Table Of ContentINFECTIOUS COMPLICATIONS IN
TRANSPLANT RECIPIENTS
PERSPECTIVES ON CRITICAL CARE
INFECTIOUS DISEASES
Jordi Rella, MD., Series Editor
1. N. Singh and 1M. Aguado (eds.): Infectious Complications in
Transplant Recipients. 2000. ISBN 0-7923-7972-1.
INFECTIOUS COMPLICATIONS IN
TRANSPLANT RECIPIENTS
edited by
Nina Singh, M.D.
Infectious Diseases Section
Veterans Affairs Medical Center
and University of Pittsburgh,
Thomas E. Starzl Transplantation Institute
Pittsburgh, Pennsylvania, U.S.A.
and
Jose M. Aguado, M.D.
Infectious Diseases Unit
Department of Microbiology
Hospital "12 de Octubre"
Av de Andalucia km 5,400
E-28041 Madrid, SPAIN
1irI..
"
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data
Infectious complications in transplant patients / edited by Nina Singh and Jose M. Aguado.
p. ; cm.--(Perspectives on critica! care infectious diseases; 1)
Inc1udes bibliographical references and index.
ISBN 978-1-4613-5536-6 ISBN 978-1-4615-1403-9 (eBook)
DOI 10.1007/978-1-4615-1403-9
1. Transplantation of organs, tissues, etc.---Complications. 2. Nosocomia! infections. 1.
Singh, Nina. II. Aguado, Jose M. III. Series.
[DNLM: l.Organ Transplantation-adverse effects. 2. Critica! Care. 3.
Infection-etiology. 4. Postoperative Complications. WO 660 1437 2001]
RCI12.14572001
617.9'5-<1c21
()().()64624
Copyright ® 2001 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers. in 2001
Softcover reprint ofthe hardcover Ist edition 2001
Ali rights reserved. No part of this publication may be reproduced, stored in a retrieval
system or transmitted in any form or by any means, mechanical, photo-copying, recording,
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Springer Science+Business Media, LLC.
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The Publisher olfers discounts on this book for course use and bulk purchases.
For further information, send email [email protected].
CONTENTS v
Contributors IX
Introduction
Xl
Jordi Rello
Preface
X1l1
Nina Singh and Jose M. Aguado
1. Criteria for Accepting Donors for Organ
Transplantation with Proven or Suspected Infection
North American Perspective: 1
Francis L. Delmonico
European Perspective: 17
Tomas Pumarola and
Asuncion Moreno y Marino Blanes
2. Community Respiratory Viral Infections: An
Overlooked Cause of Morbidity and Mortality in
Transplant Recipients
North American Perspective: 31
Lisa R. Young and Scott M. Palmer
European Perspective: 57
Nfuia Rabella
3. Advances in Cytomegalovirus Diagnostic Testing
and Their Implications for Management of
Cytomegalovirus Infection in Transplant Recipients
North American Perspective: 75
John A. Zaia and Karen M. Molinder
European Perspective: 93
Paolo Grossi
vi
4. Posttransplant Fever in Critically III Organ
Transplant Recipients
North American Perspective: 113
Nina Singh
European Perspective: 133
Patricia Munoz and Emilio Bouza
5. Approach Towards Infectious Pulmonary
Complications in Lung Transplant Recipients
North American Perspective: 149
Kevin M. Chan
European Perspective: 177
Julian de la Torre-Cisneros
6. Antifungal Prophylaxis and Therapy:
Controversies and Emerging Issues
North American Perspective: 193
Edward A. Dominguez
European Perspective: 211
Jan G. Tollemar
7. Role of Neuroimaging in the Diagnostic Evaluation
of Central Nervous System Lesions and Infections
in Organ Transplant Recipients
North American Perspective: 231
Melanie B. Fukui
European Perspective: 249
Luis C. Pons and Carlos Aguilera
vii
8. Antimicrobial Resistance in Organ Transplant
Recipients
North American Perspective: 265
David L. Paterson
European Perspective: 283
Jim Wade
Index 303
CONTRIBUTORS
Kevin M. Chan David L. Paterson
Department of Medicine Istituto Mediterraneo Per I
