High-Potency Sweetener Composition With Antioxidant and

62 Pages·2013·6.21 MB·English

US 20070116838Al
(19) United States
(12) Patent Application Publication (10) Pub. No.: US 2007/0116838 A1
Prakash et al. (43) Pub. Date: May 24, 2007
(54) HIGH-POTENCY SWEETENER Publication Classi?cation
COMPOSITION WITH ANTIOXIDANT AND
COMPOSITIONS SWEETENED THEREWITH (51) Int. Cl.
A23L 1/236 (2006.01)
(75) Inventors: Indra Prakash, Alpharetta, GA (US); (52) Us. or. ............................................................ ..426/548
Grant E. DuBois, Roswell, GA (US)
Correspondence Address: (57) ABSTRACT
SUTHERLAND ASBILL & BRENNAN LLP
999 PEACHTREE STREET, N.E.
The present invention relates generally to functional sweet
ATLANTA, GA 30309 (US)
ener compositions comprising non-caloric or low-caloric
natural and/ or synthetic, high-potency sweeteners and meth
(73) Assignee: The Coca-Cola Company, Atlanta, GA
ods for making and using them. In particular, the present
(Us)
invention relates to different functional sweetener composi
(21) Appl. No.: 11/556,095 tions comprising at least one non-caloric or low-caloric
natural and/or synthetic, high-potency sweetener, at least
(22) Filed: Nov. 2, 2006 one sweet taste improving composition, and at least one
functional ingredient, such as antioxidants. The present
Related US. Application Data invention also relates to functional sweetener compositions
and methods that can improve the tastes of non-caloric or
(60) Provisional application No. 60/ 739,302, ?led on Nov. low-caloric high-potency sweeteners by imparting a more
23, 2005. Provisional application No. 60/739,124, sugar-like taste or characteristic. In particular, the functional
?led on Nov. 23, 2005. Provisional application No. sweetener compositions and methods provide a more sugar
60/805,2l6, ?led on Jun. 19, 2006. Provisional appli like temporal pro?le, including sweetness onset and sweet
cation No. 60/805,209, ?led on Jun. 19, 2006. ness linger, and/or a more sugar-like ?avor pro?le.
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US 2007/0116838 A1 May 24, 2007
HIGH-POTENCY SWEETENER COMPOSITION
WITH ANTIOXIDANT AND COMPOSITIONS -continued
SWEETENED THEREWITH
Functional Food Health Bene?t
RELATED APPLICATION DATA
Fruits, vegetables, and ?ber-containing Reduced risk of cancer
grain products
[0001] The present application claims priority under 35
Diets lOW in dietary fat
USC § 119 to US. Provisional Application No. 60/739, Folate Reduced risk of neural tube
302, entitled “Natural High-Potency Sweetener Composi birth defects
tions With Improved Temporal Pro?le And/Or Flavor Pro Dietary sugar alcohol Reduced risk of dental
?le, Methods For Their Formulations, and Uses,” ?led on caries (cavities)
Nov. 23, 2005; US. Provisional Application No. 60/739,
124, entitled “Synthetic SWeetener Compositions With
[0005] Although not yet approved by the FDA for the
Improved Temporal Pro?le and/or Flavor Pro?le, Methods
purposes of labeling, numerous other functional foods are
for Their Formulation, and Uses,” ?led on Nov. 23, 2005;
believed to provide health bene?ts beyond those listed
US. Provisional Application No. 60/805,209, entitled
“Natural High-Potency Tabletop SWeetener Compositions above, such as reduced in?ammation.
