Immunoglobulin Genes

463 Pages·1995·25.4 MB·English

by  T. Honjo

Immunoglobulin Genes
Second edition
Immunoglobulin Genes
Second edition
Dedicated to the memory of Georges Kohler
Immunoglobulin Genes
Second edition
Edited by
T. Honjo
Kyoto University, Japan
F. W. AIt
Howard Hughes Medical Institute Research Laboratories,
The Children's Hospital, Boston
ACADEMIC PRESS
Harcourt Brace & Company, Publishers L
London, San Diego, New York, Boston, Sydney, Tokyo, Toronto
ACADEMIC PRESS LIMITED
24-28 Oval Road
LONDON NW1 7DX, UK
U. S. Edition Published by
ACADEMIC PRESS INC.
San Diego, CA 92101, USA
This book is printed on acid-free paper
Copyright (cid:14)9 1995 ACADEMIC PRESS LIMITED
All rights reserved
B lympohocyte tolerance in the mouse, pages 365-378, and Immunoglobulin variable region gene
segments in human autoantibodies, pages 379-396, are US government works in the public domain and
not subject to copyright.
No part of this book may be reproduced or transmitted in any form or by any means,
electronic or mechanical including photocopying, recording, or any information storage
and retrieval system without permission in writing from the publisher
A catalogue record for this book is available from the British Library
ISBN 0 12 053640 4
Typeset by Phoenix Photosetting, Chatham
Printed and bound by Hartnolls Ltd, Bodmin, Cornwall
Contents
Contributors vii
Foreword xi
Preface to first edition xv
Preface to second edition xvii
PART I: B CELLS
1 B-cell differentiation in humans
P D Burrows, H W Schroeder Jr and M D Cooper
2 The role of B cell and pre-B-cell receptors in
development and growth control of the B-lymphocyte
cell lineage 33
F Melchcrs
3 The maturation of the antibody response 57
C Milstein and C Rada
4 Development of B-cell subsets 83
S M Wells, A M Stall, A B Kantor and L A Herzenberg
5 Regulation of B-cell differentiation by stromal cells 103
E A Faust, D C Saffran and O N Witte
6 Antigen receptors on B lymphocytes 129
M Reth
PART II: ORGANIZATION AND REARRANGEMENT OF
IMMUNOGLOBULIN GENES
7 Immunoglobulin heavy chain loci of mouse and human 145
T Honjo and F Matsuda
8 The human immunoglobulin ~= genes 173
H G Zachau
9 Immunoglobulin ~ genes 193
E Selsing and L E Daitch
vi Contents
10 The variable region gene assembly mechanism 205
A Okada and F WAlt
11 Regulation of class switch recombination of the
immunoglobulin heavy chain genes 235
J Zhang, F Alt and T Honjo
12 Generation of diversity by post-rearrangement
diversification mechanisms: the chicken and the
sheep antibody repertoires 267
J-C Weill and C-A. Reynaud
13 Immunoglobulin heavy chain genes of rabbit 289
K L Knight and C Tunyaplin
14 The structure and organization of immunoglobulin
genes in lower vertebrates 315
J P Rast, M K Anderson and G W Litman
PART III" IMMUNOGLOBULIN GENE EXPRESSION
15 Ig gene expression and regulation in Ig transgenic mice 345
U Storb
16 B-lymphocyte tolerance in the mouse 365
D Nemazee
17 Immunoglobulin variable region gene segments in
human autoantibodies 379
K N Potter and J D Capra
18 Regulation of immunoglobulin gene transcription 397
K Calame and S Ghosh
Index 423
Contributors
FW AIt
Howard Hughes Medical Institute Research Laboratories, The Children's
Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
MK Anderson
Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street
South, St Petersburg, FL 33701-4899, USA
PD Burrows
Division of Developmental and Clinical Immunology, Departments of Micro-
biology, Medicine and Pediatrics, University of Alabama at Birmingham, 263
Wallace Tumor Institute, UAB Station, Birmingham, AL, USA
K Calame
Columbia University College of Physicians and Surgeons, Department of
Microbiology, 701 West 168th Street, New York, NY 10032-2704, USA
JD Capra
Southwestern Medical School, Department of Microbiology, 5323 Harry
Hines Boulevard, Dallas, TX 75235, USA
MD Cooper
