Table Of ContentMACROMOLECULES
AND
BEHAVIOR
Second Edition
MACROMOLECULES
AND
BEHAVIOR
Second Edition
EDITED BY
John Gaito
YORK UNIVERSITY
TORONTO, ONTARIO, CANADA
..
_.~.. !,
11'
APPLETON-CENTURY-CROFTS
Educational Division
MEREDITH CORPORATION
New York
Copyright © 1972 by Meredith Corporation
Softcover reprint of the hardcover 1st edition 1972
All rights reserved. This book, or parts thereof,
must not be used or reproduced in any manner
without written permission. For information
address the publisher, Appleton-Century-Crofts,
Educational Division, Meredith Corporation, 440
Park Avenue South, New York, New York 10016.
7101-1
Library of Congress Catalog Card Number: 76-150497
ISBN-13: 978-1-4684-6044-5 e-ISBN-13: 978-1-4684-6042-1
DOl: 10.1007/978-1-4684-6042-1
Copyright © 1966 by Meredith Publishing Company
390-34301-3
Mark R. Rosenzweig, Edward L. Bennett, and Marian C. Diamond. "Chemi
cal and Anatomical Plasticity of Brain: Replications and Extensions,
1970." In Macromolecules and Behavior. 2d ed. Edited by John Gaito.
ERRATA
Page
206 Lines duplicated. Delete lines 12-15 ("Even though .•.
Rosenzweig et al., 1962.").
Line 29. Replace "reprinted" with "cited."
211 Insert side heading, CHEMICAL PROCEDURES, after line 7.
Line 14. Replace lIessay" with "assay_ II
Before reaction number 1 insert the following sentence: "The
successive synthetic reactions involved in the synthesis of
ACh from acetate and choline may be formulated as follows:"
213 Line 34. Replace "3 m CHC3-CH30H-H20" with "3 ml CHC13-
CH30H-H20'"
Line 37. Replace "HC04" with HCI04."
214 Line 1. Replace "1 N HC04" with "1 N HCl04."
215-216 A/G and A:G are used interchangeably but should, of course, be
consistent.
216 Line 25. Replace "lBO" with "l,BOO."
Cortex
220 Table 1. Heading of second column on right should be Rest
Cortex
rather than Rest.
222 Replace "Firchroin" with "Ferchroin."
TBW vs.
224 Table 2. Right-hand column heading should be Total Cortex
TBW vs. Rest of Brain
rather than Total Cortex.
Rest of Brain
227 Line 8. Replace "Firchminll with "Ferchmin."
Cortex
22B Table 3. Heading of second column on right should be Rest
Cortex
rather than Rest.
229 Line 26. The following material was omitted after the word
"was": "-10.5 percent (p<. 001) and the mean IC-SC difference, ".
Line 27. Replace IISCI! with IIEe.1I
Cortex
230 Table 4. Right-hand column heading should be Rest rather
Cortex
than Rest.
Cortex
231 Table 5. Right-hand column heading should be Rest rather
Cortex
than Rest.
231 The units of measurement for AChE/wt and ChE/wt were omitted.
They should be as follows:
"AChE activity is expressed in units of nanomoles acetylthio
choline hydrolyzed/min/mg."
"ChE activity is expressed in units of nanomoles butyrylthio
choline hydrolyzed/min/mg."
233 Line 23. Replace "context" with "cortex."
234 Line 15. Replace "duration" with "durations."
Line 25. Replace "1970" with "1971."
235 Table 7. Restore line omitted from 25-day group:
Total brain 2.8*** 1.0** -0.9
~
241 Table 10. Right-hand column heading should be Rest rather
Cortex
than Rest.
251 Line 23. Replace "house" with "housed."
Cortex
252 Table 14. Right-hand column heading should be Rest rather
Cortex
than Rest.
258 Line 20. Before the word "Environmental" insert (2).
260 Line 22. Replace "These" with "Three."
261 In line 1 the following material was omitted after the word
"environment," completely changing the meaning of the sentence:
"leads to more rapid maturation of the brain or because the
impoverished environment"
Line 5. Replace It£ewll with "fewer. II
263 Line 16. Replace Kretch " with "Krech ...
II
Line 30. Replace "Richard II with "Ricard."
265 Line 20. Replace "contradictedll with IIcontradict. II
Bottom line. Replace "three" with "four."
274 Bottom line. Replace "Phychobio1." with "Psychobio1."
276 In Leslie reference, add "E." after "Chargoff."
In Logan reference, replace "Biochem. L." with "Biochem. J."
In Rosenblatt reference, replace "1970" with "1971."
277 Under Rosenzweig, the following reference was omitted:
Rosenzweig, M. R., Bennett, E. L., and Diamond, M. C. {1967).
In: Psychopathology of Mental Development, Zubin, J.,
and Jervis, G., eds. New York: Grune and Stratton.