With Improved Temporal and/or Flavor Pro?les, Methods for [0006] Functional ingredients generally are classi?ed into
Their Formulation, and Uses,” ?led on Jun. 19, 2006; and categories such as carotenoids, dietary ?ber: fatty acids,
US. Provisional Application No. 60/805,216, entitled ?avonoids, isothiocyanates, phenols, plant sterols and
“Rebaudioside A Composition and Method for Purifying stanols (phytosterols and phytostanols); polyols; prebiotics/
Rebaudioside A,” ?led on Jun. 19, 2006. These applications probiotics; phytoestrogens; soy protein; sul?des/thiols;
are hereby incorporated by reference in their entirety.
amino acids; proteins; vitamins; and minerals. Functional
ingredients also may be classi?ed based on their health
FIELD OF THE INVENTION
bene?ts, such as cardiovascular, cholesterol-reducing, and
anti-in?ammatory.
[0002] The present invention relates generally to a func
tional sWeetener and orally ingestible compositions contain [0007] Health trends also have promoted an increased use
ing same. of non-caloric high-potency sWeeteners in consumer diets.
Although natural caloric sWeetener compositions, such as
BACKGROUND OF THE INVENTION sucrose, fructose, and glucose, provide the most desirable
[0003] Nutrition usually focuses on the relationship taste to consumers, they are caloric. Numerous natural and
synthetic high-potency sWeeteners are non-caloric; hoWever,
betWeen food and human health from the perspective of
they exhibit sWeet tastes that have different temporal pro
ensuring all essential nutrients are adequately supplied and
?les, maximal responses, ?avor pro?les, mouthfeels, and/or
utiliZed to optimiZe health and Well being. As diseases
adaptation behaviors than that of sugar.
typically related to nutritional de?ciency Were managed,
there has been a recognition that many nutrients have health [0008] For example, the sWeet tastes of natural and syn
bene?ts beyond basic nutrition. Accordingly, functional thetic high-potency sWeeteners are sloWer in onset and
ingredients have been identi?ed as playing a key role in an longer in duration than the sWeet taste produced by sugar
individual’s overall health. and thus change the taste balance of a food composition.
Because of these differences, use of natural and synthetic
[0004] “Functional ingredients” offer potential health ben
high-potency sWeeteners to replace a bulk sWeetener, such
e?ts beyond basic nutrition When incorporated into foods,
as sugar, in a food or beverage, causes an unbalanced
beverages, and other orally ingested products. Such ingre
temporal pro?le and/or ?avor pro?le. In addition to the
dients have been shoWn to help reduce the risk of or manage
difference in temporal pro?le, high-potency sWeeteners gen
a number of health concerns, including cancer, heart and erally exhibit (i) loWer maximal response than sugar, (ii) olf
cardiovascular disease, gastrointestinal health, menopausal
tastes including bitter, metallic, cooling, astringent, licorice
symptoms, osteoporosis, and vision. Since 1993, the United
like taste, etc., and/or (iii) sWeetness Which diminishes on
States Food and Drug Administration (FDA) has approved
iterative tasting. It is Well knoWn to those skilled in the art
numerous health claims for the labeling of food products
of food/beverage formulation that changing the sWeetener in
With information related to the health bene?ts of functional
a composition requires re-balancing of the ?avor and other
food (U .S. Food and Drug Administration, A Food Labeling
taste components (e.g., acidulants). If the taste pro?le of
Guide (2000)).
natural and synthetic high-potency sWeeteners could be
modi?ed to impart speci?c desired taste characteristics to be
more sugar-like, the type and variety of compositions that
may be prepared With that sWeetener Would be expanded
Functional Food Health Bene?t
signi?cantly. Accordingly, it Would be desirable to selec
Potassium Reduced risk of high blood tively modify the taste characteristics of natural and syn
Diets lOW in sodium pressure and stroke thetic high-potency sWeeteners.
Plant sterol and stanol esters Reduced risk of coronary
Soy protein heart disease [0009] It also Would be desirable to improve the taste of
Fruits, vegetables, and grain products that ingestible compositions that include functional ingredients
contain ?ber, particularly soluble ?ber
to promote their use and the resulting health bene?ts.
