Table Of ContentDorsett D. Smith
the health effects of t
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Asbestos e
the health effects of
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Asbestos
An Evidence-based Approach l
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The health-related effects of asbestos have long been mired in
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controversy, with industry and plaintiff attorneys playing a significant f
role. This comprehensive book provides a balanced and extensive e
evidence-based critical analysis of the literature concerning asbestos- c An Evidence-based
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related diseases, from a scientific and historical perspective. The book
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presents a carefully referenced review of the medical literature on the Approach
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health effects of asbestos, and reflects the extensive experience of the
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author in evaluating patients with asbestos-related disorders.
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Key features: s
• Comprehensive — unbiased review of the medical literature relating b
to asbestos, the most-studied occupational agent, including
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over 5,000 bibliographic references relating to asbestos and/or
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mesothelioma
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• Clinical — presented from the perspective of a pulmonologist o
B-Reader with extensive experience in evaluating patients with
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asbestos-related disease
• Balanced — provides the reader with perspective through a critical
appraisal of the many complex issues related to asbestos exposure
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About the author: r
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Dorsett D. Smith MD, FCCP, FACP, FACOEM is Clinical Professor of t
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Medicine, Division of Respiratory Diseases and Critical Care, D
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University of Washington Medical School, Seattle, Washington S
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K25926
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the health effects of
Asbestos
An Evidence-based Approach
the health effects of
Asbestos
An Evidence-based Approach
Dorsett D. Smith
MD, FCCP, FACP, FACOEM
Clinical Professor of Medicine, Division of Respiratory
Diseases and Critical Care, University of Washington
Medical School, Seattle, Washington, USA
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2016 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20150909
International Standard Book Number-13: 978-1-4987-2840-9 (eBook - PDF)
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This book is dedicated to John Butler MB, CHB, past Professor of Medicine,
Pulmonary Disease, and Physiology at the University of Washington Medical
School, Seattle, in gratitude for his encouragement in the study of asbestos-related
disorders, and to the library staff of the Providence Medical Center in Everett and
Spokane, Washington, for their tireless support for more than 40 years.
Contents
Introduction ix
1 How to critically read and find truth in the medical scientific literature 1
2 Limitations of epidemiologic exposure studies on the health
effects of asbestos 5
Sources of bias 11
3 Clinical toxicology of asbestos 27
Mineralogy 27
Ingestion 38
Skin contact and other routes of exposure 38
Asbestos fiber toxic mechanisms 38
Deposition and clearance of asbestos fibers 39
Occupational exposures and regulations 47
Asbestos exposures to building occupants 49
Asbestos exposures in outdoor ambient air 50
Asbestos in drinking water and food 50
4 History of asbestos commercial use and discovery of adverse
health effects: Asbestosis 53
5 What is asbestosis and what is not: Radiology and pathology
correlates 65
6 The association of lung cancer and asbestosis 79
Asbestos and animal studies 86
Pathophysiology 89
The Helsinki criteria 94
7 The effect of smoking and lung cancer 103
8 Asbestos-related pleural disease 109
9 Disability and impairment in asbestosis and asbestos-related
diffuse pleural disease 129
10 The evolution of workers’ compensation and employer responsibility 137
11 Does asbestos cause additional malignancies other than lung
cancer and mesothelioma? 143
Asbestos and renal cancer 143
Asbestos and upper GI tract cancer 146
vii
viii Contents
Carcinoma of the larynx: The role of asbestos 163
The role of HPV: The elephant in the room 193
Non-Hodgkin’s lymphoma and asbestos exposure 199
Ovarian cancer and asbestos exposure 206
Autoimmune disease 208
12 Asbestos exposure and mesothelioma 211
Early discovery: 1767–1900 213
Histologic controversy: 1900–1942 214
Definition and suspicion: 1943–1960 216
Association and causation: 1960–1973 220
13 The many causes of mesothelioma 243
Known naturally occurring mesotheliogenic mineral fibers 244
14 Other causes of mesothelioma not related to asbestiform
mineral fibers 251
15 Mesothelioma and asbestos fiber type 257
16 Chrysotile and mesothelioma 271
The fiber toxicology of chrysotile asbestos 280
17 The tremolite hypothesis 287
18 Mesothelioma latency and risk 295
Risk modeling 300
19 Household and neighborhood exposure to asbestos 307
20 What did asbestos pipe insulation manufacturers and the U.S.
Navy understand about the risk to manufacturing employees
and end users? 325
Naval and shipyard exposure 327
21 The intervention of government to provide safety standards 333
NIOSH/ACGIH standards 336
22 Is there a safe or risk-free level of asbestos exposure? 343
How do we define risk? 352
Some commonplace risks for death 355
Glossary 361
