Table Of ContentLung Transplantation
Editedby
NicholasR.Banner
RoyalBromptonandHarefieldNHSTrustand
NationalHeartandLungInstitute,ImperialCollegeLondon
JuliaM.Polak
ImperialCollegeLondon
and
MagdiH.Yacoub
HarefieldResearchFoundationandImperialCollegeLondon
CAMBRIDGE UNIVERSITY PRESS
Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo
Cambridge University Press
The Edinburgh Building, Cambridge CB2 8RU, UK
Published in the United States of America by Cambridge University Press, New York
www.cambridge.org
Information on this title: www.cambridge.org/9780521651110
© Cambridge University Press 2003
This publication is in copyright. Subject to statutory exception
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no reproduction of any part may take place without the written
permission of Cambridge University Press.
First published 2003
This digitally printed version 2007
A catalogue record for this publication is available from the British Library
ISBN 978-0-521-65111-0 hardback
ISBN 978-0-521-03677-1 paperback
Every effort has been made in preparing this book to provide accurate and up-to-date
information which is in accord with accepted standards and practice at the time of
publication. Nevertheless, the authors, editors and publisher can make no warranties
that the information contained herein is totally free from error, not least because clinical
standards are constantly changing through research and regulation. The authors, editors
and publisher therefore disclaim all liability for direct or consequential damages resulting
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Cambridge University Press has no responsibility for the persistence or
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or will remain, accurate or appropriate.
To Ursula and Mary
N.R.B.
To Daniel
J.M.P.
To Marianne
M.H.Y.
Contents
Listofcontributors ix
Preface xv
PartI Pulmonarydisease
1 Primarypulmonaryhypertension:
pathophysiologyandtherapy 3
StuartRich
2 Geneticsofpulmonaryhypertension 11
RichardC.TrembathandRachelHarrison
3 Pathologyofpulmonaryhypertension 19
AnneE.BishopandJuliaM.Polak
4 Pulmonaryhypertensionandtherightventricle 29
NorbertF.Voelkel,RubinM.Tuder,CarlyneCool,Mark
Geraci,RobertQuaifeandMichaelBristow
5 Emphysema 39
GordonL.Snider
6 Alpha-1-antitrypsindeficiency 54
DuncanC.S.Hutchison
7 Bronchiectasis 61
MaryT.Keogan
8 Cysticfibrosis 71
MargaretE.Hodson
vii
viii Contents
9 Diffuselungdisease 85 20 Infectiouscomplications 250
R.M.duBois KeithMcNeil,JulietFowerakerandTimWreghitt
10 Explantpathology 96 21 Cytomegalovirusinfection 261
SusanStewart NicholasR.Banner
22 Imaging 274
PartII Lungtransplantation
R.JaneChambers
11 Overview 113 23 Transplantpathology 294
MagdiH.YacoubandEmmaJ.Birks MargaretM.Burke
12 Patientselectionandindicationsforlung 24 Haematology 326
tranplantation 120 DavidCummins
JanetR.Maurer
25 Psychology 337
13 Singleandbilaterallungtransplantation 132 ClaireN.HallasandJoWray
JohnDark
26 Thecurrentstatusoflungtransplantation 353
14 Combinedheartandlungtransplantation 141
AllanR.Glanville
RosemaryRadley-Smith,AsgharKhaghaniand
NicholasR.Banner
15 Anaesthesiaandintensivecare 158 PartIII Futuredirections
MichaelJ.BoscoeandShaneJ.George
27 Tissueengineering 367
16 Medicalmanagement 176
LarryL.Hench,JulianR.Jones,RubiaF.S.Lenzaand
PaulA.Corris
WanderL.V.Vasconcelos
17 Immunologicalmechanismsofgraft
28 Xenotransplantation 374
injury 185
AgnesM.Azimzadeh,CarstenSchroederandRichardN.
MarleneL.RoseandIanV.Hutchinson
PiersonIII
18 Pharmacologicalimmunosuppression 205
29 Theartificiallung 386
NicholasR.BannerandHaifaLyster
BrackG.HattlerandWilliamJ.Federspiel
19 Chroniclungallograftdysfunction 243
MarshallI.Hertz Index 399
Contributors
AgnesM.Azimzadeh
ResearchAssistant
DepartmentofCardiothoracicSurgery
VanderbiltUniversityMedicalCenter
2986TheVanderbiltClinic
Nashville
TN37323-5734
USA
Presentaddress
AssistantProfessorofSurgery
UniversityofMaryland
CardiacSurgeryN4W94
22SouthGreeneSt.
