Hepatitis C Virus II: Infection and Disease

371 Pages·2016·5.79 MB·English

by  Tatsuo Miyamura

Tatsuo Miyamura · Stanley M. Lemon
Christopher M. Walker · Takaji Wakita
Editors
Hepatitis C
Virus II
Infection and Disease
Hepatitis C Virus II
Tatsuo Miyamura (cid:129) Stanley M. Lemon (cid:129)
Christopher M. Walker (cid:129) Takaji Wakita
Editors
Hepatitis C Virus II
Infection and Disease
Editors
TatsuoMiyamura StanleyM.Lemon
NationalInstituteofInfectiousDiseases DepartmentsofMedicineandMicrobiology
Tokyo,Japan &Immunology
TheUniversityofNorthCarolina
ChapelHill,NorthCarolina
USA
ChristopherM.Walker TakajiWakita
CenterforVaccinesandImmunity NationalInstituteofInfectiousDiseases
TheResearchInstituteatNationwide Tokyo,Japan
Children’sHospital
Columbus,Ohio
USA
ISBN978-4-431-56099-9 ISBN978-4-431-56101-9 (eBook)
DOI10.1007/978-4-431-56101-9
LibraryofCongressControlNumber:2016951214
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Contents
PartI ChronicHepatitisC
NaturalHistoryofChronicHepatitisC. . . . . . . . . . . . . . . . . . . . . . . . . 3
MarcG.GhanyandT.JakeLiang
TheMultifacetedFeaturesofHCVInfectionBeyondtheLiver. . . . . . . 57
KazuhikoKoike
HepaticFibrosisinHepatitisC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
MelissaA.SheikoandHugoR.Rosen
HepatocellularCarcinomaandHepatitisCVirus. . . . . . . . . . . . . . . . . 109
Sheng-HanWang,Shiou-HweiYeh,andPei-JerChen
HCV,Alcohol,andtheLiver. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
TerenceN.Bukong,BanishreeSaha,andGyongyiSzabo
ExtrahepaticReplicationofHCV. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165
Wen-ChiSu,KeigoMachida,andMichaelM.C.Lai
PartII HCVInfectionsinSpecialPopulations
HepatitisCVirusInfectioninPregnancyandChildhood. . . .. . . . . . .. 187
JessicaWen,SamanthaOhmer,andJonathanHonegger
PartIII ApproachestoTherapy
HostGeneticsandResponsestoAntiviralTherapyinChronic
HepatitisC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
YasuhitoTanakaandMasashiMizokami
ViralVariationandResponsetoTherapy. . . . . . . . . . . . . . . . . . . . . . . 243
ShinyaMaekawaandNobuyukiEnomoto
v
vi Contents
HCVNS3/4AProteaseInhibitorsandtheRoadtoEffective
Direct-ActingAntiviralTherapies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257
NicolasTremblay,AlexYoungPark,andDanielLamarre
MechanismofActionofDirect-ActingAntivirals:NewInsights
intotheHCVLifeCycle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
SaraE.WillifordandDavidR.McGivern
ModelingHCVDynamicsinClinicalPracticetoPersonalizeAntiviral
Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303
PieroColombatto,FerruccioBonino,LuigiCivitano,FilippoOliveri,
GabrieleRicco,SergioIannazzo,andMauriziaR.Brunetto
PartIV PreventionandControlofHCVInfection
ProphylacticVaccinesfortheHepatitisCVirus. . . . . . . . . . . . . . . . . . 325
AndreaL.Cox
GlobalControlofHepatitisCVirusInfection. . . . . . . . . . . . . . . . . . . . 347
TatsuoMiyamura
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369
Contributors
FerruccioBonino UPMCInstituteforHealth,ChiancianoTerme,Italy
MauriziaR.Brunetto HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy
TerenceN.Bukong DepartmentofMedicine,UniversityofMassachusettsMed-
icalSchool,Worcester,MA,USA
Pei-Jer Chen Department of Microbiology, National Taiwan University College
ofMedicine,Taipei,Taiwan
