Isozymes. Molecular Structure

848 Pages·1975·17.877 MB·English

by  Clement Markert (Eds.)

Organizing Committee
and
Editorial Board
CLEMENT L. MARKERT
Chairman and Editor
Department of Biology
Yale University
New Haven, Connecticut
BERNARD L. HORECKER JOHNG. SCANDALIOS
Roche Institute of Department of Biology
Molecular Biology University of South Carolina
Nutley, New Jersey Columbia, South Carolina
ELLIOTS. VESELL GREGORY S.WHITT
Department of Pharmacology Provisional Department of
Pennsylvania State University Genetics and Development
College of Medicine University of Illinois
Hershey, Pennsylvania Urban a, Illinois
Isozymes
I
Molecular Structure
EDITED BY
Clement L. Markert
Department of Biology
Yale University
ACADEMIC PRESS New York San Francisco London Ί975
A Subsidiary of Harcourt Brace Jovanovich, Publishers
ACADEMIC PRESS RAPID MANUSCRIPT REPRODUCTION
COPYRIGHT © 1975, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
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United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
24/28 Oval Road, London NW1
Library of Congress Cataloging in Publication Data
International Conference on Isozymes, 3d, Yale Univer-
sity, 1974
Isozymes.
Bibliography: v. 1, p.
Includes index.
CONTENTS: v. 1. Molecular structure
1. Isoenzymes-Congresses. I. Markert, Clement
Lawrence, (date) ed. II. Title.
QP601.148 1974 574.1'925 74-31288
ISBN 0-12-472701-8 (v. 1)
PRINTED IN THE UNITED STATES OF AMERICA
Contributors
H. Aebi Medizinisch-chemisches Institut der Universität Berne, CH — 3000,
Berne 9, Switzerland
Klaus Apel The Biological Laboratories, Harvard University, 16 Divinity
Avenue, Cambridge, Massachusetts 02138
William J. Arnold Division of Rheumatic and Genetic Diseases, Departments
of Medicine and Biochemistry, Duke University Medical Center, Durham,
North Carolina 27710
Isabelle Audit Unite 91 de I 'N.S.E.R.M. - Hopital Henri Mondor, 94010
Creteil, France
William M. Awad, Jr. Departments of Medicine and Biochemistry, University
of Miami School of Medicine, P.O. Box 520875 Biscayne Annex, Miami,
Florida 33152
David P. Baccanari Burroughs Wellcome Co., 3030 Cornwallis Road, Research
Triangle Park, North Carolina 27709
John A. Badwey Biochemistry Department, University of Massachusetts,
Amherst, Massachusetts 01002
Bohdan Bakay Department of Pediatrics, School of Medicine, University of
California at San Diego, La Jolla, California 92037
Joann Basabe Department of Biological Chemistry, California College of
Medicine, University of California, Irvine, California 92664
Kirstan Bazzell Oklahoma Medical Research Foundation, Oklahoma City,
Oklahoma 73100
Kathy B. Benveniste Laboratory of Developmental Biology and Anomalies,
National Institute of Dental Research, National Institutes of Health, Bethesda,
Maryland 20014
Will Bloch Department of Chemistry, Reed College, Portland, Oregon 97202
Lawrence Bogorad The Biological Laboratories, Harvard University, 16 Divinity
Avenue, Cambridge, Massachusetts 021 38
Emory H. Braswell Biological Sciences Group, University of Connecticut,
Storrs, Connecticut 06268
ix
CONTRIBUTORS
John R. Cann Department of Biophysics and Genetics, University of Colorado
Medical Center, Denver, Colorado 80220
J. M. Cardenas Department of Biochemistry and Biophysics, Oregon State
University, Corvallis, Oregon 97331
F. J. Casteilino Department of Chemistry, University of Notre Dame, Notre
Dame, Indiana 46556
Stephen D. Cederbaum Division of Medical Genetics, Mental Retardation Unit,
UCLA Neuropsychiatric Institute, Los Angeles, California 90024
Sungman Cha Division of Biological and Medical Sciences, Brown University,
Providence, Rhode Island 02912
Lee Chao Genetics and Cell Biology Section, Biological Sciences Group, The
University of Connecticut, Storrs, Connecticut 06268
John Cheney Department of Botany and Forest Pathology, State University
New York, College of Environmental Science and Forestry, Syracuse, New
York 13210
Soo II Chung Laboratory of Biochemistry, National Institute of Dental
Research, National Institutes of Health, Bethesda, Maryland 20014
Major L. Cohn Department of Anesthesiology, School of Medicine, University
of Pittsburgh, Pittsburgh, Pennsylvania 15261
J. A. Cortner Department of Pediatrics and Internal Medicine, State University
of New York at Buffalo, and the Children's Hospital, Buffalo, New York 14222
Rody P. Cox Division of Human Genetics, Departments of Medicine and
Pharmacology, New York University Medical Center, New York, New York