Diets lOW in dietary saturated fat and
cholesterol SUMMARY OF THE INVENTION
Calcium Reduced risk of
osteoporosis [0010] Generally, this invention addresses the above
described need by providing a functional sWeetener compo
US 2007/0116838 A1 May 24, 2007
sition having improved temporal pro?le and/or ?avor pro?le instance, features illustrated or described as part of one
and a method for improving the temporal pro?le and/or embodiment, can be used on another embodiment to yield a
?avor pro?le of a functional sWeetener composition. In still further embodiment. Thus, it is intended that the present
another particular embodiment, this invention provides a invention cover such modi?cations and variations Within the
functional sWeetened composition comprising a sWeetenable scope of the appended claims and their equivalents.
composition in combination With a functional sWeetener
[0018] Embodiments of this invention include functional
composition having an improved temporal pro?le and/or
sWeetener compositions and functional sWeetened compo
?avor pro?le, and a method for improving the temporal
sitions comprising at least one natural and/or synthetic
pro?le and/or ?avor pro?le of the functional sWeetened
high-potency sWeetener- at least one sWeet taste improving
composition. In particular, this invention improves the tem
composition, and at least one functional ingredient. Also
poral pro?le and/or ?avor pro?le by imparting a more
embodied in this invention are methods for making func
sugar-like temporal pro?le and/or ?avor pro?le. More par
tional sWeetener compositions and functional sWeetened
ticularly, this invention comprises a functional sWeetener
compositions.
composition or a functional sWeetened composition com
prising at least one antioxidant; at least one high-potency I. Functional Ingredients
sWeetener; and at least one sWeet taste improving compo
sition. [0019] In a particular embodiment, a sWeetener composi
tion comprises at least one natural and/or synthetic high
[0011] Objects and advantages of the invention Will be set
potency sWeetener, at least one sWeet-taste improving com
forth in part in the folloWing description, or may be obvious position, and at least one functional ingredient. The
from the description, or may be learned through practice of
functional ingredient desirably comprises at least one anti
the invention. Unless otherWise de?ned, all technical and oxidant.
scienti?c terms and abbreviations used herein have the same
meaning as commonly understood by one of ordinary skill [0020] In the context of biology and physiology, free
in the art to Which this invention pertains. Although methods radicals are natural byproducts of normal oxidative pro
and compositions similar or equivalent to those described cesses in cells. An example of an abundant free radical is
herein can be used in practice of the present invention, nitric oxide, which affects signaling functions in physiologi
suitable methods and compositions are described Without cal processes. Free radicals are highly reactive and unstable
intending that any such methods and compositions limit the because they have unpaired electrons. For example, free
invention herein. radials cause breaks and base changes in DNA chains, Which
can initiate carcinogenesis, or cause peroxidation of poly
BRIEF DESCRIPTION OF THE DRAWINGS unsaturated fatty acid residues, Which can lead to impair
ment of membrane function. In addition, free radicals gen
[0012] FIG. 1 is a poWder x-ray diffraction scan of rebau
erally produce another unstable product, and thus start
dioside A polymorph Form 1 on a plot of the scattering
undesirable chain reactions. For instance free radicals can
intensity versus the scattering angle 20 in accordance With
cause cumulative oxidative damage, Which can result in
an embodiment of this invention.
chronic diseases such as cancer, arteriosclerosis, arthritis,
[0013] FIG. 2 is a poWder x-ray diffraction scan of rebau cataracts, and age-related macular degeneration.
dioside A polymorph Form 2 on a plot of the scattering
[0021] To combat the effects of free radicals and reduce
intensity versus the scattering angle 20 in accordance With
damage to cells and biomolecules, the foods rich in antioxi
an embodiment of this invention.
dants may be consumed. As used herein “antioxidant” refers
[0014] FIG. 3 is a poWder x-ray diffraction scan of rebau to any substance Which inhibits, suppresses, or reduces
dioside A polymorph Form 3A on a plot of the scattering oxidative damage to cells and biomolecules. Without being
intensity versus the scattering angle 20 in accordance With bound by theory, it is believed that antioxidants inhibit,
an embodiment of this invention. suppress, or reduce oxidative damage to cells or biomol
ecules by stabiliZing free radicals before they can cause
[0015] FIG. 4 is a poWder x-ray diffraction scan of rebau
harmful reactions. As such, antioxidants may prevent or
dioside A polymorph Form 3B on a plot of the scattering
postpone the onset of some degenerative diseases.
