Handbook of Biomedical Telemetry

767 Pages·2014·12.866 MB·English

by  K. S. Nikita

HANDBOOK OF
BIOMEDICAL
TELEMETRY
IEEE Press
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IEEE Press Editorial Board
Tariq Samad, Editor in Chief
George W. Arnold Mary Lanzerotti Linda Shafer
Dmitry Goldgof Pui-In Mak MengChu Zhou
Ekram Hossain Ray Perez George Zobrist
Kenneth Moore, Director of IEEE Book and Information Services (BIS)
HANDBOOK OF
BIOMEDICAL
TELEMETRY
Editedby
KONSTANTINAS.NIKITA
IEEE Engineering in Medicine
and Biology Society, Sponsor
IEEE Press Series in Biomedical Engineering
Metin Akay, Series Editor
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LibraryofCongressCataloging-in-PublicationData:
Handbookofbiomedicaltelemetry/editedbyKonstantinaS.Nikita.
p.;cm.
Includesbibliographicalreferences.
Summary:“HandbookofBiomedicalTelemetrydescribesthemaincomponentsofatypical
biomedicaltelemetrysystemaswellasitstechnicalchallenges.AuthorK.S.Nikitaaddresses
technologiesforbiomedicalsensinganddesignofbiomedicaltelemetrydeviceswithspecialemphasis
onpowering/integrationissuesandmaterialsforbiomedicaltelemetryapplications.Coveringbiomedical
telemetrydevices,biosensornetworktopologiesandstandards,clinicalapplications,wearableand
implantabledevices,andtheeffectsonthemobilehealthcaresystem,thiscompendiumisamusthavefor
professionalengineersaswellasresearchersandgraduatestudents”–Providedbypublisher.
ISBN978-1-118-38861-7(cloth)
I.Nikita,KonstantinaS.,editorofcompilation.II.InstituteofElectricalandElectronicsEngineers.
[DNLM:1.Telemetry.2.BiosensingTechniques.QT34]
R857.M3
610.28′4–dc23
2013051203
PrintedintheUnitedStatesofAmerica
10987654321
Thisbookisdedicatedto
MariaandElias

CONTENTS
PREFACE xxi
ACKNOWLEDGMENTS xxiii
CONTRIBUTORS xxv
1 IntroductiontoBiomedicalTelemetry 1
KonstantinaS.Nikita
1.1 WhatisBiomedicalTelemetry? 1
1.2 SignificanceofArea, 3
1.3 TypicalBiomedicalTelemetrySystem, 4
1.4 ChallengesinBiomedicalTelemetry, 5
1.4.1 SpectrumRegulations, 5
1.4.2 SensingTechnologies, 7
1.4.3 AdvancedMaterials, 8
1.4.4 DataandPowerCircuits, 9
1.4.5 BiocompatibilityIssues, 10
1.4.6 StandardizationandInteroperability, 11
1.4.7 PrivacyandSecurity, 12
1.4.8 BiomedicalTelemetryTowardTelemedicine, 12
1.4.9 PatientSafety, 13
1.5 CommercialMedicalTelemetryDevices, 14
1.5.1 WearableDevices, 14
1.5.2 ImplantableDevices, 15
1.5.3 IngestibleDevices, 18
1.6 OverviewofBook, 19
References, 23
vii
viii CONTENTS
PARTI BIOMEDICALTELEMETRYDEVICES 27
2 DesignConsiderationsofBiomedicalTelemetryDevices 29
DominikCirmirakisandAndreasDemosthenous
2.1 Introduction, 29
2.2 EnergyTransferTypes, 30
2.3 ArchitectureofInductivelyCoupledBiomedicalTelemetry
Devices, 31
2.3.1 InductiveLinkFundamentals, 32
2.3.2 CouplingCompensation, 36
2.3.3 RectificationandVoltageRegulation, 37
2.3.4 TransmitterPowerAmplifier, 38
2.4 DataTransmissionMethods, 39
2.4.1 Downlink, 39
2.4.2 Uplink, 42
2.5 SafetyIssues, 44
2.5.1 ImplantHeating, 45
2.5.2 TransmissiontoHumanBody, 46
2.5.3 TransmissionfromHumanBody, 46
2.6 Conclusion, 51
References, 51
3 SensingPrinciplesforBiomedicalTelemetry 56
AthanasiosLioumpas,GeorgiaNtouni,andKonstantinaS.Nikita
3.1 Introduction, 56
3.2 BiosensorStructure, 57
3.2.1 DesignConstraints, 57
3.3 ElectrochemicalBiosensors, 59
3.3.1 AmperometricElectrochemicalBiosensors, 60
3.3.2 PotentiometricElectrochemicalBiosensors, 61
3.3.3 ImpedimetricElectrochemicalBiosensors, 62
3.4 OpticalBiosensors, 63
3.4.1 IntegratedOpticalBiosensors, 64
3.4.2 InterferometricArchitectures, 64
3.4.3 BiosensorsBasedonAntiresonantReflectingOptical
Waveguides, 66
3.4.4 BiosensorsBasedonSurfacePlasmonResonance, 66
3.5 Thermal/CalorimetricBiosensors, 67
3.6 PiezoelectricBiosensors, 69
3.7 OtherTypesofBiosensors, 71
3.7.1 MagneticBiosensors, 71
3.7.2 PyroelectricBiosensors, 71
3.7.3 IonChannelBiosensors, 72