handbook of the behavioral neurobiology of serotonin - Stoa

849 Pages·2009·9.98 MB·English

HANDBOOK OF THE BEHAVIORAL
NEUROBIOLOGY OF SEROTONIN
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HANDBOOK OF THE BEHAVIORAL
NEUROBIOLOGY OF SEROTONIN
Edited by
CHRISTIAN P. MÜLLER AND BARRY L. JACOBS
AMSTERDAM • BOSTON • HEIDELBERG • LONDON
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First edition 2010
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To our loved ones
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Susyn Berger
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Contents
Preface xi
List of Contributors xiii
Section 1: Functional Anatomy of the Serotonergic System
1 .1 Evolution of Serotonin: Sunlight to Suicide
Efrain C. Azmitia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
1 .2 Genetic Organization of the Serotonergic System
Ursula M. D’Souza and Ian W. Craig . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
1 .3 The Neuroanatomy of the Serotonergic System
Jean -Pierre Hornung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
1 .4 Ultrastructure of the Serotonin Innervation in the Mammalian Central Nervous System
Laurent Descarries, Mustapha Riad and Martin Parent . . . . . . . . . . . . . . . . . . . . . . . . . 65
1 .5 Classification and Signaling Characteristics of 5-HT Receptors
Jo ë l Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin . . . . . . . . . . . . . . . . . . 103
1 .6 Distribution of 5-HT Receptors in the Central Nervous System
Guadalupe Mengod, Roser Cort é s, M. Teresa Vilar ó and Daniel Hoyer . . . . . . . . . . . . . . . . 123
1 .7 Measuring Serotonin Activity in vivo in the Brains of Animals and Humans
Charles A. Marsden . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Section 2: The Neurophysiology of Serotonin
2 .1 Activity of Brain Serotonergic Neurons in Relation to Physiology and Behavior
Barry L. Jacobs and Casimir A. Fornal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
2 .2 Electrophysiology of Serotonin Receptors
Gerard J. Marek . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
2 .3 Tryptophan Hydroxylase and Serotonin Synthesis Regulation
Hiroyuki Hasegawa and Kazuhiro Nakamura . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
2 .4 The Degradation of Serotonin: Role of MAO
Marco Bortolato, Kevin Chen and Jean C. Shih . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
2 .5 Cellular Effects of Serotonin in the CNS
Rodrigo Andrade and Sheryl G. Beck . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
2 .6 Serotonergic Feedback Control
Trevor Sharp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
2 .7 Tryptophan Depletion and Serotonin Release – A Critical Reappraisal
Matthijs G.P. Feenstra and Geoffrey van der Plasse . . . . . . . . . . . . . . . . . . . . . . . . . . . 249
vii
viii Contents
2 .8 Serotonin Interaction with Other Transmitter Systems
Albert Adell, Anal í a Bortolozzi, Lloren ç D í az-Mataix, Noem í Santana,
Pau Celada and Francesc Artigas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
2 .9 Serotonergic Regulation of Rhythmical Activity of the Brain, Concentrating on the Hippocampus
Robert P. Vertes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
2 .10 5-HT Neurons and Central CO Chemoreception
2
Carolin I. Dohle and George B. Richerson . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
Section 3: Serotonin and Behavioral Control
3 .1 Serotonin and Development
Patricia M. Whitaker-Azmitia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309
3 .2 Serotonin and Basal Sensory – Motor Control
Robert J. Carey . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325
3 .3 Role of the Serotonergic System in Appetite and Ingestion Control
Michelle D. Lee and Peter G. Clifton . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
3 .4 Serotonin and Sexual Behavior
Lynda Uphouse and Jutatip Guptarak . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 347
3 .5 Serotonin in Mood and Emotion
Julie G. Hensler . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 367
3 .6 Serotonin and the Neurobiology of Anxious States
Christopher A. Lowry and Matthew W. Hale . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379
3 .7 Role of Serotonin in Brain Reward and Regulation of Alcohol Drinking Behavior
W. J. McBride . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399
3 . 8 Role of Central Serotonin in Impulsivity and Compulsivity: Comparative Studies in
Experimental Animals and Humans
Trevor W. Robbins and Molly J. Crockett . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415
3 .9 Experimental Studies on the Role(s) of Serotonin in Learning and Memory Functions
Jean -Christophe Cassel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 429
3 .10 Social Behavior and Serotonin
Elif Aysimi Duman and Turhan Canli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 449
3 .11 Serotonin in Pain and Pain Control
Claudia Sommer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 457
Section 4: Serotonin in Disease Conditions
4 .1 The Impact of Stress on Serotonergic Neurotransmission
Astrid C.E. Linthorst and Johannes M.H.M. Reul . . . . . . . . . . . . . . . . . . . . . . . . . . . . 475
Contents ix
4 .2 The Role of Serotonin in Depression
Gregory V. Carr and Irwin Lucki . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 493
4 .3 The Role of Serotonin in Drug Addiction
Christian P. M ü ller, Martin E. Pum, Gunter Schumann and Joseph P. Huston . . . . . . . . . . . . . 507
4 .4 The Serotonergic System in Obsessive-Compulsive Disorder
Addy van Dijk, Andre Klompmakers and Damiaan Denys . . . . . . . . . . . . . . . . . . . . . . . 547
4 .5 The Role of Serotonin in Attention-Deficit Hyperactivity Disorder (ADHD)
Robert D. Oades . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 565
4 .6 Serotonin and Schizophrenia
Boris B. Quednow, Mark A. Geyer and Adam L. Halberstadt . . . . . . . . . . . . . . . . . . . . . 585
4 .7 Serotonin and Serotonin Receptors in Hallucinogen Action
Adam L. Halberstadt and David E. Nichols . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 621
4 .8 The Role of Serotonin in Cortical Development: Implications for Autism Spectrum Disorder
Christine F. Hohmann and Mary E. Blue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 637
4 .9 Serotonin in Panic and Anxiety Disorders
Francisco S. Guimar ã es, H é lio Zangrossi Jr, Cristina M. Del Ben and
Frederico G. Graeff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 667
4 .10 Serotonin and Aggression
Isabel M. Quadros, Aki Takahashi and Klaus A. Miczek . . . . . . . . . . . . . . . . . . . . . . . . 687
4 .11 Altered Serotonin Function in Anorexia and Bulimia Nervosa
Vikas Duvvuri, Ursula F. Bailer and Walter H. Kaye . . . . . . . . . . . . . . . . . . . . . . . . . . 715
4 .12 Genetic, Epigenetic and Environmental Factors in Serotonin-Associated Disease Conditions
Eva Friedel and Andreas Heinz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 731
4 .13 The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression
Olivia F. O’Leary, John F. Cryan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 749
4 .14 Functional Pharmacogenetics of Serotonin Receptors in Psychiatric Drug Action
Olga O. Yevtushenko and Gavin P. Reynolds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 791
Index 807