intensity versus the scattering angle 20 in accordance With
an embodiment of this invention. [0022] Examples of suitable antioxidants for embodiments
of this invention include, but are not limited to, vitamins,
[0016] FIG. 5 is a poWder-x-ray diffraction scan of rebau
vitamin cofactors, minerals, hormones, carotenoids, caro
dioside A polymorph Form 4 on a plot of the scattering
tenoid terpenoids, non-carotenoid terpenoids, ?avonoids,
intensity versus the scattering angle 20 in accordance With
?avonoid polyphenolics (e.g., bio?avonoids), ?avonols, ?a
an embodiment of this invention.
vones, phenols, polyphenols, esters of phenols, esters of
polyphenols, non?avonoid phenolics, isothiocyanates, and
DETAILED DESCRIPTION OF THE
combinations thereof. In some embodiments, the antioxidant
INVENTION
may include vitamin A, vitamin C, vitamin E, ubiquinone,
[0017] Reference noW Will be made in detail to the pres mineral selenium, manganese, melatonin, ot-carotene,
ently proffered embodiments of the invention. Each example [3-carotene, lycopene, lutein, Zeanthin, crypoxanthin, reser
is provided by Way of explanation of embodiments of the vatol, eugenol, quercetin, catechin, gossypol, hesperetin,
invention, not limitation of the invention. In fact, it Will be curcumin, ferulic acid, thymol, hydroxytyrosol, tumeric,
apparent to those skilled in the art that various modi?cations thyme, olive oil, lipoic acid, glutathinone, gulamine, oxalic
and variations can be made in the present invention Without acid, tocopherol-derived compounds, butylated hydroxyani
departing from the spirit or scope of the invention. For sole (BHA), butylated hydroxyoluene (BHT), ethylenedi
US 2007/0116838 A1 May 24, 2007
aminetetraacetic acid (EDTA), tert-butylhydroquinone, ace the range of about 90 mg to about 270 mg per 240 mL
tic acid, pectin, tocotrienol, tocopherol, coenZyme Q10, serving. In other embodiments, green tea extract is present
Zeaxanthin, astaxanthin, canthaxantin, saponins, limonoids, in the compositions of this invention in an amount in the
kaempfedrol, myricetin, isorhamnetin, proanthocyanidins, range of about 500 mg to about 600 mg per 240 mL serving.
quercetin, rutin, luteolin, apigenin, tangeritin, hesperetin,
naringenin, erodictyol, ?avan-3-ols (e.g., anthocyanidins), [0025] In some embodiments, proanthocyanidins, procya
gallocatechins, epicatechin and its gallate forms, epigallo nidins, or combinations thereof can inhibit tumor cell
growth, reduce blood lipid, glucose, and/or insulin, act as an
catechin and its gallate forms (ECOC) thea?avin and its
gallate forms, thearubigins, isotlavone phytoestrogens, anti-in?ammatory agent, increase endurance, and/or act as
genistein, daidZein, glycitein, anythocyanins, cyaniding, neuroprotection, for example. Suitable sources of proantho
delphinidin, malvidin, pelargonidin, peonidin, petunidin, cyanidins and procyanidins for embodiments of this inven
ellagic acid, gallic acid, salicylic acid, rosmarinic acid, tion include, but are not limited to, red grapes, pur‘ple grapes,
cinnamic acid and its derivatives (e.g., ferulic acid), chlo cocoa, chocolate, grape seeds, red wine, cacao beans, cran
berry, apple peel, plum, blueberry, black currants, choke
rogenic acid, chicoric acid, gallotannins, ellagitannins,
berry, green tea, sorghum, cinnamon, barley, red kidney
anthoxanthins, betacyanins and other plant pigments, sily
bean, pinto bean, hops, almonds, haZelnuts, pecans, pista
marin, citric acid, lignan, antinutrients, bilirubin, uric acid,
R-ot-lipoic acid, N-acetylcysteine, emblicanin, apple extract, chio, pycnogenol, and colorful berries. According to par
apple skin extract (applephenon), rooibos extract red, rooi ticular embodiments of the present invention, grape seed
extract is present in the compositions of this invention in an
bos extract, green hawthorn berry extract, red raspberry
amount in the range of about 100 mg to about 200 mg per
extract, green coffee antioxidant (GCA), aronia extract 20%
240 mL serving. In other embodiments, cocoa extract is
grape seed extract (VinOseed), cocoa extract, hops extract,
present in the compositions of this invention in an amount in
mangosteen extract, mangosteen hull extract, cranberry
the range of about 400 mg to about 500 mg per 240 mL
extract, pomegranate extract, pomegranate hull extract,
serving.