CONTRIBUTORS
JOSEPH ALTMAN
Purdue University, Lafayette, Indiana
STANLEY H. APPEL
Duke University, Durham, North Carolina
SAMUEL H. BARONDES
University of California (San Diego), La To lla, California
EDWARD L. BENNETI
University of California (Berkeley), Berkeley, California
JAMES BONNER
California Institute of Technology, Pasadena, California
MARIAN C. DIAMOND
University of California (Berkeley), Berkeley, California
J. A. DEUTSCH
University of California (San Diego) , La To lla, California
JOHN GAITO
York University, Toronto, Ontario, Canada
EDWARD GLASSMAN
University of North Carolina, Chapel Hill, North Carolina
HOLGER HYDEN
Institute of Neurobiology, Faculty of Medicine, University of Goteborg,
Goteborg, Sweden
ZAFAR IQBAL
All-India Institute of Medical Science, New Delhi, India
vi / Contributors
BRANISLAV D. JANKOVIC
Microbiological Institute, University of Belgrade; Department of Experimental
Immunology, Institute of Immunology and Virology, and Immunology Unit,
I nstitute for Biological Research, Belgrade, Yugoslavia
EDWARD KOENIG
State University of New York (Buffalo), Buffalo, New York
PAUL W. LANGE
Institute of Neurobiology, Faculty of Medicine, University of Goteborg,
Goteborg, Sweden
SIDNEY OCHS
Indiana University Medical Center, Indianapolis, Indiana
LEONID Z. PEVZNER
Pavlov Institute of Physiology of the Academy of Sciences of the U.S.S.R.,
Leningrad, U.S.5.R.
KARL H. PRIBRAM
Stanford University, Stanford, California
MARK R. ROSENZWEIG
University of California (Berkeley), Berkeley, California
LARRY R. SQUIRE
U niwrsity of California (San Diego) , La To lla, California
G. P. TALWAR
All-India Institute of Medical Science, New Delhi, India
GEORGES UNGAR
Baylor College of Medicine, Houston, Texas
JOHN E. WILSON
University of North Carolina, Chapel Hill, North Carolina
CONTENTS
CONTRIBUTORS / V
PREFACE / ix
PREFACE TO THE FIRST EDITION / X
I. Introduction
1. INTRODUCTION / 3
John Caito
II. Products of DNA Activation
2. MACROMOLECULES-FuNCTIONAL AND BIOCHEMICAL CORRELATES / 13
C. P. Talwar and Zafar Iqbal
3. BRAIN FUNCTION AND RNA / 39
Edward Glassman and John E. Wilson
4. MACROMOLECULES AND BRAIN FUNCTION / 47
John.Gaito
5. INHIBITORS OF CEREBRAL PROTEIN OR RNA SYNTHESIS
AND MEMORY / 61
Larry R. Squire and Samuel H. Barondes
6. BIOLOGICAL ASSAYS FOR THE MOLECULAR CODING OF
ACQUIRED INFORMATION / 83
Georges Ungar
7. BIOLOGICAL ACTIVITY OF ANTIBRAIN ANTIBODY
AN INTRODUCTION TO IMMUNONEUROLOGY / 99
Branislav D. Jankovic
vii
viii / Contents
8. CORRELATION OF THE S-100 BRAIN PROTEIN WITH BEHAVIOR / 131
Holger Hyden and Paul W. Lange
III. Macromolecules and Intracellular, Intercellular, and
Synaptic Events
9. AxOPLASMIC FLOW-THE FAST TRANSPORT SYSTEM IN MAMMALIAN
NERVE FIBERS / 147
Sidney Ochs
10. A MOLECULAR BASIS FOR REGIONAL DIFFERENTIATION OF THE
EXCITABLE MEMBRANE / 167
Edward Koenig
11. MACROMOLECULAR SYNTHESIS IN SYNAPSES / 185
Stanley H. Appel
12. CHEMICAL AND ANATOMICAL PLASTICITY OF BRAIN:
REPLICATIONS AND EXTENSIONS, 1970 / 205
Mark R. Rosenzweig, Edward L. Bennett, and Marian C. Diamond
13. MACROMOLECULAR CHANGE AND THE SYNAPSE / 279
J. A. Deutsch
14. AUTORADIOGRAPHIC EXAMINATION OF BEHAVIORALLY INDUCED CHANGES
IN THE PROTEIN AND NUCLEIC ACID METABOLISM OF THE BRAIN / 305
Joseph Altman
15. MACROMOLECULAR CHANGES WITHIN NEURON-NEUROGLIA UNIT DURING
BEHAVIORAL EVENTS / 335
Leonid Z. Pevzner
IV. Models of Memory
16. MOLECULAR BIOLOGICAL ApPROACHES TO THE STUDY
OF MEMORY / 361
James Bonner
17. SOME DIMENSIONS OF REMEMBERING: STEPS TOWARD
NEUROPSYCHOLOGICAL MODEL OF MEMORY / 367
Karl H. Pribram
INDEX / 395
PREFACE
In the five years since the publication of the First Edition, a tremendous
amount of research has been conducted attempting to relate macromolecules
and behavior. New approaches to the overall problem have developed. Several
chapters of the First Edition were not continued in this edition; most of those
which were included have been revised thoroughly. A number of chapters by
other contributors were invited to help round out the volume. New chapters
are those by Glassman and Wilson; Squire and Barondes; Ungar; Jankovic;
Hyden and Lange; Koenig; Appel; Rosenzweig, Bennett, and Diamond; and
Deutsch. This edition should provide a representative view of the important
research and theorizing which is occurring in this area.
This volume is built around two important topics: Products of DNA Activa
tion (Section II) and Macromolecules and Intracellular, Intercellular, and
Synaptic Events (Section III). The Introduction (Section I) leads to these
topics, and Models of Memory (Section IV) attempts to provide an integration
of these topics with brain function.
The preparation of this volume was facilitated by grants from the National
Research Council (Canada) and by Contract No. Nom 4935(00) with the
Physiological Psychology Division of the Office of Naval Research (U .S.A.) .
October 1971 John Gaito
ix
