Hoffman and Abeloff’s Hematology-Oncology Review

403 Pages·2017·5.968 MB·English

by  Claudine Isaacs, Sanjiv Agarwala, Bruce Cheson, Alice Ma, John Marshall, Naiyer Rizvi

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Hoffman and Abeloff’s
HEMATOLOGY-
ONCOLOGY
REVIEW
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Hoffman and Abeloff’s
HEMATOLOGY-
ONCOLOGY
REVIEW
Editor
Claudine Isaacs, MD Naiyer A. Rizvi, MD
Professor of Medicine and Oncology Director of Thoracic Oncology and
Co-Director, Breast Cancer Program Immunotherapeutics
Medical Director, Fisher Center for Hereditary Division of Hematology and Oncology
Cancer and Clinical Genomics Research Columbia University Medical Center
Georgetown University New York, New York
Washington, District of Columbia
Bruce D. Cheson, MD
Professor of Medicine
Section Editors
Head of Hematology
Sanjiv S. Agarwala, MD Director of Hematology Research
Professor and Chief Lombardi Comprehensive Cancer Center
Department of Oncology and Hematology Georgetown University
St. Luke’s Cancer Center Washington, District of Columbia
Temple University
Bethlehem, Pennsylvania Alice D. Ma, MD
Professor of Medicine
John L. Marshall, MD Hemophilia and Thrombosis Center
Chief, Division of Hematology/Oncology University of North Carolina – Chapel Hill
MedStar Georgetown University Hospital Chapel Hill, North Carolina
Associate Director, Clinical Research
Lombardi Comprehensive Cancer Center
Georgetown University
Washington, District of Columbia
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
HOFFMAN AND ABELOFF’S HEMATOLOGY-ONCOLOGY REVIEW ISBN: 978-0-323-42975-7
Copyright © 2018 by Elsevier, Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic
or mechanical, including photocopying, recording, or any information storage and retrieval system,
without permission in writing from the publisher. Details on how to seek permission, further infor-
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www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the
Publisher (other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our understanding, changes in research methods, professional practices, or medical treat-
ment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evalu-
ating and using any information, methods, compounds, or experiments described herein. In using
such information or methods they should be mindful of their own safety and the safety of others,
including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the
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tions, or ideas contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Names: Isaacs, Claudine, editor.
Title: Hoffman and Abeloff’s hematology-oncology review / editor, Claudine
Isaacs ; section editors, Sanjiv Agarwala, John Marshall, Naiyer Rizvi,
Bruce Cheson, Alice Ma.
Other titles: Hematology-oncology review
Description: First edition. | Philadelphia, PA : Elsevier, [2018] | Includes
bibliographical references and index.
Identifiers: LCCN 2017029350 | ISBN 9780323429757 (pbk. : alk. paper)
Subjects: | MESH: Neoplasms | Hematologic Diseases | Examination Questions
Classification: LCC RC266.5 | NLM QZ 18.2 | DDC 616.99/40076--dc23 LC
record available at https://lccn.loc.gov/2017029350
Content Strategist: Kayla Wolfe
Content Development Specialist: Lisa Barnes
Publishing Services Manager: Patricia Tannian
Senior Project Manager: Cindy Thoms
Book Designer: Ashley Miner
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To all of our colleagues, contributors, trainees,
and patients who have taught us so much
The Editors
The authors would like to thank Lisa Barnes and Kayla Wolfe
for their valuable contributions in publishing this book.
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CONTRIBUTORS
Ghassan K. Abou-Alfa, MD Corey Cutler, MD, MPH, FRCP(C)
Assistant Attending Physician Associate Professor of Medicine
Memorial Sloan Kettering Cancer Center Harvard Medical School
Assistant Professor Senior Physician
Weill Medical College at Cornell University Department of Medical Oncology
New York, New York Dana-Farber Cancer Institute
Boston, Massachusetts
Sanjiv S. Agarwala, MD
Professor and Chief Don S. Dizon, MD
Department of Oncology and Hematology Head of Women’s Cancers
St. Luke’s Cancer Center Lifespan Cancer Institute