pomegranate seed extract, hawthorn berry extract, pomella
pomegranate extract, cinnamon hark extract, grape skin [0026] In particular embodiments, anthocyanins can
extract, bilberry extract, pine bark extract, pycnogenol,
inhibit tumor cell growth, can reduce blood lipid, glucose,
elderberry extract, mulberry root extract, wolfberry (gogi)
and/or insulin, act as an anti-in?ammatory agent, cause
extract, blackberry extract, blueberry extract, blueberry leaf
vasodilatory activity, and/or act as neuroprotection, for
extract, raspberry extract, turmeric extract, citrus bio?a example. Suitable sources of anthocyanins for embodiments
vonoids, black currant, ginger, acai powder, green coffee
of this invention include, but are not limited to, red berries,
bean extract, green tea extract, and phytic acid, or combi blueberries, bilberry, cranberry, raspberry, cherry, pome
nations thereof. In alternate embodiments, the antioxidant granate, strawberry, elderberry, choke berry, red grape skin,
may comprise a synthetic antioxidant such as butylated pur‘ple grape skin, grape seed, red wine, black currant, red
hydroxytolune or butylated hydroxyanisole, for example.
currant, cocoa, plum, apple peel, peach, red pear, red cab
Other sources of suitable antioxidants for embodiments of bage, red onion, red orange, and blackberries. According to
this invention include, but are not limited to, fruits, veg particular embodiments of the present invention, blueberry
etables, tea, cocoa, chocolate, spices, herbs, rice, organ
extract is present in the compositions of this invention in an
meats from livestock, yeast, whole grains, or cereal grains.
amount in the ranoe of about 400 mg to about 500 mg per
[0023] Particular antioxidants belong to the class of phy 240 mL serving.
tonutrients called polyphenols (also known as “polypheno
[0027] In some embodiments quercetin, rutin, or combi
lics”), which are a group of chemical substances found in
nations thereof can inhibit tumor cell growth, can reduce
plants, characterized by the presence of more than one
phenol group per molecule. A variety of health bene?ts may blood lipid, glucose, and/or insulin, act as an anti-in?am
derived from polyphenols, including prevention of cancer, matory agent, cause vasodilatory activity, and/or act as
neuroprotection, for example. Suitable sources of quercetin
heart disease, and chronic in?ammatory disease and
improved mental strength and physical strength, for and rutin for embodiments of this invention include, but are
not limited to, red apples, onions, kale, bog whortleberry,
example. Suitable polyphenols for embodiments of this
lingonberrys, chokeberry, cranberry, blackberry, blueberry,
invention, include catechins, proanthocyanidins, procyani
dins, anthocyanins, quercerin, rutin, reservatrol, iso?avones, strawberry, raspberry, black currant, green tea, black tea,
curcumin, punicalagin, ellagitannin, hesperidin, naringin, plum, apricot, parsley, leek, broccoli, chili pepper, berry
wine, and ginkgo. According to particular embodiments of
citrus ?avonoids, chlorogenic acid, other similar materials,
the present invention, apple peel extract is present in the
and combinations thereof.