10016
David M. Dawson Department of Neurology, Children's Hospital Medical
Center and Harvard Medical School, Boston, Massachusetts 02115
George J. Doellgast Tufts Cancer Research Center and the Department of
Pathology (Oncology), Tufts University School of Medicine, 136 Harrison
Avenue, Boston, Massachusetts 02111
John A. Duley Department of Biochemistry, La Trobe University, Bundoora,
3083, Victoria, Australia
R. D. Dyson Department of Biochemistry and Biophysics, Oregon State
University, Corvallis, Oregon 97331
D. J. Ecobichon Department of Pharmacology, Faculty of Medicine, Dalhousie
University, Halifax, N. S., Canada
Masaharu Eguchi Laboratory of Genetics, Kyoto Technical University,
Matsugasaki, Kyoto, Japan
x
CONTRIBUTORS
W. Eventoff Department of Biological Sciences, Purdue University, West
Lafayette, Indiana 47907
William N. Fishbein Biochemistry Branch, Armed Forces Institute of Pathology,
Washington, D.C. 20306
Rachel A. Fisher MRC Human Biochemical Genetics Unit, University College,
London, England
William H. Fishman Tufts Cancer Research Center and the Department of
Pathology (Oncology), Tufts University School of Medicine, 136 Harrison
Avenue, Boston, Massachusetts 02111
Michael Flashner, SUNY College of Environmental Science and Forestry,
Syracuse, New York 13210
Tova Francus Department of Microbiology, Columbia University, New York,
New York 10032
Thomas D. Gelehrter, M.D. Department of Human Genetics, University of
Michigan Medical School, Ann Arbor, Michigan 48104
Larry Gerace Rockefeller University, New York, New York 10021
Nimai K. Ghosh Division of Human Genetics, Departments of Medicine and
Pharmacology, New York University Medical Center, New York, New York
10016
Robert W. Gracy Department of Chemistry, North Texas State University,
Denton, Texas 76203
Jerry M. Greene Department of Neurology, Children's Hospital Medical Center
and Harvard Medical School, Boston, Massachusetts 02115
David H. Griffin Department of Botany and Forest Pathology, State University
of New York, College of Environmental Science and Forestry, Syracuse, New
York 13210
Martin J. Griffin Oklahoma Medical Research Foundation, Oklahoma City,
Oklahoma 73100
Albert Grossman Department of Pharmacology, New York University School
of Medicine, New York, New York 10016
M. L. Hackert Department of Biological Sciences, Purdue University, West
Lafayette, Indiana 47907
James W. Hardin The Biological Laboratories, Harvard University, 16 Divinity
Avenue, Cambridge, Massachusetts 02138
Harry Harris MRC Human Biochemical Genetics Unit, University College,
London, England
XI
CONTRIBUTORS
Norman B. Hecht Department of Biology, Tufts University, Medford,
Massachusetts 02155
Roger S. Holmes School of Science, Griffith University, Nathan, Brisbane,
Queensland. 4111., Australia
D. A. Hopkinson MRC Human Biochemical Genetics Unit, Galton Laboratory,
University College, London, England
B. L. Horecker Roche Institute of Molecular Biology, Nutley, New Jersey
07110
Paul A. Horgen Department of Botany, University of Toronto, Erindale
Campus, Mississauga, Ontario, Canada
Kenneth H. Ibsen Department of Biological Chemistry, California College of
Medicine, University of California, Irvine, California 92664
Ronald W. Johnson Department of Pharmacology, New York University School
of Medicine, New York, New York 10016
K. K. Kannan Department of Molecular Biology, The Wallenberg Laboratory,
Uppsala University, Uppsala, Sweden
Cecil J. Kelly Division of Biological and Medical Sciences, Brown University,
Providence, Rhode Island 02912
Philip M. Kelley Department of Microbiology, Washington University School
of Medicine, St. Louis, Missouri 63110
William N. Kelley Division of Rheumatic and Genetic Diseases, Departments
of Medicine and Biochemistry, Duke University Medical Center, Durham,
North Carolina 27710
William C. Kenney Department of Biochemistry and Biophysics, University of
California, San Francisco, California, 94143 and Division of Molecular Biology,
Veterans Administration Hospital, San Francisco, California 94121
Chi-Wei Lin Tufts Cancer Research Center and Department of Pathology,
Tufts University School of Medicine, Boston, Massachusetts 02111
Helga Lundgren SUNY College of Environmental Science and Forestry,
Syracuse, New York 13210
Clement L. Markert Department of Biology, Yale University, New Haven,
Connecticut 06520
ivy R. McManus Department of Biochemistry, Faculty of Arts and Sciences,
University of Pittsburgh, Pittsburgh, Pennsylvania 15261
