Table Of ContentKinetic Models
of
Trace Element
and
Mineral Metabolism
during
Development
Edited by
K.N. Siva Subramanian
Meryl E. Wastney
CRC Press
Taylor&FrancisGroup
Boca Raton London New York
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ISBN 13: 978-0-8493-4736-8 (hbk)
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Library of Congress Card Number 95-21093
Library of Congress Cataloging-in-Publication Data
Kinetic models of trace element and mineral metabolism during development / [edited byj K.N. Siva
Subramanian and M.E. Waslney.
p. cm.
Includes bibliographical references and index.
ISBN 0-8493-4736-X
1. Trace elements-Metabolism-Math—e matical models-Congresses. 2. Trace elements in nutrition
-Congresses. 3. Children-Nutrition Congresses. 4. Pregnancy-Nutritional aspects-Congresses.
I. Siva Subramanian, K.N. (Kolinjavadi N.), 1945- . II. Wastney, M.E.
[DNLM: 1. Trace Elements-metabolism-congresses. 2. Minerals-metabolism-congresses. 3.
Growth-congresses. 4. Human Development-congresses. 5. Models, Theoretical-congresses. QU
130.5 K51 1995]
QP534.K56 1995
612.3'924'015118-dc20
DNLM/DLC
for Library of Congress 95-21093
CIP
CONTENTS
Contributors vii
Preface xi
I. PREGNANCY AND LACTATION
1. Use of Mineral Stable Isotopes in the Study of Nutrient
Homeostasis During Human Pregnancy and Lactation 1
. - .
P B. MoserVeillon, K. Y Patterson, and C. Veillon
2. Kinetic Overview: Modeling Calcium Metabolism in Pregnant
and Lactating Cows 11
C. F. Ramberg, Jr.
.
3 Calcium Metabolism in Pregnancy and Lactation: An
Individual Study 29
A. L. Yergey, S. A. Abrams, N. E. Vieira,
N. V. Esteban, and F. Bronner
4. Copper Metabolism in Dairy Cows: Development of a Model
Based on a Stable Isotope Tracer 37
W. T. Buckley
II. NEONATES AND CHILDREN
5. Zinc Kinetics in Humans 53
M. E. Wastney and K. N. Siva Subramanian
6. Stable Isotope Studies of Zinc Kinetic Metabolism in Infants 65
N. F. Krebs, C. Reidinger, J. Westcott, L. V. Miller,
P. V. Fennessey, and K. M. Hambidge
7. Determination of Mineral Absorption by Very Low
Birthweight Preterm Infants with the Stable Isotope Extrinsic
Tag Approach 73
R. A. Ehrenkranz and M. Janghorbani
III. ADOLESCENTS AND ADULTS
8. Determination of Requirements 95
W. Mertz
9. Contributions of Mathematical Models to Understanding of
Human Iodide Metabolism 99
M. T. Hays
in
IV Contents
10. Zinc that Exchanges with Zinc in Plasma Within Two Days:
Variation with Dietary Zinc 117
M. Hambidge, L. Miller, V. Naake, H. Zhaoyi,
N. Krebs, J. Westcott, and P. Fennessey
11. Calcium Metabolism in Adolescents 129
.
C. M Weaver
12. Stable Isotopes of Copper, Molybdenum, and Zinc Used
Simultaneously for Kinetic Studies of their Metabolism 133
J. R. Turnlund
13. Reference Values for Trace Elements in Human Clinical
Specimens: With Special Reference to Biomonitoring and
Specimen Suitability 145
.
V Iyengar
.
IV DISORDERS
14. Studies of Calcium Metabolism in Children with Chronic
Illnesses 159
S. A. Abrams
15. Historical Overview of Copper Kinetics 171
M. A. Dunn
.
