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About International Journal of Universal Pharmacy and Bio Sciences
- Paracetamol is a commonly used analgesic and antipyretic, but its mechanism of action is not fully understood. While it inhibits COX enzymes, it does so weakly and is a poor anti-inflammatory. - COX enzymes (COX-1, COX-2) convert arachidonic acid to prostaglandins, which mediate pain and inflammation. COX-1 is constitutive while COX-2 is inducible. - A COX-1 splice variant named COX-3 was discovered that is more sensitive to inhibition by paracetamol, helping explain its mechanism. However, the existence and function of COX-3 remains controversial.
Detailed Information
| Author: | ['Pallavi Prakash'] |
|---|---|
| Publication Year: | 2020 |
| Pages: | 9 |
| Language: | English |
| Format: | |
| Price: | FREE |
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