Table Of ContentHandbook of Nanotechnology in
Nutraceuticals
Nanotechnology has been emerging as an important tool in the nutraceutical and food industries
to improve the overall quality of life. Nanotechnology has established a new horizon by bestow-
ing modified properties on nanomaterials and applying them to the production of nanoformula-
tions, nutritional supplements, and the food industry. The Handbook of Nanotechnology in
Nutraceuticals highlights the impact of nanotechnology on the food industries.
The book focuses on the application of nanotechnology in nutraceuticals and the food industry to
improve the overall quality of life. The book also addresses some important applications of nano-
nutraceuticals in the treatment of different diseases, such as oxidative stress, cancer, neurodegenera-
tive disorders, cardiovascular diseases, and so on.
Features
• Presents a scientometric approach to analyze the emergence of nano-nutraceuticals in can-
cer prevention and treatment
• Examines various strategies employed to prepare nanocarrier systems, such as nanopar-
ticles, nanostructure lipids, phospholipid-based nanocarriers, polysaccharide-based nano-
structures, and metal nanoparticles
• Discusses various regulatory issues related to nanotechnology and their application in dif-
ferent fields
This book is a valuable reference for nanotechnologists, scientists, and researchers working in the
field of food technology, food science, pharmaceuticals, and nutraceuticals.
Handbook of Nanotechnology in
Nutraceuticals
Edited by
Shakeel Ahmed
Tanima Bhattacharya
Annu
Akbar Ali
First edition published 2023
by CRC Press
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and by CRC Press
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CRC Press is an imprint of Taylor & Francis Group, LLC
© 2023 selection and editorial matter, Shakeel Ahmed, Tanima Bhattacharya, Annu, Akbar Ali; individual chapters, the
contributors
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Library of Congress Cataloging-in-Publication Data
Names: Ahmed, Shakeel, 1989- editor. Title: Handbook of nanotechnology in nutraceuticals /
edited by Shakeel Ahmed, Tanima Bhattacharya, Annu, Akbar Ali. Description: First edition. |
Boca Raton : CRC Press, 2023. | Includes bibliographical references and index.
Identifiers: LCCN 2022020034 (print) | LCCN 2022020035 (ebook) | ISBN 9781032127910
(hardback) | ISBN 9781032155678 (paperback) | ISBN 9781003244721 (ebook)
Subjects: LCSH: Functional foods--Handbooks, manuals, etc. | Nanotechnology. Classification:
LCC QP144.F85 H358 2023 (print) | LCC QP144.F85 (ebook) | DDC 572/.33--dc23/eng/20220720
LC record available at https://lccn.loc.gov/2022020034
LC ebook record available at https://lccn.loc.gov/2022020035
ISBN: 978-1-032-12791-0 (hbk)
ISBN: 978-1-032-15567-8 (pbk)
ISBN: 978-1-003-24472-1 (ebk)
DOI: 10.1201/9781003244721
Typeset in Times
by Deanta Global Publishing Services, Chennai, India
Contents
Preface..............................................................................................................................................vii
Editors ...............................................................................................................................................ix
Contributors ......................................................................................................................................xi
Chapter 1 Nanoceuticals: Mystifying Composites at the Interface of Nutrition, Medicine,
and Technology ............................................................................................................1
Niloy Chatterjee and Pubali Dhar
Chapter 2 Scope of Nanotechnology in Nutraceuticals: Analysis, Challenges and
Opportunities ..............................................................................................................51
Gurleen Kaur, Rajinder Kaur, and Sukhminderjit Kaur
Chapter 3 Systematic Review Analysis of Emerging Nano-Nutraceuticals in Cancer
Prevention and Treatment Using a Scientometric Approach .....................................63
Madhulika Bhati , Ranjana Aggarwal, Swathi Sreekuttan, Zahra Shekason,
Asha Anish Madhavan, and Reshmi S. Nair
Chapter 4 Strategic Design of a Nanocarrier System for Nutraceuticals....................................79
Chenmala Karthika, Mehrukh Zehravi, Rokeya Akter, and Md. Habibur Rahman
Chapter 5 Nanostructured Lipids as a Bioactive Compound Carrier .........................................97
Peeyush Kaushik, Deepali Tomar, Anjoo Kamboj, Hitesh Malhotra, and
Rupesh K. Gautam
Chapter 6 Role of β-Glucans in Dyslipidemia and Obesity ......................................................123
