Immunology and Blood Transfusion: Proceedings of the Seventeenth International Symposium on Blood Transfusion, Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe

294 Pages·1993·15.57 MB·English

by  E. Vellenga (auth.)

IMMUNOLOGY AND BLOOD TRANSFUSION
DEVELOPMENTS IN HEMATOLOGY AND IMMUNOLOGY
Volume 28
The titles published in this series are listed at the end of this volume.
Immunology and
Blood Transfusion
Proceedings of the Seventeenth International Symposium on Blood Transfusion,
Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe
edited by
C. Th. SMIT SIBINGA and P. C. DAS
Red Cross Blood Bank Groningen-Drenthe, The Netherlands
and
T. H. THE
Professor of Clinical Immunology,
University of Groningen,
The Netherlands
SPRINGER SCIENCE+BUSINESS MEDIA, B.V.
Library of Congress Cataloging-in-Publication Data
Immunology and blood transfusion / edited by C.Th. Smit Sibinga and
P.C. Das and T.H. The.
p. cm.
Includes index.
ISBN 978-1-4613-6352-1 ISBN 978-1-4615-3094-7 (eBook)
DOI 10.1007/978-1-4615-3094-7
1. Blood—Transfusion—Congresses. 2. Immunohemato1ogy-
-Congresses. I. Smit Sibinga, C. Th. II. Das, P. C. III. The, T.
H.
[DNLM: 1. Blood Transfusion—congresses. 2. Blood Cells-
-immunology—congresses. 3. Blood Groups—immunology—congresses.
W1 DE997VZK v. 28 1993 / WB 356 335 1993]
RM171.I455 1993
615' .39—dc20
DNLM/DLC
for Library of Congress 93-5012
ISBN 978-1-4613-6352-1
Printed on acid-free paper
All Rights Reserved
© 1993 Springer Science+Business Media Dordrecht
Originally published by Kluwer Academic Publishers in 1993
Softcover reprint of the hardcover 1st edition 1993
No part of the material protected by this copyright notice may be reproduced or
utilized in any form or by any means, electronic or mechanical,
including photocopying, recording or by any information storage and
retrieval system, without written permission from the copyright owner.
Baxter
Acknowledgement
Thispublicationhas beenmadepossiblethroughth~ supportofBaxter,whichis
gratefullyacknowledged.
VII
CONTENTS
ModeratorsandSpeakers XI
Foreword 'xIII
I. PrinciplesandFundamentals
CytokinesandCellMediatedImmunology 3
W.H.A. Dokter
Transfusion-inducedImmuneTolerance .1l
H.T. Meryman
PotentialInvolvementofFreeRadicalReactionsinInactivatingAntigen
PresentingCellsbyUltraviolet-B Irradiation 2l
T.A.Takahashi
AlloimmunizationandPlateletTransfusionRefractoriness .37
A. Brand
Graft-versus-hostDisease 45
J.Jansen
Anti-idiotypicRegulationoftheAlloimmuneResponseinPatients
TransfusedwithPlateletConcentrates : 57
lW. Semple
Discussion 65
II. ProcessingAspects
OptionsforPreventionofTCellAlloactivationbyBloodTransfusions 77
F.H.J.Claas
UseofMonoclonalAntibodiesforImmunePurginginBoneMarrow
Transplantation 85
E.Racadot
VIII
ReductionoftheImmunogenicCapacityofBloodComponentsfor
thePreventionofAlloimmunizationtoWhiteCells 99
P.Rebulla
TheEffectofPlateletsinRedCellConcentratesontheLeukocyte
DepletionCapacityofLeukocyteDepletionFilters .109
I. Steneker
LeukocyteDepletionofRedCellPreparations: FourthFilterGeneration
Leadsto410gReduction. HowFarCan/ShouldWeGo? .121
E.Richter
ImmuneTargetingofT-lymphocytes .129
L.deLeij
HumoralFunctionsofImmunoglobulin: RelationshiptoPurification
TechnologyofIntravenousImmunoglobulin .137
P.L.Yap
ImmuneAdsorptionChromatographyforProteinPurification 151
J.P. Tharakan
Discussion .161
III. LaboratoryAspects
ImmunologicalPrinciplesinRoutineQualityControlImmunocharacteristics
andFunctionTests .173
J.G. Huisman
TheEmergingRoleofMHCMoleculesasSignalTransducingReceptors.....187
T.A. Chatila
FlowCytometryinTransfusionMedicine .195
B.Houwen
NewApplicationsofMolecularDiagnosticsinLaboratoryTestSystems 219
L.R.Overby
Discussion 231
IV.ClinicalImmunologyandBloodTransfusion
ProspectsandLimitationsofAdoptiveImmunotherapyandGene
Therapy 239
M.Cottier-Fox
ClinicalStrategiesforthePreventionofPlateletAlloimmunization 245
EJ.Lee
IX
ImmuneMediatedTransfusionReactions: BystanderImmuneCytolysis-
AFrequentlyOverlookedMechanismofHemolysis? .255
B.A. van Dijk
BloodTransfusionandCancer: ModulationorTolerance? 261
lG.A.Houbiers
BloodProductInducedImmunomodulationandItsClinicalConsequences...275
H.G. Watson
TransfusionMedicineandImmunologicalResearch: Perspectiveforthe
Future 285
T.H. The
Discussion 289
Index 297
XI
MODERATORS AND SPEAKERS
Moderators
T.H.The(chairman) UniversityHospitalGroningen,Groningen, NL
P.c. Das RedCrossBloodBankGroningen-Drenthe,
Groningen,NL
L.deLeij - UniversityHospitalGroningen,Groningen,NL
H.T. Meryman - JeromeH. HollandLaboratory,Rockville, MD, USA
L.c. Overby Alamo,CA,USA
P.Rebulla BloodTransfusionCentre,Milan,I
C.Th. SrnitSibinga RedCrossBloodBankGroningen-Drenthe,
Groningen,NL
Speakers
A. Brand RedCrossBloodBankLeiden,Leiden, NL
T.Chatila HarvardMedicalSchool,Boston,MA,USA
F.H.J.Claas - UniversityHospitalLeiden,Leiden, NL
M.Cottier-Fox - NationalInstituteofHealth,Bethesda,MD, USA
B.A. van Dijk BloodTransfusionService,UniversityHospital
Nijmegen,Nijmegen,NL
W.N.Drohan JeromeH. HollandLaboratory,Rockville, MD,USA
J.G.A. Houbiers - RedCrossBloodBankLeiden,Leiden, NL
B.Houwen LornaLindaUniversitySchoolofMedicine,
LornaLinda,CA,USA
H. Huisman CentralLaboratoryoftheNetherlandsRedCross
BloodTransfusionService,Amsterdam,NL
J.Jansen - MethodistHospitalofIndiana,Indianapolis,IN,USA
XII
EJ.Lee - UniversityofMarylandCancerCenter,Baltimore,MD,
USA
E.Racadot - RegionalBloodTransfusionCentre,Besan~on, F
E. Vellenga - UniversityHospitalGroningen,Groningen,NL
H. Watson - RoyalInfirmaryofEdinburgh,Edinburgh, UK
P.L. Yap - Edinburgh& SouthEastScotlandBloodTransfusion
Service,Edinburgh, UK
Prepareddiscussants
E.Richter - InstituteforTransfusionMedicine,Berlin,D
T.Takahashi HokkaidoRedCrossBloodCenter,Sapporo,J
J.W. Semple - BloodBankSt. Michael'sHospital,Toronto,C
I.Steneker - RedCrossBloodBankAmsterdam, Amsterdam, NL