E. A. Meighen Department of Biochemistry, McGill University, Montreal,
Quebec, Canada
XII
CONTRIBUTORS
David B. Millar Laboratory of Physical Biochemistry, Naval Medical Research
Institute, National Naval Medical Center, Bethesda, Maryland 20014
Kenneth D. Munkres Laboratory of Molecular Biology, University of Wisconsin,
Madison, Wisconsin 53704
K. Nagarajan Biochemistry Branch, Armed Forces Institute of Pathology,
Washington, D.C. 20306
Ernst A. Noltmann Department of Biochemistry, University of California,
Riverside, California 92502
B. Notstrand Department of Molecular Biology, The Wallenberg Laboratory,
Uppsala University, Uppsala, Sweden
Maria S. Ochoa Departments of Medicine and Biochemistry, University of
Miami School of Medicine, P.O. Box 520875, Biscayne Annex, Miami,
Florida 33Ί52
Janis O'Donnell Department of Biology, The Johns Hopkins University,
Baltimore, Maryland 21218
Regina Pietruszko Center of Alcohol Studies, Rutgers University, New
Brunswick, New Jersey 08903
Jean Rosa Unite 91 de l'N.S.E.R.M. - Hopital Henri Mondor, 94010 Creteil,
France
Raymonde Rosa Unite 91 de l'N.S.E.R.M. - Hopital Henri Mondor, 94010
Creteil, France
M. G. Rossmann Department of Biological Sciences, Purdue University,
West Lafayette, Indiana 47907
Milton J. Schlesinger Department of Microbiology, Washington University
School of Medicine, St. Louis, Missouri 63110
B. Scherz Medizinisch-chemisches Institut der Universität Berne, CH-3000,
Berne. 9. Switzerland
J. D. Schnatz Department of Pediatrics and Internal Medicine, State University
of New York at Buffalo, and the Children's Hospital, Buffalo, New York 14222
Marcia Schwartz Department of Biology, The Johns Hopkins University,
Baltimore, Maryland 21218
Warren Scurzi Biochemistry Branch, Armed Forces Institute of Pathology,
Washington, D.C. 20306
G. F. Sensabaugh Forensic Science Program, School of Criminology, University
of California, Berkeley, California 94720
XIII
CONTRIBUTORS
James B. Shaklee Provisional Department of Genetics and Development,
University of Illinois at Urbana-Champaign, Urbana, Illinois 61801
G. E. Siefring, Jr. Department of Chemistry, University of Notre Dame,
Notre Dame, Indiana 46556
Steven Siegel Departments of Medicine and Biochemistry, University of Miami
School of Medicine, P.O. Box 520875 Biscayne Annex, Miami, Florida 33152
Jane Smith The Biological Laboratories, Harvard University, 16 Divinity
Avenue, Cambridge, Massachusetts 02138
J. M. Sodetz Department of Chemistry, University of Notre Dame, Notre
Dame, Indiana 46556
William Sofer Department of Biology, The Johns Hopkins University, Baltimore,
Maryland 21218
Carolyn J. Spencer Department of Human Genetics, University of Michigan
Medical School, Ann Arbor, Michigan 48104
Joseph F. Speyer Genetics and Cell Biology Section, Biological Sciences Group,
The University of Connecticut, Storrs, Connecticut 06268
S. J. Steindel Department of Biological Sciences, Purdue University, West
Lafayette, Indiana 47907
J. J. Strandholm Department of Biochemistry and Biophysics, Oregon State
University, Corvallis, Oregon 97331
Stuart W. Tannenbaum SUNY College of Environmental Science and Forestry,
Syracuse, New York 13210
William Timberlake Department of Botany and Forest Pathology, State
University of New York, College of Environmental Science and Forestry,
Syracuse, New York 13210
Patricia Trippet Department of Biological Chemistry, California College of
Medicine, University of California, Irvine, California 92664
Orestes Tsolas Roche Institute of Molecular Biology, Nutley, New Jersey
07110
Bruce J. Turner The Rockefeller University, New York, New York 10021
Bryan M. Turner Division of Medical Genetics, Department of Pediatrics,
Mount Sinai School of Medicine of the City University of New York,
New York, New York 10029
I. Vaara Department of Molecular Biology, The Wallenberg Laboratory,
Uppsala University, Uppsala, Sweden
XIV
CONTRIBUTORS
Richard B. Vallee Laboratory of Molecular Biology, The University of
Wisconsin, Madison, Wisconsin 53706
Klaus D. Vosbeck Departments of Medicine and Biochemistry, University of
Miami School of Medicine, P.O. Box 520875 Biscayne Annex, Miami, Florida
33152
E. W. Westhead Biochemistry Department, University of Massachusetts,
Amherst, Massachusetts 01002
Beulah M. Woodfin Department of Biochemistry, School of Medicine,
University of New Mexico, Albuquerque, New Mexico 87131
S. R. Wyss Medizinisch-chemisches Institut der Universität Berne, CH-3000,
Berne 9, Switzerland