Howard Hughes Medical Institute, Department of Pediatrics and
Microbiology, University of Alabama at Birmingham, 263 Wallace Tumor
Institute, UAB Station, Birmingham, AL 35294, USA
LE Daitch
Tufts University School of Medicine, Department of Pathology, 136 Harrison
Avenue, Boston, MA 02111, USA
EA Faust
Howard Hughes Medical Institute Research Laboratories, University of
California, Los Angeles, 5-748 MacDonald Building, 10833 Le Conte
A venue, Los Angeles, CA 90024-1662, USA
S Ghosh
Howard Hughes Medical Institute, Yale University, 295 Congress Avenue,
154 BCMM, New Haven, CT 06510, USA
LA Herzenberg
Stanford University School of Medicine, Department of Genetics, Immuno-
genetics and Ceil Sorting Laboratory, Stanford, CA 94305-1662, USA
viii Contributors
T Honjo
Faculty of Medicine, Department of Medical Chemistry, Kyoto University,
Yoshida, Sakyo-ku, Kyoto 606, JAPAN
AB Kantor
Department of Microbiology, College of Physicians & Surgeons, Columbia
University, New York, NY, USA
KL Knight
Loyola University Chicago, Stritch School of Medicine, Department of Micro-
biology and Immunology, 2160 South First Avenue, Maywood, IL 60153,
USA
GW Litman
Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street
South, St Petersburg, FL 33701-4899, USA
F Matsuda
Kyoto University, Center for Molecular Biology and Genetics, Shogo-in
Kawaharacho 53, Sakyo-ku, Kyoto 606, JAPAN
F Melchers
Basel Institute for Immunology, Grenzacherstrasse 487, Posffach, CH-4005
Basel, SWITZERLAND
C Milstein
Laboratory of Molecular Biology, Medical Research Council, Hills Road,
Cambridge CB2 2QH, UK
D Nemazee
National Jewish Center, Department of Pediatrics, 1400 Jackson Street,
Denver, CO 80206, USA
A Okada
Howard Hughes Medical Institute Research Laboratories, The Children's
Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
KN Potter
Southwestern Medical School, Department of Microbiology, 5323 Harry
Hines Boulevard, Dallas, TX 75235, USA
C Rada
Laboratory of Molecular Biology, Medical Research Council, Hills Road,
Cambridge CB2 2QH, UK
JP Rast
Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street
South, St Petersburg, FL 33701-4899, USA
M Reth
MPI fur Immunbiologie, Posffach 79011, D-7800 Freiburg, GERMANY
Contributors ix
C-A Reynaud
Institut Necker, Facult6 de Medicine, Necker-Enfants Malades, 156 rue de
Vaugirard, 75730 Paris cedex 15, FRANCE
DC Saffran
Howard Hughes Medical Institute Research Laboratories, University of
California, Los Angeles, 5-748 MacDonald Building, 10833 Le Conte
A venue, Los Angeles, CA 90024-1662, USA
HW Schroeder, Jr
Division of Developmental and Clinical Immunology, Departments of Micro-
biology, Medicine and Pediatrics, University of Alabama at Birmingham, 263
Wallace Tumor Institute, UAB Station, Birmingham, AL, USA
E Selsing
Tufts University School of Medicine, Department of Pathology, 136 Harrison
A venue, Boston, MA 02111, USA
AM Stall
Department of Microbiology, College of Physicians & Surgeons, Columbia
University, New York, NY, USA
U Storb
University of Chicago, Department of Molecular Genetics and Cell Biology,
920 East 58th Street, Chicago, IL 60637, USA
C Tunyaplin
Loyola University Chicago, Stritch School of Medicine, Department of Micro-
biology and Immunology, 2160 South First Avenue, Maywood, IL 60153,
USA
J-C Weill
Institut Necker, Facult6 de Medicine, Necker-Enfants Malades, 156 rue de
Vaugirard, 75730 Paris cedex 15, FRANCE
SM Wells
Department of Microbiology, College of Physicians & Surgeons, Columbia
University, New York, NY, USA
ON Witte
Howard Hughes Medical Institute Research Laboratories, University of
California, Los Angeles, 5-748 MacDonald Buil~'ng, 10833 Le Conte
A venue, Los Angeles, CA 90024-1662, USA
HG Zachau
InstitEit for Physiologische Chemie der Universit~t MEmchen, MEmchen,
Germany.
J Zhang :'
The Rockefeller University, 1230 York Avenue, Box 167, New York, NY
10021, USA.