Male Fertility and Its Regulation

473 Pages·1985·15.13 MB·English

by  B. Silvestrini

Male Fertility
and its Regulation
Advances in Reproductive Health Care
Series Editor: E. S. E. Hafez
LHRH and Its Analogs: Contraception and
Therapeutic Applications
Edited by B.H. Vickery, J.J. Nestor Jr. and E.S.E. Hafez
Spontaneous Abortion
Edited by E. S. E. Hafez
Voluntary Termination of Pregnancy
Edited by E. S. E. Hafez
Biomedical Aspects of IUDs
Edited by H. Hasson, W.A.A. van Os and E.S.E. Hafez
Prostaglandins and Fertility Regulation
Edited by M. Toppozada, M. Bygdeman and E.S.E. Hafez
Male Fertility and Its Regulation
Edited by T.J. Lobi and E. S. E. Hafez
Advances in
Reproductive Health Care
Male Fertility
and its Regulation
Editors
T.J. Lobi and E.S. E. Hafez
M.TP PRESS LIM.ITED
~
~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP
LANCASTER / BOSTON / THE HAGUE / DORDRECHT
Published in the UK and Europe by
MTP Press Limited
Falcon House
Lancaster, England
British Library Cataloguing in Publication Data
Male fertility and its regulation.-
(Advances in reproductive health care)
1. Fertility, Human 2. Birth control
I. LobI. T.J. II. Hafez, E.S.E. III. Series
612'.61 QP253
Published in the USA by
MTP Press
A division of Kluwer Boston Inc
190 Old Derby Street
Hingham, MA 02043, USA
Library of Congress Cataloging in Publication Data
Main entry under title:
Male fertility and its regulation.
(Advances in reproductive health care)
Based on the proceedings from the Symposium on Male Fertility and Its Regulation
which was held as part of the Reproductive Health Care Congress, 10-15 Oct. 1982 in
Kaanapali, Hawaii.
Includes bibliographies and index.
1. Generative organs, Male-Effect of drugs on-Congresses. 2. Contraceptive
drugs-Congresses.
I. Lobi, T.J. II. Hafez, E.S.E. (Elsayed Saad Eldin), 1922- . III. Symposium on
Male Fertility and Its Regulation (1982: Kaanapali, Hawaii) IV. Reproductive Health
Care International Symposium (1982: Kaanapali, Hawaii) V. Series. [ONLM:
1. Contraceptive Agents, Male-congresses. 2. Fertility-drug effects
congresses. 3. Genitalia, Male-physiology-congresses. 4. Gossypol
pharmacodynamics-congresses. QV 177 M2455 1982]
RC877.M35 1984 613.9'432 84-23408
ISBN-13: 978-94-010-8667-7 e-ISBN-13: 978-94-009-4894-5
DOl: 10.1007/978-94-009-4894-5
Copyright © 1985 MTP Press Limited
Softcover reprint of the hardcover 1s t edition 1985
All rights reserved. No part of this publication
may be reproduced, stored in a retrieval
system, or transmitted in any form or by any
means, electronic, mechanical. photocopying,
recording or otherwise, without prior permission
from the publishers.
