Infectious Agents Associated Cancers: Epidemiology and Molecular Biology

277 Pages·2017·5.56 MB·English

Advances in Experimental Medicine and Biology 1018
Qiliang Cai
Zhenghong Yuan
Ke Lan Editors
Infectious Agents
Associated
Cancers:
Epidemiology and
Molecular Biology
Advances in Experimental Medicine
and Biology
Volume 1018
Editorial Board
IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA
JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA
RODOLFO PAOLETTI, University of Milan, Milan, Italy
NIMA REZAEI, Tehran University of Medical Sciences Children’s Medical
Center, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Qiliang Cai • Zhenghong Yuan • Ke Lan
Editors
Infectious Agents Associated
Cancers: Epidemiology
and Molecular Biology
Editors
Qiliang Cai Zhenghong Yuan
Key Laboratory of Medical Molecular Key Laboratory of Medical Molecular
Virology (Ministries of Education and Virology (Ministries of Education and
Health), School of Basic Medical Science Health), School of Basic Medical Science
Fudan University Fudan University
Shanghai, People’s Republic of China Shanghai, People’s Republic of China
Ke Lan
State Key Laboratory of Virology, College
of Life Science
Wuhan University
Wuhan, People’s Republic of China
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-981-10-5764-9 ISBN 978-981-10-5765-6 (eBook)
DOI 10.1007/978-981-10-5765-6
Library of Congress Control Number: 2017954956
© Springer Nature Singapore Pte Ltd. 2017
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Preface
Recent advances in the fields of molecular biology and epidemiology have led to
significant development of studying revelations between infectious agents and
cancer, and provide valuable insights into the molecular basis of carcinogenesis.
Since the first oncogenic virus was discovered by Rous in 1911, many infectious
agents including viruses, bacteria, and parasites are known to associate with about one-
fifth of all human cancers worldwide. Their impact on global health is significant.
Despite that the link between cancer and microbe infection has been recognized
in chickens over ten decades ago, the mechanistic basis for cell transformation
became clearer until 1970. The discoveries of oncogenes/proto-oncogenes and
tumor suppressors, as well as insights into cell growth factors, cell cycle regulation,
checkpoints, and their operative protein factors, further promoted the understanding
of infectious agents-associated cancers. Today in 2017, although close association
between viruses and cancer has been established only in seven human viruses (HBV,
HCV, HPV, HTLV, EBV, KSHV, and MCV), other infectious microbes including
HIV, bacteria (H. pylori), parasites (blood flukes/liver flukes), and prions as pre-
sented in many of the chapters in the book illustrate a potential association with a
variety of human cancers. The interplay between microbes and various microenvi-
ronment factors, including stress, inflammation, and deregulation of immune
responses, is currently a hot topic in the field of microbe-related cancer.
A few important scientific concepts detailed in the various chapters include the
animal tumor models, the coinfection of different microbes, the interplay between
microbe and microenvironmental stress, the multistepped process for cell transfor-
mation caused by infectious microbe, and the common and various mechanisms
used by different types of infectious microbes. From such mechanistic and transla-
tional research, we hope that safe and more effective therapeutic drugs or vaccines
against specific cancers will ensue in the future.
This book emerged from a desire to provide an up-to-date progress of human
cancers and their infectious causes. The editors have made great efforts to bring
together teams of expert authors from all aspects of infectious microbes associated
with cancer in this book. As tumor virologists, they have personally witnessed many
pivotal advances in infectious causes of human cancers. It is therefore appropriate
v
vi Preface
for them and all authors to review current and past exciting discoveries on human
infectious oncology, to share with a larger audience, particularly for colleagues and
students. To make the list of infectious agents complete, this book includes not only
viruses but also bacteria, parasites, and prions. However, the emphasis is on viruses,
as viruses have more complex interactions with hosts, and new breakthroughs in
oncovirology are to be expected.
I believe this book will help the readers to better understand the pathogenesis of
human cancers, particularly those that are associated with infectious microbes, and
assist in the development of new and more effective strategies toward prevention
and treatment of cancer in the future.
