Table Of ContentMaMMalian
Tox i c o l o g y
E B Mohamed B. Abou-Donia
ditEd y
Mammalian Toxicology
Mammalian Toxicology
Edited by
Mohamed B. Abou-Donia
Thiseditionfirstpublished2015
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LibraryofCongressCataloging-in-PublicationData
Mammaliantoxicology/editedbyMohamedB.Abou-Donia.
pagescm
Includesindex.
ISBN978-1-119-94041-8(cloth)
1.Mammals–Effectofchemicalson. 2.Toxicitytesting. 3.Toxicology. I.Abou-Donia,MohamedB.
QL739.2.M3562015
591.7′14–dc23
2014035960
AcataloguerecordforthisbookisavailablefromtheBritishLibrary.
ISBN:9781119940418
Setin10/12.5ptTimesbyAptaraInc.,NewDelhi,India
1 2015
I dedicate this book to my loving wife, Martha, and my children, Rick, Sheref, and Suzy.
About the Editor
Professor Mohamed Bahie Abou-Donia is Professor of Pharmacology and Cancer Biology at Duke University
MedicalCenter.HealsoholdsasecondaryappointmentasaProfessorofNeurobiology.Prof.Abou-Doniaobtained
hisBSdegreefromAlexandriaUniversity,EgyptandhisPh.D.fromtheUniversityofCaliforniaatBerkeley.After
obtaining his Ph.D. he held a Post-Doctoral position at Texas A&M University followed by an Assistant Professor
positionatAlexandriaUniversityjustbeforejoiningDukeUniversityMedicalCenter.HeisaCertifiedToxicologist
bytheAmericanBoardofToxicologyandtheAcademyofToxicologicalSciences.HewastheDeputyDirectorofthe
ToxicologyProgramatDukeUniversityfrom1981to1995,andin2004wasawardedaprestigiousFulbrightAward
tostudytheimpactofpesticidesontheenvironmentinEgypt.Hisresearchprogramisdirectedtowardunderstanding
thebasic mechanisms by which chemicals, including pesticides, solvents, industrial chemicals, heavy metals, drugs
and nerve agents, adversely affect the nervous system. Prof. Abou-Donia is most well-known for defining two new
concepts in toxicology: (i) Organophosphate-Induced Delayed Neurotoxicity (OPIDN); and (ii) Organophosphate-
InducedChronicNeurotoxicity(OPICN).Theseconceptshaveledtoanunderstandingofthemechanismsbywhich
early exposure to organophosphates can have lasting effects that are manifest late in life, and have also led to the
developmentofalikelyexplanationforGulfWarVeterans’Illnesses(GWVI).Prof.Abou-Donia’slaboratorywasthe
first to investigate the mechanisms of the GWVI, demonstrate the involvement of combined chemical exposure and
stressinthedevelopmentofthisdisease,anddeveloptreatmentfortheveterans.Duringthepastfewyearshehasbeen
engagedinresearchtodefinenervoussysteminjuryresultingfromoccupationalexposuretochemicals.Specifically,he
hasdevelopedaninnovativenewperipheralbloodtestthatcandeterminethepotentialforbraininjuryfromchemicals,
traumaandothernervoussystemdiseases.Hisresearchprogramhasbeenfundedbyprivateorganizations,including
theRockefellerFoundationandtheWorldHealthOrganization,aswellasfederalagenciessuchasNIESH,NIOSH,
EPA,USDA,andDOD.Prof.Abou-Donia’sresearchhashadapositiveimpactonpublicpolicyinitiativestoregulate
environmentalandoccupationalexposuretohazardouschemicals.Hehasbeenaskedtoparticipateinmanylegislative
proceedingsandhastestifiedbeforeCongress(US),HouseofLords(UK)andtheBundestag(Germany)onabroad
rangeofrelatedtopics,suchasorganophosphateexposureandGulfWarsyndrome,farmersexposedtosheep-dip,and
airemissionsinaircraft.HeparticipatedinastudyontheinvolvementofMMRvaccineinthedevelopmentofautism
inchildrenintheUK.Prof.Abou-DoniateachesClinicalToxicology,MammalianToxicology,Neurotoxicologyand
CaseStudiesinToxicologytograduateandundergraduatestudents.Duringhisacademiccareerhehaspublishedover
300exceptionallywell-citedpapersonvariousaspectsofenvironmentalandmammaliantoxicology,aswellasatext
book,Neurotoxicology.Prof.Abou-DoniawasamemberoftheDukeUniversityAnimalCareandUseCommitteefor
15years,andcurrentlyisamemberoftheExecutiveCommitteeforAdmissionofMedicalStudents.
Description:Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Start