compositions of this invention in an amount in the range of
[0024] In particular embodiments, catechins such as, but
about 0.5 g to about 1 g per 240 mL serving. In other
not limited to, epigallocatechin gallate (EGCG), can inhibit
embodiments, ginkgo extract is present in the compositions
tumor cell growth, reduce lipid, glucose, and/or insulin, act
of this invention in an amount in the range of about 120 mg
as an anti-in?ammatory agent, increase endurance, and/or
to 320 mg about per 240 mL serving.
act as neuroprotection, for example. Suitable sources of
catechins for embodiments of this invention include, but are [0028] In some embodiments, resveratrol can inhibit
not limited to, green tea, white tea, black tea, oolong tea, tumor cell growth, can reduce lipid, glucose, and/or insulin,
chocolate, cocoa, red wine, grape seed, red grape skin, act as an anti-in?ammatory agent, prevent heart disease,
purple grape skin, red grape juice, pur‘ple grape juice, and/or act as neuroprotection, for example. Suitable sources
berries, pycnogenol, and red apple peel. According to par of resveratrol for embodiments of this invention include, but
ticular embodiments of the present invention, EGCG is are not limited to, red grapes, peanuts, cranberry, blueberry,
present in the compositions of this invention in an amount in bilberry, mulberry, Japanese Itadori tea, and red wine.
US 2007/0116838 A1 May 24, 2007
According to particular embodiments of the present inven compositions of this invention in an amount in the range of
tion, grape seed extract is present in the compositions of this about 200 mg to about 300 mg per 240 mL serving.
invention in an amount in the range of about 100 mg to 200 According to particular embodiments of the present inven
mg about per 240 mL serving. tion apple peel extract is present in the compositions of this
[0029] In particular embodiments, iso?avones can inhibit invention in an amount in the range of about 0.5 g to about
tumor cell groWth, reduce lipid, glucose, and/or insulin, act 1 g per 240 mL serving.
as an anti-in?ammatory agent, act as neuroprotection, pro
[0034] It is Well knoWn to those of ordinary skill in the art
tect bone, and/or enhance thermogenesis, for example. Suit
that phytonutrients, plant extracts, and herbal compositions
able sources of iso?avones for embodiments of this inven
may be used in their natural and/ or modi?ed form. Modi?ed
tion include, but are not limited to, soy beans, soy products,
phytonutrients, plant extracts, and herbal compositions
legumes, alfalfa spouts, chickpeas, peanuts, and red clover.
include phytonutrients, plant extracts, and herbal composi
According to particular embodiments of the present inven
tion, iso?avone is present in the compositions of this inven tions Which have been altered naturally. For example, a
modi?ed phytonutrient includes, but is not limited to, phy
tion in an amount in the range of about 50 mg to about 130
mg per 240 mL serving. In other embodiments, soy protein tonutrients Which have been fermented, contacted With
is present in the compositions of this invention in an amount enZyme, or derivatiZed or substituted on the phytonutrient.
In one embodiment, modi?ed phytonutrients may be used
in the range of about 0.1 g to 10 g about per 240 mL serving.
individually or in combination With unmodi?ed phytonutri
[0030] In some embodiments, curcumin can inhibit tumor ents. For the sake of brevity, hoWever, in the description of
cell groWth, can reduce lipid, glucose, and/or insulin, act as embodiments of this invention, a modi?ed phytonutrient is
an anti-in?ammatory agent, and/or act as neuroprotection, not described expressly as an alternative to an unmodi?ed
for example. Suitable sources of curcumin for embodiments phytonutrient, but it should be understood that modi?ed
of this invention include, but are not limited to, turmeric and phytonutrients can be substituted for or combined With
mustard. According to particular embodiments of the present phytonutrients in any embodiment disclosed herein. The
invention, curcumin is present in the compositions of this same embodiments Would be applicable to plant extracts and
invention in an amount in the range of about 200 mg to 400 other herbal compositions. Plant extracts include extracts
mg about per 240 mL serving. In other embodiments, from foliage, stems, bark, fruit, seed, and any other plant
turmeric extract is present in the compositions of this
matter.
