Handbook of Clinical Trials in Ophthalmology

336 Pages·2014·7.028 MB·English

by  AK Gupta, Vinod Kumar Aggarwal, Neha Goel, Barun Kumar Nayak

Handbook of Clinical Trials in
Ophthalmology

Handbook of Clinical Trials in
Ophthalmology
AK Gupta
ms (aiims) fams
Director (Academic)
ICARE Eye Hospital and Postgraduate Institute, NOIDA, UP, India
Director (Academic)
Shroff Eye Centre, Kailash Colony, New Delhi, India
Formerly
Director
Guru Nanak Eye Centre, New Delhi, India
Dean
Maulana Azad Medical College, New Delhi, India
Dean
Medical faculty, University of Delhi, India
Vinod Kumar Aggarwal
ms (mamc) dnb mnams frcs (Glasg)
Assistant Professor
University College of Medical Sciences and GTB Hospital
Delhi, India
Neha Goel
ms (mamc) dnb frcs (Glasg)
Consultant (Vitreoretina and Uvea)
ICARE Eye Hospital and Postgraduate Institute
NOIDA, UP, India
Foreword
Barun Kumar Nayak
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Handbook of Clinical Trials in Ophthalmology
First Edition: 2014
ISBN: 978-93-5090-774-0
Printed at
Dedicated to
All those involved in conduction of these trials

Foreword
Medical science is constantly changing and has evolved over centuries. Each
discipline in medicine has developed into many subspecialties. Today, we
are in an era of evidence-based medicine, for which clinicians have to keep
themselves updated in the knowledge and research related to their particular
field. All clinicians can neither have access to full text of all articles nor have the
time to go through them.
Handbook of Clinical Trials in Ophthalmology is authored by AK Gupta,
Vinod Kumar Aggarwal and Neha Goel, in response to a timely perceived
requirement. They have collected and summarized the major clinical trials in
different subspecialties in the field of ophthalmology. Each of the nineteen
chapters deals with important clinical trials of a particular subspecialty. The
format presented includes all the essential aspects of a trial, such as purpose
of study with background, study design, number of subjects with inclusion
and exclusion criteria, and outcomes measures. It is followed by results with
conclusion nicely summarized without any distortion of facts.
The special feature is the summary of important facts in a tabular format at
the end of each chapter giving a “bird’s eye view” of all the trials included in that
chapter. Authors have also given the expanded form of all the abbreviations
used in the text in the beginning of the book for ready reference.
Authors have done a commendable job on the topic which is need of the
hour and I personally salute them. All ophthalmologists, whether a clinician, a
postgraduate student or a teacher, will find this book useful. No ophthalmologist
can afford to miss this book and should keep it in the bookshelf for ready
reference.
I am thankful to the authors for sharing this book with me before publication
and giving me the honour of writing a foreword.
Barun Kumar Nayak MD
Head, Department of Ophthalmology
P. D. Hinduja National Hospital and Medical Research Centre
Mumbai, India
Editor: Journal of Clinical Ophthalmology and Research
Past Editor: Indian Journal of Ophthalmology

Preface
The impact of clinical trials on the practice of medicine cannot be under-
estimated. Anyone involved in healthcare today must know the basics of
running and interpreting clinical trial data. In order to form opinions and make
judgments, clinicians require access to reliable sources of evidence. Ideally,
this data should be easily accessible to the practitioners in order to implement
the latest findings in their respective field. Also, for students in this area of
specialization, this data is an invaluable resource of information on previously
conducted research. Not only does this add to their clinical acumen, this
knowledge is frequently tested in all examinations and reviews.
Although the clinical trials in the field of ophthalmology are numerous,
yet one would need to spend considerable time and effort to locate each
relevant one and learn from it. This book offers every clinical ophthalmologist
complete guidance as it compiles the results of the latest multicenter clinical
trials in the practice of ophthalmology with relevant references. The trials have
been organized into chapters, covering all ophthalmic subspecialties. Each
pertinent trial is described under similar subject headings/styles and has been
formatted accordingly for easy reading and recall. A summary at the end of
each chapter has been provided for easy reference. All the trials have been
listed alphabetically and indexed at the end.
Such significant consolidated information can be uniquely valuable to a
wide audience. The individual studies can be traced for details as the book
provides all the relevant references. This handbook is not distorting any facts
or adding any other perspective, suggestions or implications. It is an effort to
provide a convenient and quick reference for the vast data available. All the
major and latest clinical trials have been recorded but it must be understood
that the list is not exhaustive.
Knowledge of these trials in clinical practice can lead to significant
improvements in patient care and patient outcome in ophthalmology.
General ophthalmologists will have the current standard of patient care across
the spectrum of ophthalmology at their fingertips, in an easily digestible
format. Residents reviewing the major subspecialties for board exams,
comprehensive ophthalmologists keeping abreast of all areas of ophthalmology,
and subspecialists interested in future direction of their area of focus, will all find
this book a good reference.
A K Gupta
Vinod Kumar Aggarwal
Neha Goel