16 Compartmental Analysis of Intestinal Iron Absorption and
Mucosal Iron Kinetics 187
G. D. McLaren, M. H. Nathanson, and G. M. Saidel
17. Chromium (III) Metabolism in Diabetic Patients 205
O. M. Do Canto, T. Sargent (III) and J. C. Liehn
18. A Calcium-based Model of Human Lead Kinetics 221
E. J. O Flaherty
V. ENVIRONMENTAL HEALTH
19. Some Constitutive Modifiers of the Kinetic and Dynamic
-
Behavior of Non essential Metals 233
D. J Thomas
,
20. An Overview of Selenium Kinetics in Humans 241
B, H. Patterson, L. A. Zech, C. A. Swanson, and
O. A. Levander
21. The Kinetics of Intravenously-Administered Inorganic
Mercury in Humans 265
L. L. Hall, P. V. Allen, H. L. Fisher, and B. Most
VI. CALCIUM METABOLIC DYNAMICS
22. Overview of Calcium Metabolic Dynamics 281
A. L. Yergey
Contents v
23. Interpretation of Stable Isotope Studies of Calcium Absorption
and Kinetics 283
S. A. Abrams, N. E. Vieira, and A. L. Yergey
24. Calcium Homeostasis - an Old Problem Revisited 291
F. Bronner and W. D. Stein
25. Generalized Stochastic Compartmental Models of Calcium
Metabolism 305
J. H. Malis and D. M. Allen
26. Frequency Response of the Calcium Control System 333
R. E. Goans, S. A. Abrams, N. E. Vieira, and
A. L. Yergey
27. Regulation in Oscillatory Models. 341
S. Hurwitz
28. Optimal Sampling for the Determination of Calcium
Metabolism 347
A. Aldroubi, P. Basser, and N. Vieira
29. Determination of Bone Resorption 355
R, Eastell
.
VII MODELING THEORY AND SOFTWARE
30. Kinetic Models to Describe Populations: A Strategy for
Summarizing the Results of Multiple Studies 359
R. Boston, A. Lyne, T. McNabb, K. Pettigrew, P. Greif,
C. Ramberg, and L. Zech
31. SAAMEASE: The Language of SAAM and CONSAM 373
L. A. Zech and P. C. Greif
INDEX 389
APPENDIX
Diskette containing CONSAM program and models
THE EDITORS
.
K. N Siva Subramanian, M.D. is a Professor, Department of Pediatrics and
Obstetrics and Gynecology, Georgetown University Medical Center, Washington,
D.C. He obtained his M.B.B.S. (M.D.) degree from Madras University in 1969 and
is board certified in Pediatrics and Neonatal-Perinatal Medicine. He has been Chief
of Neonatal-Perinatal Medicine and Director of Nurseries at Georgetown Univer
sity Hospital since 1981. He is currently Chair of the Georgetown University
Hospital Committee on Bioethics. He is a member of the American Medical
Association,theAmericanSociety of Parenteral andEnteral Nutrition,theInterna
tional Society for Trace Element Research in Humans, the Society for Bioethics
Consultation, and a Fellow of the American Academy of Pediatrics, the Kennedy
InstituteofEthics,and theAmericanCollegeof Nutrition.Heislisted inthe Who's
Who in Science and Engineering and Who’sWho in the World.
He has published over 40 articles and books, presented numerous lectures
nationally and internationally, and has trained over 40 fellows in neonatal/perinatal
medicine. His current interests are in infant mortality reduction, bioethics-decision
making in critical care nursery, and trace element metabolism in newborn infants.
Mery!E. Wastney, Ph.D. is an Associate Professor, Department of Pediatrics,
Georgetown University Medical Center, Washington, D.C. She graduated with a
B.Ag.Sc. (1st Class Honors) in 1976 and a Ph.D. in 1980 from Lincoln College,
University of Canterbury, New Zealand. She was a Fogarty Fellow in the Labora
tory of Mathematical Biology, NCI, NIH, Bethesda, MD for 3 years and joined the
Department of Pediatrics at Georgetown University in 1983.