Key Laboratory of Medical Molecular Virology Yumei Wen
(Ministries of Education and Health)
School of Basic Medical Science
Fudan University
Shanghai, People’s Republic of China
Contents
1 Overview of Infectious Causes of Human Cancers .............................. 1
Qiliang Cai and Zhenghong Yuan
2 Hepatitis B Virus-Associated Hepatocellular Carcinoma ................... 11
Youhua Xie
3 Human Papillomavirus-Related Cancers ............................................. 23
Yanyun Li and Congjian Xu
4 Merkel Cell Polyomavirus: A New DNA Virus Associated
with Human Cancer ................................................................................ 35
Margo MacDonald and Jianxin You
5 Current Progress in EBV-Associated B-Cell Lymphomas .................. 57
Yonggang Pei, Alexandria E. Lewis, and Erle S. Robertson
6 EBV Infection and Glucose Metabolism
in Nasopharyngeal Carcinoma .............................................................. 75
Jun Zhang, Lin Jia, Chi Man Tsang, and Sai Wah Tsao
7 Kaposi’s Sarcoma-Associated Herpesvirus:
Epidemiology and Molecular Biology ................................................... 91
Shasha Li, Lei Bai, Jiazhen Dong, Rui Sun, and Ke Lan
8 Hepatitis C Virus-Associated Cancers .................................................. 129
Zhigang Yi and Zhenghong Yuan
9 Human T-Cell Leukemia Virus Type 1 Infection
and Adult T-Cell Leukemia .................................................................... 147
Chi-Ping Chan, Kin-Hang Kok, and Dong-Yan Jin
10 Malignancies in HIV-Infected and AIDS Patients ............................... 167
Yongjia Ji and Hongzhou Lu
11 Bacterial Infection and Associated Cancers ......................................... 181
Caixia Zhu, Yuyan Wang, Cankun Cai, and Qiliang Cai
vii
viii Contents
12 Parasite-Associated Cancers (Blood Flukes/Liver Flukes) ................. 193
Meng Feng and Xunjia Cheng
13 Prion Protein Family Contributes to Tumorigenesis
via Multiple Pathways ............................................................................ 207
Xiaowen Yang, Zhijun Cheng, Lihua Zhang, Guiru Wu,
Run Shi, Zhenxing Gao, and Chaoyang Li
14 Murine Gammaherpesvirus 68: A Small Animal Model
for Gammaherpesvirus- Associated Diseases ........................................ 225
Sihan Dong, J. Craig Forrest, and Xiaozhen Liang
15 Infection of KSHV and Interaction with HIV:
The Bad Romance ................................................................................... 237
Jie Qin and Chun Lu
16 Interplay Between Microenvironmental Abnormalities
and Infectious Agents in Tumorigenesis ................................................ 253
Qing Zhu, Feng Gu, Caixia Zhu, Yuyan Wang, Fang Wei,
and Qiliang Cai
Contributors
Lei Bai Key Laboratory of Molecular Virology and Immunology, Institute Pasteur
of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of China
Cankun  Cai Key Laboratory of Medical Molecular Virology (Ministries of
Education and Health), School of Basic Medical Sciences, Fudan University,
Shanghai, People’s Republic of China
Qiliang  Cai Key Laboratory of Medical Molecular Virology (Ministries of
Education and Health), School of Basic Medical Science, Fudan University,
Shanghai, People’s Republic of China
Chi-Ping Chan School of Biomedical Sciences, The University of Hong Kong,
Pokfulam, Hong Kong
Xunjia Cheng Department of Medical Microbiology and Parasitology, Institute
of Biomedical Sciences, School of Basic Medical Sciences, Fudan University,
Shanghai, People’s Republic of China
Zhijun  Cheng Department of the First Abdominal Surgery, Jiangxi Tumor
Hospital, Nanchang, People’s Republic of China
Jiazhen Dong Key Laboratory of Molecular Virology and Immunology, Institute
Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of
China
Sihan  Dong Key Laboratory of Molecular Virology & Immunology, Institut
Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People’s Republic of
China
Meng Feng Department of Medical Microbiology and Parasitology, Institute of
Biomedical Sciences, School of Basic Medical Sciences, Fudan University,
Shanghai, People’s Republic of China
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