Table Of ContentLiving Related
Transplantation
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Living Related
Transplantation
editors
Nadey Hakim
Ruben Canelo
Vassilios Papalois
Hammersmith Hospital London, UK
Imperial College Press
ICP
Published by
Imperial College Press
57 Shelton Street
Covent Garden
London WC2H 9HE
Distributed by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
LIVING RELATED TRANSPLANTATION
Copyright © 2010 by Imperial College Press
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
photocopy is not required from the publisher.
ISBN-13 978-1-84816-497-0
ISBN-10 1-84816-497-1
Typeset by Stallion Press
Email:
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Contents
Contributors ix
Foreword xiii
1. Ethical Issues in Living Donor Transplantation 1
Vassilios Papalois and Evangelos Mazaris
Introduction 1
Ethical Issues 2
Conclusion 27
References 28
2. Live Kidney Transplantation 39
Nicos Kessaris, Vassilios Papalois,
Ruben Canelo and Nadey Hakim
Introduction 39
The Donor 40
The Recipient 57
Conclusions 57
References 58
3. Live-Donor Liver Transplantation in Adults 65
Sheung Tat Fan and Chi Leung Liu
History 65
Donor Evaluation 67
Recipient Evaluation 72
Donor Left Hepatectomy 72
Recipient Hepatectomy and Left-Liver Graft Implantation 76
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vi Contents
Donor Right Hepatectomy 78
Recipient Hepatectomy and Right-Liver Graft Implantation 81
Postoperative Care of the Donor 83
Postoperative Management of the Recipient 84
Donor Complications and Outcome 85
Recipient Outcome 86
Impact of LDLT 87
References 88
4. Living Donor Pancreas Transplantation 95
David Sutherland, John Najarian and Rainer Gruessner
Introduction 95
Living-Donor Islet Transplants 97
Living-Donor Segmental Pancreas Transplants 100
Perspectives 104
References 107
5. Living Donor Small Bowel Transplantation 119
World Experience and Register
Enrico Benedetti, Giuliano Testa, Fabrizio Panaro
and Nicola Morelli
Introduction 119
Indications 121
Contraindications 123
Donor Evaluation 123
Recipient Evaluation 125
Surgical Procedures 126
Post-Transplant Care 130
Postoperative Complications and Management 133
Graft versus Host Disease (GVHD) 136
Report from the United Network of Organ Sharing 137
(UNOS) and the Intestinal Transplant Registry (ITR)
Conclusions 138
Acknowledgments 139
References 139
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6. Living Donor Lobar Lung Transplantation 143
Hiroshi Date and Nobuyoshi Shimizu
Introduction 143
Evaluation and Selection in the Donor 144
Evaluation and Selection in the Recipient 145
Size Matching 145
Surgical Technique in the Donor 146
Surgical Technique in the Recipient 149
Complications in the Donor 151
Complications in the Recipient 152
Protocols of Immunosuppression 153
Detection and Management of Acute Rejection 153
Results After Living-Donor Lobar Lung Transplantation 156
Conclusion 159
References 160
7. Allogeneic Haematopoietic Stem Cell Transplantation 163
Eduardo Olavarria
Introduction 163
The Role of HLA in HSCT 166
Sources and Procurement of Allogeneic Haematopoietic 169
Stem Cells
Principles of Conditioning Regimens 171
Early Complications After HSCT 175
Graft versus Host Disease 178
Immune Reconstitution After HSCT 183
Infections After HSCT 185
Indications and Results 190
Final Considerations 198
References 199
Index 209
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Contributors
Enrico Benedetti
Division of Transplant Surgery
Department of Surgery
University of Illinois at Chicago
840 S. Wood St. Suite #402 (M/C958)
Chicago, IL 60612, USA
Ruben Canelo
Department of Hepatobiliary and Pancreatic Surgery
Hammersmith Hospital
Imperial College London
Du Cane Road
London W12 0NN, UK
Hiroshi Date
Department of Thoracic Surgery
Kyoto University
54 Shogoin Kawahara-cho
Sakyo-ku, Kyoto 606-8507, Japan
Sheung Tat Fan
Department of Surgery
The University of Hong Kong
Queen Mary Hospital
102 Pokfulam Road
Hong Kong, China
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