heterogeneity in acute myeloid leukemia

260 Pages·2013·7.6 MB·English

HETEROGENEITY IN ACUTE MYELOID LEUKEMIA: BASIC AND DIAGNOSTIC STUDIES
CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN HAAG
Adriaansen, Hendrik Johannes
Heterogeneity in acute myeloid leukemia: basic and diagnostic studies j Hendrik Johannes
Adriaansen. - Rotterdam: Erasmus Universiteit, Afdeling lmmunologie. - ill.
Proefschrift Rotterdam. - Met lit. opg.
ISBN 90-73436-09-5
NUGI 743
Trefw.: Myelciide leukemie.
No part of this thesis may be reproduced or transmitted in any form by any means, electronic
or mechanical, including photocopying, recording or any information storage and retrieval
system, without permission in writing from the publisher (Department of Immunology, Erasmus
University, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands).
HETEROGENEITY IN ACUTE MYElOID LEUKEMIA
Basic and diagnostic studies
HETEROGENITEIT VAN ACUTE MYELOIDE LEUKEMIE
PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Erasmus Universiteit Rotterdam
op gezag van de rector magnificus
Prof. Dr. C.J. Rijnvos
en volgens besluit van het College van Dekanen.
De openbare verdediging zal plaatsvinden op
woensdag iS november 1992 om 13.45 uur
door
Hendrik Johannes Adriaansen
geboren te Rotterdam.
PROMOTIECOMMISSIE:
Promotoren: Prof. Dr. J.J.M. van Dongen
Prof. Dr. R. Benner
overige leden: Prof. Dr. B. Lowenberg
Dr. Ph.M. ~uin
Dit proefschrift werd bewerkt binnen de afdeling lmmunologie van de Faculteit der
Geneeskunde en Gezondheidswetenschappen, Erasmus Universiteit Rotterdam. Hetonderzoek
werd mede mogelijk gemaakt door de Sophia Stichting Wetenschappelijk Onderzoek en de
Nederlandse Kankerbestrijding (Koningin Wilhelmina Fonds).
't"
Dit proefschrift werd gedrukt door Haveka B.V. te Alblasserdam.
In de drukkosten werd bijgedragen door Becton Dickinson Image Cytometry Systems B.V.,
Coulter Electronics Nederland, ITK Diagnostics B.V., Lederle Nederland en Ortho Diagnostic
Systems.
Aan Petra
Aan mijn ouders

7
HETEROGENEITY IN ACUTE MYELOID LEUKEMIA
Basic and diagnostic studies
CONTENTS
Chapter 1: General introduction 11
1.1 Normal and abnormal hematopoiesis 13
1.2 Epidemiology of AML 16
1.3 Biology of AML 19
1.4 Diagnosis of AML 20
1.5 Prognosis and treatment of AML 24
1.6 Scope of the thesis 28
Chapter 2: Immunological marker analysis 49
2.1 Immunological marker analysis of cells in the various hematopoietic
differentiation stages and their malignant counterparts
Published in: Ruiter DJ, Fleuren GJ, Warnaar SO, eds. Application of monoclonal
antibodies in tumor pathology. Dordrecht: M Nijhoff Publishers, 1987:87-116. 51
2.2 Immunological marker analysis of myeloid disorders, with special
emphasis on fiow cytometric techniques 87
2.3 Expression of the myeloid differentiation antigen CD33 depends on
the presence of human chromosome 19 in human-mouse hybrids
Published in: Ann Hum Genet 7990;54:115-119. 115
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Chapter 3: lmmunophenotype ol acute myeloid leukemias with specific
chromosome aberrations 121
3.1 Chromosome abnormalities in AML 123
3.2 Translocation (6;9) may be associated with a specific terminal
deoxynucleotidyl transferase positive immunological phenotype in AML
Published in: Leukemia 1988;2:136-140. 139
3.3 Acute myeloid leukemia M4 with bone marrow eosinophilia {M4Eo)
and inv(16){p13q22) exhibits a specific CD2+ immunophenotype
Submitted for publication. 149
Chapter 4: Expression of terminal deoxynucieotidyl transferase in AMl:
Implications for the detection of minimal residual disease 165
4.1 Double marker analysis for terminal deoxynucleotidyl transferase
and myeloid antigens in acute myeloid leukemia patients and
healthy subjects
Published in: Haematol Blood Transfus 1990;33:41-49. 167
4.2 Terminal deoxynucleotidyl transferase positive subpopulations occur in
the majority of AML: Implications for the detection of minimal disease
Published In: Leukemia 1990;4:404-410. 177
4.3 Detection of residual disease in AML patients by use of double
immunological marker analysis for terminal deoxynucleotidyl
transferase and myeloid markers
Leukemia, in press. 191
4.4 Immunoglobulin and T cell receptor gene rearrangements in acute
myeloid leukemias. Analysis of 54 cases and a review of the literature
Published in: Leukemia 1997;5:744-751. 207
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Chapter 5: General discussion 221
5.1 Associations between immunophenotype and karyotype 223
5.2 Detection of immature subpopulations in AML 225
5.3 Why is terminal deoxynucleotidyl transferase expressed in AML? 226
5.4 Detection of minimal residual disease 229
5.5 Conclusion 233
Summary 239
Samenvatting 243
Abbreviations 249
Dankwoord 251
Curriculum vitae 255
Publications 256