Table Of ContentKallikrein-relatedpeptidases
Novelcancer-relatedbiomarkers
Magdolen,Sommerhoff,FritzandSchmitt(Eds.)
Kallikrein-related peptidases
Volume 1
Characterization, regulation, and interactions
within the protease web
ViktorMagdolen,ChristianP.Sommerhoff,HansFritz,andManfredSchmitt(Eds.)
ISBN978-3-11-026036-6
e-ISBN978-3-11-026037-3
DeGruyter,Berlin2012
Volume 2
Novel cancer-related biomarkers
ViktorMagdolen,ChristianP.Sommerhoff,HansFritz,andManfredSchmitt(Eds.)
ISBN978-3-11-030358-2
e-ISBN978-3-11-030366-7
DeGruyter,Berlin2012
Kallikrein-related
peptidases
Volume 2
Novel cancer-related biomarkers
Editors
Viktor Magdolen, Christian P.Sommerhoff,
Hans Fritz, and ManfredSchmitt
Editors
Prof.Dr.ViktorMagdolen Prof.Dr.HansFritz
FrauenklinikderTUMünchen LMUMünchen/KlinikumInnenstadt
KlinikumrechtsderIsar AbteilungfürKlinischeChemieundKlinische
IsmaningerStr.22 BiochemieinderChirurgischenKlinikund
81675München Poliklinik
[email protected] Nussbaumstraße20
80336München
Prof.Dr.ChristianP.Sommerhoff
[email protected]
InstitutfürLaboratoriumsmedizin
KlinikumderLMUMünchen Prof.Dr.ManfredSchmitt
Nussbaumstraße20 FrauenklinikderTUMünchen
80336München KlinikumrechtsderIsar
[email protected] IsmaningerStraße22
81675München
[email protected]
Coverimage:UndifferentiatedovariancancertumortissuespecimenstainedforKLK6withmono-
specificpolyclonalrabbitantibody623A(immunizedandaffinity-purifiedwithasyntheticpeptide
representingaminoacids109-119ofKLK6)andtheDAKOEnVisionperoxidasepolymersystem
(browncolor).Nucleiwerecounterstainedwithhematoxylin(bluecolor).Reference:Seizetal.
(2012).Stromalcell-associatedexpressionofkallikrein-relatedpeptidase6(KLK6)indicatespoor
prognosisofovariancancerpatients.Biol.Chem.393,391-401.
Thisbookcontains16figuresand11tables.
ISBN978-3-11-030358-2
e-ISBN978-3-11-030366-7
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detailedbibliographicdataareavailableintheinternetathttp://dnb.dnb.de.
©2012WalterdeGruyterGmbH,Berlin/Boston
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Preface
Itwaschallengingtobringsomesemblanceofordertotheincreasingbodyofinforma-
tiononkallikrein-relatedpeptidases(KLKs)innormalphysiologyandunderpatho-
physiological conditions. We therefore decided to cover contributions of authors,
eachofthemanexpertinthefield,intwovolumesofthebookonKallikrein-related
peptidases. Volume 1, containing fifteen review chapters, highlights the genomic
andproteomicorganizationofKLKs,including3D-structures,substrateandinhibi-
tor specificity of KLKs, interaction and regulation of KLKs within the proteolytic
web,andtheimportanceofKLKsfortoothdevelopment,thephysiologicalfunction
ofseminalKLKs,andfornon-malignantdiseasessuchasthoseoftheskinandthe
centralnervoussystem.
DifferentfromVolume1,thesecondvolumepresentsaselectionofreviewarticles
focusing on the clinical utility of KLKs in various types of solid malignant tumors.
ThetenchapterscontainedinVolume2summarizetheclinicalimportanceofdiverse
KLKsinseveralmajortypesofcancer,e.g.thatofthelung,thegastrointestinaland
urogenitaltract,thebreast,andcancersofthehead&neck.Eachchapterisorganized
suchthatitprovidesanoverviewandinterpretationoftheclinicalimpactofcertain
KLKsinthesetypesofmalignancies.
AllchaptersofVolume1and2arecomprehensive,withanextensivelistofcited
literaturereferencesandeachisdesignedtostandonitself,sothatthereaderdoes
notneedtoreferbacktopreviousreportsforbackgroundinformation.Wewishyou
enjoyablereading!
