Instrumentation for a Better Tomorrow: Proceedings of a Symposium in Honor of Arnold Beckman

77 Pages·2006·7.31 MB·English

by  National Research Council

I N S T R U M E N T A T I O N
F O R A B E T T E R T O M O R R O W
PROCEEDINGS OF A SYMPOSIUM IN HONOR OF ARNOLD BECKMAN
Board on Physics and Astronomy
Division on Engineering and Physical Sciences
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II INSTRUMENTATION FOR A BETTER TOMORROW
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INSTRUMENTATION FOR A BETTER TOMORROW III
BOARD ON PHYSICS AND ASTRONOMY
BURTON RICHTER,Stanford University,Chair
ANNEILA L.SARGENT,California Institute ofTechnology,Vice Chair
ELIHU ABRAHAMS,Rutgers University
JONATHAN BAGGER,Johns Hopkins University
RONALD C.DAVIDSON,Princeton University
RAYMOND J.FONCK,University ofWisconsin at Madison
ANDREA M.GHEZ,University ofCalifornia at Los Angeles
PETER GREEN,University ofTexas at Austin
LAURA H.GREENE,University ofIllinois at Urbana-Champaign
WICK HAXTON,University ofWashington
FRANCES HELLMAN,University ofCalifornia at Berkeley
ERICH P.IPPEN,Massachusetts Institute ofTechnology
MARC A.KASTNER,Massachusetts Institute ofTechnology
CHRISTOPHER F.McKEE,University ofCalifornia at Berkeley
JOSE ONUCHIC,University ofCalifornia at San Diego
JULIA M.PHILLIPS,Sandia National Laboratories
WILLIAM PHILLIPS,National Institute ofStandards and Technology
THOMAS M.THEIS,IBM T.J.Watson Research Center
C.MEGAN URRY,Yale University
STAFF
DONALD C.SHAPERO,Director
TIMOTHY I.MEYER,Senior Program Officer
MICHAEL H.MOLONEY,Senior Program Officer
ROBERT L.RIEMER,Senior Program Officer
NATALIA J.MELCER,Program Officer
BRIAN D.DEWHURST,Senior Program Associate
PAMELA A.LEWIS,Program Associate
DAVID B.LANG,Research Associate
VAN AN,Financial Associate
PHILLIPD.LONG,Senior ProgramAssistant
IV INSTRUMENTATION FOR A BETTER TOMORROW
Acknowledgments
T
his symposium and these proceedings would not have been possible but for
the inspiration,dedication,and hard work of many people.In particular,the
gracious contributions oftime and effort ofthe staffat the Arnold and Mabel
Beckman Foundation,the Arnold and Mabel Beckman Center ofthe National
Academies,Beckman Coulter,Inc.,and the Chemical Heritage Foundation were critical to
making this project a success.The speakers themselves gave generously of their time and
expertise to reflect on the legacy of a great man and to offer their thoughts on where the
future will take us.
Among the many individuals to whom we express our heartfelt thanks and appreciations,
we specially recognize the following: Jacqueline Dorrance and Kathlene Williams of the
Arnold and Mabel Beckman Foundation; Amber Westberg of the Arnold and Mabel
Beckman Center; James C. Osborne, Pat Ashton, and Sarah Nessl of Beckman Coulter,
Inc.; Charles Casey and A.J. Ribes of the American Chemical Society; Robert Lukens,
David Brock,and Robert Hicks of the Chemical Heritage Foundation;Gerald Gallwas of
the Board of the Arnold and Mabel Beckman Foundation; Barbara Schlein of the
President’s Office at the National Academy of Engineering; Sharon Baker of the
Chancellor’s Office at the University of California at Irvine;and all of the dedicated staff
at the National Academies’Board on Physics and Astronomy,including Timothy Meyer,
Richard Rowberg,Don Shapero,and Pamela Lewis.Finally,conversations with the staffof
the Institute ofMedicine and the Beckman Institute at the University ofIllinois at Urbana-
Champaign and with Francis J.DiSalvo,David C.Clarke,Laura Greene,Frances Hellman,
Venkatesh Narayanamurti,Richard Smalley,Paul Ferrara,Harry Gray,Nathan Rosenberg,
and Dragana Brzakovic were invaluable.
INSTRUMENTATION FOR A BETTER TOMORROW V
Acknowledgment of Reviewers
This report has been reviewed in draft form by individuals chosen for their diverse
perspectives and technical expertise,in accordance with procedures approved by
the National Research Council’s Report Review Committee.The purpose ofthis
independent review is to provide candid and critical comments that will assist
the institution in making its published report as sound as possible and to ensure that the
report meets institutional standards for objectivity and evidence. The review comments
and draft manuscript remain confidential to protect the integrity of the deliberative
process.We wish to thank the following individuals for their review ofthis report:
Scott Fraser,California Institute ofTechnology
Gerald Gallwas,Beckman Foundation
Barbara Jones,IBM Almaden Research Center
Pierre Wiltzius,University ofIllinois at Urbana-Champaign
Although the reviewers listed above have provided many constructive comments and
suggestions,responsibility for the final content ofthis report rests entirely with the author-
ing committee and the institution.
VI INSTRUMENTATION FOR A BETTER TOMORROW

Contents
Foreword 1
PART I
A Daughter’s Remembrances 5
Finding the Sweet Spot ofOpportunity 7
PART II
A Lifetime ofExperience in the Growth ofModern Instrumentation for
Organic Chemistry 19
Molecular and Systems Biology 26
Compelling Science and Synchrotron X-ray Sources 30
Chemistry at the Nanoscale Frontier 36
Nanoscale Science and Engineering 39
Forensic Science and Technology 43
Clinical Medicine 47
PART III
The Evolving Relationship Between Instrumentation and Research
—A Panel Discussion 53
The Arnold and Mabel Beckman Center ofthe National Academies 63
INSTRUMENTATION FOR A BETTER TOMORROW IX