Table Of ContentHEALTH AND THE GUT
THE EMERGING ROLE OF
INTESTINAL MICROBIOTA IN
DISEASE AND THERAPEUTICS
Edited by
William Olds
Apple Academic Press
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ABOUT THE EDITOR
WILLIAM OLDS, MSc
William Olds has an undergraduate degree from University of Michigan,
and is currently working on his PhD at Yale University in the laboratory of
Tian Xu. His current research focuses on satiety signals from the gut and
how that communication to the brain breaks down in the pathogenesis of
obesity.
© 2015 by Apple Academic Press, Inc.
CONTENTS
Acknowledgment and How to Cite ..................................................xi
List of Contributors .......................................................................xiii
Introduction ....................................................................................xxi
PART I: INTRODUCTION: THE RAINFOREST IN THE GUT
1. Nutrition, Microbiomes, and Intestinal Inflammation ............................1
Suzanne Devkota and Eugene B. Chang
PART II: MICROBIOME'S ROLE IN OBESITY
2. Gut Microbiota: In Sickness and in Health............................................11
M. José Huertas, and Carmen Michán
3. Microbial Reprogramming Inhibits Western Diet-Associated
Obesity .......................................................................................................17
Theofi los Poutahidis, Markus Kleinewietfeld, Christopher Smillie,
Tatiana Levkovich, Alison Perrotta, Siddheshvar Bhela,
Bernard J. Varian,Yassin M. Ibrahim, Jessica R. Lakritz,
Sean M. Kearney, Antonis Chatzigiagkos, David A. Hafl er,
Eric J. Alm, Susan E. Erdman
4. Increased Gut Permeability and Microbiota Change Associate
with Mesenteric Fat Infl ammation and Metabolic Dysfunction in
Diet-Induced Obese Mice ........................................................................ 45
Yan Y. Lam, Connie W. Y. Ha, Craig R. Campbell,
Andrew J. Mitchell, Anuwat Dinudom, Jan Oscarsson,
David I. Cook, Nicholas H. Hunt, Ian D. Caterson,
Andrew J. Holmes, and Len H. Storlien
5. Bacteroides uniformis CECT 7771 Ameliorates Metabolic and
Immunological Dysfunction in Mice with High-Fat-Diet Induced
Obesity ...................................................................................................... 71
Paola Gauffi n Cano, Arlette Santacruz, Ángela Moya,
and Yolanda Sanz
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viii Contents
6. Supplementation of Lactobacillus curvatus HY7601 and
Lactobacillus plantarum KY1032 in Diet-Induced Obese Mice
Is Associated with Gut Microbial Changes and Reduction in
Obesity .....................................................................................................107
Do-Young Park, Young-Tae Ahn, Se-Hoon Park, Chul-Sung Huh, Sae-Rom Yoo,
Rina Yu, Mi-Kyung Sung, Robin A. McGregor, and Myung-Sook Choi
PART III: INFLAMMATION AND INNATE IMMUNITY
7. Antimicrobial Peptides and Gut Microbiota in Homeostasis
and Pathology ..........................................................................................139
Maureen J. Ostaff, Eduard Friedrich Stange, and Jan Wehkamp
8. Matrix Metalloproteinase 13 Modulates Intestinal Epithelial
Barrier Integrity in Infl ammatory Diseases by Activating TNF ........187
Roosmarijn E. Vandenbroucke, Eline Dejonckheere,
Filip Van Hauwermeiren, Sofi eLodens, Riet De Rycke,
Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin, and Claude Libert
PART IV: NUTRITION'S EFFECT ON THE MICROBIOME
9. Impact of a Synbiotic Food on the Gut Microbial Ecology and
Metabolic Profi les ...................................................................................227
Beatrice Vitali, Maurice Ndagijimana, Federica Cruciani,
Paola Carnevali, Marco Candela, Maria Elisabetta Guerzoni,
and Patrizia Brigidi
10. Diet-Microbiota Interactions and their Implications for
Healthy Living .......................................................................................255
Ian B. Jeffery and Paul W. O’Toole
PART V: USING THE MICROBIOME TO IDENTIFY AND CURE
DISEASE
11. Prebiotics, Faecal Transplants and Microbial Network Units to
Stimulate Biodiversity of the Human Gut Microbiome ......................281
Pieter Van den Abbeele, Willy Verstraete, Sahar El Aidy,
Annelies Geirnaert, and Tom Van de Wiele
12. Microbiota and Healthy Aging: Observational and Nutritional
Intervention Studies ...............................................................................295
Harald Brüssow
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Contents ix
13. Gut Pharmacomicrobiomics: The Tip of an Iceberg of Complex
Interactions between Drugs and Gut-Associated Microbes ...............315
Rama Saad, Mariam R. Rizkallah, and Ramy K. Aziz
14. Fame and Future of Fecal Transplantations: Developing
Next-Generation Therapies with Synthetic Microbiomes...................339
Willem M. de Vos
Author Notes ....................................................................................................363
Index .................................................................................................................369
© 2015 by Apple Academic Press, Inc.