Contents
List of Contributors ix
Preface xiii
I. NON-HORMONAL ANTIFERTILITY AGENTS
3-lndazole-carboxylic acids as male antifertility
agents 3
B. Silvestrini, V. Cio/i, C. DeMartino and P.Scorza Barcellona
2 Chemotherapeutic agents and male reproduction 13
P.K. Bajpai and K.J. Anderson
3 Effects of 5-thio-o-glucose on male fertility 25
J.R. Daniel and R.L. Whistler
II. DRUGS AND MALE FERTILITY
4 Therapeutic drug effects on male reproductive
function 39
C. G. Smith and J.E. Harclerode
5 Reversible male infertility induced by sulphasalazine 49
C. O'Morain, P. Smethurst and A.J. Levi
6 Effects of illicit drugs on male reproduction 55
J. Harclerode and C. G. Smith
7 Effects of abused substances on male reproductive
development 77
S. Dalterio and A. Bartke
III. GOSSYPOL
8 Gossypol chemistry and plant distribution 93
L.A. Jones
v
CONTENTS
9 Toxicological effects of gossypol 111
A.A. Nomeir and M.B.Abou-Donia
10 Biochemical and nutritional considerations of
gossypol intake 135
J.E. Braham and R. Bressani
11 Gossypol contraception and mechanism of action 155
S.P. Xue (Shieh)
12 Gossypol inhibition of boar spermatozoal enzymes 175
w.-
W. Tso, C.-S. Lee and M.-Y. W. Tso
13 Gossypol modulation of testosterone secretion and
metabolism 185
G.F. Paz and Z. T. Homonnai
14 Gossypol inhibition of LDH-X 193
C.-Y.G. Lee, Y.S. Moon, A. Duleba, A.F. Chen and V. Gomel
IV. ENVIRONMENTAL AGENTS AFFECTING FERTILITY
15 Environmental chemical effects on testicular
function 203
I.P. Lee and L.L. Russell
16 Consequences to the progeny of paternal drug
exposure 225
B. Robaire, J.M. Trasler and B.F. Hales
17 Animal tests employed to assess the effects of drugs
and chemicals on reproduction 245
T.A.Marks
18 Effects of phenoxy acid herbicides and TCDD on
male reproduction 269
J. C. Lamb IV and J.A. Moore
19 Human spermatogenesis and fertility following
exposure to dibromochloropropane (DBCP) 287
G. Potashnik
V. HORMONES AND HORMONE ANTAGONISTS
20 LHRH and its analogues: potential for male
contraception and for therapy of androgen
dependent syndromes 303
B.H. Vickery
vi
CONTENTS
21 Direct regulation of Leydig cell functions by
neuropeptides 319
E. Y.Adashi and A.J W. Hsueh
22 Non-steroidal inhibitors of androgen transport and
metabolism 331
G. G. Rousseau, JI. Quivy, C.F. Rolin Jacquemyns,
D.A.N Sirett, M. T. deReviers, M.C. Viguier-Martinez,
S. Delpech and G. Colas
23 Danazol plus testosterone enanthate in male langur
monkey 343
NK. Lohiya and D.P. Sharma
24 Inhibin and male contraception 351
A.R. Sheth, B.S. Sarvamangala, K.A. Krishman and
G.R.Vanage
VI. BLOOD-TESTICULAR AND EPIDIDYMAL BARRIERS
25 The blood-epididymis barrier 371
B. T.Hinton
26 The tenacity of the blood-testis and blood
epididymal barriers 383
T. T. Turner and S. S. Howards
VII. SPERM PHYSIOLOGY
27 Sperm maturation and transport 397
L. C. Ellis and B.R. Nemetallah
28 Ionic mechanisms of sperm motility initiation 411
P. Y.D. Wong and W.M. Lee
29 Reproductive effects of sperm surface antibodies 417
R. Bronson, G. Cooper and D. Rosenfeld
30 Sperm calcium homeostasis during maturation 437
M.P. Bradley and I. T. Forrester
31 The zona-free hamster egg sperm penetration assay 451
NJ Spirtos, S.A. Hamdi, M.E. Hull and NJ Cossler
Index 467
vii
List of Contributors
M.B. ABOU-DONIA R. BRONSON
Department of Pharmacology, Box Department of Obstetrics/Gynecology,
3813, Duke University Medical Center, North Shore University Hospital, Cor
Durham, North Carolina 27710, USA nell University Medical College, 300
