Table Of ContentISCHEMIC PRECONDmONING:
THE CONCEPT OF ENDOGENOUS CARDIOPROTECTION
DEVELOPMENTS IN CARDIOVASCULAR MEDICINE
S. Sideman, R. Beyar and A. G. Kleber (eds.): Cardiac Electrophysiology, Circulation, and
Transport. Proceedings of the 7th Henry Goldberg Workshop (Berne, Switzerland, 1990).
1991. ISBN 0-7923-1145-0.
D. M. Bers: Excitation-Contraction Coupling and Cardiac Contractile Force. 1991. ISBN
0-7923-1186-8.
A.-M. Salmasi and A. N. Nicolaides (eds.): Occult Atherosclerotic Disease. Diagnosis, Assess-
ment and Management. 1991. ISBN 0-7923-1188-4.
J. A. E. Spaan: Coronary Blood Flow. Mechanics, Distribution, and Control. 1991. ISBN 0-
7923-1210-4.
R. W. Stout (ed.): Diabetes and Atherosclerosis. 1991. ISBN 0-7923-1310-0.
A. G. Herman (ed.): Antithrombotics. Pathophysiological Rationale for Pharmacological Inter-
ventions. 1991. ISBN 0-7923-1413-1.
N. H. J. Pijls: Maximal Myocardial Perfusion as a Measure of the Functional Significance of
Coronary Arteriogram. From a Pathoanatomic to a Pathophysiologic Interpretation of the
Coronary Arteriogram. 1991. ISBN 0-7923-1430-1.
J. H. C. Reiber and E. E. v. d. Wall (eds.): Cardiovascular Nuclear Medicine and MRI.
Quantitation and Clinical Applications. 1992. ISBN 0-7923-1467-0.
E. Andries, P. Brugada and R. Stroobrandt (eds.): How to Face "the Faces" of Cardiac Pacing.
1992. ISBN 0-7923-1528-6.
M. Nagano, S. Mochizuki and N. S. Dhalla (eds.): Cardiovascular Disease in Diabetes. 1992.
ISBN 0-7923-1554-5.
P. W. Serruys, B. H. Strauss and S. B. King III (eds.): Restenosis after Intervention with New
Mechanical Devices. 1992. ISBN 0-7923-1555-3.
P. J. Winter (ed.): Quality of Life after Open Heart Surgery. 1992. ISBN 0-7923-1580-4.
E. E. van der Wall, H. Sochot, A. Righetti and M. G. Niemeyer (eds.): What is new in Cardiac
Imaging? SPECT, PET and MRI. 1992. ISBN 0-7923-1615-0.
P. Hanrath, R. Uebis and W. Krebs (eds.): Cardiovascular Imaging by Ultrasound. 1992. ISBN
0-7923-1755-6.
F. H. Messerli (ed.): Cardiovascular Disease in the Elderly, 3rd ed. 1992. ISBN 0-7923-1859-5.
J. Hess and G. R. Sutherland (eds.): Congenital Heart Disease in Adolescents and Adults. 1992.
ISBN 0-7923-1862-5.
J. H. C. Reiber and P. W. Serruys (eds.): Advances in Quantitative Coronary Arteriography.
1992. ISBN 0-7923-1863-3.
A.-M. Salmasi and A. S. Iskandrian (eds.): Cardiac Output and Regional Flow in Health and
Disease. 1993. ISBN 0-7923-1911-7.
J. H. Kingma, N. M. van Hemel and K. J. Lie (eds.): Atrial Fibrillation, a Treatable Disease?
1992. ISBN 0-7923-2008-5.
B. Ostadal, N. S. Dhalla (eds.): Heart Function in Health and Disease. 1993. ISBN 0-7923-
2052-2.
D. Noble and Y. E. Earm (eds.): Ionic Channels and Effect of Taurine on the Heart. Proceed-
ings of an International Symposium (Seoul, Korea, 1992). 1993. ISBN 0-7923-2199-5.