BaltimoreMD21201-1595
USA
[email protected]
NicholasR.Banner
ConsultantinCardiologyandTransplantMedicine
RoyalBromptonandHarefieldNHSTrust
HarefieldHospital
Harefield
Middlesex
UB96JH
UK
[email protected]
EmmaJ.Birks
SpecialistRegistrarinCardiology
HarefieldResearchFoundation
HarefieldHospital
Harefield
Middlesex
UBP6JH
UK
[email protected]
ix
x Contributors
AnneE.Bishop CarlyneCool
SeniorLecturer AssistantProfessor
TissueEngineeringandRegenerativeMedicineCentre DepartmentofPathology
ImperialCollegeFacultyofMedicine UniversityofColoradoHealthSciencesCenter
ChelseaandWestminsterHospital UniversityofColarado
369FulhamRoad HealthScienceCenter
London 4200East9thAvenue#C310
SW109NH Denver
[email protected] CO80220–3706
USA
MichaelJ.Boscoe
ConsultantAnaesthetist
PaulA.Corris
HarefieldHospital
ProfessorofThoracicMedicine
Harefield
TheFreemanHospital
Middlesex
HighHeaton
UB96JH
NewcastleuponTyne
UK
NE77DN
[email protected]@aol.com
UK
[email protected]
MichaelBristow
ProfessorofMedicine
DavidCummins
DivisionofCardiology
ConsultantHaematologist
UniversityofColoradoHealthSciencesCenter
HarefieldHospital
UniversityofColarado
Harefield
HealthScienceCenter
Middlesex
4200East9thAvenue#C310
UB96JH
Denver
UK
CO80220–3706
[email protected]
USA
MargaretM.Burke JohnDark
ConsultantHistopathologist ProfessorofCardiothoracicSurgery
HarefieldHospital RegionalCardiothoracicCentre
Harefield TheFreemanHospital
Middlesex NewcastleuponTyne
UB96JH NE77DN
UK UK
[email protected] [email protected]
R.JaneChambers R.M.duBois
ConsultantRadiologist ProfessorofRespiratoryMedicine
HarefieldHospital RoyalBromptonHospital
Harefield SydneyStreet
Middlesex London
UB96JH SW36NP
UK UK
[email protected] [email protected]
Contributors xi
WilliamJ.Federspiel ClaireN.Hallas
DepartmentofChemicalEngineering,Departmentsof HealthPsychologist
SurgeryandBioengineering HarefieldHospital
McGowanInstituteofRegenerativeMedicine Harefield
UniversityofPittsburgh Middlesex
PittsburghPA15219 UB96JH
USA UK
[email protected] [email protected]
JulietFoweraker RachelHarrison
ConsultantMicrobiologist ResearchFellow
MicrobiologyLaboratory DivisionofMedicalGenetics
PapworthHospital AdrianBuilding
PapworthEverard UniversityofLeicester
Cambridgeshire UniversityRoad
CB38RE Leicester
UK LE17RH
[email protected] [email protected]
ShaneJ.George BrackG.Hattler
ConsultantinAnaesthesiaandIntensiveCare ProfessorofSurgery
HarefieldHospital ArtificialLungProgram
Harefield UniversityofPittsburgh
Middlesex 200LothropStreet
UB96JH C-700
UK Pittsburgh
[email protected] PA15213
USA
MarkGeraci [email protected]
AssociateProfessor
DivisionofPulmonarySciencesandCriticalCare LarryL.Hench
Medicine ProfessorofMaterials
UniversityofColoradoHealthSciencesCenter CentreforTissueRegenerationandRepair
UniversityofColarado ImperialCollegeofScienceTechnologyandMedicine
HealthScienceCenter PrinceConsortRoad
4200East9thAvenue#C310 London
Denver SW72BP
CO80220–3706 UK
USA [email protected]
AllanR.Glanville MarshallI.Hertz
AssociateProfessorofMedicine ProfessorofPulmonary/CriticalCareMedicine
StVincent’sHospital PulmonaryMedicine/LungTransplantProgram
Xavier4 UniversityofMinnesota
VictoriaStreet 420DelawareStreetSE
Darlinghurst 276MayoMailRoom
Sydney Minneapolis
NSW2010 MN55455
Australia USA
[email protected] [email protected]
xii Contributors
MargaretHodson A.Khaghani
ProfessorofRespiratoryMedicine ClinicalDirectorofTransplantation
DepartmentofCysticFibrosis HarefieldHospital
RoyalBromptonHospital Harefield
SydneyStreet Middlesex
London UB96JH
SW36NP UK
UK [email protected]
[email protected]
RubiaF.S.Lenza
DuncanC.S.Hutchison ResearchAssociate
ConsultantinRespiratoryMedicine FederalUniversityofMinasGerais
King’sCollegeHospital DepartmentofMetallurgicalandMaterialsEngineering
DenmarkHill RuaEspiritoSanto,35–200Andar
London 30160–030BeloHorizonte
SE59RS MG
UK Brazil
[email protected]
HaifaLyster
IanV.Hutchinson TransplantPharmacist
ProfessorofImmunology HarefieldHospital
ManchesterUniversity Harefield
OxfordRoad Middlesex
Manchester UB96JH
M139PL UK
UK [email protected]
[email protected]
JanetR.Maurer
JulianR.Jones MedicalDirector
ResearchAssociate LIFESOURCETransplantNetwork
DepartmentofMaterials CIGNAHealthCare
ImperialCollegeofScienceTechnologyandMedicine 900CottageGroveRoad
PrinceConsortRoad Bloomfield
London CT
SW72BP USA
UK [email protected]
KeithMcNeil
MaryT.Keogan ConsultantPhysician
ConsultantImmunologist PapworthHospital
PapworthHospital PapworthEverard
PapworthEverard Cambridge
Cambridge CB38RE
CB38RE UK
UK Presentaddress
Presentaddress DepartmentofThoracicMedicine
ConsultantImmunologist PrinceCharlesHospital
BeaumontHospital RodeRoad
DepartmentofImmunology Chermside
BeaumontRoad Brisbane
Dublin9 Queensland4032
Ireland Australia
[email protected] keith–[email protected]
