c onsultTehdee. x haustiinvdee x,
ourc ontenitti, s c onstanrtelvyi saendd u pdateOdu.r r evisiporno cesses preparefdr omo ver1 75,00e0n trieisn,c ludienngt rifeosr d rugs
A guidteoM artinvdiail e
(approvneadm ess,y nonymsa,n dc hemicnaalm es)p,r eparatiotnhsev, e ryn aturoef t heiorr igtihne yc annobte r eliuepdo nf ord efinitive
pharmacologaincdat lh erapeugtriocu pasn,d c liniucsaels( diseasied entificoafat siuobns tanTchee.u seo fs ucht ermcsh angersa pidalnyd,
treatmernetv iewAss). i np revioeudsi tiotnhse,i ndeixs a rrangedc anv aryb etweedni ffergeenotg raphlioccaalt ioannsda, n yg ivenna me
alphabeti'cwaolrldy- by-wroartdh'te hra 'nl etter-byT-hleei tntdeerx' m.a y potentibael alpyp liteodm oret hano nes ubstanocree vent oa
indicattheecs o luminn w hicthh er elevaenntt rayp peaarssw elals t he mixtuorefs ubstanFcuerst.h ermoerset,a bliosrhw eedl rle cognigseende ric
pagea ndi nw hicvho lumteh ee ntrmya yb ef oundT.oi mprovcel aritdyr ugn ameso rh erbanla mesh aves ometimbeese nm isuseadss treteetr ms
andt hee asoef l ocatioofin n deexn trileosn,gc hemicnaalm esh ave forc ompleteulnyr elatseudb stancIenso .r detro e nablteh er eadetro
beeno mittferdo mt hei ndex. distingtuhiesmhf romt heb etter valsiydnaotneydmi sn t hei ndexs,u ch
o Cyrilliincd exB.o thn on-propriaentdap rryo prientaamreys m ayb e namesa rei ncludienid t alaincdsi nq uotation marks.
founidn C yrilallipch abetoircdaelirn t hisse ction. CAS Registrnyu mbersC.h emical AbsSterravcit(csCe A S)r egistry
numberasr ep rovidwehde,r ea vailafbolree a,c hm onograpshu bstantcoe
Thmeo ngropahs helrpe aderresf etroo theirn formatsiyosnt ems. Nufmobvrea rrsi ous forms
Chapters wMiatrhtiinn daalreec omposeodf a ni ntroducotfiv oanr yingo ft hem onograpshu bstanacreel istweidt ht hev ariatiinof no rmg iveinn
lengtha,n d a seto fm onographdse scriinbgi ndividduraulg sE.a ch parentheses.
monograpbhe ginwsi thit tsi tslyen,o nymisnE ngliasnhd o thelra nguages,A TC codesC.o desf romt heA natomicTahle rapeuCthiecm ic(alA TC)
identificcaotdoersay,n dc hemicaanld p harmaceutiincfaolr mataiboonu t classificsaytsitoe(nms eeh ttp://www.whochca.vneob )e enp rovided,
thec ompoundi,n cludainnygp harmacoposetiaanld arTdhsi.is s f ollowewdh erea vailabfloere, a chm onograph substtoha enlcper eaderresf etro
by oneo r mores ectiodness cribpihnagr macologaincdat lh erapeutoitch eri nformatisoyns temTsh.e codes assiignn tehde equivalent
informataiboonu tth ed rugo rs ubstanAc tey.p icmaoln ograpihn cludesc:l assifiscyasttieofmno rv eterinmaerdyi cin(eAsT CV et-sehet tp://www.
o Nomenclature whocc.no/atcavnedt h)e rbamle dicinheasv eb eeni ncludewdh ere
o Usesa ndA dministration possible.
o AdversEef fects UNITc odesT.h eu niquien grediiednetn tifwiheircsha, r eg eneratbeyd
o TreatmeonfAt d versEef fects thej oinFtD A/USP SubstRaengcies traStyisotne hma veb eenp rovided,
o Precautions wherea vailaNbulmeb.e rfso rv ariofuosr mosf t hem onograpohrr elated
o Interactions substanacreels i stweidt ht hev ariatiinof no rmg iveinn p arentheses.