Temple University Director of Medical Oncology
Bethlehem, Pennsylvania Rhode Island Hospital
Associate Professor of Medicine
Jeanny B. Aragon-Ching, MD, FACP Warren Alpert Medical School of Brown University
Clinical Program Director of Genitourinary Cancers Providence, Rhode Island
Inova Schar Cancer Institute
Associate Professor of Medicine Nathan Fowler, MD
Virginia Commonwealth University Associate Professor of Medicine
Fairfax, Virginia Co-Director, Clinical and Translational Research
Lead, New Drug Development Program
Nilofer Azad, MD Department of Lymphoma/Myeloma
Associate Professor University of Texas – MD Anderson Cancer Center
Department of Gastrointestinal Oncology Houston, Texas
Johns Hopkins Medical Institutions
Baltimore, Maryland Geoffrey Gibney, MD
Co-Leader Melanoma Program
Julie Brahmer, MD, MSc Lombardi Comprehensive Cancer Center
Associate Professor of Oncology MedStar Georgetown University Hospital
Department of Medical Oncology Washington, District of Columbia
Johns Hopkins Kimmel Cancer Center
Baltimore, Maryland Ann Gramza, MD
Medical Oncology Director of Head and Neck Cancer
Susana Campos, MD, MPH Lombardi Comprehensive Cancer Center
Medical Oncology Medical Oncologist
Dana-Farber Cancer Institute Head and Neck and Endocrine Cancers
Assistant Professor of Medicine Washington Cancer Institute
Harvard Medical School MedStar Washington Hospital Center
Boston, Massachusetts Washington, District of Columbia
Edward Chu, MD, MMS, BS Peter Hammerman, MD, PhD
Professor and Chief Dana-Farber Cancer Institute
Division of Hematology-Oncology Boston, Massachusetts
University of Pittsburgh School of Medicine
Deputy Director
University of Pittsburgh Cancer Institute
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
vii
viii Contributors
Christine L. Hann, MD, PhD Christopher H. Lieu, MD
Assistant Professor Assistant Professor
Department of Oncology Division of Medical Oncology
Johns Hopkins University School of Medicine University of Colorado Denver
Baltimore, Maryland Denver, Colorado
Steven Horwitz, MD Caio Max Rocha Lima, MD
Medical Oncologist Associate Director for Translational Research
Memorial Sloan Kettering Cancer Center Gibbs Cancer Center and Research Institute,
New York, New York Spartanburg, South Carolina
David Ilson, MD, PhD Filipa Lynce, MD
Attending physician Assistant Professor
Gastrointestinal Oncology Service Department of Medicine
Department of Medicine Lombardi Comprehensive Cancer Center
Memorial Sloan Kettering Cancer Center MedStar Georgetown University Hospital
New York, New York Washington, District of Columbia
Fabio M. Iwamoto, MD Alice D. Ma, MD
Columbia University Medical Center Professor of Medicine
New York, New York Hemophilia and Thrombosis Center
University of North Carolina – Chapel Hill
Marc J. Kahn, MD, MBA Chapel Hill, North Carolina
Peterman-Prosser Professor, Sr. Associate Dean
Department of Medicine Ravi A. Madan, MD
Section of Hematology/Medical Oncology Clinical Director, Genitourinary Malignancies Branch
Tulane University School of Medicine National Cancer Institute Center for Cancer Research
New Orleans, Louisiana Bethesda, Maryland
Nikhil I. Khushalani, MD Molly Weidner Mandernach, MD, MPH
Vice-Chair and Associate Member Assistant Professor, Hematology/Oncology
Cutaneous Oncology Department of Medicine
H. Lee Moffitt Cancer Center University of Florida
Associate Professor Gainesville, Florida
Department of Oncological Sciences
Morsani College of Medicine Erica Mayer, MD, MPH
University of South Florida Assistant Professor of Medicine
Tampa, Florida Susan F. Smith Center for Women’s Cancers
Dana-Farber Cancer Institute
Ann Steward LaCasce, MD, MMSc Assistant Professor in Internal Medicine
Assistant Professor of Medicine Harvard Medical School
Medical Oncology Boston, Massachusetts
Dana-Farber Cancer Institute
Boston, Massachusetts Jason Meadows, MD
Assistant Attending, Supportive Care Service
Andrew B. Lassman, MS, MD Memorial Sloan Kettering Cancer Center
Chief, Neuro-Oncology Division New York, New York
Department of Neurology
Columbia University Medical Center Ara Metjian, MD
Medical Director Assistant Professor
Clinical Protocol & Data Management Office Division of Hematology
Herbert Irving Comprehensive Cancer Center Department of Medicine
New York, New York Duke University
Durham, North Carolina