Informing the prevention, diagnosis and management of acute rheumatic fever and rheumatic heart

272 Pages·2015·1.52 MB·English

ResearchOnline@JCU

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Rémond, Marc Gerard Wootton (2014) Informing the
prevention, diagnosis and management of acute rheumatic
fever and rheumatic heart disease in Aboriginal
Australian and Torres Strait Islander populations. PhD
thesis, James Cook University.

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Title Page

Informing the Prevention, Diagnosis and Management of
Acute Rheumatic Fever and Rheumatic Heart Disease in
Aboriginal Australian and Torres Strait Islander Populations

Thesis submitted by Marc Gerard Wootton Rémond
BSc (Hons I), Llb (Hons II), Dip Arts, Grad Dip Arts
November 2014

for the degree of Doctor of Philosophy
School of Medicine and Dentistry
James Cook University

Contribution of Others
This “thesis by publication” includes papers which the candidate co-authored with a
number of colleagues. The nature and extent of the intellectual input of each author,
including the candidate, for each of the included papers is outlined below.
The candidate was solely responsible for writing the introduction and discussion of this
thesis with editorial input from his supervisors.
Chapter Details of Publication on which Nature and extent of the intellectual
Number chapter is based input of each author, including the
candidate
Ch. 2 Rémond, M.G.W., and Maguire, Rémond and Maguire developed the
G.P. (2012). Primordial and structure and themes of the review.
primary prevention of acute Rémond performed a literature search and
rheumatic fever and rheumatic wrote the first draft of the paper in
heart disease in Australia. In, The consultation with, and under the guidance
Australian guideline for of, Maguire. Maguire revised and edited
prevention, diagnosis and the review and created the figures.
management of acute rheumatic Editorial input was provided by the lead
fever and rheumatic heart disease authors and other members of the writing
(2nd edition) (pp. 19-29). Darwin, group of the guideline.
Northern Territory: Menzies
School of Health Research.
Ch. 2 Rémond M., Maguire G. (2011). Maguire and Rémond developed the
RHD: Women and Pregnancy. themes of the paper. Rémond undertook a
O&G Magazine. The Royal literature review and wrote the first draft
Australian and New Zealand of the paper. Maguire provided editorial
College of Obstetricians and assistance to revise the paper. Rémond
Gynaecologists (RANZCOG), 47- produced the figures and tables.
50.
i
Chapter Details of Publication on which Nature and extent of the intellectual
Number chapter is based input of each author, including the
candidate
Ch. 2 Rémond M.G.W., Coyle M.E., Rémond and Maguire developed the
Mills J.E., and Maguire G.P. concept and themes of the paper. Coyle
Approaches to improving undertook the primary literature search.
adherence to secondary Rémond prepared the first draft of the
prophylaxis for rheumatic fever paper and undertook further literature
and rheumatic heart disease: a searches. Rémond prepared figures.
literature review with a global Maguire revised the paper and provided
perspective. Cardiology in Review further intellectual input into the
(in press). discussion. Mills and Coyle provided final
editorial assistance.
Ch. 3 Rémond MG, Wark EK, and Rémond, Wark and Maguire developed
Maguire GP. (2013). Screening for concepts and themes for the paper.
rheumatic heart disease in Rémond and Wark conducted a literature
Aboriginal and Torres Strait search. Rémond prepared first draft of the
Islander children. Journal Of paper. Maguire and Wark provided
Paediatrics And Child Health. 49: editorial assistance in revising the paper.
526-531.