She is a member of the American Institute of Nutrition, the American Institute
of Clinical Nutrition, the International Society for Trace Element Research in
Humans, and a Fellow of the American College of Nutrition. She was the recipient
of the W.O. Rennie Memorial Prize, the Lincoln Senior Scholarship, the Shirtcliffe
Fellowship, the Sir James Gunson Scholarship, the University Grants Committee
PostgraduateScholarship,and an NIHFogartyVisitingFellowship.Sheisanauthor
of26articlesandchaptersand haspresentedover20invitedlecturesandworkshops
on modeling biological systems. Her current interests are trace element and mineral
metabolism in infants and adolescents.
vi
CONTRIBUTORS
Steven A. Abrams, USDA/ARS Children’s Nutrition Research Center, Depart
ment of Pediatrics, Baylor College of Medicine, Houston, TX 77030
Akram Aldroubi, Biomedical Engineering and Instrumentation Program, NIH,
Bethesda, MD 20892
David M. Allen, Department of Statistics, University of Kentucky, Lexington,
KY 40506
.
Paul V Allen, Food Safety Research Unit, USDA, Western Regional Research
Center, Albany, CA 94710
Peter Basser, Biomedical Engineering and Instrumentation Program, NIH,
Bethesda, MD 20892
.
Raymond C Boston, Clinical Studies, School of Veterinary Medicine, University
of Pennsylvania, Kennett Square, PA 19348
Felix Bronner, Department of Biostructure and Function, The University of
Connecticut Health Center, Farmington, CT 06030
Wayne T. Buckley, Agriculture Canada Research Station, P.O. Box 1000,
Agassiz, British Columbia, CANADA VOM 1A0
Odilon Antonio Marcuzzo do Canto, Departmento de Fisica- CCNE, Universi
-
dade Federal de Santa Maria Campus Camobi, 97119 Santa Maria/RS,
BRAZIL
Michael A. Dunn, Department of Food Science and Human Nutrition, 1800
-
East West Road, University of Hawaii, Honolulu, HI 96822
Richard Eastell, Department of Human Metabolism and Clinical Biochemistry,
The University of Sheffield Medical School, Sheffield, S5 7AU, U.K.
.
Richard A Ehrenkranz, Department of Pediatrics, Yale University School of
Medicine, 333 Cedar St, New Haven, CT 06510
N.V. Esteban, Department of Pediatrics, Albert Einstein Medical Center, N.Y.
Paul V. Fennessey, Center for Human Nutrition, University of Colorado Health
Sciences Center, 4200 E. Ninth Ave, Denver, CO 80262
Henry L. Fisher, Pharmacokinetics Branch, Health Effects Research Laborato
ry, U.S. Environmental Protection Agency, Research Triangle Park, NC
27711
Ronald Goans, Laboratory of Theoretical and Physical Biology NICHD, NIH,
Bethesda, MD 20892
vn
Vlll Contributors
Peter Greif, Laboratory of Mathematical Biology, DCBD, National Cancer
Institute, NIH, Bethesda, MD 20892
Larry L. Hall, Pharmacokinetics Branch, Health Effects Research Laboratory,
U.S. Environmental Protection Agency, Research Triangle Park, NC 27711
K. Michael Hambidge, Center for Human Nutrition, University of Colorado
Health Sciences Center, 4200 E. Ninth Ave, Denver, CO 80262
Marguerite T. Hays, Department of Veterans Affairs Medical Center, (151),
3801 Miranda Ave, Palo Alto, CA 94304
Shmuel Hurwitz, Institute of Animal Science, The Volcani Center, Bet-Dagan
50250, ISRAEL
Venkatesh G. Iyengar, International Human Nutrition Project, NIST, Gaithers
burg, MD 20899
Morteza Janghorbani, President, BioChemAnalysis Corporation, 2201 W
Campbell Park Dr., Chicago, IL 60612
Nancy F. Krebs, Department of Pediatrics, University of Colorado Health
Sciences Center, 4200 E. Ninth Ave, Denver, CO 80262
.
Orville A Levander, Beltsville Human Nutrition Research Center, USDA/ARS,
Beltsville, MD 20705
Jean Claude Liehn, Institut Jean-Godinet, Reims, FRANCE
.