Division of Pulmonary and Transplant e Terapie Ad Alta
Critical Care Medicine Ad Alto Specializzazione
Henry Ford Hospital and Health Systems Piazza Sett' angeli 10
2799 Grand Avenue Boulevard 1-90134 Palermo
Detroit, MI 48202 Italy
Luis C. Pons
Francis L. Delmonico Carlos Aguilera
New England Organ Bank Institut de Diagnostic per la Imatge
One Gateway Center (Centre Bellvitge)
Newton, MA 02158 Hospital Duran i Reynals
08907 L'Hospitale de Llobregat
Edward A. Dominguez Spain
Departments of Internal Medicine
(Infectious Diseases) Thomas Pumarola
and Surgery (Transplantation) Asuncion Moreno y Marino B1anes
University of Nebraska Medical Center Microbiology Department
Omaha, NE 68198-5400 and Infectious Diseases Department
Hospital Clinic
Melanie B. Fukui Hospital La Fe de Valencia
Department ofNeuroradiology Spain
University of Pittsburgh Medical Center
200 Lothrop St., Room 0132
Pittsburgh, PA 15213
Nuria Rabella
Paolo Grossi Servei de Microbiologia
Istituto di Clinica delle Malattie Infettive Hospital de la Santa Creu I Sant Pau
IRCCS San Matteo Barcelona, 08025, Spain
Universita di Pavia
1-27100 Pavia 27100, Italy Nina Singh
Veterans Affairs Medical Center and
Patricia Mufioz University of Pittsburgh
Emilio Bouza Thomas E. Starzl Transplantation
Servico de Microbiologia Clinica University Drive C
y Enfermedades Infeciosas Pittsburgh, PA 15240
Hospital General Universitario
"Gregorio Marmon" Jan Tollemar
Calle Doctor Esquredo 46 Institute, Huddinge University
1-28700 Madrid Hospital
Spain Dept. of Transplantation Surgery
Karolinska Institute
S-141 86 Stockholm, Sweden
x
Julian de la Torre-Cisneros
Infectious Diseases Section
Reina Sofi University Hospital
14004-Cordoba, Spain
Jim Wade
Dulwich Public Health Laboratory
and Medical Microbiology
Guy's, King's & St. Thomas' Medical School
3rd Floor Pathology Block
Bessemer Road
London SE5 9PJ, United Kingdom
Lisa R. Young
Scott M. Palmer
Departments of Pediatrics and Medicine
Duke University Medical Center
Durham, NC 27710
John A. Zaia
Karen M. Molinder
Beckman Research Institute of
the City of Hope National Medical Center
Department of Virology
Duarte, CA 91010
PERSPECTIVES ON CRITICAL CARE INFECTIOUS DISEASES
An Introduction to the Series
Different models of intensive care medicine have been developed worldwide,
involving surgeons, anesthetists, internists and critical care physicians. All
intensive care departments of hospitals have in common, the highest incidence
of antibiotic consumption, the highest incidence of nosocomial infections and
are grouping community-acquired infections with high degrees of severity.
Intensive care areas of hospitals have the largest number of infection
outbreaks and require differentiated strategies of prevention.
The specific characteristics of the involved population require differentiated
approaches in diagnosis and therapy from those required in classical
infectious problems. The specific pharmacodynamic conditions of patients
requiring mechanical ventilation or continuous renal replacement, require
participation of experts in pharmacology.
The specific objective of this Series is to update therapeutic implications and
discuss controversial topics in specific infectious problems involving
critically ill patients. Each topic will be discussed by two authors
representing the different management perspectives for these controversial
and evolving topics. The Guest Editors, one from North America and one
from Europe, have invited contributors to present the most recent findings and
the specific infectious disease problems and management techniques for
critically ill patients, from their perspective.
Jordi Rello, M.D.
Series Editor