Hitesh Malhotra, Peeyush Kaushik, Anjoo Kamboj, and Rupesh K. Gautam
Chapter 7 Nanotechnology-Based Delivery of Non-Opioid Therapy for Opioid Addiction ....149
Mohd Adzim Khalili Rohin , Atif Amin Baig, Norhaslinda Ridzwan, and
Norhayati Abd Hadi
Chapter 8 Phospholipid-Based Nanoplatforms: Evolving as Promising Carriers for
Therapeutic Intervention ..........................................................................................183
Amrita Chakraborty and Pubali Dhar
Chapter 9 Investigating the Potential of Multifunctional Nanoparticle-Based
Nutraceuticals in Targeted Therapeutics ..................................................................223
Giselle Amanda Borges e Soares, Ali H. Hamzah, and Tanima Bhattacharya
v
vi Contents
Chapter 10 Polysaccharide-Based Nanostructures as Nutraceutical Carriers ............................263
V.B. Poornima, Richa Katiyar, Shivali Banerjee, Antonio Patti, and Amit Arora
Chapter 11 Metal Nanoparticles in Encapsulation and Delivery Systems of Food
Ingredients and Nutraceuticals .................................................................................301
H.C. Ananda Murthy , Gezahegn Tadesse Ayanie, Tegene Desalegn Zeleke,
Yilkal Dessie Sintayehu, and C.R. Ravikumar
Chapter 12 Applications of Nanotechnology-Based Approaches for Targeted Delivery of
Nutraceuticals ...........................................................................................................329
Hitesh Chopra , Shivani Sharma, Saba Yousaf, Rahat Naseer, Shakeel Ahmed,
and Atif Amin Baig
Chapter 13 Application of Nano-Nutraceuticals in Medicines ...................................................347
Kanika Sharma, Ahmed Salim, Shreyas R. Murthy, Gunjan Sharma, and
Rupesh K. Gautam
Chapter 14 Nano-Nutraceuticals and Oxidative Stress ...............................................................377
Rahat Naseer , Sadia Nawaz, Muzna Munir, Hitesh Chopra, Uday Younis
Hussein Abdullah, Shakeel Ahmed, and Atif Amin Baig
Chapter 15 Nano-Nutraceuticals for the Treatment of Cancer ...................................................399
Saba Yousaf, Fouzia Qamar, Zirwah Tahir, Zoya Faisal, Muniba Khaliq,
Aiza Talat, Umar Bacha, Aaiza Naveed, Hitesh Chopra, Uday Younis
Hussein Abdullah, Shakeel Ahmed, and Atif Amin Baig
Chapter 16 Nano-Nutraceuticals in Neurodegenerative Disorders .............................................417
Wardah Ali, Zirwah Tahir, Uday Younis Hussein Abdullah, Shakeel Ahmed,
and Atif Amin Baig
Chapter 17 Use of Nano-Nutraceuticals as Anti-Inflammatory Tools in Cardiovascular
Disease .....................................................................................................................431
Rajat Goyal, Anjali Saharan, and Rupesh K. Gautam
Chapter 18 Nanotechnology and Regulatory Issues ...................................................................441
Abhijit Gupta , Saurabh Gupta, and Gunjan Mukherjee
Index ..............................................................................................................................................461
Preface
The rise in microbial resistance has shifted people’s preference away from artificial medications
and food supplements towards natural ones, particularly health-protecting foods. The result-
ing products, which serve as nutraceuticals, represent a new perspective in the food industries.
The term nutraceuticals is a combination of nutrition and pharmaceuticals. Nutraceuticals are
defined as natural substances that are foods or functional foods or parts of food containing bio-
active phytochemicals that deliver therapeutic or health benefits, and which can also be used as
a means of disease prevention and treatment. Similarly, it is determined by the implications that
can hold a critical quality of essential nutrients such as vitamins, carbohydrates, minerals, pro-
teins, lipids, and so on. Further, the scope of nutrition has been expanded to disease risk failure.
The success of nutraceuticals can be attributed to their ability to provide desirable therapeutic
benefits while minimizing the side effects associated with the use of pharmaceutical substances
in the prevention and treatment of various diseases. Nutraceuticals have been proven to protect
against a number of diseases, including cancer, diabetes, and neurodegenerative disorders.
However, the poor solubility of most phytochemicals in gastrointestinal fluid results in incom-
plete absorption and finally, no biological activity. Also, the resultant low bioavailability is a major
concern and a subject of investigation. In order to address this issue, the principles of nanotechnol-
ogy could provide a new way for efficient delivery of these nutraceuticals with the aim of enhancing
their biological activity.