NTUCenterforGenomicMedicine,NationalTaiwanUniversityCollegeofMed-
icine,Taipei,Taiwan
Graduate Institute of Clinical Medicine, National Taiwan University College of
Medicine,Taipei,Taiwan
Department of Internal Medicine, National Taiwan University Hospital and
NationalTaiwanUniversityCollegeofMedicine,Taipei,Taiwan
LuigiCivitano HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy
PieroColombatto HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy
AndreaL.Cox DivisionofInfectiousDiseases,JohnsHopkinsUniversitySchool
ofMedicine,Baltimore,MD,USA
Nobuyuki Enomoto First Department of Internal Medicine, University of
Yamanashi,Chuo,Yamanashi,Japan
MarcG.Ghany LiverDiseasesBranch,NationalInstituteofDiabetesandDiges-
tiveandKidneyDiseases,NationalInstitutesofHealth,Bethesda,MD,USA
JonathanHonegger NationwideChildren’sHospital,TheOhioStateUniversity,
Columbus,OH,USA
vii
viii Contributors
SergioIannazzo SIHSHealth-Economics-Consulting,Turin,Italy
KazuhikoKoike DepartmentofGastroenterology,GraduateSchoolofMedicine,
TheUniversityofTokyo,Tokyo,Japan
Michael M.C. Lai Institute of Molecular Biology, Academia Sinica, Taipei,
Taiwan
Research Center for Emerging Viruses, China Medical University Hospital, Tai-
chung,Taiwan
Daniel Lamarre De´partement de Me´decine, Universite´ de Montre´al, Montre´al,
QC,Canada
T.JakeLiang LiverDiseasesBranch,NationalInstituteofDiabetesandDigestive
andKidneyDiseases,NationalInstitutesofHealth,Bethesda,MD,USA
Keigo Machida Department of Molecular Microbiology and Immunology, Uni-
versityofSouthernCalifornia,LosAngeles,CA,USA
Shinya Maekawa First Department of Internal Medicine, University of
Yamanashi,Chuo,Yamanashi,Japan
TatsuoMiyamura NationalInstituteofInfectiousDiseases,Tokyo,Japan
MasashiMizokami TheResearch Center forHepatitis&Immunology,National
CenterforGlobalHealthandMedicine,Ichikawa,Chiba,Japan
Samantha Ohmer Medical Scientist Training Program, The Ohio State Univer-
sity,Columbus,OH,USA
FilippoOliveri HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy
Alex Young Park De´partement de Me´decine, Universite´ de Montre´al, Montre´al,
QC,Canada
GabrieleRicco HepatologyUnit,UniversityHospitalofPisa,Pisa,Italy
Hugo R. Rosen Department of Medicine, Division of Gastroenterology and
Hepatology,UniversityofColoradoDenverSchoolofMedicine,Aurora,CO,USA
Banishree Saha Department of Medicine, University of Massachusetts Medical
School,Worcester,MA,USA
Melissa A. Sheiko Department of Pediatrics, Digestive Health Institute, Univer-
sityofColoradoDenverSchoolofMedicine,Aurora,CO,USA
Wen-Chi Su Research Center for Emerging Viruses, China Medical University
Hospital,Taichung,Taiwan
Gyongyi Szabo Department of Medicine, University of Massachusetts Medical
School,Worcester,MA,USA
Contributors ix
Yasuhito Tanaka Department of Virology, Liver Unit, Nagoya City University
GraduateSchoolofMedicalSciences,Nagoya,Japan
NicolasTremblay De´partementdeMe´decine,Universite´ deMontre´al,Montre´al,
QC,Canada
Sheng-Han Wang Department of Microbiology, National Taiwan University
CollegeofMedicine,Taipei,Taiwan
JessicaWen UniversityofPennsylvania,Philadelphia,PA,USA
Shiou-Hwei Yeh Department of Microbiology, National Taiwan University
CollegeofMedicine,Taipei,Taiwan
NTU Center for Genomic Medicine, National Taiwan University College of
Medicine,Taipei,Taiwan
Part I
Chronic Hepatitis C