Community Drive, Manhasset, New
E.Y. ADASHI York 11030, USA
Department of Obstetrics/Gynecology,
University of Maryland Hospital and
A.F. CHEN
School of Medicine, Room 11 -011,
Beckman Microbics Operations, 6200
Frank Bressler Research Bldg, 655
EI Camino Real, Carlbad, Canada
W. Baltimore Street, Baltimore, Mary
92008
land 21201, USA
V. F. CIOLI
K.J. ANDERSON
F. Angelini Research Institute, Viale
Kettering Medical Center, Kettering,
Amelia 70, 00181 Rome, Italy
Ohio 45429, USA
P.K. BAJPAI G.COLAS
Department of Biology, University of IN RA, Reproductive Physiology
Dayton, Dayton, Ohio 45469, USA Laboratory, F-37380 Nouzilly, France
A.BARTKE G. COOPER
Department of Obstetrics/Gynecology, Department of Obstetrics/Gynecology,
Southern Illinois University School of North Shore University Hospital, Cor
Medicine, Southern Illinois University nell University Medical College, 300
at Carbondale, Carbondale, Illinois, Community Drive, Manhasset, New
62901, USA York 11030, USA
M.P. BRADLEY
N.J. COSSLER
Department of Surgery, Adams Bldg.,
Department of Obstetrics/Gynecology,
University of Otogo, Dunedin, New
Wayne State University, 4707 St. An
Zealand
toine, Detroit, Michigan 48201, USA
J.E. BRAHAM
S. DALTERIO
Agricultural Sciences, Institute of Nu
Department of Pharmacology, The
trition of Central America and Panama,
University of Texas Health Science
P.O. Box 1188, Guatemala City, Gua
Center, 7703 Floyd Curl Drive, San
temala, Central America
Antonio, Texas 78284, USA
R. BRESSANI
Agricultural Sciences, Institute of Nu J.R. DANIEL
trition of Central America and Panama, Department of Food & Nutrition, Pur
P.O. Box 1188, Guatemala City, Gua due University, West Lafayette, Indi
temala, Central America ana 47907, USA
ix
LIST OF CONTRIBUTORS
S. DELPECH B.T. HINTON
Reproductive Physiology Laboratory, Department of Anatomy, Box 439,
INRA. F-37380 Nouzilly, France University of Virginia, School of Med
icine, Charlottesville, Virginia 22908,
C. DE MARTINO USA
Regina Elena Institute for Cancer Re
search, Via Ie Regina Elena 291, 00161 Z.T. HOMONNAI
Rome, Italy Institute for the Study of Fertility, Ma
ternity Hospital, Tel Aviv Medical
Centre, Tel Aviv University Medical
M.T.de REVIERS
School, P.O. Box 7079, Tel Aviv
Reproductive Physiology Laboratory,
61070, Israel
INRA. F-37380 Nouzilly, France
S.S. HOWARDS
A. DULEBA Department of Urology, Box 422, Uni
Department of Obstetrics/Gynecology, versity of Virginia, School of Medicine,
The University of British Columbia, Charlottesville, Virginia 22908, USA
Vancouver, BC, V6T 2B5, Canada
A.J.W. HSUEH
L.C. ELLIS Department of Reproductive Medi
Department of Biology UMC-53, Utah cine, M-025, University of California,
State University, Logan, Utah 84322, School of Medicine,San Diego, La
USA Jolla, California 92093, USA
M.E. HULL
I.T. FORRESTER
Department of Reproductive Endocri
Department of Biochemistry, Univer
nolgy and Infertility, Wayne State Uni
sity of Otago, Box 56, Dunedin, New
versity, 275 E. Hancock Avenue, De
Zealand
troit, Michigan, 48201, USA
V. GOMEL
L.A. JONES
Department of Obstetrics/Gynecology,
National Cottonseed Products
New Grace Hospital, 4900 Oak Street,
Association, Inc., P.O. Box 12023,
Vancouver, Canada V6H 3V5
Memphis, Tennessee 38112, USA
E.S. E. HAFEZ K.A. KRISHNAN
Reproductive Life Center, Medical Institute for Research in Reproduction,
University of South Carolina, Depart Jehangir Merwanji Street Parel, Bom
ment of Physiology, 171 Ashley, Char bay 400 012, India
leston, South Carolina 29425, USA