o Pharmacokinetics Atomica nd moleculawre ightsA.t omiwce ightasr eb aseodn the
Sectiobnesg iwni tuhn referenscuemdm artye xbta,s ed loinc enpsreodd uctt abloefA tomiWce ightass reviins2 e0d1 1b yt heC ommissioonnI sotopic
informatainodon t hehri gh-quavlailtiyd astoeudr ceTsh.im sa yo ptionalAlbyu ndancaensd A tomiWce ightIsn,t ernatUinoinoaonlf P uraen dA pplied
bef ollowbeyda bstraocrrt esf erentceexdet x pandionngp articpuolianrt sC,h emist(rIyU PACa)n db aseodn the1 2Cs cal(es epe. x iv)M.o lecular
andp rovidian lge ad-tiont hep ublishleidt eraftruormew hichw e derivew eighatrse g ivecno rrecttoeo dn ep lacoefd ecimaolrst of ousri gnificant
ouri nformation. figurfeosrr elatwievieg hotfsl estsh an1 00.
Listosf s inglaen dm ulti-ingrepdrioepnrti etaanrdyn on-proprietary
preparatairoegn isv eant t hee ndo fe achm onograph. Pharmacopoeias
Thes elecptheadr macopoieniw ahsi ceha chs ubstanacpep eaarrsel istAe d.
Nomenclature descriptoifo tnh es ubstanacned a summaryo ft hep harmaceutical
Then omenclature soefec atcihmo onn ograpmha yi nclutdhee f ollowinign formattihoaantp peairnst heB ritiEsuhr,o peaonrU, S P harmacopoiesi as
information: alsion cludCeudr.r encto pieosft hep harmacopoeainadts h eiard denda
Titleasn ds ynonymsT.h et itolfee achm onograpihsi nE ngliswhi,t h shoulbde c onsultfeodrc onfirmatanidof no rd etaiolfss t andards.
prefereunscuea lbleyi nggi vetno I nternational NonpNraompersi etTahreyp harmacopoecioavser eidn cluBdrei tiBsrhi,t iVseht erinCahryi,n ese,
(INN)B,r itiAsphp roveNda mes( BAN)a,n dU niteSdt atAedso pteNda mes EuropeaFnr,e ncGhe,r manI,n ternatioIntaall,i Jaanp,a nePsoel,i sShp,a nish,
(USAN)T.h es3e authoriatriees sh ownw herea ppropriAa tEeu.r opeanS wisUsn,i teSdt at(eisn cludtihneNg a tionFaolr mularya)n,d V ietnamTehsee.
Direct(i9v2e/ 27/EErCeq)u irtehseu seo fR ecommendeIdn ternatioanbablr eviatfioornt sh esep harmacopoeairaesi ncludiend thel isotf
NonproprieNtaamreys ( riNNsi)n t hel abelloifnm ge dicinparlo ductasb breviatuisoendis nM artind(asleepe .i x)w,h icahl sion cluddeest aiolfs
throughomuetm bers tatoefts h eE uropeaUnn ioann dw herte heB AN and thee ditiaonnd /osru pplemencto(nss)u lted.
