Table Of ContentO C L
OXFORD CARDIOLOGY LIBRARY
Hypertension
O C L
OXFORD CARDIOLOGY LIBRARY
Hypertension
THIRD EDITION
Edited by
Sunil K. Nadar
Senior Consultant Cardiologist, Sultan Qaboos University
Hospital, Muscat, Oman
Gregory Y. H. Lip
Price-Evans Chair of Cardiovascular Medicine, University of
Liverpool, UK; National Institute for Health Research (NIHR)
Senior Investigator; Consultant Cardiologist (Hon), Liverpool
Heart & Chest Hospital NHS Trust, Liverpool, UK
Great Clarendon Street, Oxford, OX2 6DP,
United Kingdom
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First Edition published in 2009
Second Edition published in 2015
Third Edition published in 2023
Impression: 1
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British Library Cataloguing in Publication Data
Data available
Library of Congress Control Number: 2022941530
ISBN 978–0–19–887067–8
DOI: 10.1093/ med/ 9780198870678.001.0001
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drug dosages in this book are correct. Readers must therefore always check
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Acknowledgement to contributors
of previous editions
The editors would like to thank the authors of the first and second editions whose
excellent text and contributions have been continued into this third edition:
Mehmood Sadiq Butt
Girish Dwivedi
Shridar Dwivedi
Deepak Goyal
Pravin Jha
V. J. Karthikeyan
Mohammed Khan
Ayush Khurana
John Kurien
Rajesh Nambiar
Vasudevan A. Raghavan
Kully Sandhu
Jaspal Taggar
Viji Samuel Thomson
Timothy Watson
Shamil Yusuf
Contents
Contributors xi
List of symbols and abbreviations xv
Part 1 Epidemiology, pathogenesis, and diagnosis
1 Epidemiology of hypertension 3
Sunil K. Nadar and Stephanie L. Harrison
2 Pathophysiology of hypertension 11
Sheon Mary, Giacomo Rossitto, and Christian Delles
3 Secondary hypertension 21
Gurbhej Singh and Gurpreet Singh Wander
4 Diagnosis and investigation of hypertension 31
Martin Wolley and Michael Stowasser
Part 2 Complications of hypertension
5 Hypertension: a cardiovascular risk factor 41
Thomas Salmon, James Hatherley, and Rajiv Sankaranarayan
6 Left ventricular hypertrophy 49
Yuichiro Yano and Sunil K. Nadar
7 Atrial fibrillation and hypertension 59
Mohammed Najeeb Al- Rawahi
8 The brain in hypertension 67
Arunodaya R. Gujjar
9 The kidneys in hypertension 77
Sarah Ahmad and Jordana B. Cohen
10 The eye in hypertension 85
Peck Lin Lip
viii • contents
Part 3 Management of hypertension
11 Overview of guidelines on management of hypertension 95
Gregory Y. H. Lip and Sunil K. Nadar
12 Hypertension and cardiovascular risk management 107
James P. Sheppard and Sunil K. Nadar
13 Non- pharmacological management of hypertension 115
Benjamin J. R. Buckley and Stephanie J. Finnie
14 Diuretics in hypertension 125
Harsh Goel and Ashish Kumar
15 Beta blockers in hypertension 137
Hatim Al- Lawati
16 Calcium channel blockers in hypertension 147
Stephanie Lip and Sandosh Padmanabhan
17 Blockers of the renin– angiotensin– aldosterone system in hypertension 157
Ify R. Mordi and Chim C. Lang
18 Other antihypertensive agents 167
Shankar Patil, Muzahir Tayebjee, and Sunil K. Nadar
19 Renal denervation 177
Vikas Kapil
20 Improving medication adherence in hypertension 185
Hassan Al-R iyami and Deirdre A. Lane
Part 4 Special conditions
21 Hypertension in pregnancy: physiopathological, preventive,
therapeutic, and long- term considerations 197
Gloria Valdés
22 Hypertensive emergencies 213
Alena Shantsila
contents • ix
23 Treatment of the older adult 223
Asangaedem Akpan
24 Diagnosis and management of resistant hypertension 229
Fang- Fei Wei, Chen Liu, and Jan A. Staessen
25 Hypertension in patients with diabetes mellitus 239
Daniel J. Cuthbertson
Index 247