H. M. Piper (ed.): Ischemia-reperfusion in Cardiac Surgery. 1993. ISBN 0-7923-2241-X.
ISCHEMIC PRECONDITIONING:
THE CONCEPT OF ENDOGENOUS
CARDIOPROTECTION
Edited by
KARIN PRZYKLENK
ROBERT A. KLONER
The Heart Institute
The Hospital of the Good Samaritan
Los Angeles, CA
DEREK M. YELLON
Department of Academic Cardiology
University College Hospital
London, United Kingdom
....
"SPRINGE R SCIENCE+BUSINESS MEDIA, LLC
Copyright © 1994 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1994
Softcover reprint ofthe hardcover lst edition 1994
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system
or transmitted in any form or by any means, mechanica1, photo-copying, recording, or other-
wise, without the prior written permission of the publisher,
Springer Science+Business Media, LLC.
Printed on acid:free paper.
Library of Congress Cataloging-in-Publication Data
Ischemie preconditioning: the concept of endogenous
cardioprotection / edited by Karin Przyklenk, Robert A. Kloner and Derek M. Yellon.
p. cm. - (Developments in cardiovascular medicine; DlCM 148)
Includes index.
ISBN 978-1-4613-6114-5 ISBN 978-1-4615-2602-5 (eBook)
DOI 10.1007/978-1-4615-2602-5
1. Myocardial infarction-Prevention. 2. Coronary heart disease. 3. Heart-
Adaptation. 1. Przyklenk, Karin, 1956- . II. Kloner, Robert A. III. Yellon, Derek M.
IV. Series. V. Series: Developments in cardiovascular medicine; v. 148.
[DNLM: 1. Myocardial Ischemia. 2. Myocardial Diseases-prevention & control.
3. Adaptation, Physiological. W1 DE997VME v. 148]
RC68S.I6I83 1993
616.1 '23-dc20
DNLMIDLC
for Library of Congress 93-21904
CIP
CONTENTS
List of contributors Vll
Preface xi
Acknowledgements XlIl
I: ISCHEMIC PRECONDITIONING: BENEFITS AND LIMITATIONS
IN EXPERIMENTAL MODELS OF ISCHEMIAIREPERFUSION
1. What is ischemic preconditioning? 3
CHARLES E. MURRY, ROBERT B. JENNINGS, and KEITH A. REIMER
2. Preconditioning and ischemia- and reperfusion-induced arrhythmias 19
CLIVE S. LAWSON and DAVID J. HEARSE
3. Preconditioning and myocardial contractile function 41
MICHEL OVIZE, ROBERT A. KLONER, and KARIN PRZYKLENK
4. Preconditioning and the coronary vasculature 61
BARBARA BAUER, ROBERT A. KLONER, and KARIN PRZYKLENK
D: MECHANISMS OF CARDIOPROTECTION BY PRECONDITIONING:
THEORIES AND CONTROVERSIES
5. Role of altered energy metabolism in ischemic preconditioning 75
KEITH A. REIMER, RICHARD S. VANDER HEIDE, CHARLES E. MURRY,
and ROBERT B. JENNINGS
6. Stress proteins, heat stress, and myocardial protection 105
MICHAEL S. MARBER, RICHARD J. HEADS, and DEREK M. YELLON
vi Contents
7. Role of ATP-sensitive potassium channels in ischemic preconditioning 125
GARRETT J. GROSS, ZHENHAI YAO, and JOHN A. AUCHAMPACH
8. Adenosine and the antiinfarct effects of preconditioning 137
JAMES M. DOWNEY, YONGGE LIU, and KIRST! YTREHUS
9. Synopsis of ischemic preconditioning: What have we learned since 1986? 153
KARIN PRZYKLENK, ROBERT A. KLONER, and PETER WHITTAKER
m: ISCHEMIC PRECONDmONlNG: LABORATORY
CURIOSITY OR CLINICAL PROMISE?