INNd iffeirnet dh ep astth eB AN hasb eenc hangetdoa ccorwdi tthh er iNN. Severcaolu ntraireesp artiteots h eC onventioonnt heE laboratoifao n
Them ajore xceptitoont hicso nventiiostn h er etentiooftn h en ames EuropeaPnh armacopoTehiiams.e anst hatth emyu sta doptth es tandards
adrenalainnden oradrenaltihneesb,ee intgh et ermuss eda st het itloefs oft heE uropeaPnh armacopoTehieas.ce o untraireesc urrenAtulsyt ria,
them onograpihnst heE uropePahna rmacopoaenidta h ereftohreoe f ficiBaell giuBmo,s niaan dH erzegoviBnual,g arCirao,a tiCay,p rust,h eC zech
namesi nt hem embers tatIenss .o mea pprovneadm esi ti sg enerpaoll itcoy RepublDiecn,m arkE,s tonFiian,l anFdr,a ncGee,r manyG,r eecHeu,n gary,
use' ff'o r' phi'n s ulph'at,f' o r' tha'n,d ' if'o r' y'f;o trh irse asoenn triiens IcelaInrde,l aIntda,l Lya,t viLai,t huanLiuax,e mbourMga,l taM,on tenegro,
alphabetliicsastlhs o ulbde s oughitna lternastpievlel iinftg hse e xpectedt heN etherlanNdosr,w ayP,o landP,o rtugaRlo,m aniaS,e rbiSal,o vak
spellianrgens o tf oundI.n evitatbhleyrm ea y bes omei nconsisteonfc iReesp ubliScl,o veniSap,a inS,w edenS,w itzerlTaunrdk,e yU,k rainteh,e
stywliet ho ldearp provneadm esb utw herever potshseni abmlees u sedf or UniteKdi ngdomt,h eF ormeYru goslav RepoufMb alciecd oniaan,d t he
drugosr r adicianlM sa rtindhaalvee b eena lterienda ccordawnicteh t he EuropeaUnn ionH.e ncet heE uropeaPnh armacopoiesci iat eidnt hed rug
guidelionnet sh eu seo fI NNsf oprh armaceutsiucbaslt anFcoersa .t abloef monograplhi sotfsp harmacoporeaitahset rh ant hesien dividnuaatli onal
contracntaemde sf ori onasn dg roups uisnae pdp rovneadm esa ndt itlepsh armacopoeias.
seep.x ii. Officpiraelp aratmiaoinnsl,fy r omt hec urreBnrti tiEsuhr,o peaann,dU S
Thisse ctiaolns ion cludneasm esg iveans s ynonymssu cha sc ommonly Pharmacopoeairaels i,s taettd h ee ndo fd rugm onographs.
useda bbreviantaemde sL;a tivne rsioonfst het itlienst he European
PharmacopoEenigal;i sAhm,e ricaSnp,a nisahn,dL atisny nonymnsa;m es Pharmaceuitnifcoarlm ation
usedi no thelra nguagwehse n thesmea y notb e readiildye ntifiaIbnlfeo;r matoinot nh ec hemicaanld p hysicparlo pertoifee asc hs ubstanicse
manufacturceordse'n umbersa;n dc hemicanla mesB.A N namesf or givewnh eni ti sl iketloyb eo fu seo ri nterebsutto, n lyw heni ti sc ertain
substanccoem binatiaonndsU niteSdt atPehsa rmacEyq uivalNeanmte s thaitta ppliteots h ef ormo fs ubstanbceei ndge scriibnet dh em onograph.
(PENf)o dro sagfeo rmcso ntaintiwnogo rm orea ctiivneg rediaernegt isv en Percentasgter engthUsn.l esost herwisstea tesdo,l utioofns so liidns
int het exotf t her elevamnotn ographtsh;e snea mess tawritt ht hep refixl iquiadrsee xpressasep de rcentwa /gveo, f l iquiidnls i quiadsps e rcentage
'Co-'. v/va,n do fg aseisnl iquiadsps e rcentwa/gwe.
Offictiiatll aensd s ynonymuss edi nt heB ritiEsuhr,o peaann,d U S SolubiliTthye.f igurgeisv efno rs olubiilnie tayc hm onographha ve
Pharmacopoeairaegs i veinn t hes ectioonn p harmacopoewihaesr et he generalbleye no btainferdo mt hem ajorp harmacopoeiinwa hsi cht he
relevapnhta rmacoposeuibaslt anicsde e scribed. substanicsde e scribbeudt,s houlndo tb e considered abUsnolleustse .
StreeNta mes.S treteertm sa ndo thesrl nagn amesf ord rugosf a buse otherwiisned icatiend t het extt,h ef iguraerse f ors olubilaitt y
arei ncludfeodgr u idanocnel ayn ds houlbdeu sewdi tcha utioBne.c ausoef temperatubreetsw ee1n5 degreeasn d 25 degreeTsh.e information
