Table Of ContentHandbook of Experimental Pharmacology 223
Bernd Nilius
Veit Flockerzi Editors
Mammalian
Transient Receptor
Potential (TRP)
Cation Channels
Volume II
Handbook of Experimental Pharmacology
Volume 223
Editor-in-Chief
W. Rosenthal, Berlin
Editorial Board
J.E. Barrett, Philadelphia
V. Flockerzi, Homburg
F.B. Hofmann, München
P. Geppetti, Florence
M.C. Michel, Ingelheim
P. Moore, Singapore
C.P. Page, London
Forfurthervolumes:
http://www.springer.com/series/164
.
Bernd Nilius (cid:129) Veit Flockerzi
Editors
Mammalian Transient
Receptor Potential (TRP)
Cation Channels
Volume II
Editors
BerndNilius VeitFlockerzi
LaboratoryIonChannelResearch Institutfu¨rExperimentelleu.Klinische
CampusGasthuisberg PharmakologieundToxikologie
KULeuvenDepartment Universita¨tdesSaarlandes
CellMolMedicin Homburg,Germany
Leuven,Belgium
ISSN0171-2004 ISSN1865-0325(electronic)
ISBN978-3-319-05160-4 ISBN978-3-319-05161-1(eBook)
DOI10.1007/978-3-319-05161-1
SpringerChamHeidelbergNewYorkDordrechtLondon
LibraryofCongressControlNumber:2014937453
#SpringerInternationalPublishingSwitzerland2014
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Preface
Whenwe,in2007,editedthefirstissueontransientreceptorpotentialchannelinthe
HandbookofExperimentalPharmacology,wewereallveryexcitedbytheprogress
inthisfieldalthoughonlyonedecadeaftercloningthefirstTRPchannelhadpassed.
At this time, somewhat less than 5,000 papers were published on TRP channel
(January1,1960,untilDecember31,2006).Ifwechecknowtheperiod(January1,
2007, until January 13, 2014), additional 9,300 papers can be found in a PubMed
search.1 Needlesstosay,thegeneralinterestonthese28membersoftheTrpgene
family which encode ion channels is nearly exponentially growing. Therefore, it
seemedtobeindicated,althoughmanyexcellentbooksonTRPchannelshavebeen
publishedmeanwhile,tojumpintoanewadventureeditingacomprehensivesource
bookinthissuccessfulSpringerHandbookseriesagainonthesametopic.Thisisnot
onlyanupdateofthe2007bookbutalsoanimpressiveintroductionofnovelareas
which TRP channels have entered. The 2007 view that TRP channels are mainly
cell sensors with an intriguing variability concerning the modes of activation has
dramatically extended into the evolutionary field, the structural approach, and
especially the advent of the important role of TRP channels in hereditary and
acquired diseases. Important new data concerning the role of TRP channels in
intracellular compartments are included. We also refer to the still controversial
topic how TRP channels are involved in store-dependent Ca2+ entry. Indeed, the
TRPfieldexpansiondidnotlosethefastspeed.Itisextendingintosofarunexpected
areas.Thegainofknowledgehasreachedsuchanextentthatwehavenotbeenable
to restrict the source book into a single volume; rather, we had to agree on a
two-volume publication. In the first volume, we go through all the known TRP
channels. Leading experts in the field summarize features of individual TRP
channels starting with the description of the gene, expression patters, associated
proteins, biophysical and biochemical function properties, and transgenic animal
models and closing with cellular TRP functions, dysfunctions, and their role in
diseases.Thesecondvolumestartswithachapteronsensorpropertiesandfunctions
1Theusedsearchstringwas(“transientreceptorpotential”ORtrpa*ORtrpc*ORtrpm*ORtrpp*
ORtrpv*ORPKD*ORstim1ORstim2ORorai1ORorai2ORorai3ORtrpa*).Notethatthis
search included also the main players of store-operated Ca2+ entry, because of the still often
reportedlinkstoTRPasalsodiscussedinVolume2.
v
vi Preface
of TRP channels. This was highlighted in the 2007 book but is not very much
extended.Surprisingnewfeaturesarereported,e.g.,newinsightsintothermo-and
light-sensing,novelrolesorTRPsintasteperceptionandchemesthesis,andespe-
ciallytheirfunctionalimportanceaschemosensorsforgasotransmitters,including
oxygen sensing, which was evidenced only in the last 5 years. In the second part,
more general topics related to TRP functions and features are discussed such as
channel structure; TRPs as targets of pharmacological modulation, including a
wealth of natural compounds; and the exciting discovery of novel channel toxins.
NewaspectsarediscussedconcerningtheroleofTRPsasimportantplayersinthe
physiology of reproduction and in neural networks which control reproductive
behavior opening a TRP window into neuroendocrinology, i.e., their role in
hormone-secreting cells. We finish this book with some critical remarks on the
currentstateofTRPresearch,controversies,andsurprises.