J.C. LAMB IV
B.F. HALES Fertility & Reproduction Group, Na
Centre for the Study of Reproduction, tional Institute of Environmental
Department of Pharmacology, McGill Health Sciences, National Toxicology
University, 3655 Drummond Street Program, P.O. Box 12233, Research
Montreal, Quebec H3G 1 Y6, Canada Triangle Park, North Carolina 27709,
USA
S.A. HAMDI
C.-S. LEE
Department of Obstetrics/Gynecology,
Department of Biochemistry, The
Wayne State University, 275 E. Han
Chinese University of Hong Kong,
cock Avenue, Detroit, Michigan,
Shatin, N.T., Hong Kong
48201, USA
C.-Y.G. LEE
J. HARCLERODE Department of Obstetrics/Gynecology,
Department of Biology, Bucknell Uni The University of British Columbia,
versity, Lewisburg, Pennsylvania Vancouver, British Columbia V6T 2B5,
17837, USA Canada
x
LIST OF CONTRIBUTORS
I. P. LEE G.F. PAZ
Laboratory of Reproductive & Devel Institute for the Study of Fertility, Ma
opmental Toxicology, National Insti ternity Hospital, Tel Aviv Medical Cen
tute of Environmental Health Sciences, ter, Tel Aviv University Medical
Research Triangle Park, North Carolina School, P.O. Box 7079, Tel Aviv
27709, USA 61070, Israel
W.M. LEE G. POTASHNIK
Department of Physiology, University Infertility Clinic, Department of
of Hong Kong, Li Shu Fan Bldg., Sas Obstetrics/Gynecology, Soroka Uni
soon Road, Hong Kong versity Hospital and Faculty of Health
Sciences at the Ben Gurion University
A.J. LEVI of the Negev, Beer-Sheba, Israel
Sheva, Israel 84 101
Northwich Park Hospital, Clinical Re
search Centre, Watford Road, Harrow,
J.1. QUIVY
Middlesex HA1 3UJ, UK
International Institute of Cellular &
Molecular Pathology, UCL 7529, Av
T.J. LOBL
enue Hippocrate 75, B-1200 Brussels,
Biotechnology Research, The Upjohn
Belgium
Company, Kalamazoo, Michigan
49001, USA B. ROBAIRE
Centre for the Study of Reproduction,
N.K. LOHIYA Department of Pharmacology, McGill
Reproductive Physiology Section, De University, 3655 Drummond Street,
partment of Zoology, University of Ra Montreal, Quebec H3G 1 Y6, Canada
jasthan, Jaipur 302 004, India
C.F.ROLIN JACQUEMYNS
T.A. MARKS International Institute of Cellular ,\
Teratology & Reproduction, The Up Molecular Pathology, UCL 7529, Av
john Company, 301 Henrietta Street, enne Hippocrate 75, B-1200 Brussels,
Kalamazoo, Michigan 49001, USA Belgium
D. ROSENFELD
V.S. MOON
Department of Obstetrics/Gynecology,
Department of Obstetrics/Gynecology,
North Shore University Hospital, Cor
The University of British Columbia,
nell University Medical College, 300
Vancouver, BC, V6T 2B5, Canada
Community Drive, Manhasset. New
York 11030, USA
J.A. MOORE
Environmental Protection Agency, Rm. G.G. ROUSSEAU
637, East Tower, TS-788, 401 M St., UCL 7529, Avenue Hippocrate 75, B-
SW, Washington, DC 20460, USA 1200 Brussels, Belgium
C.O'MORAIN L. L. RUSSELL
Department of Medical Physiology &
Northwich Park Hospital, Clinical Re
Pharmacology, Southern Illinois Uni
search Centre, Watford Road, Harrow,
versity, School of Medicine, Carbon
Middlesex HA1 3UJ, UK
dale, Illinois 62901, USA
B.R. NEMETALLAH B.S. SARVAMANGALA
Department of Physiology, Faculty of Institute for Research in Reproduction,
Veterinary Medicine, Edfina, Alexan Indian Council of Medical Research,
dria University, Egypt Jehangir Merwanji Street. Parel, Bom
bay 400 012, India
A.A. NOMEIR
Department of Pharmacology, Duke P.SCORZA BARCELLONA
University Medical Center, Box 3813, F. Angelini Research Institute, Via Ie
Durham, North Carolina 27710, USA Amelia 70, 00181 Rome, Italy
xi