Nanotechnology has been emerging as an important tool in the nutraceutical and food industries
to improve the overall quality of life. Nanotechnology has established a new horizon by bestowing
modified properties on nanomaterials and applying them to the production of nanoformulations,
nutritional supplements, and the food industry. The application of nanotechnology can increase
solubility, improve quality, enhance lifetime, advance bioavailability, enable controlled release, and
protect the overall stability of micronutrients. For the efficient delivery of encapsulated nutraceuti-
cals, a number of formulation techniques have been developed, including nanoemulsions, micelles,
nanocapsules, nanoparticles, nanocrystals, and so on. Besides improving the bioavailability of the
nutraceuticals and their therapeutic efficacy, such nanoformulations provide targeted delivery and
sustained release.
The book Handbook of Nanotechnology in Nutraceuticals is a comprehensive description
and review of recent advances and applications of nanotechnology in nutraceuticals. The book
contains a total of 18 chapters. Chapters 1 and 2 mainly focus on the applications of nanotech-
nology in the field of nutraceuticals. The challenges and opportunities of nanoceuticals in future
market scenarios are analyzed. Chapter 3 presents a scientometric approach to analyze the emer-
gence of nano-nutraceuticals in cancer prevention and treatment. Chapters 4 to 11 analyze vari-
ous strategies employed to prepare nanocarrier systems, such as nanoparticles, nanostructure
lipids, phospholipid-based nanocarriers, polysaccharide-based nanostructures, metal nanopar-
ticles, and so on, for nutraceuticals and therapeutic applications. Chapters 12 to 17 present the
applications of nano-nutraceuticals in different fields, such as medicine, oxidative stress, cancer
treatment, neurodegenerative disorders, cardiovascular diseases, and so forth. Finally, Chapter
18 discusses the various regulatory issues related to nanotechnology and their application in
different fields.
Therefore, this book will serve as an important reference for nanotechnologists, scientists,
and researchers working in the fields of food technology, food science, pharmaceuticals, and
nutraceuticals.
vii
viii Preface
Finally, the editors would like to extend their sincere gratitude to all the contributors for provid-
ing help, support, and their contribution to accomplish this mission.
Shakeel Ahmed
Tanima Bhattacharya
Annu
Akbar Ali
Jammu and Kashmir, India
Editors
Dr. Shakeel Ahmed is an Assistant Professor of Chemistry in the Higher
Education Department, Government of Jammu and Kashmir, India. He
obtained a first degree in general science from the Government Postgraduate
College Rajouri (University of Jammu) followed by a master’s degree and
doctoral degree in chemistry from Jamia Millia Islamia, a central univer-
sity, New Delhi. He has published several research publications in the areas
of green nanomaterials and biopolymers for various applications, including
biomedical, packaging, and water treatment. He has published more than 20
books in the areas of nanomaterials and green materials with publishers of
international repute. He is the recipient of the Young Scientist Award and
Professor of the Year Award—2020. His name has been listed among the top 2% of scientists in the
world in the area of polymer chemistry.
Dr. Tanima Bhattacharya is a formulation scientist, who completed a
doctoral degree in food processing and nutrition science from the Indian
Institute of Engineering Science and Technology, Shibpur, West Bengal,
India, and gained overseas postdoctoral experience from the College of
Chemistry and Chemical Engineering, Hubei University of China. She is
interested in the fabrication of biocompatible nanostructures and studying
their properties and applications in the areas of food science and technol-
ogy and biomedical sciences. She has published several research articles in
internationally reputed journals. She is the recipient of a number of awards
from the Oil Technology Association India, the Council of Scientific and
Industrial Research–Indian Institute of Chemical Technology, American Oil Chemist Society, and
West Bengal State Council (Science Congress) for contribution to research.
Dr. Annu is an Assistant Professor in the Department of Chemistry in
Lingaya’s Vidyapeeth, Haryana, India. She is an Honorary Assistant
Professor in the Department of Science and Engineering at the Novel
Global Community Education Foundation, Australia. She worked as a
Project Assistant at the Indian Institute of Technology Delhi in 2020. She
obtained her graduation and postgraduation degrees in chemistry from the
University of Allahabad and a doctoral degree in chemistry from Jamia
Millia Islamia, a central university, New Delhi. She has published several
scientific research articles in international peer-reviewed journals and many
book chapters with publishers of international repute. Her research inter-
ests include the fabrication and modification of sustainable bionanocomposites, biomaterials, green
synthesis of nanoparticles, hybrid nanomaterials, and modification of biopolymers and composite
nanomaterials for their applications in the biomedical field, food packaging, nutraceuticals, textiles,
and environmental sustainability.
ix