ii
Chapter Details of Publication on which Nature and extent of the intellectual
Number chapter is based input of each author, including the
candidate
Ch. 3 Rémond MG, Atkinson D, White All authors contributed to the
A, Hodder Y, Brown AD, development of the research question.
Carapetis JR, and Maguire GP. Maguire created a funding proposal.
Rheumatic Fever Follow-Up Rémond wrote the first draft of the paper.
Study (RhFFUS) protocol: a Maguire created the map. Rémond created
cohort study investigating the the hierarchy image. All authors edited
significance of minor and revised the paper to produce the final
echocardiographic abnormalities text.
in Aboriginal Australian and
Torres Strait Islander children.
BMC cardiovascular disorders.
2012;12:111.
Ch. 3 Rémond MGW, Atkinson DN, The authors co-developed the research
White A, Brown ADH, Carapetis question. Rémond (with assistance from
JR, Remenyi B, Roberts K, and employed project staff) collected the data.
Maguire GP. Are minor Remenyi read all the echocardiograms
echocardiographic changes collected during the study. Rémond and
associated with an increased risk Remenyi entered all project data onto
of acute rheumatic fever or databases. Rémond cleaned the data and
rheumatic heart disease? undertook data analysis with the
Submitted to Circulation. assistance of Maguire. Rémond and
Maguire drafted the paper. Rémond
created the tables. All authors contributed
to the revision and editing of the paper.
iii
Chapter Details of Publication on which Nature and extent of the intellectual
Number chapter is based input of each author, including the
candidate
Ch. 4 Rémond, M. G., Severin, K. L., All authors contributed to the
Hodder, Y., Martin, J., Nelson, C., development of the research question.
Atkinson, D., & Maguire, G. P. Severin, Hodder and Rémond undertook
(2013). Variability in disease data collection with the assistance of
burden and management of employed project staff. Rémond entered
rheumatic fever and rheumatic data into a database, cleaned the data and
heart disease in two regions of undertook data analysis. Rémond and
tropical Australia. Internal Maguire wrote the first draft of the paper
medicine journal, 43(4), 386-393. with Rémond developing the tables and
Maguire developing the map. All authors
contributed to the revision and editing of
the final paper.
Ch. 4 Baskerville, C. A., Hanrahan, B. All authors contributed to the
B., Burke, A. J., Holwell, A. J., development of the research question.
Rémond, M. G., & Maguire, G. P. Baskerville, Hanrahan, Burke, and
(2012). Infective endocarditis and Holwell collected the data. Rémond
rheumatic heart disease in the cleaned the data, undertook data analysis,
north of Australia. Heart, lung & and created the tables. Rémond and
circulation, 21(1), 36-41. Maguire wrote the first draft of the paper.
Maguire produced the map. All authors
contributed to the revision and editing of
the paper to produce a final manuscript.

iv
Chapter Details of Publication on which Nature and extent of the intellectual
Number chapter is based input of each author, including the
candidate
Appendix Rémond, M. G., Wheaton, G. R., Wheaton, Walsh and Prior developed and
1 Walsh, W. F., Prior, D. L., & delivered presentations at the CSANZ
Maguire, G. P. (2012). Acute Indigenous Cardiovascular Health
Rheumatic Fever and Rheumatic Conference on the major themes covered
Heart Disease - Priorities in in this article. Rémond collated the
Prevention, Diagnosis and information that was presented in these
Management. A Report of the presentations, undertook further literature
CSANZ Indigenous searches and, in conjunction with
Cardiovascular Health Maguire, further developed the themes
Conference, Alice Springs 2011. and a framework for the paper. Rémond
Heart Lung Circ, 21(10), 632-638. wrote the first draft of the paper. Maguire
provided primary editing input. Wheaton,
Walsh and Prior provided final editorial
input.

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The candidate received financial support via a number of scholarships while undertaking
this degree. These comprised:
• NHMRC Postgraduate Scholarship
• Queensland Health Scholarship
• James Cook University Scholarship

The candidate was supervised while undertaking this PhD by Professor Graeme Maguire,
Associate Professor David Atkinson, Dr. Andrew White, and Associate Professor Alan
Clough.

The Rheumatic Fever Follow-Up Study (RhFFUS), presented in chapter 3 of this thesis,
was funded by the Australian Government through a grant from the National Health and
Medical Research Council (NHMRC project grant application 1005951).

The research presented and reported in this thesis was conducted in accordance with the
National Health and Medical Research Council (NHMRC) National Statement on Ethical
Conduct in Human Research, 2007. The research study received human research ethics
approval from the JCU Human Research Ethics Committee Approval Number H4136.

vi
Acknowledgements
To my old mate Dr. G without whom this thesis would never have been contemplated let
alone completed. For your unfailing support, encouragement, assistance and friendship I
am eternally grateful. You truly went beyond the call of duty to keep me on track, on time
and on song (most of the time).
To my supervisory panel, Prof. Graeme Maguire, A/Prof. David Atkinson, Dr. Andrew
White, and A/Prof. Alan Clough. Thank you for sharing your time, expertise, and review
skills so generously. You certainly made the PhD journey as painless as humanly possible.
To “Prof.” Hodder. Thank you for your humour, your persistence, your non-stop support,
your uncanny ability to get things moving, and your proof-reading. You really have earned
your grey-nomad pilgrimage.
To Rhona Dawson. The Kimberley is all the richer for your presence and your laughter was
critical in maintaining some semblance of sanity during those long, hot and bothersome
road trips. Thank you.
To Jodi Lennox. Your energy and joie de vivre were a godsend in the dusty Centre. Thanks
for all your dedication, your enthusiasm, and your unparalleled 4WD driving skills.
To all those people with ARF/RHD, and their families, who were involved in the projects
described in this thesis. Thank you for generously giving of your time to be part of this
research and I hope there are real improvements in the delivery of ARF/RHD care that arise
out of these findings.
To all the health staff who assisted in recruitment, data collection and securing access to
relevant information sources. Thank you for all your help.
Thanks also to all the echo sonographers who travelled northern and central Australia to
perform the screenings for our study and to Dr. Bo Remenyi for reporting the
echocardiograms.
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