invention in an amount in the range of about 400 mg to about
500 mg per 240 mL serving. [0035] Generally, the amount of antioxidant present in the
functional sWeetener composition varies Widely depending
[0031] In particular embodiments, punicalagin, ellagitan
on the particular functional sWeetener composition and the
nin, or combinations thereof can inhibit tumor cell groWth,
desired antioxidant. Those of ordinary skill in the art Will
reduce lipid, glucose, and/or insulin, act as an anti-in?am
readily acertain the appropriate amount of antioxidant for
matory agent, and/or act as neuroprotection, for example.
each functional sWeetener composition. For example, in one
Suitable sources of punicalagin and ellagitannin for embodi
embodiment, the functional sWeetener composition may
ments of this invention include, but are not limited to,
comprise up to 55 mg to 65 mg of vitamin C per 240 mL
pomegranate, raspberry, strawberry, Walnut, and oak-aged
serving (i.e., the recommended daily amount). In other
red Wine. According to particular embodiments of the
embodiments, the functional sWeetener composition may
present invention, pomegranate extract is present in the
comprise up to 1 mg to 3 mg of vitamin E per 240 mL
compositions of this invention in an amount in the range of
serving. In yet other embodiments, the functional sWeen
about 400 mg to about 500 mg per 240 mL serving.
tened composition may comprise up to 250 pg to 350 pg of
[0032] In some embodiments, citrus ?avonoids, such as vitamin A per 240 mL serving. In still other embodiments,
hesperidin or naringin, can inhibit tumor cell groWth, reduce the functional sWeetener composition may comprise up to 25
lipid, glucose, and/or insulin, act as an anti-in?ammatory ppm to 35 ppm of polyphenol per 240 mL serving. In other
agent. act as neuroprotection, and/or protect bone, for embodiments, the functional sWeetener composition may
example. Suitable sources of citrus ?avonids, such as hes comprise up to 5 mg to 15 mg of coenZyme Q10 per 240 mL
serving.
peridin or naringin, for embodiments of this invention
include, but are not limited to, oranges, grapefruits, and
[0036] Generally, the amount of antioxidant present in the
citrus juices. According to particular embodiments of the
functional sWeetened composition varies Widely depending
present invention, citrus polyphenol is present in the com
on the particular functional sWeetened composition and the
positions of this invention in an amount in the range of about
desired antioxidant. Those of ordinary skill in the art Will
1310 mg to about 260 mg per 240 mL serving.
readily acertain the appropriate amount of antioxidant for
[0033] In particular embodiments, chlorogenic acid can each functional sWeetened composition. For example, in one
inhibit tumor cell groWth, reduce lipid, glucose, and/or embodiment, the functional sWeetened composition may
insulin, act as an anti-in?ammatory agent, and/or act as comprise up to 55 mg to 65 mg of vitamin C per 240 mL
neuroprotection, for example. Suitable sources of chloro serving (i.e., the recommended daily amount). In other
genic acid for embodiments of this invention include, but are embodiments, the functional sWeetened composition may
not limited to, green coffee, yerba mate, red Wine, grape comprise up to 1 mg to 3 mg of vitamin E per 240 mL
seed, red grape skin, purple grape skin, red grape juice, serving. In yet other embodiments, the functional sWeen
purple grape juice, apple juice, cranberry, pomegranate, tened composition may comprise up to 250 pg to 350 pg of
blueberry, straWberry, sun?oWer, Echinacea, pycnogenol, vitamin A per 240 mL serving. In still other embodiments,
and apple peel. According to particular embodiments of the the functional sWeetened composition may comprise up to
present invention, green coffee extract is present in the 25 ppm to 35 ppm of polyphenol per 240 mL serving. In