Heat Shock Factor

300 Pages·2016·6.89 MB·English

by  Akira Nakai (eds.)

Akira Nakai Editor
Heat Shock
Factor
Heat Shock Factor
ThiSisaFMBlankPage
Akira Nakai
Editor
Heat Shock Factor
Editor
AkiraNakai
DepartmentofBiochemistryandMolecularBiology
YamaguchiUniversitySchoolofMedicine
Ube,Japan
ISBN978-4-431-55850-7 ISBN978-4-431-55852-1 (eBook)
DOI10.1007/978-4-431-55852-1
LibraryofCongressControlNumber:2015958662
SpringerTokyoHeidelbergNewYorkDordrechtLondon
©SpringerJapan2016
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Preface
All organisms sense varying conditions in the environment that they live in, and
respond and ultimately adapt to them through sophisticated mechanisms. These
adaptive mechanisms play pivotal roles for homeostasis and biological defense;
therefore, the elucidation of the adaptive mechanisms has grown to be major
researchfieldinmolecularbiology.Aprominentsystemamongthemisaprimitive
and evolutionally conserved adaptive mechanism called heat shock response,
which induces the heat shock proteins against proteotoxic stress including high
temperature.
Ithasbeen53yearssincethediscoveryoftheheatshockresponse(in1962),and
27yearsafterthemolecularcloningofthekeyregulator,heatshockfactor(HSF)
(isolatedin1988).Thisadaptiveresponsetohightemperatureorproteinmisfolding
is a fundamental mechanism to maintain the capacity of protein homeostasis, or
proteostasis,andisevolutionallyconservedamongalllivingorganisms,including
bacteria and humans, on the earth. Furthermore, physiological and pathological
rolesofHSFhavebeenextensivelystudiedinfruitfly,worm,andmousemodelsfor
the last 18 years (starting in 1997). It has been revealed that HSF plays roles in
developmentofthebrain,reproductiveandsensoryorgans,andinageing,inflam-
mation, and circadian rhythm. Analysis of the mechanisms have uncovered that
HSFexertsawiderangeofeffectsongeneexpressionandepigeneticstatusonthe
whole genome. Moreover, loss or gain of HSF function is also closely related to
protein-misfoldingdiseasesincludingneurodegenerativediseases,psychiatricdis-
eases,heartdiseases,andcancers.Therefore,HSFisnowthoughttobeapromising
therapeutictargetfortreatmentoftheserefractorydiseases.
Atthispoint(2015),weshouldbringalargeamountofHSF-relatedinformation,
describe core observations about molecular mechanisms and pathophysiological
roles, and provide fundamental concepts on the basis of information from diverse
aspectsinonebook.Theaimofthispublicationistoprovidearesourceontheheat
shock response and HSFfor undergraduatestudents. This book willnotonlybea
guide of the heat shock response and HSF to be understandable to students and
v
vi Preface
youngresearchersinotherfields,butwillalsobeacornerstoneforfutureworksin
the field related to the heat shock response and HSF. I would like to take this
opportunitytothankalltheauthorsfortheircontributionsandthestaffmembersat
SpringerJapanfortheirenthusiasmandeffort.
Yamaguchi,Japan AkiraNakai
Contents
PartI TheBasisofHSFBiology
1 ProteostasisandAdaptationtoHighTemperatureStress. . . . . . . . 3
AkiraNakai
2 StructureandFunctionoftheHSFFamilyMembers. . . . . . . . . . . 31
RyosukeTakiiandMitsuakiFujimoto
3 RegulationofHSFActivationandRepression. . . . . . . . . . . . . . . . 51
EiichiTakakiandAkiraNakai
4 TranscriptionalRegulationbyHSF. . . . . . . . . . . . . . . . . . . . . . . . 73
MitsuakiFujimoto
PartII PhysiologicalRolesofHSF
5 HSF1RegulationinAgingandItsRoleinLongevity. . . . . . . . . . . 93
NettaShemeshandAnatBen-Zvi
6 HSFModulatesNeuralDevelopmentUnderNormalandStress
Conditions. . . . . . . . . .. . . . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . 115
SeijiIshiiandKazueHashimoto-Torii
7 HSFMaintainsSensoryOrgans. . . . . . . . . . . . . . . . . . . . . . . . . . . 131
KazumaSugahara,KeTan,AkiraNakai,andHiroshiYamashita
8 HSFIsRequiredforGametogenesis. . . . . . . . . . . . . . . . . . . . . . . . 147
KojiShiraishi
9 HSFRegulatesImmuneandInflammatoryResponse. . . . . . . . . . . 165
SachiyeInouye
10 HeatShockFactorsModulateCircadianRhythms. . . . . . . . . . . . . 197
TsuyoshiHirotaandYoshitakaFukada
vii
viii Contents
PartIII DiseasesAssociatedwithHSFFunction
11 HSFInhibitstheProgressionofAge-RelatedNeurodegenerative
Diseases. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . . . . 213
NaohideKondo,MasahisaKatsuno,YuichiRiku,andGenSobue
12 HSFandHeartDiseases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
JieYuanandYunzengZou
13 HSFSupportsCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
MakotoChuma
14 HSF1ActivationbySmallChemicalCompoundsfor
theTreatmentofNeurodegenerativeDiseases. . . . .. . . . . . . . . . .. 277
NobuhiroFujikake,ToshihideTakeuchi,andYoshitakaNagai
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
Part I
The Basis of HSF Biology