Hormone Replacement Therapy and Osteoporosis

198 Pages·2000·3.62 MB·English

by  H. P. G. Schneider (auth.), J. Kato, H. Minaguchi, Y. Nishino (eds.)

Ernst Schering Research Foundation Workshop
Supplement 4
Hormone Replacement Therapy and Osteoporosis
Springer-Verlag Berlin Heidelberg GmbH
Ernst Schering Research Foundation Workshop
Supplement 4
Hormone
Replacement Therapy
and Osteoporosis
J. Kato, H. Minaguchi, Y. Nishino
Editors
With 74 Figures and 15 Tables
Springer
Series Editors: G. Stock and M. Lessl
ISSN 0947-6075
ISBN 978-3-662-04023-2
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Schering-Forschungsgesellschaft <Berlin>:
[Ernst Schering Research Foundation Workshop / Supplement].
Ernst Schering Research Foundation Workshop. Supplement. -1-...
Erscheint unregelmaBig. -Bibliographische Deskription nach 5 (1999)
Reihe Supplemnt zu: Schering-Forschungsgesellschaft <Berlin>: Ernst Schering Re
search Foundation Workshop
4. Hormone replacement therapy and osteoporosis. -2000
Hormone replacement therapy and osteoporosis / Ernst Schering Research Foundation. J.
Kato ... ed.
(Ernst Schering Research Foundation Workshop: Supplement; 4)
ISBN 978-3-662-04023-2 ISBN 978-3-662-04021-8 (eBook)
DOI 10.1007/978-3-662-04021-8
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Preface
This book presents the Proceedings of the International Joint Work
shop of Nihon Schering and the Ernst Schering Research Foundation
on "Hormone Replacement Therapy," which took place on 9-11 No
vember 1998 in Osaka, Japan.
In cases of advanced age, hormone replacement therapy (HRT) is
becoming increasingly important both for women's health and for the
doctors in our profession. In-depth understanding of HRT is needed.
The organizers and editors intended the workshop to consist of six ses
sions, as follows:
1. Overview of HRT
2. Basic aspects of steroid hormones
3. HRT and the brain
4. The influence of HRT on lipids and the cardiovascular system
5. HRT and bone
6. HRT - its effects and risks
It was also intended that each session should be a combination of basic
and clinical lectures.
Without a basic understanding of sex steroid hormones in targets
such as the reproductive organs, including the breast and uterus, and
the brain, as well as non-targets (bone), possibilities for improving
treatment would not emerge. This we firmly believe.
The front-runners from at home and abroad in this field joined the
workshop to provide the most advanced knowledge and state-of-the-art
information, basic and clinical, regarding HRT.
VI Preface
The participants in the workshop
Active and useful discussions and comments also emerged during
the course of the workshop.
funza Kata, Hiroshi Minaguchi, Yukishige Nishina
Table of Contents
General Aspects of Worldwide HRT Use
HP.G. Schneider ........ .
2 General Aspects of HRT in Japan
T. Aono, K. Azuma, M. Irahara .. 29
3 Recent Advances in Steroid Receptor Research:
Focusing on Estrogen Receptors
M. Muramatsu, S. Ogawa, T. Watanabe, K. Ikeda, H Hiroi,
A. Orimo, S. Inoue . . . . . . . . . . . . . . . .. 43
4 Global Effects of Estrogens
in the Adult Central Nervous System
D.W. Pfaff . ............. . 63
5 HRT and Brain Function - Clinical Aspects
T. Ohkura, K. Isse, K. Tanaka, K. Akazawa, M. Hamamoto,
N. Iwasaki . . . . . . . . . . . . . . . . . . . . . . . . . .. 75
6 Hormone Replacement Therapy and Lipids
H Honjo, M. Urabe, K. Tanaka, T. Kashiwagi, T. Okubo,
H Tsuchiya, K. Iwasa, N. Kikuchi, T. Yamamoto 99
7 HRT and the Vascular System-
Direct Action of Estrogen on Vascular Smooth Muscle Cells
M. Nozaki . . . . . . . . . . . . . . . . . . . . . . . . . . . 115
VIII Table of Contents
8 The Place of Estriol Add-Back Therapy in Women Treated
with GnRH Agonist, with Reference to Bone Protection
T. Yano, A. Kikuchi, H. Matsumi, Y. Wang, H. Nakayama,
Y. Taketani ......................... 127
9 Hypoestrogenic Bone Loss and HRT: The Predictive Value
of Biochemical Markers of Bone Turnover
H. Minaguchi, M.G. Zhang, M. Taga ............ 143
10 HRT and Climacteric Symptoms:
Characteristics in Japanese Women
T. Aso ............... . 165
11 The Mechanisms of Bone Loss due to Estrogen Deficiency:
Possible Role of Increased B-Lymphopoiesis
in Bone Resorption
C. Miyaura .......................... 171
Subject Index ......................................... 185
Previous Volumes Published in this Series .................. 187
List of Editors and Contributors
Editors
J. Kato
Teikyo Heisei Junior College, 6-29-1 Ichiharadai, lchihara-shi,
Chiba, 290-0192, Japan
H. Minaguchi
Minaguchi Hospital, 1-7-7 Minamicho, Kichijoji Musashino-shi,
Tokyo,ISO-0003,Japan
Y. Nishino
Preclinical Development Department, Nihon Schering K.K.,
6-64, Nishimiyahara 2-Chome, Yodogawa-ku, Osaka-shi,
Osaka, 532-0004, Japan
Contributors
K. Akazawa
Dokkyo Medical University, Department of Obstetrics and Gynecology,
Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya-shi,
Saitama, 343-8555, Japan
T. Aono
Tokushima University, School of Medicine,
Department of Obstetrics and Gynecology, 3-18-15 Kuramoto-cho,
Tokushima-shi, Tokushima, 770-8503, Japan
x
List of Editors and Contributors
T. Aso
Tokyo Medical and Dental University, School of Medicine,
Department of Obstetrics and Gynecology, 1-5-45 Yushima, Bunkyo-ku,
Tokyo, 113-0034, Japan
K. Azuma
Tokushima University, School of Medicine,
Department of Obstetrics and Gynecology, 3-18-15, Kuramoto-cho,
Tokushima-shi, Tokushima, 770-8503, Japan
M. Hamamoto
Dokkyo Medical University, Department of Obstetrics and Gynecology,
Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya-shi,
Saitama, 343-8555, Japan
H. Hirai
Saitama Medical School, Department of Biochemistry, 38 Morohongo,
Moroyama-machi, Irima-gun, Saitama, 350-0495, Japan
H. Honjo
Kyoto Prefectural University of Medicine,
Department of Obstetrics and Gynecolgy, 465 Kajii-cho, Hirokojiagaru,
Kawaramachidori, Kamigyo-ku, Kyoto, 602-0841, Japan
K. Ikeda
Saitama Medical School, Department of Biochemistry, 38 Morohongo,
Moroyama-machi; lrima-gun, Saitama, 350--0495, Japan
S.Inoue
Saitama Medical School, Department of Biochemistry, 38 Morohongo,
Moroyama-machi, Irima-gun, Saitama, 350--0495, Japan
M.Irahara
Tokushima University, School of Medicine,
Department of Obstetrics and Gynecology, 3-18-15, Kuramoto-cho,
Tokushima-shi, Tokushima, 770-8503, Japan
K. Isse
Dokkyo Medical University, Department of Obstetrics and Gynecology,
Koshigaya Hospital, 2-1-50 Minami-koshigaya, Koshigaya-shi,
Saitama, 343-8555, Japan