10. Is preconditioning relevant to clinical medicine? 173
ROBERT A. KLONER and KARIN PRZYKLENK
Index 189
LIST OF CONTRIBUTORS
John A. Auchampach, PhD
Postdoctoral Fellow
Cardiovascular Diseases Research and Adhesion Biology
The Upjohn Company
301 Henrietta Street
Kalamazoo, MI 49001
Barbara Bauer, MD
Department of Cardiology
Medizinische Universitatsklinik Wiirzburg
Josef Schneider Strasse 2
Bau4
Luitpoldkrankenhaus
8700 Wiirzburg
Germany
James M. Downey, PhD
Professor of Physiology
Department of Medical Physiology
University of South Alabama
MSB 3024
Mobile, AL 36688
viii List of contributors
Garrett J. Gross, PhD
Professor of Pharmacology and Toxicology
Department of Pharmacology and Toxicology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
Richard J. Heads
Research Fellow
The Hatter Institute for Cardiovascular Studies
Department of Academic Cardiology
University College Hospital
Gower Street
London WC1E 6AU
United Kingdom
Prof. David J. Hearse, PhD DSc
Director of Research
Cardiovascular Research
The Rayne Institute
St. Thomas' Hospital
London SE1 7EH
United Kingdom
Robert B. Jennings, MD
James B. Duke Professor of Pathology
Department of Pathology
Box 3712
Duke University Medical Center
Durham, NC 27710
Robert A. Kloner, MD, PhD
Director of Research
Heart Institute, Hospital of the Good Samaritan
Professor of Medicine, Section of Cardiology
University of Southern California
616 South Witmer Street
Los Angeles, CA 90017
Clive S. Lawson, MRCP
Registrar in Cardiology
The London Chest Hospital
Bonner Road
London E2 9JX
United Kingdom
List of contributors ix
Yongge Liu
Department of Medical Physiology
University of South Alabama
MSB 3024
Mobile, AL 36688
Michael S. Marber, MRCP
Honorary Senior Registrar in Cardiology
British Heart Foundation Intermediate Fellow
The Hatter Institute for Cardiovascular Studies
Department of Academic Cardiology
University College Hospital
Gower Street
London WC1E 6AU
United Kingdom
Charles E. Murry, MD, PhD
Acting Instructor in Pathology
Department of Pathology
RC-72
University of Washington Medical Center
Seattle, W A 98135
Michel Ovize, MD
Adjunct Assistant Professor
Department of Cardiology
Hopital Cardiologique Louis Pradel
Service du Pro J. Delaye
59, Boulevard Pinel
69003 Lyon
France
Karin Przyklenk, PhD
Assistant Director of Research and Director of Cardiac Function
Heart Institute, Hospital of the Good Samaritan
Associate Professor of Research Medicine, Section of Cardiology
University of Southern California
616 South Witmer Street
Los Angeles, CA 90017
Keith A. Reimer, MD, PhD
Professor of Pathology
Head, Cardiovascular Pathology
Department of Pathology
Box 3712
Duke University Medical Center
Durham, NC 27710
x List of contributors
Richard S. Vander Heide, MD
Cardiac Pathology Fellow
Department of Pathology
Box 3712
Duke University Medical Center
Durham, NC 27710
Peter Whittaker, PhD
Director of Microscopy
Heart Institute/Hospital of the Good Samaritan
Assistant Professor of Research Medicine
University of Southern California
616 South Witmer Street
Los Angeles, CA 90017
Zhenhai Yao, MD
Visiting Scientist
Department of Pharmacology and Toxicology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
Derek M. Yellon, PhD
Professor of Cellular Cardiology
Head of Division of Cardiology
Director, The Hatter Institute for Cardiovascular Studies
Department of Academic Cardiology
University College Hospital
Gower Street
London WC1E 6AU
United Kingdom
Kirsti Ytrehus, MD, PhD
Assistant Professor of Physiology
Department of Physiology
University of Tromso
Tromso, Norway
[Currently on sabbatical in
Department of Medical Physiology
University of South Alabama
MSB3024
Mobile, AL 36688