ManfredSchmitt,ChristianP.Sommerhoff,HansFritz,andViktorMagdolen
List of contributing authors
JaneBayani YingDong
DepartmentofPathologyandLaboratory InstituteofHealthandBiomedicalInnovation
Medicine QueenslandUniversityofTechnology
MountSinaiHospital KelvinGrove,Australia
Toronto,Canada e-mail:[email protected]
e-mail:[email protected] Chapter5
Chapter9
JuliaDorn
JudithA.Clements FrauenklinikderTechnischenUniversität
InstituteofHealthandBiomedicalInnovation München
QueenslandUniversityofTechnology KlinikumrechtsderIsar
KelvinGrove,Australia Munich,Germany
e-mail:[email protected] e-mail:[email protected]
Chapter5 Chapter6,7
YvesCourty RuthA.Fuhrman-Luck
INSERMU1100 InstituteofHealthandBiomedicalInnovation
FacultyofMedicine QueenslandUniversityofTechnology
UniversityF.Rabelais KelvinGrove,Australia
Tours,France e-mail:[email protected]
e-mail:[email protected] Chapter5
Chapter1
NathalieHeuzé-Vourc’h
MarinaDevetzi INSERMU1100/EA6305
DepartmentofCellularPhysiology FacultyofMedicine
G.PapanicolaouResearchCenterofOncology UniversityF.Rabelais
SaintSavvasCancerHospital Tours,France
Athens,Greece e-mail:[email protected]
and Chapter1
DepartmentofBiologicalApplications
andTechnology DietmarW.Hutmacher
FacultyofScienceandTechnology FacultyofBuiltEnvironmentandEngineering
UniversityofIoannina InstituteofHealthandBiomedicalInnovation
Ioannina,Greece and
e-mail:[email protected] AustralianProstateCancerResearchCentre
Chapter2 Queensland
QueenslandUniversityofTechnology
EleftheriosP.Diamandis e-mail:[email protected]
DepartmentofPathology&LaboratoryMedicine Chapter5
MountSinaiHospital
Toronto,Canada RongJiang
e-mail:[email protected] DepartmentofHumanGenetics
Chapter6,7,9 EmoryUniversity
Atlanta,GA,USA
e-mail:[email protected]
Chapter3
VIII Listofcontributingauthors
JeffreyJohnson ViktorMagdolen
DepartmentofChemistry&Biochemistry FrauenklinikderTechnischenUniversität
HarperCancerResearchInstitute München
UniversityofNotreDame KlinikumrechtsderIsar
NotreDame,IN,USA Munich,Germany
e-mail:[email protected] e-mail:[email protected]
Chapter3 Chapter5
MarionKiechle KonstantinosMavridis
FrauenklinikderTechnischenUniversität DepartmentofBiochemistryandMolecular
München Biology
Munich,Germany UniversityofAthens
e-mail:[email protected] Athens,Greece
Chapter6 e-mail:[email protected]
Chapter10
HannuKoistinen
DepartmentofClinicalChemistry ValentinaMilou
UniversityofHelsinki OntarioInstituteforCancerResearch
Helsinki,Finland Toronto,Canada
e-mail:[email protected] e-mail:[email protected]
Chapter4 Chapter7
VathanyKulasingam BarbaraSchmalfeldt
DepartmentofClinicalBiochemistry FrauenklinikderTechnischenUniversität
UniversityHealthNetwork München
Toronto,Canada KlinikumrechtsderIsar
e-mail:[email protected] Munich,Germany
Chapter7 e-mail:[email protected]
Chapter7
DanielaLoessner
InstituteofHealthandBiomedicalInnovation ManfredSchmitt
QueenslandUniversityofTechnology FrauenklinikderTechnischenUniversität
KelvinGrove,Australia München
e-mail:[email protected] KlinikumrechtsderIsar
Chapter5 Munich,Germany
e-mail:[email protected]
Liu-YingLuo Chapter2,6,7,10
ResearchandDiagnosticSystems
Minneapolis,MN,USA AndreasScorilas
e-mail:[email protected] DepartmentofBiochemistryandMolecular
Chapter6 Biology
UniversityofAthens
Athens,Greece
e-mail:[email protected]
Chapter10
Listofcontributingauthors IX
ZonggaoShi AnnaTaubenberger
HarperCancerResearchInstitute FacultyofBuiltEnvironmentandEngineering
UniversityofNotreDame InstituteofHealthandBiomedicalInnovation
NotreDame,IN,USA KelvinGrove,Australia
e-mail:[email protected] e-mail:[email protected]
Chapter3 Chapter5
ShirlySieh MaroulioTalieri
FacultyofBuiltEnvironmentandEngineering DepartmentofCellularPhysiology
AustralianProstateCancerResearchCentre G.PapanicolaouResearchCenterofOncology
Queensland SaintSavvasCancerHospital
QueenslandUniversityofTechnology Athens,Greece
KelvinGrove,Australia e-mail:[email protected]
e-mail:[email protected] Chapter2,3
Chapter5
NicoleM.A.White
M.SharonStack St.Michael’sHospital
DepartmentofChemistryandBiochemistry Toronto,Canada
HarperCancerResearchInstitute e-mail:[email protected]
UniversityofNotreDame Chapter8
NotreDame,IN,USA
e-mail:[email protected] GeorgeM.Yousef
Chapter3 DepartmentofLaboratoryMedicine
St.Michael’sHospital
Ulf-HåkanStenman Toronto,Canada
DepartmentofClinicalChemistry e-mail:[email protected]
UniversityofHelsinki Chapter8
Helsinki,Finland
email:[email protected]
Chapter4