A Lyne, Computer Services, Murdoch University, Murdoch, WA 6150,
AUSTRALIA
James H. Matis, Department of Statistics, Texas A&M University, College
-
Station, TX 77843 3143
Gordon D. McLaren, Department of Veterans Affairs Medical Center and
Department of Medicine, University of North Dakota School of Medicine,
Southeast Campus, Fargo, ND 58102
T. McNabb, Clinical Studies, School of Veterinary Medicine University of
Pennsylvania, Kennett Square, PA 19348
Walter Mertz, Beltsville Human Nutrition Research Center, U.S. Department of
Agriculture, Agricultural Research Service, Beltsville, MD 20705
.
Leland V Miller, Center for Human Nutrition, University of Colorado Health
Sciences Center, 4200 E. Ninth Ave, Denver, CO 80262
Phylis Moser-Veillon, Department of Human Nutrition and Food Systems,
University of Maryland, College Park, MD 20742
Bernard Most, ManTech Environmental Technology, Inc., Research Triangle
Park, NC 27709
Vernon Naake, Center for Human Nutrition, University of Colorado Health
Sciences Center 4200 E. Ninth Ave, Denver, CO 80262
Contributors ix
Michael H. Nathanson, Department of Medicine, Yale University School of
Medicine, New Haven, CT 06510
Ellen J. O’Flaherty, Department of Environmental Health, University of
Cincinnati, College of Medicine, 3223 Eden Avenue, Cincinnati, OH
-
45267 0056
Blossom H. Patterson, Biometry Branch, DCPC, National Cancer Institute,
NIH, Bethesda MD 20892
Kristine Y. Patterson, Vitamin and Mineral Nutrition Laboratory, Beltsville
Human Nutrition Research Center, USDA, Beltsville, MD 20705
.
K Pettigrew, NIMH, NIH, Bethesda, MD 20892
.
Charles F Ramberg, Jr., Center for Animal Health and Productivity, University
of Pennsylvania, School of Veterinary Medicine, Kennett Square, PA 19348
Carol Reidinger, Center for Human Nutrition, University of Colorado Health
Sciences Center, 4200 E. Ninth Ave, Denver, CO 80262
Gerald M. Saidel, Department of Biomedical Engineering, Case Western
Reserve University, Cleveland, OH 44106
Thornton Sargent (III), Research Medicine and Radiation Biophysics Division,
Lawrence Berkeley Laboratory, Berkeley, CA 94705
Wilfred D. Stein, Silberman Institute of Life Sciences, The Hebrew University
of Jerusalem, Jerusalem 91904, ISRAEL
K. N. Siva Subramanian, Division of Neonatology, Georgetown University
Medical Center, 3800 Reservoir Rd., N.W., Washington, D.C. 20007
Christine A. Swanson, Environmental Epidemiology Branch, DCE, National
Cancer Institute, NIH, Bethesda, MD 20892
DavidJ.Thomas, Pharmacokinetics Branch, Experimental Toxicology Division,
Health Effects Research Laboratory, U.S. Environmental Protection Agen
cy, Research Triangle Park, NC 27711
Judith R. Turnlund, USDA, ARS, Western Human Nutrition Research Center,
P. O. Box 29997, Presidio of San Francisco, San Francisco, CA 94129
Claude Veillon, Vitamin and Mineral Nutrition Laboratory, Beltsville Human
Nutrition Research Center, USDA, Beltsville, MD 20705
Nancy V. Vieira, Section on Metabolic Analysis and Mass Spectrometry, LTPB,
NICHD, NIH, Bethesda, MD 20892
Meryl E. Wastney, Division of Neonatology, Georgetown University Medical
Center, 3800 Reservoir Rd., N.W., Washington, DC 20007
Connie M. Weaver, Department of Foods and Nutrition, Purdue University,
-
1264 Stone Hall, West LaFayette, IN 47907 1264
Jamie Westcott, Center for Human Nutrition, University of Colorado Health
Sciences Center, 4200 E. Ninth Ave, Denver, CO 80262