We hope that this book will guide a large reader community through the
fascinatingworldoftheTRPchannelfamilyfrombasicsciencetopathophysiology
anddisease.Maythisvoluminoussource/textbookalsohelptoestablishinteractions
between the fundamental and clinical research and the research in drug discovery
and development! We are convinced that this book is “translational” in the best
meaning of this word. Despite the many advances in the understanding of the
molecularmechanismsandfunctionfeaturesofTRPchannel,thereisstillatremen-
dousneedformorein-depthunderstandingofthestructureofTRPchannels,their
implementation in diverse signal cascades, and more mechanistic insight into
channel function at the molecular and systemic level, as well as the need for
identifyingselectivepharmacologicaltoolsandnewtherapeutictargetsanddevel-
opingnewtreatmentoptions.Wehopethisbookstimulatesfurtherresearch.Finally,
wemayconcludethatwemightbestillinaperiodoftheendofthebeginningrather
than the beginning of the end! The editors wish to thank all authors for excellent
contribution and also Wilma McHugh (Springer) for all expert support and very
helpfuleditorialadvice!
Leuven,Belgium BerndNilius
Homburg,Germany VeitFlockerzi
Contents for Volume II
PartV TRPsasSpecialCellSensors
TRPChannelsandThermosensation. . . . . . . . . . . . . . . . . . . . . . . . . . . 729
ThomasVoets
TRPsinMechanosensingandVolumeRegulation. . . . . . . . . . . . . . . . . 743
TimD.Plant
TRPsasChemosensors(ROS,RNS,RCS,Gasotransmitters). . . . . . . . 767
ShunichiShimizu,NobuakiTakahashi,andYasuoMori
PhotosensitiveTRPs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 795
RogerC.Hardie
TRPsinTasteandChemesthesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 827
StephenD.Roper
TRPsandPain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 873
JaneE.Sexton,JeffreyVernon,andJohnN.Wood
TRPsinHearing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 899
DamianoZaniniandMartinC.Go¨pfert
TRPsinOlfaction. . . . .. . . . .. . . . .. . . . .. . . . . .. . . . .. . . . .. . . . .. 917
FrankZufall
PartVI GeneralTopics
EvolutionarilyConserved,MultitaskingTRPChannels:
LessonsfromWormsandFlies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 937
KartikVenkatachalam,JunjieLuo,andCraigMontell
StructuralBiologyofTRPChannels. . . . . . . . . . . . . . . . . . . . . . . . . . . 963
UteA.HellmichandRachelleGaudet
High-ResolutionViewsofTRPV1andTheirImplications
fortheTRPChannelSuperfamily. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 991
UteA.HellmichandRachelleGaudet
vii
viii ContentsforVolumeII
PhysiologicalFunctionsandRegulationofTRPCChannels. . . . . . . . . . 1005
HweiLingOng,LorenaB.deSouza,KwongTaiCheng,
andInduS.Ambudkar
TheTRPCs–STIM1–OraiInteraction. . . . . . . . . . . . . . . . . . . . . . . . . . 1035
SeokChoi,JozsefMaleth,ArchanaJha,KyuPilLee,MinSeukKim,
InsukSo,MaliniAhuja,andShmuelMuallem
TheTRPCFamilyofTRPChannels:RolesInferred(Mostly)
fromKnockoutMiceandRelationshiptoORAIProteins. . . . . . . . . . . 1055
YanhongLiao,JoelAbramowitz,andLutzBirnbaumer
TRPs:ModulationbyDrug-LikeCompounds. . . . . . . . . . . . . . . . . . . . 1077
MichaelSchaefer
TRPChannelsinReproductive(Neuro)Endocrinology. . . . . . . . . . . . . 1107
TreseLeinders-ZufallandUlrichBoehm
ModulationofTRPIonChannelsbyVenomousToxins. . . . . . . . . . . . . 1119
JanSiemensandChristinaHanack
PhosphoinositideRegulationofTRPChannels. . . . .. . . . . . .. . . . . . .. 1143
TiborRohacs
TRPModulationbyNaturalCompounds. . . . . . . . . . . . . . . . . . . . . . . . 1177
FlaviaCarlaMeotti,Edine´iaLemosdeAndrade,andJoa˜oB.Calixto
WhatDoWeReallyKnowandWhatDoWeNeedtoKnow:
SomeControversies,Perspectives,andSurprises. . . . . . . . . . . . . . . . . . 1239
BerndNiliusandVeitFlockerzi
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1281
Contents for Volume I
TRPs:TrulyRemarkableProteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
VeitFlockerziandBerndNilius
PartI TheTRPCSubfamily
TRPC1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
VasylNesinandLeonidasTsiokas
TRPC2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
BarbaraA.Miller
TRPC3:AMultifunctionalSignalingMolecule. . . . . . . . . . . . . . . . . . . 67
MichaelaLichteneggerandKlausGroschner
TRPC4-andTRPC4-ContainingChannels. . . . . . . . . . . . . . . . . . . . . . 85
MarcFreichel,VolodymyrTsvilovskyy,andJuanE.Camacho-London˜o
TRPC5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
AlexanderV.Zholos
TRPC6:PhysiologicalFunctionandPathophysiologicalRelevance. . . . 157
AlexanderDietrichandThomasGudermann
TransientReceptorPotentialCanonical7:ADiacylglycerol-Activated
Non-selectiveCationChannel. .. . . . . . . .. . . . . . .. . . . . . .. . . . . . . .. 189
XuexinZhangandMohamedTrebak
PartII TheTRPVSubfamily
TRPV1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207
StuartBevan,TalisiaQuallo,andDavidA.Andersson
TRPV2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247
ItaruKojimaandMasahiroNagasawa
ix
