Kopsihainanines A and B, two unusual alkaloids from Kopsia

19 Pages·2011·0.88 MB·English

Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanines A and B, two unusual alkaloids from
Kopsia hainanensis

Jia Chen, Jian-Jun Chen, Xiaojun Yao, and Kun Gao*
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and
Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of
China

Supporting information Page
Kopsihainanine A: 1H NMR in CDCl (Varian Mercury-600) S2
3
Kopsihainanine A: 1H NMR in CDCl (Varian Mercury-600) S3
3
Kopsihainanine A: 13C NMR in CDCl (Varian Mercury-600, 125 MHz) S4
3
Kopsihainanine A: HSQC in CDCl S5
3
Kopsihainanine A: HMBC in CDCl S6
3
Kopsihainanine A: 1H-1H COSY in CDCl S7
3
Kopsihainanine A: 1H-1H COSY in CDCl S8
3
Kopsihainanine A: ROESY in CDCl S9
3
Kopsihainanine A: IR S10
Kopsihainanine A: HRESIMS S11

Kopsihainanine B: 1H NMR in CDCl (Varian Mercury-600) S12
3
Kopsihainanine B: 13C NMR in CDCl (Varian Mercury-600, 125 MHz) S13
3
Kopsihainanine B: HSQC in CDCl S14
3
Kopsihainanine B: HMBC in CDCl S15
3
Kopsihainanine B: IR S16
Kopsihainanine B: HRESIMS S17
Table S1: Cartesian coordinates of calculated Kopsihainanine A (1) S18
Microplate assay for AChE activity. S19
S1
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
3 14
O
6 N 17 15
HO
21 20
9 168 7 H 19
10
2 18
11 13 N
12 H
Structure of kopsihainanine A (1)
Kopsihainanine A: 1H NMR in CDCl (Varian Mercury-600)
3

S2
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: 1H NMR in CDCl (Varian Mercury-600)
3

S3
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: 13C NMR in CDCl (Varian Mercury-600, 125 MHz)
3

S4
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: HSQC in CDCl
3

S5
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: HMBC in CDCl
3

S6
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: 1H-1H COSY in CDCl
3

S7
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: 1H-1H COSY in CDCl
3

S8
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: ROESY in CDCl
3

S9
Electronic Supplementary Material (ESI) for Organic and Biomolecular Chemistry
This journal is © The Royal Society of Chemistry 2011
Kopsihainanine A: IR

S10